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Dermatopathic lymphadenitis

MedGen UID:
124427
•Concept ID:
C0272398
•
Disease or Syndrome
Synonyms: Dermatopathic lymphadenopathy; Dermatopathic Lymphadenopathy; Lipomelanotic reticuloendothelial cell hyperplasia
SNOMED CT: Dermatopathic lymphadenitis (36585007); Dermatopathic lymphadenopathy (36585007); Lipomelanotic reticuloendothelial cell hyperplasia (36585007)

Definition

Regional lymph node enlargement with a distinctive reactive process that is characterized by paracortical hyperplasia composed of interdigitating dendritic cells, Langerhans cells, macrophages containing melanin pigment, and small T-cells, due to chronic inflammatory skin disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermatopathic lymphadenitis

Professional guidelines

PubMed

Benign non-infectious causes of lymphadenopathy: A review of cytomorphology and differential diagnosis.
Monaco SE, Khalbuss WE, Pantanowitz L
Diagn Cytopathol 2012 Oct;40(10):925-38. Epub 2012 Feb 20 doi: 10.1002/dc.21767. PMID: 22351626
The histiocytoses: clinical presentation and differential diagnosis.
Gonzalez CL, Jaffe ES
Oncology (Williston Park) 1990 Nov;4(11):47-60; discussion 60, 62. PMID: 2150325
Histiocytoses of lymph nodes: biology and differential diagnosis.
Jaffe ES
Semin Diagn Pathol 1988 Nov;5(4):376-90. PMID: 3064218

Recent clinical studies

Etiology

Lymphoma and Other Lymph Node Pathologies Among Adult Patients with Lymphadenopathy in Abakaliki, Nigeria.
Ugwu NI, Iyare FE, Ugwu CN, Edegbe FO, Ezeokoli EO, Eni UE, Ugwu GC, Okparaoka SU, Uzoigwe JC, Omoruyi KA, Otuu O, Dilibe UC
Niger J Clin Pract 2024 Jan 1;27(1):68-73. Epub 2024 Feb 5 doi: 10.4103/njcp.njcp_450_23. PMID: 38317037
Histopathology and expression of the chemokines CXCL10, CXCL13, and CXCR3 and the endogenous TLR-4 ligand S100A8/A9 in lymph nodes of patients with adult-onset Still's disease.
Kim HA, Kim YH, Jeon YK, Yang WI, Kwon JE, Han JH
Sci Rep 2019 May 17;9(1):7517. doi: 10.1038/s41598-019-44032-6. PMID: 31101882Free PMC Article
Degree of CD25 expression in T-cell lymphoma is dependent on tissue site: implications for targeted therapy.
Jones D, Ibrahim S, Patel K, Luthra R, Duvic M, Medeiros LJ
Clin Cancer Res 2004 Aug 15;10(16):5587-94. doi: 10.1158/1078-0432.CCR-0721-03. PMID: 15328201
Langerhans cell histiocytosis in lymph nodes. Cytomorphologic diagnosis and pitfalls.
Kakkar S, Kapila K, Verma K
Acta Cytol 2001 May-Jun;45(3):327-32. doi: 10.1159/000327626. PMID: 11393062
Paracortical alteration in lymphadenopathic and tumor-draining lymph nodes: histologic study.
Ree H, Fanger H
Hum Pathol 1975 May;6(3):363-72. doi: 10.1016/s0046-8177(75)80098-0. PMID: 1079509

Diagnosis

A Patient with 22q11.2 Deletion Syndrome Presenting with Systemic Skin Rash and Dermatopathic Lymphadenitis of Unusual Histology.
Otsuki Y, Kobayashi H, Arai Y, Inoue N, Matsubayashi T, Koide M, Yamakawa M
Am J Case Rep 2020 Aug 26;21:e924961. doi: 10.12659/AJCR.924961. PMID: 32843611Free PMC Article
Histopathology and expression of the chemokines CXCL10, CXCL13, and CXCR3 and the endogenous TLR-4 ligand S100A8/A9 in lymph nodes of patients with adult-onset Still's disease.
Kim HA, Kim YH, Jeon YK, Yang WI, Kwon JE, Han JH
Sci Rep 2019 May 17;9(1):7517. doi: 10.1038/s41598-019-44032-6. PMID: 31101882Free PMC Article
Benign non-infectious causes of lymphadenopathy: A review of cytomorphology and differential diagnosis.
Monaco SE, Khalbuss WE, Pantanowitz L
Diagn Cytopathol 2012 Oct;40(10):925-38. Epub 2012 Feb 20 doi: 10.1002/dc.21767. PMID: 22351626
Dermatopathic lymphadenitis. The spectrum and significance of its morphologic features.
Gould E, Porto R, Albores-Saavedra J, Ibe MJ
Arch Pathol Lab Med 1988 Nov;112(11):1145-50. PMID: 3178430
Atypical lymphadenopathies of the head and neck.
Weaver DK
Crit Rev Clin Lab Sci 1981;15(1):1-24. doi: 10.3109/10408368109105867. PMID: 6276076

