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Alternating hemiplegia

MedGen UID:
124456
Concept ID:
C0278110
Disease or Syndrome
Synonyms: Crossed Hemiplegia; Crossed Hemiplegias; Hemiplegia, Crossed; Hemiplegias, Crossed
SNOMED CT: Alternating hemiplegia (404689008); Crossed hemiplegia (404689008)
 
Monarch Initiative: MONDO:0016210
Orphanet: ORPHA209978

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlternating hemiplegia

Professional guidelines

PubMed

Mikati MA, Panagiotakaki E, Arzimanoglou A
Eur J Paediatr Neurol 2021 May;32:A4-A5. Epub 2021 May 4 doi: 10.1016/j.ejpn.2021.05.004. PMID: 33975787
Samanta D
Pediatr Neurol 2020 Feb;103:12-20. Epub 2019 Nov 1 doi: 10.1016/j.pediatrneurol.2019.10.003. PMID: 31836335
Cross JH
Semin Fetal Neonatal Med 2013 Aug;18(4):192-5. Epub 2013 Apr 30 doi: 10.1016/j.siny.2013.04.003. PMID: 23642846

Recent clinical studies

Etiology

Patel SH, Panagiotakaki E, Papadopoulou MT, Fons C, De Grandis E, Vezyroglou A, Balestrini S, Hong H, Liu B, Prange L, Arzimanoglou A, Vavassori R, Mikati MA
J Child Neurol 2023 Oct;38(10-12):597-610. Epub 2023 Sep 20 doi: 10.1177/08830738231197861. PMID: 37728088
Hashimoto Y, Greene C, Munnich A, Campbell M
Fluids Barriers CNS 2023 Mar 28;20(1):22. doi: 10.1186/s12987-023-00424-5. PMID: 36978081Free PMC Article
Poole J, Zagaglia S, Demurtas R, Farrell F, Walker MC, Sisodiya SM, Balestrini S, Vivekananda U
PLoS One 2022;17(9):e0268720. Epub 2022 Sep 30 doi: 10.1371/journal.pone.0268720. PMID: 36178910Free PMC Article
Severino M, Pisciotta L, Tortora D, Toselli B, Stagnaro M, Cordani R, Morana G, Zicca A, Kotzeva S, Zanaboni C, Montobbio G, Rossi A, De Grandis E; IBAHC Consortium
J Neurol 2020 May;267(5):1300-1311. Epub 2020 Jan 16 doi: 10.1007/s00415-020-09698-3. PMID: 31950366
Heinzen EL, Arzimanoglou A, Brashear A, Clapcote SJ, Gurrieri F, Goldstein DB, Jóhannesson SH, Mikati MA, Neville B, Nicole S, Ozelius LJ, Poulsen H, Schyns T, Sweadner KJ, van den Maagdenberg A, Vilsen B; ATP1A3 Working Group
Lancet Neurol 2014 May;13(5):503-14. doi: 10.1016/S1474-4422(14)70011-0. PMID: 24739246Free PMC Article

Diagnosis

Ananthavarathan P, Kamourieh S
Handb Clin Neurol 2023;198:221-227. doi: 10.1016/B978-0-12-823356-6.00005-6. PMID: 38043964
Calame DG, Moreno Vadillo C, Berger S, Lotze T, Shinawi M, Poupak J, Heller C, Cohen J, Person R, Telegrafi A, Phitsanuwong C, Fiala K, Thiffault I, Del Viso F, Zhou D, Fleming EA, Pastinen T, Fatemi A, Thomas S, Pascual SI, Torres RJ, Prior C, Gómez-González C, Biskup S, Lupski JR, Maric D, Holmgren M, Regier D, Yano ST
Brain 2023 Aug 1;146(8):3162-3171. doi: 10.1093/brain/awad124. PMID: 37043503Free PMC Article
Vezyroglou A, Akilapa R, Barwick K, Koene S, Brownstein CA, Holder-Espinasse M, Fry AE, Németh AH, Tofaris GK, Hay E, Hughes I, Mansour S, Mordekar SR, Splitt M, Turnpenny PD, Demetriou D, Koopmann TT, Ruivenkamp CAL, Agrawal PB, Carr L, Clowes V, Ghali N, Holder SE, Radley J, Male A, Sisodiya SM, Kurian MA, Cross JH, Balasubramanian M
Neurology 2022 Oct 4;99(14):e1511-e1526. Epub 2022 Jul 18 doi: 10.1212/WNL.0000000000200927. PMID: 36192182Free PMC Article
Blumenfeld AE, Victorio MC, Berenson FR
Semin Pediatr Neurol 2016 Feb;23(1):18-22. Epub 2016 Jan 22 doi: 10.1016/j.spen.2016.01.007. PMID: 27017017
Heinzen EL, Arzimanoglou A, Brashear A, Clapcote SJ, Gurrieri F, Goldstein DB, Jóhannesson SH, Mikati MA, Neville B, Nicole S, Ozelius LJ, Poulsen H, Schyns T, Sweadner KJ, van den Maagdenberg A, Vilsen B; ATP1A3 Working Group
Lancet Neurol 2014 May;13(5):503-14. doi: 10.1016/S1474-4422(14)70011-0. PMID: 24739246Free PMC Article

