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Cytomegalovirus pneumonia

MedGen UID:
124443
Concept ID:
C0276253
Disease or Syndrome
Synonyms: CMV Pneumonia; CMV pneumonia; Cytomegalic inclusion virus pneumonia; Cytomegaloviral (CMV) pneumonia; Cytomegaloviral Pneumonia; Cytomegaloviral pneumonia; Cytomegaloviral pneumonitis; Cytomegalovirus caused pneumonia; Cytomegalovirus Pneumonia; cytomegalovirus pneumonia
SNOMED CT: Cytomegaloviral pneumonitis (7678002); Cytomegaloviral pneumonia (7678002); Cytomegalic inclusion virus pneumonia (7678002); Cytomegaloviral (CMV) pneumonia (7678002)
 
Monarch Initiative: MONDO:0024354

Definition

Pneumonia caused by cytomegalovirus. Most humans are exposed to cytomegalovirus. Healthy individuals do not develop signs and symptoms of infection. Patients with weakened immune system (e.g., AIDS patients, cancer patients who are being treated with chemotherapy, and patients who have received bone marrow or solid organ transplants) develop signs and symptoms of infection. They include cough, shortness of breath, fatigue, malaise, fever, muscle and joint pain, and excessive sweating. [from NCI]

Professional guidelines

PubMed

Ljungman P
Semin Respir Infect 1995 Dec;10(4):209-15. PMID: 8668848
Zaia JA
Clin Infect Dis 1993 Nov;17 Suppl 2:S392-9. doi: 10.1093/clinids/17.supplement_2.s392. PMID: 8274605
Verdonck LF, de Gast GC, Dekker AW, de Weger RA, Schuurman HJ, Rozenberg-Arska M
Bone Marrow Transplant 1989 Mar;4(2):187-9. PMID: 2539877

Recent clinical studies

Etiology

Luyt CE, Bréchot N, Chastre J
Curr Opin Infect Dis 2014 Apr;27(2):194-9. doi: 10.1097/QCO.0000000000000049. PMID: 24492750
Travi G, Pergam SA
J Intensive Care Med 2014 Jul-Aug;29(4):200-12. Epub 2013 Feb 6 doi: 10.1177/0885066613476454. PMID: 23753231Free PMC Article
Cascio A, Iaria C, Ruggeri P, Fries W
Int J Infect Dis 2012 Jul;16(7):e474-9. Epub 2012 May 22 doi: 10.1016/j.ijid.2012.03.008. PMID: 22622153
Ljungman P
Semin Respir Infect 1995 Dec;10(4):209-15. PMID: 8668848
Klotman ME, Hamilton JD
Semin Respir Infect 1987 Jun;2(2):95-103. PMID: 2827281

Diagnosis

Govender K, Msomi N, Moodley P, Parboosing R
Future Microbiol 2021 Dec;16:1401-1414. Epub 2021 Nov 23 doi: 10.2217/fmb-2021-0147. PMID: 34812046
Travi G, Pergam SA
J Intensive Care Med 2014 Jul-Aug;29(4):200-12. Epub 2013 Feb 6 doi: 10.1177/0885066613476454. PMID: 23753231Free PMC Article
Salomon N, Perlman DC
Semin Respir Infect 1999 Dec;14(4):353-8. PMID: 10638515
Ljungman P
Semin Respir Infect 1995 Dec;10(4):209-15. PMID: 8668848
Klotman ME, Hamilton JD
Semin Respir Infect 1987 Jun;2(2):95-103. PMID: 2827281

Therapy

Gocho K, Yamashita A, Iizuka N, Sato K, Imasaka K, Hamanaka N, Kimura T
Intern Med 2024 Jan 15;63(2):271-276. Epub 2023 May 24 doi: 10.2169/internalmedicine.1638-23. PMID: 37225488Free PMC Article
Travi G, Pergam SA
J Intensive Care Med 2014 Jul-Aug;29(4):200-12. Epub 2013 Feb 6 doi: 10.1177/0885066613476454. PMID: 23753231Free PMC Article
Cunha BA
Infect Dis Clin North Am 2010 Mar;24(1):147-58. doi: 10.1016/j.idc.2009.10.008. PMID: 20171550Free PMC Article
Ison MG, Fishman JA
Clin Chest Med 2005 Dec;26(4):691-705, viii. doi: 10.1016/j.ccm.2005.06.013. PMID: 16263406
Ljungman P
Semin Respir Infect 1995 Dec;10(4):209-15. PMID: 8668848

Prognosis

Luyt CE, Bréchot N, Chastre J
Curr Opin Infect Dis 2014 Apr;27(2):194-9. doi: 10.1097/QCO.0000000000000049. PMID: 24492750
Cunha BA
Infect Dis Clin North Am 2010 Mar;24(1):147-58. doi: 10.1016/j.idc.2009.10.008. PMID: 20171550Free PMC Article
Uberti-Foppa C, Lillo F, Terreni MR, Puglisi A, Guffanti M, Gianotti N, Lazzarin A
Chest 1998 Apr;113(4):919-23. doi: 10.1378/chest.113.4.919. PMID: 9554626
Stokes DC
Curr Opin Pediatr 1994 Jun;6(3):272-9. PMID: 8061736
Klotman ME, Hamilton JD
Semin Respir Infect 1987 Jun;2(2):95-103. PMID: 2827281

Clinical prediction guides

Yildirim E, Kilickan L, Aksoy SH, Gozukucuk R, Kilic HH, Tomak Y, Dalkilic O, Tanboga IH, Kilickan FDB
Medicine (Baltimore) 2023 Mar 3;102(9):e33132. doi: 10.1097/MD.0000000000033132. PMID: 36862905Free PMC Article
Shiraki K, Sato N, Sakai K, Matsumoto S, Kaszynski RH, Takemoto M
Pharmacol Ther 2022 Jul;235:108121. Epub 2022 Feb 1 doi: 10.1016/j.pharmthera.2022.108121. PMID: 35121001Free PMC Article
Heuvelings CC, Bélard S, Janssen S, Wallrauch C, Grobusch MP, Brunetti E, Giordani MT, Heller T
Infection 2016 Feb;44(1):1-10. Epub 2015 May 14 doi: 10.1007/s15010-015-0780-z. PMID: 25972115Free PMC Article
Uberti-Foppa C, Lillo F, Terreni MR, Puglisi A, Guffanti M, Gianotti N, Lazzarin A
Chest 1998 Apr;113(4):919-23. doi: 10.1378/chest.113.4.919. PMID: 9554626
Klotman ME, Hamilton JD
Semin Respir Infect 1987 Jun;2(2):95-103. PMID: 2827281

Recent systematic reviews

Cascio A, Iaria C, Ruggeri P, Fries W
Int J Infect Dis 2012 Jul;16(7):e474-9. Epub 2012 May 22 doi: 10.1016/j.ijid.2012.03.008. PMID: 22622153

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