U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adenocarcinoma of esophagus

MedGen UID:
124636
•Concept ID:
C0279628
•
Neoplastic Process
Synonym: Esophageal adenocarcinoma
SNOMED CT: Adenocarcinoma of esophagus (276803003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005028
OMIM®: 614266
Orphanet: ORPHA99976

Definition

Esophageal adenocarcinoma (EAC) is a sub-type of esophageal carcinoma (EC; see this term) affecting the glandular cells of the lower esophagus at the junction with the stomach. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma of esophagus

Professional guidelines

PubMed

Trends in Surgical Management of Esophageal Cancer.
Thakur B, Devkota M, Thapa A
J Nepal Health Res Counc 2023 Jul 20;20(4):868-874. doi: 10.33314/jnhrc.v20i4.4202. PMID: 37489669
Columnar islands in Barrett's esophagus: Do they impact Prague C&M criteria and dysplasia grade?
Epstein JA, Cosby H, Falk GW, Khashab MA, Kiesslich R, Montgomery EA, Wang JS, Canto MI
J Gastroenterol Hepatol 2017 Sep;32(9):1598-1603. doi: 10.1111/jgh.13744. PMID: 28116788
Metabolic response evaluation by PET during neoadjuvant treatment for adenocarcinoma of the esophagus and esophagogastric junction.
Sendler A
Recent Results Cancer Res 2010;182:167-77. doi: 10.1007/978-3-540-70579-6_14. PMID: 20676880

Curated

UK NICE Guidance, NICE Guideline NG231, Barrett's oesophagus and stage 1 oesophageal adenocarcinoma: monitoring and management, 2023

Recent clinical studies

Etiology

Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
Barrett's Esophagus.
Bujanda DE, Hachem C
Mo Med 2018 May-Jun;115(3):211-213. PMID: 30228724Free PMC Article
Clinical Guidelines Update on the Diagnosis and Management of Barrett's Esophagus.
Clermont M, Falk GW
Dig Dis Sci 2018 Aug;63(8):2122-2128. doi: 10.1007/s10620-018-5070-z. PMID: 29671159
The Epidemiology of Esophageal Adenocarcinoma.
Coleman HG, Xie SH, Lagergren J
Gastroenterology 2018 Jan;154(2):390-405. Epub 2017 Aug 3 doi: 10.1053/j.gastro.2017.07.046. PMID: 28780073
Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries.
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Diagnosis

Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
Barrett's Esophagus.
Bujanda DE, Hachem C
Mo Med 2018 May-Jun;115(3):211-213. PMID: 30228724Free PMC Article
Cancer of the gastroesophageal junction: a diagnosis, classification, and management review.
Chevallay M, Bollschweiler E, Chandramohan SM, Schmidt T, Koch O, Demanzoni G, Mönig S, Allum W
Ann N Y Acad Sci 2018 Dec;1434(1):132-138. Epub 2018 Aug 23 doi: 10.1111/nyas.13954. PMID: 30138540
Gastric cancer.
Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H
Lancet 2016 Nov 26;388(10060):2654-2664. Epub 2016 May 5 doi: 10.1016/S0140-6736(16)30354-3. PMID: 27156933
Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries.
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Therapy

Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer.
Shitara K, Ajani JA, Moehler M, Garrido M, Gallardo C, Shen L, Yamaguchi K, Wyrwicz L, Skoczylas T, Bragagnoli AC, Liu T, Tehfe M, Elimova E, Bruges R, Zander T, de Azevedo S, Kowalyszyn R, Pazo-Cid R, Schenker M, Cleary JM, Yanez P, Feeney K, Karamouzis MV, Poulart V, Lei M, Xiao H, Kondo K, Li M, Janjigian YY
Nature 2022 Mar;603(7903):942-948. Epub 2022 Mar 23 doi: 10.1038/s41586-022-04508-4. PMID: 35322232Free PMC Article
First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial.
Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Shen L, Wyrwicz L, Yamaguchi K, Skoczylas T, Campos Bragagnoli A, Liu T, Schenker M, Yanez P, Tehfe M, Kowalyszyn R, Karamouzis MV, Bruges R, Zander T, Pazo-Cid R, Hitre E, Feeney K, Cleary JM, Poulart V, Cullen D, Lei M, Xiao H, Kondo K, Li M, Ajani JA
Lancet 2021 Jul 3;398(10294):27-40. Epub 2021 Jun 5 doi: 10.1016/S0140-6736(21)00797-2. PMID: 34102137Free PMC Article
Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer.
Shitara K, Bang YJ, Iwasa S, Sugimoto N, Ryu MH, Sakai D, Chung HC, Kawakami H, Yabusaki H, Lee J, Saito K, Kawaguchi Y, Kamio T, Kojima A, Sugihara M, Yamaguchi K; DESTINY-Gastric01 Investigators
N Engl J Med 2020 Jun 18;382(25):2419-2430. Epub 2020 May 29 doi: 10.1056/NEJMoa2004413. PMID: 32469182
Gastric cancer.
Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H
Lancet 2016 Nov 26;388(10060):2654-2664. Epub 2016 May 5 doi: 10.1016/S0140-6736(16)30354-3. PMID: 27156933

