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Monkeypox

MedGen UID:
124442
Concept ID:
C0276180
Disease or Syndrome
Synonym: Monkeypox virus infection
SNOMED CT: Monkey pox (359814004); Monkeypox (359814004); Mpox (359814004)
 
Monarch Initiative: MONDO:0002594

Definition

An infection that is caused by an Orthopoxvirus, which is transmitted by primates or rodents, and which is characterized by a prodromal syndrome of fever, chills, headache, myalgia, and lymphedema; initial symptoms are followed by a generalized papular rash that typically progresses from vesiculation through crusting over the course of two weeks. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMonkeypox

Professional guidelines

PubMed

Gandhi RT, Bedimo R, Hoy JF, Landovitz RJ, Smith DM, Eaton EF, Lehmann C, Springer SA, Sax PE, Thompson MA, Benson CA, Buchbinder SP, Del Rio C, Eron JJ Jr, Günthard HF, Molina JM, Jacobsen DM, Saag MS
JAMA 2023 Jan 3;329(1):63-84. doi: 10.1001/jama.2022.22246. PMID: 36454551
Huang Y, Mu L, Wang W
Signal Transduct Target Ther 2022 Nov 2;7(1):373. doi: 10.1038/s41392-022-01215-4. PMID: 36319633Free PMC Article
Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y
Drugs 2022 Jun;82(9):957-963. Epub 2022 Jun 28 doi: 10.1007/s40265-022-01742-y. PMID: 35763248Free PMC Article

Recent clinical studies

Etiology

Mitjà O, Ogoina D, Titanji BK, Galvan C, Muyembe JJ, Marks M, Orkin CM
Lancet 2023 Jan 7;401(10370):60-74. Epub 2022 Nov 17 doi: 10.1016/S0140-6736(22)02075-X. PMID: 36403582Free PMC Article
Singhal T, Kabra SK, Lodha R
Indian J Pediatr 2022 Oct;89(10):955-960. Epub 2022 Aug 10 doi: 10.1007/s12098-022-04348-0. PMID: 35947269Free PMC Article
Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, Palich R, Nori A, Reeves I, Habibi MS, Apea V, Boesecke C, Vandekerckhove L, Yakubovsky M, Sendagorta E, Blanco JL, Florence E, Moschese D, Maltez FM, Goorhuis A, Pourcher V, Migaud P, Noe S, Pintado C, Maggi F, Hansen AE, Hoffmann C, Lezama JI, Mussini C, Cattelan A, Makofane K, Tan D, Nozza S, Nemeth J, Klein MB, Orkin CM; SHARE-net Clinical Group
N Engl J Med 2022 Aug 25;387(8):679-691. Epub 2022 Jul 21 doi: 10.1056/NEJMoa2207323. PMID: 35866746
Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, Steffen R
PLoS Negl Trop Dis 2022 Feb;16(2):e0010141. Epub 2022 Feb 11 doi: 10.1371/journal.pntd.0010141. PMID: 35148313Free PMC Article
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1027-1043. Epub 2019 Apr 11 doi: 10.1016/j.idc.2019.03.001. PMID: 30981594Free PMC Article

Diagnosis

Mitjà O, Ogoina D, Titanji BK, Galvan C, Muyembe JJ, Marks M, Orkin CM
Lancet 2023 Jan 7;401(10370):60-74. Epub 2022 Nov 17 doi: 10.1016/S0140-6736(22)02075-X. PMID: 36403582Free PMC Article
Huang Y, Mu L, Wang W
Signal Transduct Target Ther 2022 Nov 2;7(1):373. doi: 10.1038/s41392-022-01215-4. PMID: 36319633Free PMC Article
Singhal T, Kabra SK, Lodha R
Indian J Pediatr 2022 Oct;89(10):955-960. Epub 2022 Aug 10 doi: 10.1007/s12098-022-04348-0. PMID: 35947269Free PMC Article
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1027-1043. Epub 2019 Apr 11 doi: 10.1016/j.idc.2019.03.001. PMID: 30981594Free PMC Article
McCollum AM, Damon IK
Clin Infect Dis 2014 Jan;58(2):260-7. Epub 2013 Oct 24 doi: 10.1093/cid/cit703. PMID: 24158414

Therapy

Karagoz A, Tombuloglu H, Alsaeed M, Tombuloglu G, AlRubaish AA, Mahmoud A, Smajlović S, Ćordić S, Rabaan AA, Alsuhaimi E
J Infect Public Health 2023 Apr;16(4):531-541. Epub 2023 Feb 9 doi: 10.1016/j.jiph.2023.02.003. PMID: 36801633Free PMC Article
Gandhi RT, Bedimo R, Hoy JF, Landovitz RJ, Smith DM, Eaton EF, Lehmann C, Springer SA, Sax PE, Thompson MA, Benson CA, Buchbinder SP, Del Rio C, Eron JJ Jr, Günthard HF, Molina JM, Jacobsen DM, Saag MS
JAMA 2023 Jan 3;329(1):63-84. doi: 10.1001/jama.2022.22246. PMID: 36454551
Hatmal MM, Al-Hatamleh MAI, Olaimat AN, Ahmad S, Hasan H, Ahmad Suhaimi NA, Albakri KA, Abedalbaset Alzyoud A, Kadir R, Mohamud R
Emerg Microbes Infect 2022 Dec;11(1):2600-2631. doi: 10.1080/22221751.2022.2132882. PMID: 36263798Free PMC Article
Singhal T, Kabra SK, Lodha R
Indian J Pediatr 2022 Oct;89(10):955-960. Epub 2022 Aug 10 doi: 10.1007/s12098-022-04348-0. PMID: 35947269Free PMC Article
Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y
Drugs 2022 Jun;82(9):957-963. Epub 2022 Jun 28 doi: 10.1007/s40265-022-01742-y. PMID: 35763248Free PMC Article

