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Childhood cerebellar astrocytic neoplasm

MedGen UID:
124480
Concept ID:
C0278594
Neoplastic Process
Synonyms: cerebellar astrocytoma, childhood; cerebellum childhood astrocytic tumor; cerebellum childhood astrocytic tumour; cerebellum juvenile astrocytoma; childhood astrocytic tumor of cerebellum; childhood astrocytic tumour of cerebellum; Childhood Astrocytoma of Cerebellum; childhood astrocytoma of cerebellum; Childhood Astrocytoma of the Cerebellum; childhood astrocytoma of the cerebellum; childhood cerebellar astrocytic neoplasm; Childhood Cerebellar Astrocytoma; childhood cerebellar astrocytoma; paediatric astrocytoma of cerebellum; paediatric astrocytoma of the cerebellum; paediatric cerebellar astrocytoma; Pediatric Astrocytoma of Cerebellum; pediatric astrocytoma of cerebellum; Pediatric Astrocytoma of the Cerebellum; pediatric astrocytoma of the cerebellum; Pediatric Cerebellar Astrocytoma; pediatric cerebellar astrocytoma
 
Monarch Initiative: MONDO:0003842

Definition

Benign and malignant astrocytomas that arise from astrocytes in the cerebellum. More than 80% of childhood cerebellar astrocytomas are pilocytic astrocytomas which have a favorable prognosis. The remainder are composed of diffuse or fibrillary subtypes with malignant astrocytomas occurring only rarely in the cerebellum during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood cerebellar astrocytic neoplasm

Professional guidelines

PubMed

Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Bonner K, Siegel KR
J Neurosci Nurs 1988 Apr;20(2):84-93. doi: 10.1097/01376517-198804000-00004. PMID: 2966218
Sutton LN
Pediatr Neurosci 1987;13(2):98-107. doi: 10.1159/000120311. PMID: 3325954

Recent clinical studies

Etiology

Okonechnikov K, Joshi P, Sepp M, Leiss K, Sarropoulos I, Murat F, Sill M, Beck P, Chan KC, Korshunov A, Sah F, Deng MY, Sturm D, DeSisto J, Donson AM, Foreman NK, Green AL, Robinson G, Orr BA, Gao Q, Darrow E, Hadley JL, Northcott PA, Gojo J, Kawauchi D, Hovestadt V, Filbin MG, von Deimling A, Zuckermann M, Pajtler KW, Kool M, Jones DTW, Jäger N, Kutscher LM, Kaessmann H, Pfister SM
Neuro Oncol 2023 Oct 3;25(10):1895-1909. doi: 10.1093/neuonc/noad124. PMID: 37534924Free PMC Article
Schraw JM, Petridou ET, Bonaventure A, Dockerty JD, Karalexi M, Ntzani E, Infante-Rivard C, Clavel J, Bracci PM, McKean-Cowdin R, Roman E, Kane E, Erdmann F, Schüz J, Mueller BA, Scheurer ME
Cancer Causes Control 2023 Nov;34(11):1005-1015. Epub 2023 Jul 8 doi: 10.1007/s10552-023-01746-3. PMID: 37421504
Beneš V 3rd, Zápotocký M, Libý P, Táborský J, Blažková J Jr, Blažková J Sr, Sumerauer D, Mišove A, Perníková I, Kynčl M, Krsková L, Koblížek M, Zámečník J, Bradáč O, Tichý M
Acta Neurochir (Wien) 2022 Jun;164(6):1459-1472. Epub 2022 Jan 19 doi: 10.1007/s00701-021-05106-5. PMID: 35043265
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Kleihues P, Burger PC, Scheithauer BW
Brain Pathol 1993 Jul;3(3):255-68. doi: 10.1111/j.1750-3639.1993.tb00752.x. PMID: 8293185

Diagnosis

Dias SF, Richards O, Elliot M, Chumas P
Adv Tech Stand Neurosurg 2024;50:147-183. doi: 10.1007/978-3-031-53578-9_5. PMID: 38592530
Schraw JM, Petridou ET, Bonaventure A, Dockerty JD, Karalexi M, Ntzani E, Infante-Rivard C, Clavel J, Bracci PM, McKean-Cowdin R, Roman E, Kane E, Erdmann F, Schüz J, Mueller BA, Scheurer ME
Cancer Causes Control 2023 Nov;34(11):1005-1015. Epub 2023 Jul 8 doi: 10.1007/s10552-023-01746-3. PMID: 37421504
Davies NP, Rose HEL, Manias KA, Natarajan K, Abernethy LJ, Oates A, Janjua U, Davies P, MacPherson L, Arvanitis TN, Peet AC
NMR Biomed 2022 Feb;35(2):e4630. Epub 2021 Oct 13 doi: 10.1002/nbm.4630. PMID: 34647377
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Kleihues P, Burger PC, Scheithauer BW
Brain Pathol 1993 Jul;3(3):255-68. doi: 10.1111/j.1750-3639.1993.tb00752.x. PMID: 8293185

