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Atonic postpartum hemorrhage

MedGen UID:
124353
•Concept ID:
C0269899
•
Pathologic Function
Synonyms: Hemorrhage, Immediate Postpartum; Immediate Postpartum Hemorrhage; Postpartum Hemorrhage, Immediate
SNOMED CT: Atonic postpartum hemorrhage (27214003); Immediate postpartum hemorrhage (27214003); Hemorrhage within 24 hours following delivery of placenta (27214003)

Definition

Cumulative blood loss of greater than or equal to 1000 ML or blood loss accompanied by signs or symptoms of hypovolemia within 24 hours following the birth process (includes intrapartum loss). (reVITALize) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtonic postpartum hemorrhage

Professional guidelines

PubMed

Atonic Postpartum Hemorrhage: Blood Loss, Risk Factors, and Third Stage Management.
Lisonkova S, Mehrabadi A, Allen VM, Bujold E, Crane JM, Gaudet L, Gratton RJ, Ladhani NN, Olatunbosun OA, Joseph KS
J Obstet Gynaecol Can 2016 Dec;38(12):1081-1090.e2. Epub 2016 Aug 17 doi: 10.1016/j.jogc.2016.06.014. PMID: 27986181
Prostaglandin E2 analogue sulprostone for treatment of atonic postpartum hemorrhage.
Schmitz T, Tararbit K, Dupont C, Rudigoz RC, Bouvier-Colle MH, Deneux-Tharaux C; Pithagore6 group
Obstet Gynecol 2011 Aug;118(2 Pt 1):257-265. doi: 10.1097/AOG.0b013e3182255335. PMID: 21775840

Recent clinical studies

Etiology

Is there a relationship between plasma, cytokine concentrations, and the subsequent risk of postpartum hemorrhage?
Jiang H, Shi H, Chen L, Yang J, Yuan P, Wang W, Pang Y, Wei Y, Zhao Y
Am J Obstet Gynecol 2022 Jun;226(6):835.e1-835.e17. Epub 2021 Dec 15 doi: 10.1016/j.ajog.2021.12.021. PMID: 34919894
Risk Factors for Atonic Postpartum Hemorrhage: A Systematic Review and Meta-analysis.
Ende HB, Lozada MJ, Chestnut DH, Osmundson SS, Walden RL, Shotwell MS, Bauchat JR
Obstet Gynecol 2021 Feb 1;137(2):305-323. doi: 10.1097/AOG.0000000000004228. PMID: 33417319Free PMC Article
Novel subtype of atonic postpartum hemorrhage: dynamic computed tomography evaluation of bleeding characteristics and the uterine cavity.
Ikeda A, Kondoh E, Chigusa Y, Mogami H, Kameyama Nakao K, Kido A, Horie A, Baba T, Hamanishi J, Mandai M
J Matern Fetal Neonatal Med 2020 Oct;33(19):3286-3292. Epub 2019 Jan 31 doi: 10.1080/14767058.2019.1571033. PMID: 30651015
Atonic Postpartum Hemorrhage: Blood Loss, Risk Factors, and Third Stage Management.
Lisonkova S, Mehrabadi A, Allen VM, Bujold E, Crane JM, Gaudet L, Gratton RJ, Ladhani NN, Olatunbosun OA, Joseph KS
J Obstet Gynaecol Can 2016 Dec;38(12):1081-1090.e2. Epub 2016 Aug 17 doi: 10.1016/j.jogc.2016.06.014. PMID: 27986181
Uterine salvage management for atonic postpartum hemorrhage using "modified lynch suture".
El-Sokkary M, Wahba K, El-Shahawy Y
BMC Pregnancy Childbirth 2016 Aug 27;16(1):251. doi: 10.1186/s12884-016-1000-2. PMID: 27567670Free PMC Article