Therapy

Immunohistochemical and molecular cytogenetic evaluation of potential targets for tyrosine kinase inhibitors in Langerhans cell histiocytosis.
Caponetti GC, Miranda RN, Althof PA, Dobesh RC, Sanger WG, Medeiros LJ, Greiner TC, Weisenburger DD
Hum Pathol 2012 Dec;43(12):2223-8. Epub 2012 Jun 27 doi: 10.1016/j.humpath.2012.03.014. PMID: 22748304
Dermatopathic lymphadenitis with generalized erythroderma in a patient with epstein-barr virus-associated hemophagocytic lymphohistiocytosis.
Lee WJ, Lee DW, Kim CH, Won CH, Chang SE, Lee MW, Choi JH, Moon KC
Am J Dermatopathol 2010 Jun;32(4):357-61. doi: 10.1097/DAD.0b013e3181b2a50f. PMID: 20010284
Atypical lymphadenopathies of the head and neck.
Weaver DK
Crit Rev Clin Lab Sci 1981;15(1):1-24. doi: 10.3109/10408368109105867. PMID: 6276076
Reticulum cell sarcoma associated with generalized neurodermatitis (atopic), atopic cataract of the left eye and dermatopathic lymphadenitis, considerably improved by treatment with potassium paraaminobenzoic acid (KPAB).
FRIEDMAN R, ZARAFONETIS CJ
AMA Arch Derm Syphilol 1954 Nov;70(5):686-8. PMID: 13206414

Prognosis

Dermatopathic lymphadenitis imitating a deep neck space infection.
Psarommatis I, Vontas H, Gkoulioni V, Mihail-Strantzia A, Bairamis T
Am J Otolaryngol 2009 Nov-Dec;30(6):419-22. Epub 2009 Mar 9 doi: 10.1016/j.amjoto.2008.07.006. PMID: 19880032
Early TCR-beta and TCR-gamma PCR detection of T-cell clonality indicates minimal tumor disease in lymph nodes of cutaneous T-cell lymphoma: diagnostic and prognostic implications.
Assaf C, Hummel M, Steinhoff M, Geilen CC, Orawa H, Stein H, Orfanos CE
Blood 2005 Jan 15;105(2):503-10. Epub 2004 Sep 30 doi: 10.1182/blood-2004-06-2220. PMID: 15459015
Report of an unusual small lymphocytic B-cell lymphoma selectively involving the B-zone of lymph node.
Carbone A, Pinto A, Gloghini A, De Re V, Alosi M, Zagonel V, Tirelli U, Attadia V, Boiocchi M, Volpe R
Cancer 1990 Jul 15;66(2):302-12. doi: 10.1002/1097-0142(19900715)66:2<302::aid-cncr2820660218>3.0.co;2-q. PMID: 2196112
Atypical lymphadenopathies of the head and neck.
Weaver DK
Crit Rev Clin Lab Sci 1981;15(1):1-24. doi: 10.3109/10408368109105867. PMID: 6276076

Clinical prediction guides

Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides.
Tada K, Hamada T, Asagoe K, Umemura H, Mizuno-Ikeda K, Aoyama Y, Otsuka M, Yamasaki O, Iwatsuki K
Eur J Dermatol 2014 Nov-Dec;24(6):670-5. doi: 10.1684/ejd.2014.2437. PMID: 25672788
Fine needle aspiration cytology of dermatopathic lymphadenitis.
Iyer VK, Kapila K, Verma K
Acta Cytol 1998 Nov-Dec;42(6):1347-51. doi: 10.1159/000332166. PMID: 9850641
Clinical, pathologic, and immunologic features of human T-lymphotrophic virus type I-associated infective dermatitis in children.
La Grenade L, Manns A, Fletcher V, Derm D, Carberry C, Hanchard B, Maloney EM, Cranston B, Williams NP, Wilks R, Kang EC, Blattner WA
Arch Dermatol 1998 Apr;134(4):439-44. doi: 10.1001/archderm.134.4.439. PMID: 9554295
Dermatopathic lymphadenitis. The spectrum and significance of its morphologic features.
Gould E, Porto R, Albores-Saavedra J, Ibe MJ
Arch Pathol Lab Med 1988 Nov;112(11):1145-50. PMID: 3178430
The paracortical area in dermatopathic lymphadenitis and other reactive conditions of the lymph node.
van der Oord JJ, de Wolf-Peeters C, de Vos R, Desmet VJ
Virchows Arch B Cell Pathol Incl Mol Pathol 1984;45(3):289-99. doi: 10.1007/BF02889871. PMID: 6146220

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