U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Chronic Lymphocytic Leukemia

MedGen UID:
124512
Concept ID:
C0278791
Neoplastic Process
Synonyms: Chronic Lymphocytic Leukemia Refractory; Refractory B-Cell Chronic Lymphocytic Leukemia; Refractory Chronic Lymphoid Leukemia; Refractory CLL

Definition

Chronic lymphocytic leukemia that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Chronic Lymphocytic Leukemia

Professional guidelines

PubMed

Woyach JA
Am J Hematol 2022 Nov;97 Suppl 2(Suppl 2):S11-S18. doi: 10.1002/ajh.26683. PMID: 36125037Free PMC Article
Harris V, Borlagdan J, Muluneh B
J Oncol Pharm Pract 2022 Jun;28(4):935-944. Epub 2022 Jan 27 doi: 10.1177/10781552211073906. PMID: 35084245
Thompson MC, Mato AR
Hematol Oncol Clin North Am 2021 Aug;35(4):793-806. Epub 2021 May 27 doi: 10.1016/j.hoc.2021.03.008. PMID: 34174986

Recent clinical studies

Etiology

Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M
N Engl J Med 2023 Jan 26;388(4):319-332. Epub 2022 Dec 13 doi: 10.1056/NEJMoa2211582. PMID: 36511784
Kater AP, Wu JQ, Kipps T, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Robak T, de la Serna J, Jaeger U, Cartron G, Montillo M, Dubois J, Eldering E, Mellink C, Van Der Kevie-Kersemaekers AM, Kim SY, Chyla B, Punnoose E, Bolen CR, Assaf ZJ, Jiang Y, Wang J, Lefebure M, Boyer M, Humphrey K, Seymour JF
J Clin Oncol 2020 Dec 1;38(34):4042-4054. Epub 2020 Sep 28 doi: 10.1200/JCO.20.00948. PMID: 32986498Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Seymour JF, Kipps TJ, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Gerecitano J, Robak T, De la Serna J, Jaeger U, Cartron G, Montillo M, Humerickhouse R, Punnoose EA, Li Y, Boyer M, Humphrey K, Mobasher M, Kater AP
N Engl J Med 2018 Mar 22;378(12):1107-1120. doi: 10.1056/NEJMoa1713976. PMID: 29562156
Pal Singh S, Dammeijer F, Hendriks RW
Mol Cancer 2018 Feb 19;17(1):57. doi: 10.1186/s12943-018-0779-z. PMID: 29455639Free PMC Article

Diagnosis

Siddiqi T, Soumerai JD, Dorritie KA, Stephens DM, Riedell PA, Arnason J, Kipps TJ, Gillenwater HH, Gong L, Yang L, Ogasawara K, Thorpe J, Wierda WG
Blood 2022 Mar 24;139(12):1794-1806. doi: 10.1182/blood.2021011895. PMID: 34699592
Fürstenau M, Hallek M, Eichhorst B
Haematologica 2019 Nov;104(11):2144-2154. Epub 2019 Oct 4 doi: 10.3324/haematol.2018.208603. PMID: 31585959Free PMC Article
Daniel C, Mato AR
Clin Adv Hematol Oncol 2017 Mar;15(3):210-218. PMID: 28398276
Woyach JA
Blood 2017 Mar 9;129(10):1270-1274. Epub 2017 Jan 17 doi: 10.1182/blood-2016-09-693598. PMID: 28096090Free PMC Article
Reagan JL, Castillo JJ
Expert Rev Anticancer Ther 2011 Feb;11(2):151-60. doi: 10.1586/era.10.223. PMID: 21342032

Therapy

Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M
N Engl J Med 2023 Jan 26;388(4):319-332. Epub 2022 Dec 13 doi: 10.1056/NEJMoa2211582. PMID: 36511784
Hillmen P, Eichhorst B, Brown JR, Lamanna N, O'Brien SM, Tam CS, Qiu L, Kazmierczak M, Zhou K, Šimkovič M, Mayer J, Gillespie-Twardy A, Shadman M, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Österborg A, Yimer HA, Salmi T, Ji M, Yecies J, Idoine A, Wu K, Huang J, Jurczak W
J Clin Oncol 2023 Feb 10;41(5):1035-1045. Epub 2022 Nov 17 doi: 10.1200/JCO.22.00510. PMID: 36395435Free PMC Article
Hillmen P, Brown JR, Eichhorst BF, Lamanna N, O'Brien SM, Qiu L, Salmi T, Hilger J, Wu K, Cohen A, Huang J, Tam CS
Future Oncol 2020 Apr;16(10):517-523. Epub 2020 Mar 24 doi: 10.2217/fon-2019-0844. PMID: 32207333
Seymour JF, Kipps TJ, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Gerecitano J, Robak T, De la Serna J, Jaeger U, Cartron G, Montillo M, Humerickhouse R, Punnoose EA, Li Y, Boyer M, Humphrey K, Mobasher M, Kater AP
N Engl J Med 2018 Mar 22;378(12):1107-1120. doi: 10.1056/NEJMoa1713976. PMID: 29562156
Pal Singh S, Dammeijer F, Hendriks RW
Mol Cancer 2018 Feb 19;17(1):57. doi: 10.1186/s12943-018-0779-z. PMID: 29455639Free PMC Article