Prognosis

The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020.
Morgan E, Soerjomataram I, Rumgay H, Coleman HG, Thrift AP, Vignat J, Laversanne M, Ferlay J, Arnold M
Gastroenterology 2022 Sep;163(3):649-658.e2. Epub 2022 Jun 4 doi: 10.1053/j.gastro.2022.05.054. PMID: 35671803
Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer.
Shitara K, Ajani JA, Moehler M, Garrido M, Gallardo C, Shen L, Yamaguchi K, Wyrwicz L, Skoczylas T, Bragagnoli AC, Liu T, Tehfe M, Elimova E, Bruges R, Zander T, de Azevedo S, Kowalyszyn R, Pazo-Cid R, Schenker M, Cleary JM, Yanez P, Feeney K, Karamouzis MV, Poulart V, Lei M, Xiao H, Kondo K, Li M, Janjigian YY
Nature 2022 Mar;603(7903):942-948. Epub 2022 Mar 23 doi: 10.1038/s41586-022-04508-4. PMID: 35322232Free PMC Article
The Epidemiology of Esophageal Adenocarcinoma.
Coleman HG, Xie SH, Lagergren J
Gastroenterology 2018 Jan;154(2):390-405. Epub 2017 Aug 3 doi: 10.1053/j.gastro.2017.07.046. PMID: 28780073
Oesophageal cancer.
Smyth EC, Lagergren J, Fitzgerald RC, Lordick F, Shah MA, Lagergren P, Cunningham D
Nat Rev Dis Primers 2017 Jul 27;3:17048. doi: 10.1038/nrdp.2017.48. PMID: 28748917Free PMC Article
Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries.
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Clinical prediction guides

The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy.
Croft W, Evans RPT, Pearce H, Elshafie M, Griffiths EA, Moss P
Mol Cancer 2022 Oct 17;21(1):200. doi: 10.1186/s12943-022-01666-x. PMID: 36253784Free PMC Article
The impact of a healthy lifestyle on the risk of esophageal and gastric cancer subtypes.
van den Brandt PA
Eur J Epidemiol 2022 Sep;37(9):931-945. Epub 2022 Aug 19 doi: 10.1007/s10654-022-00899-w. PMID: 35982188Free PMC Article
Barrett Esophagus: A Review.
Sharma P
JAMA 2022 Aug 16;328(7):663-671. doi: 10.1001/jama.2022.13298. PMID: 35972481
The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020.
Morgan E, Soerjomataram I, Rumgay H, Coleman HG, Thrift AP, Vignat J, Laversanne M, Ferlay J, Arnold M
Gastroenterology 2022 Sep;163(3):649-658.e2. Epub 2022 Jun 4 doi: 10.1053/j.gastro.2022.05.054. PMID: 35671803
Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries.
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Recent systematic reviews

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Preferred neoadjuvant therapy for gastric and gastroesophageal junction adenocarcinoma: a systematic review and network meta-analysis.
Grizzi G, Petrelli F, Di Bartolomeo M, Viti M, Texeira Moraes M, Luciani A, Passalacqua R, Ghidini M, Tomasello G, Baiocchi GL, Celotti A
Gastric Cancer 2022 Sep;25(5):982-987. Epub 2022 Jun 15 doi: 10.1007/s10120-022-01314-9. PMID: 35704113
Resistance mechanisms to HER2-targeted therapy in gastroesophageal adenocarcinoma: A systematic review.
Blangé D, Stroes CI, Derks S, Bijlsma MF, van Laarhoven HWM
Cancer Treat Rev 2022 Jul;108:102418. Epub 2022 May 30 doi: 10.1016/j.ctrv.2022.102418. PMID: 35689885
The integration of immune checkpoint inhibitors with VEGF targeted agents in advanced gastric and gastroesophageal adenocarcinoma: a review on the rationale and results of early phase trials.
Saeed A, Park R, Sun W
J Hematol Oncol 2021 Jan 12;14(1):13. doi: 10.1186/s13045-021-01034-0. PMID: 33436042Free PMC Article
Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways.
Schlottmann F, Dreifuss NH, Patti MG
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):425-433. Epub 2020 May 22 doi: 10.1080/17474124.2020.1764348. PMID: 32441160

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guidance, NICE Guideline NG231, Barrett's oesophagus and stage 1 oesophageal adenocarcinoma: monitoring and management, 2023

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...