Prognosis

Grifoni A, Zhang Y, Tarke A, Sidney J, Rubiro P, Reina-Campos M, Filaci G, Dan JM, Scheuermann RH, Sette A
Cell Host Microbe 2022 Dec 14;30(12):1662-1670.e4. Epub 2022 Dec 3 doi: 10.1016/j.chom.2022.11.003. PMID: 36463861Free PMC Article
Patel A, Bilinska J, Tam JCH, Da Silva Fontoura D, Mason CY, Daunt A, Snell LB, Murphy J, Potter J, Tuudah C, Sundramoorthi R, Abeywickrema M, Pley C, Naidu V, Nebbia G, Aarons E, Botgros A, Douthwaite ST, van Nispen Tot Pannerden C, Winslow H, Brown A, Chilton D, Nori A
BMJ 2022 Jul 28;378:e072410. doi: 10.1136/bmj-2022-072410. PMID: 35902115Free PMC Article
Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, Palich R, Nori A, Reeves I, Habibi MS, Apea V, Boesecke C, Vandekerckhove L, Yakubovsky M, Sendagorta E, Blanco JL, Florence E, Moschese D, Maltez FM, Goorhuis A, Pourcher V, Migaud P, Noe S, Pintado C, Maggi F, Hansen AE, Hoffmann C, Lezama JI, Mussini C, Cattelan A, Makofane K, Tan D, Nozza S, Nemeth J, Klein MB, Orkin CM; SHARE-net Clinical Group
N Engl J Med 2022 Aug 25;387(8):679-691. Epub 2022 Jul 21 doi: 10.1056/NEJMoa2207323. PMID: 35866746
Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM; NHS England High Consequence Infectious Diseases (Airborne) Network
Lancet Infect Dis 2022 Aug;22(8):1153-1162. Epub 2022 May 24 doi: 10.1016/S1473-3099(22)00228-6. PMID: 35623380Free PMC Article
Weaver JR, Isaacs SN
Immunol Rev 2008 Oct;225:96-113. doi: 10.1111/j.1600-065X.2008.00691.x. PMID: 18837778Free PMC Article

Clinical prediction guides

Karagoz A, Tombuloglu H, Alsaeed M, Tombuloglu G, AlRubaish AA, Mahmoud A, Smajlović S, Ćordić S, Rabaan AA, Alsuhaimi E
J Infect Public Health 2023 Apr;16(4):531-541. Epub 2023 Feb 9 doi: 10.1016/j.jiph.2023.02.003. PMID: 36801633Free PMC Article
Carvajal A, Vigil-De Gracia P
Am J Obstet Gynecol MFM 2022 Nov;4(6):100746. Epub 2022 Sep 6 doi: 10.1016/j.ajogmf.2022.100746. PMID: 36084787Free PMC Article
Tarín-Vicente EJ, Alemany A, Agud-Dios M, Ubals M, Suñer C, Antón A, Arando M, Arroyo-Andrés J, Calderón-Lozano L, Casañ C, Cabrera JM, Coll P, Descalzo V, Folgueira MD, García-Pérez JN, Gil-Cruz E, González-Rodríguez B, Gutiérrez-Collar C, Hernández-Rodríguez Á, López-Roa P, de Los Ángeles Meléndez M, Montero-Menárguez J, Muñoz-Gallego I, Palencia-Pérez SI, Paredes R, Pérez-Rivilla A, Piñana M, Prat N, Ramirez A, Rivero Á, Rubio-Muñiz CA, Vall M, Acosta-Velásquez KS, Wang A, Galván-Casas C, Marks M, Ortiz-Romero PL, Mitjà O
Lancet 2022 Aug 27;400(10353):661-669. Epub 2022 Aug 8 doi: 10.1016/S0140-6736(22)01436-2. PMID: 35952705Free PMC Article
Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM; NHS England High Consequence Infectious Diseases (Airborne) Network
Lancet Infect Dis 2022 Aug;22(8):1153-1162. Epub 2022 May 24 doi: 10.1016/S1473-3099(22)00228-6. PMID: 35623380Free PMC Article
Weaver JR, Isaacs SN
Immunol Rev 2008 Oct;225:96-113. doi: 10.1111/j.1600-065X.2008.00691.x. PMID: 18837778Free PMC Article

Recent systematic reviews

Jaiswal V, Sultana Q, Lahori S, Mukherjee D, Agrawal V, Doshi N, Shrestha AB, Huang H, Nasir YM, Naz S
Curr Probl Cardiol 2023 May;48(5):101611. Epub 2023 Jan 28 doi: 10.1016/j.cpcardiol.2023.101611. PMID: 36716982Free PMC Article
El-Qushayri AE, Reda A, Shah J
Front Immunol 2022;13:1094346. Epub 2022 Dec 14 doi: 10.3389/fimmu.2022.1094346. PMID: 36591217Free PMC Article
Kipkorir V, Dhali A, Srichawla B, Kutikuppala S, Cox M, Ochieng D, Nyaanga F, Găman MA
Trop Med Int Health 2022 Nov;27(11):961-969. Epub 2022 Oct 13 doi: 10.1111/tmi.13821. PMID: 36229989
Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, Steffen R
PLoS Negl Trop Dis 2022 Feb;16(2):e0010141. Epub 2022 Feb 11 doi: 10.1371/journal.pntd.0010141. PMID: 35148313Free PMC Article
Beer EM, Rao VB
PLoS Negl Trop Dis 2019 Oct;13(10):e0007791. Epub 2019 Oct 16 doi: 10.1371/journal.pntd.0007791. PMID: 31618206Free PMC Article

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