Prognosis

Xu W, Zhou K, Wang T, Yang S, Liu L, Hu Y, Zhang W, Ding K, Zhou J, Gao S, Xu B, Zhu Z, Liu T, Zhang H, Hu J, Ji C, Wang S, Xia Z, Wang X, Li Y, Song Y, Ma S, Tang X, Zhang B, Li J
Am J Hematol 2023 Apr;98(4):571-579. Epub 2023 Jan 22 doi: 10.1002/ajh.26826. PMID: 36683422
Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M
N Engl J Med 2023 Jan 26;388(4):319-332. Epub 2022 Dec 13 doi: 10.1056/NEJMoa2211582. PMID: 36511784
Kater AP, Wu JQ, Kipps T, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Robak T, de la Serna J, Jaeger U, Cartron G, Montillo M, Dubois J, Eldering E, Mellink C, Van Der Kevie-Kersemaekers AM, Kim SY, Chyla B, Punnoose E, Bolen CR, Assaf ZJ, Jiang Y, Wang J, Lefebure M, Boyer M, Humphrey K, Seymour JF
J Clin Oncol 2020 Dec 1;38(34):4042-4054. Epub 2020 Sep 28 doi: 10.1200/JCO.20.00948. PMID: 32986498Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Porter DL, Hwang WT, Frey NV, Lacey SF, Shaw PA, Loren AW, Bagg A, Marcucci KT, Shen A, Gonzalez V, Ambrose D, Grupp SA, Chew A, Zheng Z, Milone MC, Levine BL, Melenhorst JJ, June CH
Sci Transl Med 2015 Sep 2;7(303):303ra139. doi: 10.1126/scitranslmed.aac5415. PMID: 26333935Free PMC Article

Clinical prediction guides

Kater AP, Wu JQ, Kipps T, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Robak T, de la Serna J, Jaeger U, Cartron G, Montillo M, Dubois J, Eldering E, Mellink C, Van Der Kevie-Kersemaekers AM, Kim SY, Chyla B, Punnoose E, Bolen CR, Assaf ZJ, Jiang Y, Wang J, Lefebure M, Boyer M, Humphrey K, Seymour JF
J Clin Oncol 2020 Dec 1;38(34):4042-4054. Epub 2020 Sep 28 doi: 10.1200/JCO.20.00948. PMID: 32986498Free PMC Article
Ghia P, Pluta A, Wach M, Lysak D, Kozak T, Simkovic M, Kaplan P, Kraychok I, Illes A, de la Serna J, Dolan S, Campbell P, Musuraca G, Jacob A, Avery E, Lee JH, Liang W, Patel P, Quah C, Jurczak W
J Clin Oncol 2020 Sep 1;38(25):2849-2861. Epub 2020 May 27 doi: 10.1200/JCO.19.03355. PMID: 32459600
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Tam CS, Trotman J, Opat S, Burger JA, Cull G, Gottlieb D, Harrup R, Johnston PB, Marlton P, Munoz J, Seymour JF, Simpson D, Tedeschi A, Elstrom R, Yu Y, Tang Z, Han L, Huang J, Novotny W, Wang L, Roberts AW
Blood 2019 Sep 12;134(11):851-859. Epub 2019 Jul 24 doi: 10.1182/blood.2019001160. PMID: 31340982Free PMC Article
Hillmen P, Rawstron AC, Brock K, Muñoz-Vicente S, Yates FJ, Bishop R, Boucher R, MacDonald D, Fegan C, McCaig A, Schuh A, Pettitt A, Gribben JG, Patten PEM, Devereux S, Bloor A, Fox CP, Forconi F, Munir T
J Clin Oncol 2019 Oct 20;37(30):2722-2729. Epub 2019 Jul 11 doi: 10.1200/JCO.19.00894. PMID: 31295041Free PMC Article

Recent systematic reviews

Wen Y, Meng L, Zhang X, Gao Q
Expert Rev Hematol 2022 Sep;15(9):849-856. Epub 2022 Aug 9 doi: 10.1080/17474086.2022.2110062. PMID: 35920616
Sorensen S, Wildgust M, Sengupta N, Trambitas C, Diels J, van Sanden S, Xu Y, Dorman E
Clin Ther 2017 Jan;39(1):178-189.e5. Epub 2017 Jan 3 doi: 10.1016/j.clinthera.2016.12.001. PMID: 28062113
Liang L, Zhao M, Zhu YC, Hu X, Yang LP, Liu H
Ann Hematol 2016 Sep;95(9):1473-82. Epub 2016 Jun 21 doi: 10.1007/s00277-016-2719-6. PMID: 27329288
Police RL, Trask PC, Wang J, Olivares R, Khan S, Abbe A, Colosia A, Njue A, Sherrill B, Ruiz-Soto R, Kaye JA, Hamadani M
Clin Lymphoma Myeloma Leuk 2015 Apr;15(4):199-207. Epub 2014 Oct 2 doi: 10.1016/j.clml.2014.09.008. PMID: 25445467
Lepretre S, Jäger U, Janssens A, Leblond V, Nikitin E, Robak T, Wendtner CM
Leuk Lymphoma 2012 May;53(5):820-9. Epub 2011 Dec 13 doi: 10.3109/10428194.2011.631636. PMID: 21992675

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...