Therapy

Patel S, Maney K, Morris L, Papadopoulou MT, Prange L, Boggs A, Hunanyan A, Megvinov A, Vavassori R, Panagiotakaki E, Mikati MA
Eur J Paediatr Neurol 2024 Mar;49:55-59. Epub 2024 Feb 12 doi: 10.1016/j.ejpn.2024.02.004. PMID: 38367370
Parker LE, Wallace K, Thevathasan A, Funk E, Pratt M, Thamby J, Tran L, Prange L, Uchitel J, Boggs A, Minton M, Jasien J, Nagao KJ, Richards A, Cruse B, De-Lisle Dear G, Landstrom AP, Mikati MA
Eur J Paediatr Neurol 2022 May;38:47-52. Epub 2022 Mar 29 doi: 10.1016/j.ejpn.2022.03.007. PMID: 35390560
Samanta D
Pediatr Neurol 2020 Feb;103:12-20. Epub 2019 Nov 1 doi: 10.1016/j.pediatrneurol.2019.10.003. PMID: 31836335
Uchitel J, Helseth A, Prange L, McLean M, Ghusayni R, Sachdev M, Hunanyan A, Mikati MA
Neurology 2019 Sep 24;93(13):e1248-e1259. Epub 2019 Sep 4 doi: 10.1212/WNL.0000000000008159. PMID: 31484714
Kansagra S, Mikati MA, Vigevano F
Handb Clin Neurol 2013;112:821-6. doi: 10.1016/B978-0-444-52910-7.00001-5. PMID: 23622289

Prognosis

Poole J, Zagaglia S, Demurtas R, Farrell F, Walker MC, Sisodiya SM, Balestrini S, Vivekananda U
PLoS One 2022;17(9):e0268720. Epub 2022 Sep 30 doi: 10.1371/journal.pone.0268720. PMID: 36178910Free PMC Article
Pavone P, Pappalardo XG, Ruggieri M, Falsaperla R, Parano E
Medicine (Baltimore) 2022 Aug 5;101(31):e29413. doi: 10.1097/MD.0000000000029413. PMID: 35945798Free PMC Article
Vetro A, Nielsen HN, Holm R, Hevner RF, Parrini E, Powis Z, Møller RS, Bellan C, Simonati A, Lesca G, Helbig KL, Palmer EE, Mei D, Ballardini E, Van Haeringen A, Syrbe S, Leuzzi V, Cioni G, Curry CJ, Costain G, Santucci M, Chong K, Mancini GMS, Clayton-Smith J, Bigoni S, Scheffer IE, Dobyns WB, Vilsen B, Guerrini R; ATP1A2/A3-collaborators
Brain 2021 Jun 22;144(5):1435-1450. doi: 10.1093/brain/awab052. PMID: 33880529
Maas RPPWM, Kamsteeg EJ, Mangano S, Vázquez López ME, Nicolai J, Silver K, Fernández-Alvarez E, Willemsen MAAP
Eur J Paediatr Neurol 2018 Nov;22(6):1110-1117. Epub 2018 Aug 15 doi: 10.1016/j.ejpn.2018.07.012. PMID: 30194039
Kansagra S, Mikati MA, Vigevano F
Handb Clin Neurol 2013;112:821-6. doi: 10.1016/B978-0-444-52910-7.00001-5. PMID: 23622289

Clinical prediction guides

Vezyroglou A, Akilapa R, Barwick K, Koene S, Brownstein CA, Holder-Espinasse M, Fry AE, Németh AH, Tofaris GK, Hay E, Hughes I, Mansour S, Mordekar SR, Splitt M, Turnpenny PD, Demetriou D, Koopmann TT, Ruivenkamp CAL, Agrawal PB, Carr L, Clowes V, Ghali N, Holder SE, Radley J, Male A, Sisodiya SM, Kurian MA, Cross JH, Balasubramanian M
Neurology 2022 Oct 4;99(14):e1511-e1526. Epub 2022 Jul 18 doi: 10.1212/WNL.0000000000200927. PMID: 36192182Free PMC Article
Poole J, Zagaglia S, Demurtas R, Farrell F, Walker MC, Sisodiya SM, Balestrini S, Vivekananda U
PLoS One 2022;17(9):e0268720. Epub 2022 Sep 30 doi: 10.1371/journal.pone.0268720. PMID: 36178910Free PMC Article
Vetro A, Nielsen HN, Holm R, Hevner RF, Parrini E, Powis Z, Møller RS, Bellan C, Simonati A, Lesca G, Helbig KL, Palmer EE, Mei D, Ballardini E, Van Haeringen A, Syrbe S, Leuzzi V, Cioni G, Curry CJ, Costain G, Santucci M, Chong K, Mancini GMS, Clayton-Smith J, Bigoni S, Scheffer IE, Dobyns WB, Vilsen B, Guerrini R; ATP1A2/A3-collaborators
Brain 2021 Jun 22;144(5):1435-1450. doi: 10.1093/brain/awab052. PMID: 33880529
Pratt M, Uchitel J, McGreal N, Gordon K, Prange L, McLean M, Noel RJ, Rikard B, Rogers Boruta MK, Mikati MA
Orphanet J Rare Dis 2020 Sep 3;15(1):231. doi: 10.1186/s13023-020-01474-w. PMID: 32883312Free PMC Article
Severino M, Pisciotta L, Tortora D, Toselli B, Stagnaro M, Cordani R, Morana G, Zicca A, Kotzeva S, Zanaboni C, Montobbio G, Rossi A, De Grandis E; IBAHC Consortium
J Neurol 2020 May;267(5):1300-1311. Epub 2020 Jan 16 doi: 10.1007/s00415-020-09698-3. PMID: 31950366

Recent systematic reviews

Motavasseli D, Delorme C, Bayle N, Gracies JM, Roze E, Baude M
Toxins (Basel) 2024 Sep 13;16(9) doi: 10.3390/toxins16090392. PMID: 39330850Free PMC Article

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