Diagnosis

Menstrual, fertility and psychological impacts after uterine compression sutures for postpartum hemorrhage: a prospective cohort study.
Kwong LT, Wong SF, So PL
BMC Pregnancy Childbirth 2023 Mar 29;23(1):217. doi: 10.1186/s12884-023-05530-8. PMID: 36991358Free PMC Article
Resuscitative endovascular balloon occlusion of the aorta for life-threatening postpartum hemorrhage: A nationwide observational study in Japan.
Kamijo K, Nakajima M, Shigemi D, Kaszynski RH, Ohbe H, Goto T, Sasabuchi Y, Fushimi K, Matsui H, Yasunaga H
J Trauma Acute Care Surg 2022 Sep 1;93(3):418-423. Epub 2022 Apr 21 doi: 10.1097/TA.0000000000003650. PMID: 35444149
Is there a relationship between plasma, cytokine concentrations, and the subsequent risk of postpartum hemorrhage?
Jiang H, Shi H, Chen L, Yang J, Yuan P, Wang W, Pang Y, Wei Y, Zhao Y
Am J Obstet Gynecol 2022 Jun;226(6):835.e1-835.e17. Epub 2021 Dec 15 doi: 10.1016/j.ajog.2021.12.021. PMID: 34919894
Is early intervention using Mansoura-VV uterine compression sutures an effective procedure in the management of primary atonic postpartum hemorrhage? : a prospective study.
El Refaeey AEA, Abdelfattah H, Mosbah A, Gamal AM, Fayla E, Refaie W, Zaied A, Barakat RI, Seleem AK, Maher M
BMC Pregnancy Childbirth 2017 May 31;17(1):160. doi: 10.1186/s12884-017-1349-x. PMID: 28569213Free PMC Article
Atonic Postpartum Hemorrhage: Blood Loss, Risk Factors, and Third Stage Management.
Lisonkova S, Mehrabadi A, Allen VM, Bujold E, Crane JM, Gaudet L, Gratton RJ, Ladhani NN, Olatunbosun OA, Joseph KS
J Obstet Gynaecol Can 2016 Dec;38(12):1081-1090.e2. Epub 2016 Aug 17 doi: 10.1016/j.jogc.2016.06.014. PMID: 27986181

Therapy

The association between maternal vitamin D deficiency and postpartum hemorrhage and uterine atony.
Sörsjö Stevenazzi A, Pihl S, Blomberg M, Axelsson D
Acta Obstet Gynecol Scand 2024 Feb;103(2):286-293. Epub 2023 Nov 14 doi: 10.1111/aogs.14719. PMID: 37960966Free PMC Article
Menstrual, fertility and psychological impacts after uterine compression sutures for postpartum hemorrhage: a prospective cohort study.
Kwong LT, Wong SF, So PL
BMC Pregnancy Childbirth 2023 Mar 29;23(1):217. doi: 10.1186/s12884-023-05530-8. PMID: 36991358Free PMC Article
Risk Factors for Atonic Postpartum Hemorrhage: A Systematic Review and Meta-analysis.
Ende HB, Lozada MJ, Chestnut DH, Osmundson SS, Walden RL, Shotwell MS, Bauchat JR
Obstet Gynecol 2021 Feb 1;137(2):305-323. doi: 10.1097/AOG.0000000000004228. PMID: 33417319Free PMC Article
Uterine salvage management for atonic postpartum hemorrhage using "modified lynch suture".
El-Sokkary M, Wahba K, El-Shahawy Y
BMC Pregnancy Childbirth 2016 Aug 27;16(1):251. doi: 10.1186/s12884-016-1000-2. PMID: 27567670Free PMC Article
Uterine folding hemostasis: a simpler and safer technique for controlling atonic postpartum hemorrhage.
Li GT, Li GR, Xu HM, Wu BP, Wang XN
Arch Gynecol Obstet 2016 Oct;294(4):689-95. Epub 2016 Jan 21 doi: 10.1007/s00404-016-4009-x. PMID: 26796679

