U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Localized osteosarcoma

MedGen UID:
124467
•Concept ID:
C0278511
•
Neoplastic Process
Synonyms: Localized Osteogenic Sarcoma; localized osteogenic sarcoma; Localized Osteosarcoma; localized osteosarcoma; Osteosarcoma, Localized; osteosarcoma, localized
 
Monarch Initiative: MONDO:0002620

Definition

Osteosarcoma that is confined to a specific site without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized osteosarcoma

Professional guidelines

PubMed

Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.
Isakoff MS, Bielack SS, Meltzer P, Gorlick R
J Clin Oncol 2015 Sep 20;33(27):3029-35. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.4895. PMID: 26304877Free PMC Article
Muramyl tripeptide-phosphatidyl ethanolamine encapsulated in liposomes (L-MTP-PE) in the treatment of osteosarcoma.
Meyers PA, Chou AJ
Adv Exp Med Biol 2014;804:307-21. doi: 10.1007/978-3-319-04843-7_17. PMID: 24924182
Mifamurtide: a review of its use in the treatment of osteosarcoma.
Frampton JE
Paediatr Drugs 2010 Jun;12(3):141-53. doi: 10.2165/11204910-000000000-00000. PMID: 20481644

Recent clinical studies

Etiology

Bone Infarct-Associated Osteosarcoma: Epidemiologic and Survival Trends.
Laranga R, Focaccia M, Evangelista A, Lucarelli E, Donati DM, Spazzoli B
Oncol Res Treat 2022;45(6):326-335. Epub 2022 Jan 14 doi: 10.1159/000521986. PMID: 35034028
Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective.
Benjamin RS
Adv Exp Med Biol 2020;1257:1-10. doi: 10.1007/978-3-030-43032-0_1. PMID: 32483726
Current and future therapeutic approaches for osteosarcoma.
Harrison DJ, Geller DS, Gill JD, Lewis VO, Gorlick R
Expert Rev Anticancer Ther 2018 Jan;18(1):39-50. Epub 2017 Dec 14 doi: 10.1080/14737140.2018.1413939. PMID: 29210294
Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.
Isakoff MS, Bielack SS, Meltzer P, Gorlick R
J Clin Oncol 2015 Sep 20;33(27):3029-35. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.4895. PMID: 26304877Free PMC Article
MFH of bone and osteosarcoma show similar survival and chemosensitivity.
Jeon DG, Song WS, Kong CB, Kim JR, Lee SY
Clin Orthop Relat Res 2011 Feb;469(2):584-90. Epub 2010 Jun 18 doi: 10.1007/s11999-010-1428-z. PMID: 20559764Free PMC Article

Diagnosis

Bone Infarct-Associated Osteosarcoma: Epidemiologic and Survival Trends.
Laranga R, Focaccia M, Evangelista A, Lucarelli E, Donati DM, Spazzoli B
Oncol Res Treat 2022;45(6):326-335. Epub 2022 Jan 14 doi: 10.1159/000521986. PMID: 35034028
Malignant Bone Tumors of the Knee: How to Identify and Treat.
Voskuil R, Evenski AJ, Montgomery C, Emory CL
J Knee Surg 2019 Apr;32(4):305-314. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675828. PMID: 30449025
Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.
Isakoff MS, Bielack SS, Meltzer P, Gorlick R
J Clin Oncol 2015 Sep 20;33(27):3029-35. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.4895. PMID: 26304877Free PMC Article
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: a systemic review and meta-analysis of cohort studies.
Sun L, Li Y, Zhang J, Li H, Li B, Ye Z
J Orthop Res 2015 Jan;33(1):131-9. Epub 2014 Sep 18 doi: 10.1002/jor.22734. PMID: 25231396
New targets and approaches in osteosarcoma.
Gill J, Ahluwalia MK, Geller D, Gorlick R
Pharmacol Ther 2013 Jan;137(1):89-99. Epub 2012 Sep 14 doi: 10.1016/j.pharmthera.2012.09.003. PMID: 22983152

