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Adenocarcinoma

MedGen UID:
122
Concept ID:
C0001418
Neoplastic Process
Synonyms: Adenocarcinomas; Adenoma, Malignant; Adenomas, Malignant; Malignant Adenoma; Malignant Adenomas
SNOMED CT: Adenocarcinoma (1187332001)
 
Monarch Initiative: MONDO:0004970

Definition

A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma

Professional guidelines

PubMed

Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article

Recent clinical studies

Etiology

Baraban E, Epstein J
Surg Pathol Clin 2022 Dec;15(4):579-589. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.008. PMID: 36344176
Manabe N, Matsueda K, Haruma K
Digestion 2022;103(1):29-36. Epub 2021 Oct 29 doi: 10.1159/000519602. PMID: 34718236
Borczuk AC
Mod Pathol 2022 Jan;35(Suppl 1):28-35. Epub 2021 Oct 6 doi: 10.1038/s41379-021-00934-3. PMID: 34615984
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Mikami Y
Histopathology 2020 Jan;76(1):102-111. doi: 10.1111/his.13993. PMID: 31846534

Diagnosis

Gates JC, Gargano SM, Cherkas E, Kraus DH, Tuluc M
J Oral Maxillofac Surg 2021 Sep;79(9):1970-1976. Epub 2021 Apr 20 doi: 10.1016/j.joms.2021.03.027. PMID: 34023291
Pascoe HM, Knipe HC, Pascoe D, Heinze SB
J Med Imaging Radiat Oncol 2018 Oct;62(5):654-661. Epub 2018 Aug 6 doi: 10.1111/1754-9485.12779. PMID: 30079974
Leivo I
Head Neck Pathol 2017 Sep;11(3):295-300. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0800-7. PMID: 28321774Free PMC Article
Hruban RH, Klimstra DS
Semin Diagn Pathol 2014 Nov;31(6):443-451. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.004. PMID: 25441308Free PMC Article
Zhong M, Gersbach E, Rohan SM, Yang XJ
Arch Pathol Lab Med 2013 Mar;137(3):371-81. doi: 10.5858/arpa.2012-0076-RA. PMID: 23451748

Therapy

Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Milano G, Innocenti F, Minami H
Cancer Sci 2022 Jul;113(7):2224-2231. Epub 2022 May 26 doi: 10.1111/cas.15377. PMID: 35445479Free PMC Article
Smithy JW, O'Reilly EM
J Surg Oncol 2021 May;123(6):1475-1488. doi: 10.1002/jso.26359. PMID: 33831245Free PMC Article
Müller PC, Frey MC, Ruzza CM, Nickel F, Jost C, Gwerder C, Hackert T, Z'graggen K, Kessler U
Pharmacology 2021;106(3-4):143-153. Epub 2020 Sep 23 doi: 10.1159/000510343. PMID: 32966993
Sexton RE, Al Hallak MN, Diab M, Azmi AS
Cancer Metastasis Rev 2020 Dec;39(4):1179-1203. Epub 2020 Sep 7 doi: 10.1007/s10555-020-09925-3. PMID: 32894370Free PMC Article

Prognosis

Jakobsen E, Olsen KE, Bliddal M, Hornbak M, Persson GF, Green A
BMC Cancer 2021 Sep 3;21(1):985. doi: 10.1186/s12885-021-08696-6. PMID: 34479490Free PMC Article
Khalaf N, El-Serag HB, Abrams HR, Thrift AP
Clin Gastroenterol Hepatol 2021 May;19(5):876-884. Epub 2020 Mar 6 doi: 10.1016/j.cgh.2020.02.054. PMID: 32147593Free PMC Article
He H, Chen N, Hou Y, Wang Z, Zhang Y, Zhang G, Fu J
Thorac Cancer 2020 May;11(5):1121-1128. Epub 2020 Mar 10 doi: 10.1111/1759-7714.13311. PMID: 32154652Free PMC Article
McTiernan A, Friedenreich CM, Katzmarzyk PT, Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B, Tennant B, Vaux-Bjerke A, George SM, Troiano RP, Piercy KL; 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*
Med Sci Sports Exerc 2019 Jun;51(6):1252-1261. doi: 10.1249/MSS.0000000000001937. PMID: 31095082Free PMC Article
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article

Clinical prediction guides

Thota PN, Alkhayyat M, Gomez Cifuentes JD, Haider M, Bena J, McMichael J, Sohal DP, Raja S, Sanaka MR
J Clin Gastroenterol 2022 Feb 1;56(2):125-132. doi: 10.1097/MCG.0000000000001489. PMID: 33405434Free PMC Article
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
Gordetsky J, Epstein J
Diagn Pathol 2016 Mar 9;11:25. doi: 10.1186/s13000-016-0478-2. PMID: 26956509Free PMC Article
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179

Recent systematic reviews

Rees JR, Lao-Sirieix P, Wong A, Fitzgerald RC
Cochrane Database Syst Rev 2021 Mar 4;3(3):CD004060. doi: 10.1002/14651858.CD004060.pub3. PMID: 33661543Free PMC Article
Asthana S, Busa V, Labani S
Eur J Obstet Gynecol Reprod Biol 2020 Apr;247:163-175. Epub 2020 Feb 21 doi: 10.1016/j.ejogrb.2020.02.014. PMID: 32114321
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D
Environ Health Perspect 2014 Sep;122(9):906-11. Epub 2014 Jun 6 doi: 10.1289/ehp/1408092. PMID: 24911630Free PMC Article
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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