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Purpura simplex

MedGen UID:
124424
Concept ID:
C0272309
Disease or Syndrome
Synonym: Hereditary familial purpura simplex
SNOMED CT: Purpura simplex (277791008)
 
Monarch Initiative: MONDO:0008354
OMIM®: 179000

Clinical features

From HPO
Epistaxis
MedGen UID:
4996
Concept ID:
C0014591
Pathologic Function
Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose.
Menorrhagia
MedGen UID:
44358
Concept ID:
C0025323
Pathologic Function
Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.
Purpura
MedGen UID:
19584
Concept ID:
C0034150
Disease or Syndrome
Purpura (from Latin
Bruising susceptibility
MedGen UID:
140849
Concept ID:
C0423798
Finding
An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.
Ptosis
MedGen UID:
2287
Concept ID:
C0005745
Disease or Syndrome
The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective).

Professional guidelines

PubMed

Baek G, Kim MH, Jue MS
Skin Res Technol 2022 Nov;28(6):856-864. Epub 2022 Oct 31 doi: 10.1111/srt.13225. PMID: 36314292Free PMC Article

Recent clinical studies

Etiology

Baek G, Kim MH, Jue MS
Skin Res Technol 2022 Nov;28(6):856-864. Epub 2022 Oct 31 doi: 10.1111/srt.13225. PMID: 36314292Free PMC Article
Karadag AS, Parish LC, Lambert WC
Skinmed 2017;15(2):91-92. Epub 2017 Apr 1 PMID: 28528600
Storan ER, McEvoy MT, Wetter DA, El-Azhary RA, Camilleri MJ, Bridges AG, Davis MD
Int J Dermatol 2015 Oct;54(10):1150-6. Epub 2014 Nov 10 doi: 10.1111/ijd.12555. PMID: 25384904
Pang BK, Su D, Ratnam KV
Ann Acad Med Singap 1993 Nov;22(6):870-2. PMID: 8129346
Ratnam KV, Su WP, Peters MS
J Am Acad Dermatol 1991 Oct;25(4):642-7. doi: 10.1016/0190-9622(91)70246-x. PMID: 1791222

Diagnosis

Karadag AS, Parish LC, Lambert WC
Skinmed 2017;15(2):91-92. Epub 2017 Apr 1 PMID: 28528600
Storan ER, McEvoy MT, Wetter DA, El-Azhary RA, Camilleri MJ, Bridges AG, Davis MD
Int J Dermatol 2015 Oct;54(10):1150-6. Epub 2014 Nov 10 doi: 10.1111/ijd.12555. PMID: 25384904
MOSTO SJ, CASALA AM
Arch Dermatol 1965 Apr;91:351-6. PMID: 14275499
EL-NASR HS, EL-HEFNAWI H
J Egypt Med Assoc 1963;46:1315-26. PMID: 14162108
LOEWENTHAL LJ
Br J Dermatol 1954 Mar;66(3):95-103. doi: 10.1111/j.1365-2133.1954.tb12597.x. PMID: 13149721

Therapy

Stratakis CA, Chrousos GP
Am J Hosp Pharm 1994 Oct 15;51(20):2589-91. PMID: 7847422

Prognosis

Karadag AS, Parish LC, Lambert WC
Skinmed 2017;15(2):91-92. Epub 2017 Apr 1 PMID: 28528600
Ratnam KV, Su WP, Peters MS
J Am Acad Dermatol 1991 Oct;25(4):642-7. doi: 10.1016/0190-9622(91)70246-x. PMID: 1791222

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