Therapy

Current and future therapeutic approaches for osteosarcoma.
Harrison DJ, Geller DS, Gill JD, Lewis VO, Gorlick R
Expert Rev Anticancer Ther 2018 Jan;18(1):39-50. Epub 2017 Dec 14 doi: 10.1080/14737140.2018.1413939. PMID: 29210294
Risk-Based Therapy for Localized Osteosarcoma.
Venkatramani R, Murray J, Helman L, Meyer W, Hicks MJ, Krance R, Lau C, Jo E, Chintagumpala M
Pediatr Blood Cancer 2016 Mar;63(3):412-7. Epub 2015 Oct 26 doi: 10.1002/pbc.25808. PMID: 26501936Free PMC Article
Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.
Isakoff MS, Bielack SS, Meltzer P, Gorlick R
J Clin Oncol 2015 Sep 20;33(27):3029-35. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.4895. PMID: 26304877Free PMC Article
New targets and approaches in osteosarcoma.
Gill J, Ahluwalia MK, Geller D, Gorlick R
Pharmacol Ther 2013 Jan;137(1):89-99. Epub 2012 Sep 14 doi: 10.1016/j.pharmthera.2012.09.003. PMID: 22983152
MFH of bone and osteosarcoma show similar survival and chemosensitivity.
Jeon DG, Song WS, Kong CB, Kim JR, Lee SY
Clin Orthop Relat Res 2011 Feb;469(2):584-90. Epub 2010 Jun 18 doi: 10.1007/s11999-010-1428-z. PMID: 20559764Free PMC Article

Prognosis

Bone Infarct-Associated Osteosarcoma: Epidemiologic and Survival Trends.
Laranga R, Focaccia M, Evangelista A, Lucarelli E, Donati DM, Spazzoli B
Oncol Res Treat 2022;45(6):326-335. Epub 2022 Jan 14 doi: 10.1159/000521986. PMID: 35034028
Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective.
Benjamin RS
Adv Exp Med Biol 2020;1257:1-10. doi: 10.1007/978-3-030-43032-0_1. PMID: 32483726
Current and future therapeutic approaches for osteosarcoma.
Harrison DJ, Geller DS, Gill JD, Lewis VO, Gorlick R
Expert Rev Anticancer Ther 2018 Jan;18(1):39-50. Epub 2017 Dec 14 doi: 10.1080/14737140.2018.1413939. PMID: 29210294
Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.
Isakoff MS, Bielack SS, Meltzer P, Gorlick R
J Clin Oncol 2015 Sep 20;33(27):3029-35. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.4895. PMID: 26304877Free PMC Article
MFH of bone and osteosarcoma show similar survival and chemosensitivity.
Jeon DG, Song WS, Kong CB, Kim JR, Lee SY
Clin Orthop Relat Res 2011 Feb;469(2):584-90. Epub 2010 Jun 18 doi: 10.1007/s11999-010-1428-z. PMID: 20559764Free PMC Article

Clinical prediction guides

Age and Tumor Location Predict Survival in Nonmetastatic Osteosarcoma in Upper Egypt.
Morsy AM, Ahmed BM, Rezk KM, Ramadan IK, Aboelgheit AM, Eltyb HA, Abd Elbadee OM, El-Naggar MS
J Pediatr Hematol Oncol 2020 Mar;42(2):e66-e78. doi: 10.1097/MPH.0000000000001506. PMID: 31107367
Risk-Based Therapy for Localized Osteosarcoma.
Venkatramani R, Murray J, Helman L, Meyer W, Hicks MJ, Krance R, Lau C, Jo E, Chintagumpala M
Pediatr Blood Cancer 2016 Mar;63(3):412-7. Epub 2015 Oct 26 doi: 10.1002/pbc.25808. PMID: 26501936Free PMC Article
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: a systemic review and meta-analysis of cohort studies.
Sun L, Li Y, Zhang J, Li H, Li B, Ye Z
J Orthop Res 2015 Jan;33(1):131-9. Epub 2014 Sep 18 doi: 10.1002/jor.22734. PMID: 25231396
Targeting hedgehog-GLI-2 pathway in osteosarcoma.
Yang W, Liu X, Choy E, Mankin H, Hornicek FJ, Duan Z
J Orthop Res 2013 Mar;31(3):502-9. Epub 2012 Sep 11 doi: 10.1002/jor.22230. PMID: 22968906
MFH of bone and osteosarcoma show similar survival and chemosensitivity.
Jeon DG, Song WS, Kong CB, Kim JR, Lee SY
Clin Orthop Relat Res 2011 Feb;469(2):584-90. Epub 2010 Jun 18 doi: 10.1007/s11999-010-1428-z. PMID: 20559764Free PMC Article

Recent systematic reviews

Maintenance therapy and drug holiday in sarcoma patients: systematic review.
Lebellec L, Defachelles AS, Cren PY, Penel N
Acta Oncol 2020 Sep;59(9):1084-1090. Epub 2020 May 13 doi: 10.1080/0284186X.2020.1759825. PMID: 32400254

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...