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Esophageal squamous cell carcinoma

MedGen UID:
124635
Concept ID:
C0279626
Neoplastic Process
Synonyms: Esophageal Squamous Cell Carcinoma; Oesophageal Squamous Cell Carcinoma
SNOMED CT: Squamous cell carcinoma of esophagus (276804009); SCC - Squamous cell carcinoma of esophagus (276804009)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005580
Orphanet: ORPHA99977

Definition

Esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma (EC; see this term) that can affect any part of the esophagus, but is usually located in the upper or middle third. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Esophageal squamous cell carcinoma

Professional guidelines

PubMed

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Hirano H, Kato K
Jpn J Clin Oncol 2019 May 1;49(5):412-420. doi: 10.1093/jjco/hyz034. PMID: 30920626

Recent clinical studies

Etiology

Puhr HC, Prager GW, Ilhan-Mutlu A
ESMO Open 2023 Feb;8(1):100789. Epub 2023 Feb 13 doi: 10.1016/j.esmoop.2023.100789. PMID: 36791637Free PMC Article
Codipilly DC, Wang KK
Gastroenterol Clin North Am 2022 Sep;51(3):457-484. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.06.005. PMID: 36153105
Lam AK
Methods Mol Biol 2020;2129:1-6. doi: 10.1007/978-1-0716-0377-2_1. PMID: 32056165
Reichenbach ZW, Murray MG, Saxena R, Farkas D, Karassik EG, Klochkova A, Patel K, Tice C, Hall TM, Gang J, Parkman HP, Ward SJ, Tétreault MP, Whelan KA
Adv Cancer Res 2019;144:95-135. Epub 2019 Jun 10 doi: 10.1016/bs.acr.2019.05.004. PMID: 31349905
Codipilly DC, Qin Y, Dawsey SM, Kisiel J, Topazian M, Ahlquist D, Iyer PG
Gastrointest Endosc 2018 Sep;88(3):413-426. Epub 2018 Apr 27 doi: 10.1016/j.gie.2018.04.2352. PMID: 29709526Free PMC Article

Diagnosis

Codipilly DC, Wang KK
Gastroenterol Clin North Am 2022 Sep;51(3):457-484. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.06.005. PMID: 36153105
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Harada K, Rogers JE, Iwatsuki M, Yamashita K, Baba H, Ajani JA
F1000Res 2020;9 Epub 2020 Oct 1 doi: 10.12688/f1000research.22926.1. PMID: 33042518Free PMC Article
Uhlenhopp DJ, Then EO, Sunkara T, Gaduputi V
Clin J Gastroenterol 2020 Dec;13(6):1010-1021. Epub 2020 Sep 23 doi: 10.1007/s12328-020-01237-x. PMID: 32965635
Codipilly DC, Qin Y, Dawsey SM, Kisiel J, Topazian M, Ahlquist D, Iyer PG
Gastrointest Endosc 2018 Sep;88(3):413-426. Epub 2018 Apr 27 doi: 10.1016/j.gie.2018.04.2352. PMID: 29709526Free PMC Article