Therapy

Schraw JM, Petridou ET, Bonaventure A, Dockerty JD, Karalexi M, Ntzani E, Infante-Rivard C, Clavel J, Bracci PM, McKean-Cowdin R, Roman E, Kane E, Erdmann F, Schüz J, Mueller BA, Scheurer ME
Cancer Causes Control 2023 Nov;34(11):1005-1015. Epub 2023 Jul 8 doi: 10.1007/s10552-023-01746-3. PMID: 37421504
Grønbæk JK, Wibroe M, Toescu S, Frič R, Thomsen BL, Møller LN, Grillner P, Gustavsson B, Mallucci C, Aquilina K, Fellows GA, Molinari E, Hjort MA, Westerholm-Ormio M, Kiudeliene R, Mudra K, Hauser P, van Baarsen K, Hoving E, Zipfel J, Nysom K, Schmiegelow K, Sehested A, Juhler M, Mathiasen R; CMS study group
Lancet Child Adolesc Health 2021 Nov;5(11):814-824. Epub 2021 Oct 6 doi: 10.1016/S2352-4642(21)00274-1. PMID: 34624241
Kortmann RD, Timmermann B, Taylor RE, Scarzello G, Plasswilm L, Paulsen F, Jeremic B, Gnekow AK, Dieckmann K, Kay S, Bamberg M
Strahlenther Onkol 2003 Aug;179(8):509-20. doi: 10.1007/s00066-003-9104-9. PMID: 14509949
Slavc I, Schuller E, Czech T, Hainfellner JA, Seidl R, Dieckmann K
J Neurooncol 1998 Jun-Jul;38(2-3):213-8. doi: 10.1023/a:1005940405165. PMID: 9696374
Bonner K, Siegel KR
J Neurosci Nurs 1988 Apr;20(2):84-93. doi: 10.1097/01376517-198804000-00004. PMID: 2966218

Prognosis

Donofrio CA, Gagliardi F, Callea M, da Passano CF, Terreni MR, Cavalli A, Spina A, Acerno S, Bailo M, Elbabaa SK, Mortini P
Neurosurg Rev 2020 Feb;43(1):9-16. Epub 2018 Mar 22 doi: 10.1007/s10143-018-0969-6. PMID: 29569086
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Rickert CH, Probst-Cousin S, Gullotta F
Childs Nerv Syst 1997 Oct;13(10):507-13. doi: 10.1007/s003810050127. PMID: 9403197
Kibirige MS, Birch JM, Campbell RH, Gattamaneni HR, Blair V
Pediatr Hematol Oncol 1989;6(4):319-29. doi: 10.3109/08880018909034303. PMID: 2518326
Gilles FH, Leviton A, Hedley-Whyte T, Jasnow M
Hum Pathol 1983 Oct;14(10):834-45. doi: 10.1016/s0046-8177(83)80158-0. PMID: 6618483

Clinical prediction guides

Beneš V 3rd, Zápotocký M, Libý P, Táborský J, Blažková J Jr, Blažková J Sr, Sumerauer D, Mišove A, Perníková I, Kynčl M, Krsková L, Koblížek M, Zámečník J, Bradáč O, Tichý M
Acta Neurochir (Wien) 2022 Jun;164(6):1459-1472. Epub 2022 Jan 19 doi: 10.1007/s00701-021-05106-5. PMID: 35043265
Dasgupta A, Maitre M, Pungavkar S, Gupta T
Methods Mol Biol 2022;2423:187-214. doi: 10.1007/978-1-0716-1952-0_18. PMID: 34978700
Oh ME, Driever PH, Khajuria RK, Rueckriegel SM, Koustenis E, Bruhn H, Thomale UW
J Neurooncol 2017 Jan;131(2):267-276. Epub 2016 Oct 26 doi: 10.1007/s11060-016-2290-y. PMID: 27785688
Georgakis MK, Karalexi MA, Kalogirou EI, Ryzhov A, Zborovskaya A, Dimitrova N, Eser S, Antunes L, Sekerija M, Zagar T, Bastos J, Agius D, Florea M, Coza D, Bouka E, Bourgioti C, Dana H, Hatzipantelis E, Moschovi M, Papadopoulos S, Sfakianos G, Papakonstantinou E, Polychronopoulou S, Sgouros S, Stefanaki K, Stiakaki E, Strantzia K, Zountsas B, Pourtsidis A, Patsouris E, Petridou ET
J Neurooncol 2017 Jan;131(1):163-175. Epub 2016 Oct 14 doi: 10.1007/s11060-016-2284-9. PMID: 27743145
Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project
Nat Genet 2013 Aug;45(8):927-32. Epub 2013 Jun 30 doi: 10.1038/ng.2682. PMID: 23817572Free PMC Article

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