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Esophageal squamous cell carcinoma

MedGen UID:
124635
Concept ID:
C0279626
Neoplastic Process
Synonyms: Esophageal Squamous Cell Carcinoma; Oesophageal Squamous Cell Carcinoma
SNOMED CT: Squamous cell carcinoma of esophagus (276804009); SCC - Squamous cell carcinoma of esophagus (276804009)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005580
Orphanet: ORPHA99977

Definition

Esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma (EC; see this term) that can affect any part of the esophagus, but is usually located in the upper or middle third. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Esophageal squamous cell carcinoma

Professional guidelines

PubMed

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Takeuchi H, Ito Y, Machida R, Kato K, Onozawa M, Minashi K, Yano T, Nakamura K, Tsushima T, Hara H, Okuno T, Hironaka S, Nozaki I, Ura T, Chin K, Kojima T, Seki S, Sakanaka K, Fukuda H, Kitagawa Y; Japan Esophageal Oncology Group of the Japan Clinical Oncology Group
Int J Radiat Oncol Biol Phys 2022 Nov 1;114(3):454-462. Epub 2022 Aug 4 doi: 10.1016/j.ijrobp.2022.07.007. PMID: 35932949
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974

Recent clinical studies

Etiology

Chiang HC, Hughes M, Chang WL
Thorac Cancer 2023 Oct;14(28):2821-2829. Epub 2023 Sep 7 doi: 10.1111/1759-7714.15096. PMID: 37675608Free PMC Article
Puhr HC, Prager GW, Ilhan-Mutlu A
ESMO Open 2023 Feb;8(1):100789. Epub 2023 Feb 13 doi: 10.1016/j.esmoop.2023.100789. PMID: 36791637Free PMC Article
Codipilly DC, Wang KK
Gastroenterol Clin North Am 2022 Sep;51(3):457-484. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.06.005. PMID: 36153105
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Codipilly DC, Qin Y, Dawsey SM, Kisiel J, Topazian M, Ahlquist D, Iyer PG
Gastrointest Endosc 2018 Sep;88(3):413-426. Epub 2018 Apr 27 doi: 10.1016/j.gie.2018.04.2352. PMID: 29709526Free PMC Article

Diagnosis

Codipilly DC, Wang KK
Gastroenterol Clin North Am 2022 Sep;51(3):457-484. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.06.005. PMID: 36153105
Yang T, Hui R, Nouws J, Sauler M, Zeng T, Wu Q
J Transl Med 2022 Mar 14;20(1):127. doi: 10.1186/s12967-022-03311-z. PMID: 35287685Free PMC Article
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Harada K, Rogers JE, Iwatsuki M, Yamashita K, Baba H, Ajani JA
F1000Res 2020;9 Epub 2020 Oct 1 doi: 10.12688/f1000research.22926.1. PMID: 33042518Free PMC Article
Liu K, Zhao T, Wang J, Chen Y, Zhang R, Lan X, Que J
Cancer Lett 2019 Aug 28;458:21-28. Epub 2019 May 21 doi: 10.1016/j.canlet.2019.05.018. PMID: 31125642Free PMC Article