Therapy

Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
Codipilly DC, Wang KK
Gastroenterol Clin North Am 2022 Sep;51(3):457-484. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.06.005. PMID: 36153105
Wang ZX, Cui C, Yao J, Zhang Y, Li M, Feng J, Yang S, Fan Y, Shi J, Zhang X, Shen L, Shu Y, Wang C, Dai T, Mao T, Chen L, Guo Z, Liu B, Pan H, Cang S, Jiang Y, Wang J, Ye M, Chen Z, Jiang D, Lin Q, Ren W, Wang J, Wu L, Xu Y, Miao Z, Sun M, Xie C, Liu Y, Wang Q, Zhao L, Li Q, Huang C, Jiang K, Yang K, Li D, Liu Y, Zhu Z, Chen R, Jia L, Li W, Liao W, Liu HX, Ma D, Ma J, Qin Y, Shi Z, Wei Q, Xiao K, Zhang Y, Zhang Y, Chen X, Dai G, He J, Li J, Li G, Liu Y, Liu Z, Yuan X, Zhang J, Fu Z, He Y, Ju F, Liu Z, Tang P, Wang T, Wang W, Zhang J, Luo X, Tang X, May R, Feng H, Yao S, Keegan P, Xu RH, Wang F
Cancer Cell 2022 Mar 14;40(3):277-288.e3. Epub 2022 Mar 3 doi: 10.1016/j.ccell.2022.02.007. PMID: 35245446
Doki Y, Ajani JA, Kato K, Xu J, Wyrwicz L, Motoyama S, Ogata T, Kawakami H, Hsu CH, Adenis A, El Hajbi F, Di Bartolomeo M, Braghiroli MI, Holtved E, Ostoich SA, Kim HR, Ueno M, Mansoor W, Yang WC, Liu T, Bridgewater J, Makino T, Xynos I, Liu X, Lei M, Kondo K, Patel A, Gricar J, Chau I, Kitagawa Y; CheckMate 648 Trial Investigators
N Engl J Med 2022 Feb 3;386(5):449-462. doi: 10.1056/NEJMoa2111380. PMID: 35108470
Luo H, Lu J, Bai Y, Mao T, Wang J, Fan Q, Zhang Y, Zhao K, Chen Z, Gao S, Li J, Fu Z, Gu K, Liu Z, Wu L, Zhang X, Feng J, Niu Z, Ba Y, Zhang H, Liu Y, Zhang L, Min X, Huang J, Cheng Y, Wang D, Shen Y, Yang Q, Zou J, Xu RH; ESCORT-1st Investigators
JAMA 2021 Sep 14;326(10):916-925. doi: 10.1001/jama.2021.12836. PMID: 34519801Free PMC Article

Prognosis

Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Wang QL, Ness-Jensen E, Santoni G, Xie SH, Lagergren J
Am J Gastroenterol 2021 Apr;116(4):683-691. doi: 10.14309/ajg.0000000000001094. PMID: 33982937
Li C, Zhao S, Zheng Y, Han Y, Chen X, Cheng Z, Wu Y, Feng X, Qi W, Chen K, Xiang J, Li J, Lerut T, Li H
Eur J Cancer 2021 Feb;144:232-241. Epub 2020 Dec 26 doi: 10.1016/j.ejca.2020.11.039. PMID: 33373868
Lam AK
Methods Mol Biol 2020;2129:1-6. doi: 10.1007/978-1-0716-0377-2_1. PMID: 32056165
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261

Clinical prediction guides

Yap DWT, Leone AG, Wong NZH, Zhao JJ, Tey JCS, Sundar R, Pietrantonio F
JAMA Oncol 2023 Feb 1;9(2):215-224. doi: 10.1001/jamaoncol.2022.5816. PMID: 36480211Free PMC Article
Guo W, Tan F, Huai Q, Wang Z, Shao F, Zhang G, Yang Z, Li R, Xue Q, Gao S, He J
Front Immunol 2021;12:669750. Epub 2021 May 12 doi: 10.3389/fimmu.2021.669750. PMID: 34054840Free PMC Article
Pan C, Wang Y, Liu Q, Hu Y, Fu J, Xie X, Zhang S, Xi M, Wen J
Oncoimmunology 2021 Feb 10;10(1):1883890. doi: 10.1080/2162402X.2021.1883890. PMID: 33628625Free PMC Article
Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M
Gastroenterology 2015 Dec;149(7):1700-15. Epub 2015 Sep 12 doi: 10.1053/j.gastro.2015.08.054. PMID: 26376349
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Recent systematic reviews

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089Free PMC Article
Gao TT, Shan JH, Yang YX, Zhang ZW, Liu SL, Xi M, Liu MZ, Zhao L
BMC Cancer 2022 Sep 17;22(1):992. doi: 10.1186/s12885-022-10086-5. PMID: 36115960Free PMC Article
Inoue T, Ishihara R, Shibata T, Suzuki K, Kitagawa Y, Miyazaki T, Yamaji T, Nemoto K, Oyama T, Muto M, Takeuchi H, Toh Y, Matsubara H, Mano M, Kono K, Kato K, Yoshida M, Kawakubo H, Booka E, Yamatsuji T, Kato H, Ito Y, Ishikawa H, Tsushima T, Kawachi H, Oyama T, Kojima T, Kuribayashi S, Makino T, Matsuda S, Doki Y; Esophageal Cancer Practice Guidelines Preparation Committee
Esophagus 2022 Jul;19(3):375-383. Epub 2022 Apr 9 doi: 10.1007/s10388-022-00918-5. PMID: 35397101
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article

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