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Refractory Chronic Lymphocytic Leukemia

MedGen UID:
124512
Concept ID:
C0278791
Neoplastic Process
Synonyms: Chronic Lymphocytic Leukemia Refractory; Refractory B-Cell Chronic Lymphocytic Leukemia; Refractory Chronic Lymphoid Leukemia; Refractory CLL

Definition

Chronic lymphocytic leukemia that is resistant to treatment. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Islam P
Curr Treat Options Oncol 2023 Sep;24(9):1259-1273. Epub 2023 Jul 6 doi: 10.1007/s11864-023-01112-0. PMID: 37407887
Woyach JA
Am J Hematol 2022 Nov;97 Suppl 2(Suppl 2):S11-S18. doi: 10.1002/ajh.26683. PMID: 36125037Free PMC Article
Harris V, Borlagdan J, Muluneh B
J Oncol Pharm Pract 2022 Jun;28(4):935-944. Epub 2022 Jan 27 doi: 10.1177/10781552211073906. PMID: 35084245

Recent clinical studies

Etiology

Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M
N Engl J Med 2023 Jan 26;388(4):319-332. Epub 2022 Dec 13 doi: 10.1056/NEJMoa2211582. PMID: 36511784
Kater AP, Wu JQ, Kipps T, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Robak T, de la Serna J, Jaeger U, Cartron G, Montillo M, Dubois J, Eldering E, Mellink C, Van Der Kevie-Kersemaekers AM, Kim SY, Chyla B, Punnoose E, Bolen CR, Assaf ZJ, Jiang Y, Wang J, Lefebure M, Boyer M, Humphrey K, Seymour JF
J Clin Oncol 2020 Dec 1;38(34):4042-4054. Epub 2020 Sep 28 doi: 10.1200/JCO.20.00948. PMID: 32986498Free PMC Article
Ghia P, Pluta A, Wach M, Lysak D, Kozak T, Simkovic M, Kaplan P, Kraychok I, Illes A, de la Serna J, Dolan S, Campbell P, Musuraca G, Jacob A, Avery E, Lee JH, Liang W, Patel P, Quah C, Jurczak W
J Clin Oncol 2020 Sep 1;38(25):2849-2861. Epub 2020 May 27 doi: 10.1200/JCO.19.03355. PMID: 32459600
Seymour JF, Kipps TJ, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Gerecitano J, Robak T, De la Serna J, Jaeger U, Cartron G, Montillo M, Humerickhouse R, Punnoose EA, Li Y, Boyer M, Humphrey K, Mobasher M, Kater AP
N Engl J Med 2018 Mar 22;378(12):1107-1120. doi: 10.1056/NEJMoa1713976. PMID: 29562156
Pal Singh S, Dammeijer F, Hendriks RW
Mol Cancer 2018 Feb 19;17(1):57. doi: 10.1186/s12943-018-0779-z. PMID: 29455639Free PMC Article

Diagnosis

Bravo J, Baltasar Tello P, González Garcia E, Ríos Herranz E, Páyer AR, Terol Castera MJ, Champ D, Medina Perez A, Gironella M, Fernández Zarzoso M, Forés R, Delgado J, Garcia-Marco JA; GABRIELL Study Group/Investigators
Leuk Lymphoma 2023 May;64(5):913-926. Epub 2023 May 31 doi: 10.1080/10428194.2023.2216327. PMID: 37255002
Siddiqi T, Soumerai JD, Dorritie KA, Stephens DM, Riedell PA, Arnason J, Kipps TJ, Gillenwater HH, Gong L, Yang L, Ogasawara K, Thorpe J, Wierda WG
Blood 2022 Mar 24;139(12):1794-1806. doi: 10.1182/blood.2021011895. PMID: 34699592Free PMC Article
Fürstenau M, Hallek M, Eichhorst B
Haematologica 2019 Nov;104(11):2144-2154. Epub 2019 Oct 4 doi: 10.3324/haematol.2018.208603. PMID: 31585959Free PMC Article
Mihalyova J, Jelinek T, Growkova K, Hrdinka M, Simicek M, Hajek R
Exp Hematol 2018 May;61:10-25. Epub 2018 Mar 2 doi: 10.1016/j.exphem.2018.02.002. PMID: 29477371
Reagan JL, Castillo JJ
Expert Rev Anticancer Ther 2011 Feb;11(2):151-60. doi: 10.1586/era.10.223. PMID: 21342032

