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Paraneoplastic polyneuropathy

MedGen UID:
124380
•Concept ID:
C0270932
•
Disease or Syndrome
Synonyms: Neuropathies, Paraneoplastic; Neuropathies, Paraneoplastic Peripheral; Neuropathy, Paraneoplastic; Neuropathy, Paraneoplastic Peripheral; Paraneoplastic Neuropathies; Paraneoplastic Neuropathy; Paraneoplastic Peripheral Neuropathies; Paraneoplastic Peripheral Neuropathy; Paraneoplastic Polyneuropathies; Paraneoplastic Polyneuropathy; Peripheral Neuropathies, Paraneoplastic; Peripheral Neuropathy, Paraneoplastic; Polyneuropathies, Paraneoplastic; Polyneuropathy, Paraneoplastic
SNOMED CT: Carcinomatous neuropathy (77659000); Paraneoplastic polyneuropathy (77659000); Polyneuropathy in malignant disease (77659000); Paraneoplastic neuropathy (77659000); Carcinomatous peripheral neuropathy (77659000); Paraneoplastic peripheral neuropathy (21361000119109)
 
Monarch Initiative: MONDO:0006888

Definition

A diffuse or multifocal peripheral neuropathy caused by the effects of a distant neoplasm. It may be attributed, in part, to the immune response to neoplasm-elaborated proteins. The neuropathy may be sensory, motor, mixed or autonomic. It may be the initial presentation of an occult neoplasm. Detection and resection of the neoplasm may result in cure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaneoplastic polyneuropathy

Professional guidelines

PubMed

Chronic inflammatory demyelinating polyradiculoneuropathy-Diagnostic pitfalls and treatment approach.
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139
Paraneoplastic syndromes: an approach to diagnosis and treatment.
Pelosof LC, Gerber DE
Mayo Clin Proc 2010 Sep;85(9):838-54. doi: 10.4065/mcp.2010.0099. PMID: 20810794Free PMC Article

Recent clinical studies

Etiology

Paraneoplastic Myeloneuropathies: Clinical, Oncologic, and Serologic Accompaniments.
Shah S, Vazquez Do Campo R, Kumar N, McKeon A, Flanagan EP, Klein C, Pittock SJ, Dubey D
Neurology 2021 Jan 26;96(4):e632-e639. Epub 2020 Nov 18 doi: 10.1212/WNL.0000000000011218. PMID: 33208548Free PMC Article
Paraneoplastic neuropathies.
Graus F, Dalmau J
Curr Opin Neurol 2013 Oct;26(5):489-95. doi: 10.1097/WCO.0b013e328364c020. PMID: 23892629
Treatment for paraneoplastic neuropathies.
Giometto B, Vitaliani R, Lindeck-Pozza E, Grisold W, Vedeler C
Cochrane Database Syst Rev 2012 Dec 12;12:CD007625. doi: 10.1002/14651858.CD007625.pub2. PMID: 23235647
Paraneoplastic neurological syndromes: unusual presentations of cancer. A practical review.
Braik T, Evans AT, Telfer M, McDunn S
Am J Med Sci 2010 Oct;340(4):301-8. doi: 10.1097/MAJ.0b013e3181d9bb3b. PMID: 20460982
Paraneoplastic myasthenia gravis: immunological and clinical aspects.
Skeie GO, Romi F
Eur J Neurol 2008 Oct;15(10):1029-33. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02242.x. PMID: 18717725

Diagnosis

Chronic inflammatory demyelinating polyradiculoneuropathy-Diagnostic pitfalls and treatment approach.
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Paraneoplastic neuropathies.
Antoine JC, Camdessanché JP
Curr Opin Neurol 2017 Oct;30(5):513-520. doi: 10.1097/WCO.0000000000000475. PMID: 28682959
Paraneoplastic neuropathies.
Muppidi S, Vernino S
Continuum (Minneap Minn) 2014 Oct;20(5 Peripheral Nervous System Disorders):1359-72. doi: 10.1212/01.CON.0000455876.53309.ec. PMID: 25299287
Paraneoplastic neuropathy.
Koike H, Sobue G
Handb Clin Neurol 2013;115:713-26. doi: 10.1016/B978-0-444-52902-2.00041-2. PMID: 23931811
Paraneoplastic syndromes: an approach to diagnosis and treatment.
Pelosof LC, Gerber DE
Mayo Clin Proc 2010 Sep;85(9):838-54. doi: 10.4065/mcp.2010.0099. PMID: 20810794Free PMC Article

