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Recurrent Adrenal Cortical Carcinoma

MedGen UID:
124515
•Concept ID:
C0278818
•
Neoplastic Process
Synonyms: Recurrent Adrenal Cortex Cancer; Recurrent Adrenal Cortex Carcinoma; Recurrent Adrenocortical Carcinoma; Recurrent Carcinoma of Adrenal Cortex; Recurrent Carcinoma of the Adrenal Cortex; Relapsed Adrenal Cortex Carcinoma; Relapsed Adrenocortical Carcinoma; Relapsed Carcinoma of Adrenal Cortex; Relapsed Carcinoma of the Adrenal Cortex

Definition

The reemergence of adrenal cortical carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Adrenal Cortical Carcinoma

Professional guidelines

PubMed

American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
New perspectives for mitotane treatment of adrenocortical carcinoma.
Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P, Terzolo M
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101415. Epub 2020 Mar 5 doi: 10.1016/j.beem.2020.101415. PMID: 32179008
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884

Recent clinical studies

Etiology

Adrenocortical Carcinoma: Role of Adjuvant and Neoadjuvant Therapy.
Kenney L, Hughes M
Surg Oncol Clin N Am 2023 Apr;32(2):279-287. doi: 10.1016/j.soc.2022.10.005. PMID: 36925185
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
New perspectives for mitotane treatment of adrenocortical carcinoma.
Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P, Terzolo M
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101415. Epub 2020 Mar 5 doi: 10.1016/j.beem.2020.101415. PMID: 32179008
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884

Diagnosis

American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
Surgery for adrenocortical carcinoma: When and how?
Sinclair TJ, Gillis A, Alobuia WM, Wild H, Kebebew E
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101408. Epub 2020 Mar 3 doi: 10.1016/j.beem.2020.101408. PMID: 32265101
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
Mortality in Patients with Endogenous Cushing's Syndrome.
Javanmard P, Duan D, Geer EB
Endocrinol Metab Clin North Am 2018 Jun;47(2):313-333. doi: 10.1016/j.ecl.2018.02.005. PMID: 29754634
Malignant adrenal tumors.
Rescorla FJ
Semin Pediatr Surg 2006 Feb;15(1):48-56. doi: 10.1053/j.sempedsurg.2005.11.008. PMID: 16458846

Therapy

Adrenocortical Carcinoma: Role of Adjuvant and Neoadjuvant Therapy.
Kenney L, Hughes M
Surg Oncol Clin N Am 2023 Apr;32(2):279-287. doi: 10.1016/j.soc.2022.10.005. PMID: 36925185
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
New perspectives for mitotane treatment of adrenocortical carcinoma.
Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P, Terzolo M
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101415. Epub 2020 Mar 5 doi: 10.1016/j.beem.2020.101415. PMID: 32179008
Adrenocortical Cancer Treatment.
Long SE, Miller BS
Surg Clin North Am 2019 Aug;99(4):759-771. Epub 2019 May 27 doi: 10.1016/j.suc.2019.04.012. PMID: 31255205
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884

Prognosis

Surgery for adrenocortical carcinoma: When and how?
Sinclair TJ, Gillis A, Alobuia WM, Wild H, Kebebew E
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101408. Epub 2020 Mar 3 doi: 10.1016/j.beem.2020.101408. PMID: 32265101
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Adrenocortical Cancer Treatment.
Long SE, Miller BS
Surg Clin North Am 2019 Aug;99(4):759-771. Epub 2019 May 27 doi: 10.1016/j.suc.2019.04.012. PMID: 31255205
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
Malignant adrenal tumors.
Rescorla FJ
Semin Pediatr Surg 2006 Feb;15(1):48-56. doi: 10.1053/j.sempedsurg.2005.11.008. PMID: 16458846

Clinical prediction guides

New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study.
Puglisi S, Calabrese A, Ferraù F, Violi MA, Laganà M, Grisanti S, Ceccato F, Scaroni C, Di Dalmazi G, Stigliano A, Altieri B, Canu L, Loli P, Pivonello R, Arvat E, Morelli V, Perotti P, Basile V, Berchialla P, Urru S, Fiori C, Porpiglia F, Berruti A, Pia A, Reimondo G, Cannavò S, Terzolo M
J Clin Endocrinol Metab 2023 Sep 18;108(10):2517-2525. doi: 10.1210/clinem/dgad199. PMID: 37022947
Prognostic Value of Microscopic Tumor Necrosis in Adrenal Cortical Carcinoma.
Luconi M, Cantini G, van Leeuwaarde RS, Roebaar R, Fei L, Propato AP, Santi R, Ercolino T, Mannelli M, Canu L, de Krijger RR, Nesi G
Endocr Pathol 2023 Jun;34(2):224-233. Epub 2023 Mar 23 doi: 10.1007/s12022-023-09760-6. PMID: 36952130Free PMC Article
Multimodality Imaging of Abdominopelvic Tumors with Venous Invasion.
LeGout JD, Bailey RE, Bolan CW, Bowman AW, Chen F, Cernigliaro JG, Alexander LF
Radiographics 2020 Nov-Dec;40(7):2098-2116. Epub 2020 Oct 16 doi: 10.1148/rg.2020200047. PMID: 33064623
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884

Recent systematic reviews

Open Versus Laparoscopic Surgery in the Management of Adrenocortical Carcinoma: A Systematic Review and Meta-analysis.
Nakanishi H, Miangul S, Wang R, El Haddad J, El Ghazal N, Abdulsalam FA, Matar RH, Than CA, Johnson BE, Chen H
Ann Surg Oncol 2023 Feb;30(2):994-1005. Epub 2022 Nov 7 doi: 10.1245/s10434-022-12711-w. PMID: 36344710
Operative Management of Recurrent and Metastatic Adrenocortical Carcinoma: A Systematic Review.
Lo WM, Kariya CM, Hernandez JM
Am Surg 2019 Jan 1;85(1):23-28. PMID: 30760340Free PMC Article
Influence of hormonal functional status on survival in adrenocortical carcinoma: systematic review and meta-analysis.
Vanbrabant T, Fassnacht M, Assie G, Dekkers OM
Eur J Endocrinol 2018 Dec 1;179(6):429-436. doi: 10.1530/EJE-18-0450. PMID: 30325179
Molecular Imaging in the Management of Adrenocortical Cancer: A Systematic Review.
Wong KK, Miller BS, Viglianti BL, Dwamena BA, Gauger PG, Cook GJ, Colletti PM, Rubello D, Gross MD
Clin Nucl Med 2016 Aug;41(8):e368-82. doi: 10.1097/RLU.0000000000001112. PMID: 26825212
Minimally invasive adrenalectomy in children.
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405

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