Therapy

Odetola O, Ma S
Curr Hematol Malig Rep 2023 Oct;18(5):130-143. Epub 2023 Jun 6 doi: 10.1007/s11899-023-00700-z. PMID: 37278884Free PMC Article
Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M
N Engl J Med 2023 Jan 26;388(4):319-332. Epub 2022 Dec 13 doi: 10.1056/NEJMoa2211582. PMID: 36511784
Seymour JF, Kipps TJ, Eichhorst BF, D'Rozario J, Owen CJ, Assouline S, Lamanna N, Robak T, de la Serna J, Jaeger U, Cartron G, Montillo M, Mellink C, Chyla B, Panchal A, Lu T, Wu JQ, Jiang Y, Lefebure M, Boyer M, Kater AP
Blood 2022 Aug 25;140(8):839-850. doi: 10.1182/blood.2021015014. PMID: 35605176Free PMC Article
Hillmen P, Rawstron AC, Brock K, Muñoz-Vicente S, Yates FJ, Bishop R, Boucher R, MacDonald D, Fegan C, McCaig A, Schuh A, Pettitt A, Gribben JG, Patten PEM, Devereux S, Bloor A, Fox CP, Forconi F, Munir T
J Clin Oncol 2019 Oct 20;37(30):2722-2729. Epub 2019 Jul 11 doi: 10.1200/JCO.19.00894. PMID: 31295041Free PMC Article
Seymour JF, Kipps TJ, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Gerecitano J, Robak T, De la Serna J, Jaeger U, Cartron G, Montillo M, Humerickhouse R, Punnoose EA, Li Y, Boyer M, Humphrey K, Mobasher M, Kater AP
N Engl J Med 2018 Mar 22;378(12):1107-1120. doi: 10.1056/NEJMoa1713976. PMID: 29562156

Prognosis

Brown JR, Eichhorst B, Hillmen P, Jurczak W, Kaźmierczak M, Lamanna N, O'Brien SM, Tam CS, Qiu L, Zhou K, Simkovic M, Mayer J, Gillespie-Twardy A, Ferrajoli A, Ganly PS, Weinkove R, Grosicki S, Mital A, Robak T, Osterborg A, Yimer HA, Salmi T, Wang MD, Fu L, Li J, Wu K, Cohen A, Shadman M
N Engl J Med 2023 Jan 26;388(4):319-332. Epub 2022 Dec 13 doi: 10.1056/NEJMoa2211582. PMID: 36511784
Kater AP, Wu JQ, Kipps T, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Robak T, de la Serna J, Jaeger U, Cartron G, Montillo M, Dubois J, Eldering E, Mellink C, Van Der Kevie-Kersemaekers AM, Kim SY, Chyla B, Punnoose E, Bolen CR, Assaf ZJ, Jiang Y, Wang J, Lefebure M, Boyer M, Humphrey K, Seymour JF
J Clin Oncol 2020 Dec 1;38(34):4042-4054. Epub 2020 Sep 28 doi: 10.1200/JCO.20.00948. PMID: 32986498Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Kater AP, Seymour JF, Hillmen P, Eichhorst B, Langerak AW, Owen C, Verdugo M, Wu J, Punnoose EA, Jiang Y, Wang J, Boyer M, Humphrey K, Mobasher M, Kipps TJ
J Clin Oncol 2019 Feb 1;37(4):269-277. Epub 2018 Dec 3 doi: 10.1200/JCO.18.01580. PMID: 30523712
Porter DL, Hwang WT, Frey NV, Lacey SF, Shaw PA, Loren AW, Bagg A, Marcucci KT, Shen A, Gonzalez V, Ambrose D, Grupp SA, Chew A, Zheng Z, Milone MC, Levine BL, Melenhorst JJ, June CH
Sci Transl Med 2015 Sep 2;7(303):303ra139. doi: 10.1126/scitranslmed.aac5415. PMID: 26333935Free PMC Article