Therapy

Chronic inflammatory demyelinating polyradiculoneuropathy-Diagnostic pitfalls and treatment approach.
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Paraneoplastic neuropathies.
Graus F, Dalmau J
Curr Opin Neurol 2013 Oct;26(5):489-95. doi: 10.1097/WCO.0b013e328364c020. PMID: 23892629
Treatment for paraneoplastic neuropathies.
Giometto B, Vitaliani R, Lindeck-Pozza E, Grisold W, Vedeler C
Cochrane Database Syst Rev 2012 Dec 12;12:CD007625. doi: 10.1002/14651858.CD007625.pub2. PMID: 23235647
Paraneoplastic myasthenia gravis: immunological and clinical aspects.
Skeie GO, Romi F
Eur J Neurol 2008 Oct;15(10):1029-33. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02242.x. PMID: 18717725
Intravenous immunoglobulin therapy in paraneoplastic neurological syndromes.
Voltz R
J Neurol 2006 Sep;253 Suppl 5:V33-8. doi: 10.1007/s00415-006-5005-z. PMID: 16998752

Prognosis

Clinical relevance of serum antibodies to GD1b in immune-mediated neuropathies.
Taams NE, Notermans NC, Fokkink WR, Tio-Gillen AP, Huizinga R, Schreurs MWJ, Jacobs BC
J Peripher Nerv Syst 2018 Dec;23(4):227-234. Epub 2018 Sep 12 doi: 10.1111/jns.12285. PMID: 30101437
High resolution sonography in the evaluation of the peripheral nervous system in polyneuropathy--a review of the literature.
Goedee HS, Brekelmans GJ, van Asseldonk JT, Beekman R, Mess WH, Visser LH
Eur J Neurol 2013 Oct;20(10):1342-51. Epub 2013 May 23 doi: 10.1111/ene.12182. PMID: 23701599
Paraneoplastic myasthenia gravis: immunological and clinical aspects.
Skeie GO, Romi F
Eur J Neurol 2008 Oct;15(10):1029-33. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02242.x. PMID: 18717725
Inflammatory transverse myelitis: evolving concepts.
Pittock SJ, Lucchinetti CF
Curr Opin Neurol 2006 Aug;19(4):362-8. doi: 10.1097/01.wco.0000236615.59215.d3. PMID: 16914974
Chronic polyneuropathies in Vest-Agder, Norway.
Mygland A, Monstad P
Eur J Neurol 2001 Mar;8(2):157-65. doi: 10.1046/j.1468-1331.2001.00187.x. PMID: 11284994

Clinical prediction guides

Paraneoplastic Myeloneuropathies: Clinical, Oncologic, and Serologic Accompaniments.
Shah S, Vazquez Do Campo R, Kumar N, McKeon A, Flanagan EP, Klein C, Pittock SJ, Dubey D
Neurology 2021 Jan 26;96(4):e632-e639. Epub 2020 Nov 18 doi: 10.1212/WNL.0000000000011218. PMID: 33208548Free PMC Article
Treatment for paraneoplastic neuropathies.
Giometto B, Vitaliani R, Lindeck-Pozza E, Grisold W, Vedeler C
Cochrane Database Syst Rev 2012 Dec 12;12:CD007625. doi: 10.1002/14651858.CD007625.pub2. PMID: 23235647
Paraneoplastic neuropathy: wide-ranging clinicopathological manifestations.
Koike H, Tanaka F, Sobue G
Curr Opin Neurol 2011 Oct;24(5):504-10. doi: 10.1097/WCO.0b013e32834a87b7. PMID: 21799410
Paraneoplastic neurological disorders.
Blaes F, Tschernatsch M
Expert Rev Neurother 2010 Oct;10(10):1559-68. doi: 10.1586/ern.10.134. PMID: 20925471
Paraneoplastic myasthenia gravis: immunological and clinical aspects.
Skeie GO, Romi F
Eur J Neurol 2008 Oct;15(10):1029-33. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02242.x. PMID: 18717725

Recent systematic reviews

Treatment for paraneoplastic neuropathies.
Giometto B, Vitaliani R, Lindeck-Pozza E, Grisold W, Vedeler C
Cochrane Database Syst Rev 2012 Dec 12;12:CD007625. doi: 10.1002/14651858.CD007625.pub2. PMID: 23235647

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