Therapy

Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, Li Y, Chen H, Wei S, Sun R, Cui H, Meng Y, Liu M, Li Y, Feng R, Yu X, Zhu R, Wu Y, Li L, Yang B, Ma Y, Wang J, Zhu W, Deng D, Xi Y, Wang F, Li H, Guo S, Zhuang X, Wang X, Jiao Y, Cui Y, Zhan Q
Cancer Cell 2023 Jan 9;41(1):181-195.e9. Epub 2022 Dec 29 doi: 10.1016/j.ccell.2022.12.004. PMID: 36584672
Codipilly DC, Wang KK
Gastroenterol Clin North Am 2022 Sep;51(3):457-484. Epub 2022 Aug 29 doi: 10.1016/j.gtc.2022.06.005. PMID: 36153105
Shen L, Kato K, Kim SB, Ajani JA, Zhao K, He Z, Yu X, Shu Y, Luo Q, Wang J, Chen Z, Niu Z, Zhang L, Yi T, Sun JM, Chen J, Yu G, Lin CY, Hara H, Bi Q, Satoh T, Pazo-Cid R, Arkenau HT, Borg C, Lordick F, Li L, Ding N, Tao A, Shi J, Van Cutsem E; RATIONALE-302 Investigators
J Clin Oncol 2022 Sep 10;40(26):3065-3076. Epub 2022 Apr 20 doi: 10.1200/JCO.21.01926. PMID: 35442766Free PMC Article
Doki Y, Ajani JA, Kato K, Xu J, Wyrwicz L, Motoyama S, Ogata T, Kawakami H, Hsu CH, Adenis A, El Hajbi F, Di Bartolomeo M, Braghiroli MI, Holtved E, Ostoich SA, Kim HR, Ueno M, Mansoor W, Yang WC, Liu T, Bridgewater J, Makino T, Xynos I, Liu X, Lei M, Kondo K, Patel A, Gricar J, Chau I, Kitagawa Y; CheckMate 648 Trial Investigators
N Engl J Med 2022 Feb 3;386(5):449-462. doi: 10.1056/NEJMoa2111380. PMID: 35108470
Luo H, Lu J, Bai Y, Mao T, Wang J, Fan Q, Zhang Y, Zhao K, Chen Z, Gao S, Li J, Fu Z, Gu K, Liu Z, Wu L, Zhang X, Feng J, Niu Z, Ba Y, Zhang H, Liu Y, Zhang L, Min X, Huang J, Cheng Y, Wang D, Shen Y, Yang Q, Zou J, Xu RH; ESCORT-1st Investigators
JAMA 2021 Sep 14;326(10):916-925. doi: 10.1001/jama.2021.12836. PMID: 34519801Free PMC Article

Prognosis

Wang S, Zheng R, Arnold M, Abnet C, Zeng H, Zhang S, Chen R, Sun K, Li L, An L, Bray F, Wei W, He J
Int J Cancer 2022 Nov 1;151(9):1447-1461. Epub 2022 Jun 22 doi: 10.1002/ijc.34158. PMID: 35678331Free PMC Article
Morgan E, Soerjomataram I, Rumgay H, Coleman HG, Thrift AP, Vignat J, Laversanne M, Ferlay J, Arnold M
Gastroenterology 2022 Sep;163(3):649-658.e2. Epub 2022 Jun 4 doi: 10.1053/j.gastro.2022.05.054. PMID: 35671803
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Li C, Zhao S, Zheng Y, Han Y, Chen X, Cheng Z, Wu Y, Feng X, Qi W, Chen K, Xiang J, Li J, Lerut T, Li H
Eur J Cancer 2021 Feb;144:232-241. Epub 2020 Dec 26 doi: 10.1016/j.ejca.2020.11.039. PMID: 33373868
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261

Clinical prediction guides

Li H, Miao Y, Zhong L, Feng S, Xu Y, Tang L, Wu C, Zhang X, Gu L, Diao H, Wang H, Wen Z, Yang M
Front Immunol 2023;14:1162032. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1162032. PMID: 37187751Free PMC Article
Zhang G, Yuan J, Pan C, Xu Q, Cui X, Zhang J, Liu M, Song Z, Wu L, Wu D, Luo H, Hu Y, Jiao S, Yang B
EBioMedicine 2023 Apr;90:104515. Epub 2023 Mar 13 doi: 10.1016/j.ebiom.2023.104515. PMID: 36921563Free PMC Article
Yap DWT, Leone AG, Wong NZH, Zhao JJ, Tey JCS, Sundar R, Pietrantonio F
JAMA Oncol 2023 Feb 1;9(2):215-224. doi: 10.1001/jamaoncol.2022.5816. PMID: 36480211Free PMC Article
Guo W, Tan F, Huai Q, Wang Z, Shao F, Zhang G, Yang Z, Li R, Xue Q, Gao S, He J
Front Immunol 2021;12:669750. Epub 2021 May 12 doi: 10.3389/fimmu.2021.669750. PMID: 34054840Free PMC Article
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Recent systematic reviews

Li H, Zhang L, Yang F, Zhao R, Li X, Li H
Front Immunol 2023;14:1218386. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1218386. PMID: 37841249Free PMC Article
He W, Wang C, Li C, Nie X, Li H, Li J, Zhao N, Chen H, Miao X, Han Y, Peng L, Leng X
Front Immunol 2023;14:1118902. Epub 2023 Feb 17 doi: 10.3389/fimmu.2023.1118902. PMID: 36875107Free PMC Article
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089Free PMC Article
Wang C, Wang J, Chen Z, Gao Y, He J
Chin J Cancer 2017 Aug 17;36(1):65. doi: 10.1186/s40880-017-0232-5. PMID: 28818096Free PMC Article

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Table of contents

    Clinical resources

    Practice guidelines

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