Clinical prediction guides

Woyach JA, Stephens DM, Flinn IW, Bhat SA, Savage RE, Chai F, Eathiraj S, Reiff SD, Muhowski EM, Granlund L, Szuszkiewicz L, Wang W, Schwartz B, Ghori R, Farooqui MZH, Byrd JC
Cancer Discov 2024 Jan 12;14(1):66-75. doi: 10.1158/2159-8290.CD-23-0670. PMID: 37930156
Kater AP, Wu JQ, Kipps T, Eichhorst B, Hillmen P, D'Rozario J, Assouline S, Owen C, Robak T, de la Serna J, Jaeger U, Cartron G, Montillo M, Dubois J, Eldering E, Mellink C, Van Der Kevie-Kersemaekers AM, Kim SY, Chyla B, Punnoose E, Bolen CR, Assaf ZJ, Jiang Y, Wang J, Lefebure M, Boyer M, Humphrey K, Seymour JF
J Clin Oncol 2020 Dec 1;38(34):4042-4054. Epub 2020 Sep 28 doi: 10.1200/JCO.20.00948. PMID: 32986498Free PMC Article
Ghia P, Pluta A, Wach M, Lysak D, Kozak T, Simkovic M, Kaplan P, Kraychok I, Illes A, de la Serna J, Dolan S, Campbell P, Musuraca G, Jacob A, Avery E, Lee JH, Liang W, Patel P, Quah C, Jurczak W
J Clin Oncol 2020 Sep 1;38(25):2849-2861. Epub 2020 May 27 doi: 10.1200/JCO.19.03355. PMID: 32459600
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Hillmen P, Rawstron AC, Brock K, Muñoz-Vicente S, Yates FJ, Bishop R, Boucher R, MacDonald D, Fegan C, McCaig A, Schuh A, Pettitt A, Gribben JG, Patten PEM, Devereux S, Bloor A, Fox CP, Forconi F, Munir T
J Clin Oncol 2019 Oct 20;37(30):2722-2729. Epub 2019 Jul 11 doi: 10.1200/JCO.19.00894. PMID: 31295041Free PMC Article

Recent systematic reviews

Wen Y, Meng L, Zhang X, Gao Q
Expert Rev Hematol 2022 Sep;15(9):849-856. Epub 2022 Aug 9 doi: 10.1080/17474086.2022.2110062. PMID: 35920616
Sorensen S, Wildgust M, Sengupta N, Trambitas C, Diels J, van Sanden S, Xu Y, Dorman E
Clin Ther 2017 Jan;39(1):178-189.e5. Epub 2017 Jan 3 doi: 10.1016/j.clinthera.2016.12.001. PMID: 28062113
Liang L, Zhao M, Zhu YC, Hu X, Yang LP, Liu H
Ann Hematol 2016 Sep;95(9):1473-82. Epub 2016 Jun 21 doi: 10.1007/s00277-016-2719-6. PMID: 27329288
Police RL, Trask PC, Wang J, Olivares R, Khan S, Abbe A, Colosia A, Njue A, Sherrill B, Ruiz-Soto R, Kaye JA, Hamadani M
Clin Lymphoma Myeloma Leuk 2015 Apr;15(4):199-207. Epub 2014 Oct 2 doi: 10.1016/j.clml.2014.09.008. PMID: 25445467
Lepretre S, Jäger U, Janssens A, Leblond V, Nikitin E, Robak T, Wendtner CM
Leuk Lymphoma 2012 May;53(5):820-9. Epub 2011 Dec 13 doi: 10.3109/10428194.2011.631636. PMID: 21992675

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