Prognosis

The association between maternal vitamin D deficiency and postpartum hemorrhage and uterine atony.
Sörsjö Stevenazzi A, Pihl S, Blomberg M, Axelsson D
Acta Obstet Gynecol Scand 2024 Feb;103(2):286-293. Epub 2023 Nov 14 doi: 10.1111/aogs.14719. PMID: 37960966Free PMC Article
Is there a relationship between plasma, cytokine concentrations, and the subsequent risk of postpartum hemorrhage?
Jiang H, Shi H, Chen L, Yang J, Yuan P, Wang W, Pang Y, Wei Y, Zhao Y
Am J Obstet Gynecol 2022 Jun;226(6):835.e1-835.e17. Epub 2021 Dec 15 doi: 10.1016/j.ajog.2021.12.021. PMID: 34919894
Novel subtype of atonic postpartum hemorrhage: dynamic computed tomography evaluation of bleeding characteristics and the uterine cavity.
Ikeda A, Kondoh E, Chigusa Y, Mogami H, Kameyama Nakao K, Kido A, Horie A, Baba T, Hamanishi J, Mandai M
J Matern Fetal Neonatal Med 2020 Oct;33(19):3286-3292. Epub 2019 Jan 31 doi: 10.1080/14767058.2019.1571033. PMID: 30651015
The impact of postpartum hemorrhage on hospital length of stay and inpatient mortality: a National Inpatient Sample-based analysis.
Marshall AL, Durani U, Bartley A, Hagen CE, Ashrani A, Rose C, Go RS, Pruthi RK
Am J Obstet Gynecol 2017 Sep;217(3):344.e1-344.e6. Epub 2017 May 11 doi: 10.1016/j.ajog.2017.05.004. PMID: 28502758
Symbol "&" suture to control atonic postpartum hemorrhage with placenta previa accreta.
Li GT, Li XF, Liu YJ, Li W, Xu HM
Arch Gynecol Obstet 2015 Feb;291(2):305-10. Epub 2014 Oct 7 doi: 10.1007/s00404-014-3502-3. PMID: 25288270

Clinical prediction guides

The association between maternal vitamin D deficiency and postpartum hemorrhage and uterine atony.
Sörsjö Stevenazzi A, Pihl S, Blomberg M, Axelsson D
Acta Obstet Gynecol Scand 2024 Feb;103(2):286-293. Epub 2023 Nov 14 doi: 10.1111/aogs.14719. PMID: 37960966Free PMC Article
Menstrual, fertility and psychological impacts after uterine compression sutures for postpartum hemorrhage: a prospective cohort study.
Kwong LT, Wong SF, So PL
BMC Pregnancy Childbirth 2023 Mar 29;23(1):217. doi: 10.1186/s12884-023-05530-8. PMID: 36991358Free PMC Article
Is there a relationship between plasma, cytokine concentrations, and the subsequent risk of postpartum hemorrhage?
Jiang H, Shi H, Chen L, Yang J, Yuan P, Wang W, Pang Y, Wei Y, Zhao Y
Am J Obstet Gynecol 2022 Jun;226(6):835.e1-835.e17. Epub 2021 Dec 15 doi: 10.1016/j.ajog.2021.12.021. PMID: 34919894
Novel subtype of atonic postpartum hemorrhage: dynamic computed tomography evaluation of bleeding characteristics and the uterine cavity.
Ikeda A, Kondoh E, Chigusa Y, Mogami H, Kameyama Nakao K, Kido A, Horie A, Baba T, Hamanishi J, Mandai M
J Matern Fetal Neonatal Med 2020 Oct;33(19):3286-3292. Epub 2019 Jan 31 doi: 10.1080/14767058.2019.1571033. PMID: 30651015
Atonic Postpartum Hemorrhage: Blood Loss, Risk Factors, and Third Stage Management.
Lisonkova S, Mehrabadi A, Allen VM, Bujold E, Crane JM, Gaudet L, Gratton RJ, Ladhani NN, Olatunbosun OA, Joseph KS
J Obstet Gynaecol Can 2016 Dec;38(12):1081-1090.e2. Epub 2016 Aug 17 doi: 10.1016/j.jogc.2016.06.014. PMID: 27986181

Recent systematic reviews

Risk Factors for Atonic Postpartum Hemorrhage: A Systematic Review and Meta-analysis.
Ende HB, Lozada MJ, Chestnut DH, Osmundson SS, Walden RL, Shotwell MS, Bauchat JR
Obstet Gynecol 2021 Feb 1;137(2):305-323. doi: 10.1097/AOG.0000000000004228. PMID: 33417319Free PMC Article

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