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Paraneoplastic polyneuropathy

MedGen UID:
124380
Concept ID:
C0270932
Disease or Syndrome
Synonyms: Neuropathies, Paraneoplastic; Neuropathies, Paraneoplastic Peripheral; Neuropathy, Paraneoplastic; Neuropathy, Paraneoplastic Peripheral; Paraneoplastic Neuropathies; Paraneoplastic Neuropathy; Paraneoplastic Peripheral Neuropathies; Paraneoplastic Peripheral Neuropathy; Paraneoplastic Polyneuropathies; Paraneoplastic Polyneuropathy; Peripheral Neuropathies, Paraneoplastic; Peripheral Neuropathy, Paraneoplastic; Polyneuropathies, Paraneoplastic; Polyneuropathy, Paraneoplastic
SNOMED CT: Carcinomatous neuropathy (77659000); Paraneoplastic polyneuropathy (77659000); Polyneuropathy in malignant disease (77659000); Paraneoplastic neuropathy (77659000); Carcinomatous peripheral neuropathy (77659000); Paraneoplastic peripheral neuropathy (21361000119109)
 
Monarch Initiative: MONDO:0006888

Definition

A diffuse or multifocal peripheral neuropathy caused by the effects of a distant neoplasm. It may be attributed, in part, to the immune response to neoplasm-elaborated proteins. The neuropathy may be sensory, motor, mixed or autonomic. It may be the initial presentation of an occult neoplasm. Detection and resection of the neoplasm may result in cure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaneoplastic polyneuropathy

Professional guidelines

PubMed

Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139
Pelosof LC, Gerber DE
Mayo Clin Proc 2010 Sep;85(9):838-54. doi: 10.4065/mcp.2010.0099. PMID: 20810794Free PMC Article

Recent clinical studies

Etiology

Shah S, Vazquez Do Campo R, Kumar N, McKeon A, Flanagan EP, Klein C, Pittock SJ, Dubey D
Neurology 2021 Jan 26;96(4):e632-e639. Epub 2020 Nov 18 doi: 10.1212/WNL.0000000000011218. PMID: 33208548Free PMC Article
Graus F, Dalmau J
Curr Opin Neurol 2013 Oct;26(5):489-95. doi: 10.1097/WCO.0b013e328364c020. PMID: 23892629
Giometto B, Vitaliani R, Lindeck-Pozza E, Grisold W, Vedeler C
Cochrane Database Syst Rev 2012 Dec 12;12:CD007625. doi: 10.1002/14651858.CD007625.pub2. PMID: 23235647
Braik T, Evans AT, Telfer M, McDunn S
Am J Med Sci 2010 Oct;340(4):301-8. doi: 10.1097/MAJ.0b013e3181d9bb3b. PMID: 20460982
Skeie GO, Romi F
Eur J Neurol 2008 Oct;15(10):1029-33. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02242.x. PMID: 18717725

Diagnosis

Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Muppidi S, Vernino S
Continuum (Minneap Minn) 2014 Oct;20(5 Peripheral Nervous System Disorders):1359-72. doi: 10.1212/01.CON.0000455876.53309.ec. PMID: 25299287
Koike H, Sobue G
Handb Clin Neurol 2013;115:713-26. doi: 10.1016/B978-0-444-52902-2.00041-2. PMID: 23931811
Graus F, Dalmau J
Curr Opin Neurol 2013 Oct;26(5):489-95. doi: 10.1097/WCO.0b013e328364c020. PMID: 23892629
Pelosof LC, Gerber DE
Mayo Clin Proc 2010 Sep;85(9):838-54. doi: 10.4065/mcp.2010.0099. PMID: 20810794Free PMC Article

Therapy

Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Graus F, Dalmau J
Curr Opin Neurol 2013 Oct;26(5):489-95. doi: 10.1097/WCO.0b013e328364c020. PMID: 23892629
Giometto B, Vitaliani R, Lindeck-Pozza E, Grisold W, Vedeler C
Cochrane Database Syst Rev 2012 Dec 12;12:CD007625. doi: 10.1002/14651858.CD007625.pub2. PMID: 23235647
Skeie GO, Romi F
Eur J Neurol 2008 Oct;15(10):1029-33. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02242.x. PMID: 18717725
Voltz R
J Neurol 2006 Sep;253 Suppl 5:V33-8. doi: 10.1007/s00415-006-5005-z. PMID: 16998752

Prognosis

Taams NE, Notermans NC, Fokkink WR, Tio-Gillen AP, Huizinga R, Schreurs MWJ, Jacobs BC
J Peripher Nerv Syst 2018 Dec;23(4):227-234. Epub 2018 Sep 12 doi: 10.1111/jns.12285. PMID: 30101437
Goedee HS, Brekelmans GJ, van Asseldonk JT, Beekman R, Mess WH, Visser LH
Eur J Neurol 2013 Oct;20(10):1342-51. Epub 2013 May 23 doi: 10.1111/ene.12182. PMID: 23701599
Cortese I, Cornblath DR
J Clin Apher 2013 Feb;28(1):16-9. doi: 10.1002/jca.21266. PMID: 23420591Free PMC Article
Skeie GO, Romi F
Eur J Neurol 2008 Oct;15(10):1029-33. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02242.x. PMID: 18717725
Pittock SJ, Lucchinetti CF
Curr Opin Neurol 2006 Aug;19(4):362-8. doi: 10.1097/01.wco.0000236615.59215.d3. PMID: 16914974

Clinical prediction guides

Shah S, Vazquez Do Campo R, Kumar N, McKeon A, Flanagan EP, Klein C, Pittock SJ, Dubey D
Neurology 2021 Jan 26;96(4):e632-e639. Epub 2020 Nov 18 doi: 10.1212/WNL.0000000000011218. PMID: 33208548Free PMC Article
Giometto B, Vitaliani R, Lindeck-Pozza E, Grisold W, Vedeler C
Cochrane Database Syst Rev 2012 Dec 12;12:CD007625. doi: 10.1002/14651858.CD007625.pub2. PMID: 23235647
Koike H, Tanaka F, Sobue G
Curr Opin Neurol 2011 Oct;24(5):504-10. doi: 10.1097/WCO.0b013e32834a87b7. PMID: 21799410
Blaes F, Tschernatsch M
Expert Rev Neurother 2010 Oct;10(10):1559-68. doi: 10.1586/ern.10.134. PMID: 20925471
Skeie GO, Romi F
Eur J Neurol 2008 Oct;15(10):1029-33. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02242.x. PMID: 18717725

Recent systematic reviews

Giometto B, Vitaliani R, Lindeck-Pozza E, Grisold W, Vedeler C
Cochrane Database Syst Rev 2012 Dec 12;12:CD007625. doi: 10.1002/14651858.CD007625.pub2. PMID: 23235647

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