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Ciliary body disorder

MedGen UID:
124384
•Concept ID:
C0271100
•
Disease or Syndrome
Synonym: Ciliary body disease
SNOMED CT: Disorder of ciliary body (68575007)
 
Monarch Initiative: MONDO:0002970

Definition

A non-neoplastic or neoplastic disorder that affects the ciliary body. [from NCI]

Professional guidelines

PubMed

Matrix Metalloproteinases and Glaucoma Treatment.
Weinreb RN, Robinson MR, Dibas M, Stamer WD
J Ocul Pharmacol Ther 2020 May;36(4):208-228. Epub 2020 Apr 1 doi: 10.1089/jop.2019.0146. PMID: 32233938Free PMC Article
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Cellular signalling by primary cilia in development, organ function and disease.
Anvarian Z, Mykytyn K, Mukhopadhyay S, Pedersen LB, Christensen ST
Nat Rev Nephrol 2019 Apr;15(4):199-219. doi: 10.1038/s41581-019-0116-9. PMID: 30733609Free PMC Article
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular adverse effects of common psychotropic agents: a review.
Richa S, Yazbek JC
CNS Drugs 2010 Jun;24(6):501-26. doi: 10.2165/11533180-000000000-00000. PMID: 20443647

Diagnosis

Understanding Primary Ciliary Dyskinesia and Other Ciliopathies.
Horani A, Ferkol TW
J Pediatr 2021 Mar;230:15-22.e1. Epub 2020 Nov 23 doi: 10.1016/j.jpeds.2020.11.040. PMID: 33242470Free PMC Article
Protein Biomarkers in Uveitis.
Bansal R, Gupta A
Front Immunol 2020;11:610428. Epub 2020 Dec 3 doi: 10.3389/fimmu.2020.610428. PMID: 33343583Free PMC Article
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Therapy

Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Bronchiectasis.
Magis-Escurra C, Reijers MH
BMJ Clin Evid 2015 Feb 25;2015 PMID: 25715965Free PMC Article
Endoscopic cyclophotocoagulation.
Seibold LK, SooHoo JR, Kahook MY
Middle East Afr J Ophthalmol 2015 Jan-Mar;22(1):18-24. doi: 10.4103/0974-9233.148344. PMID: 25624669Free PMC Article
Ocular adverse effects of common psychotropic agents: a review.
Richa S, Yazbek JC
CNS Drugs 2010 Jun;24(6):501-26. doi: 10.2165/11533180-000000000-00000. PMID: 20443647
Tuberculosis.
Bonfioli AA, de Miranda SS, Campos WR, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):169-75. doi: 10.1080/08820530500231912. PMID: 16282151

Prognosis

DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Protein Biomarkers in Uveitis.
Bansal R, Gupta A
Front Immunol 2020;11:610428. Epub 2020 Dec 3 doi: 10.3389/fimmu.2020.610428. PMID: 33343583Free PMC Article
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Clinical prediction guides

Protein Biomarkers in Uveitis.
Bansal R, Gupta A
Front Immunol 2020;11:610428. Epub 2020 Dec 3 doi: 10.3389/fimmu.2020.610428. PMID: 33343583Free PMC Article
Imaging of DICER1 syndrome.
Guillerman RP, Foulkes WD, Priest JR
Pediatr Radiol 2019 Oct;49(11):1488-1505. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04429-x. PMID: 31620849
Uveal Melanoma Treatment and Prognostication.
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Recent systematic reviews

The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis.
Stålhammar G, Gill VT
Crit Rev Oncol Hematol 2022 Apr;172:103652. Epub 2022 Mar 15 doi: 10.1016/j.critrevonc.2022.103652. PMID: 35304261
Corticosteroid implants for chronic non-infectious uveitis.
Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J
Cochrane Database Syst Rev 2016 Feb 12;2(2):CD010469. doi: 10.1002/14651858.CD010469.pub2. PMID: 26866343Free PMC Article
PLATEAU IRIS--DIAGNOSIS AND TREATMENT.
Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109Free PMC Article
Bronchiectasis.
Magis-Escurra C, Reijers MH
BMJ Clin Evid 2015 Feb 25;2015 PMID: 25715965Free PMC Article
Uveal melanoma: trends in incidence, treatment, and survival.
Singh AD, Turell ME, Topham AK
Ophthalmology 2011 Sep;118(9):1881-5. Epub 2011 Jun 24 doi: 10.1016/j.ophtha.2011.01.040. PMID: 21704381

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