U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vaginal adenocarcinoma

MedGen UID:
124643
•Concept ID:
C0279668
•
Neoplastic Process
Synonyms: Adenocarcinoma of the Vagina; adenocarcinoma of the vagina; Adenocarcinoma of Vagina; adenocarcinoma of vagina; Vagina Adenocarcinoma; vagina adenocarcinoma; Vaginal Adenocarcinoma; vaginal adenocarcinoma
 
Monarch Initiative: MONDO:0020653

Definition

An adenocarcinoma arising from the vagina. Morphologic variants include the clear cell, endometrioid, mesonephric, and mucinous adenocarcinoma. [from NCI]

Professional guidelines

PubMed

Neoadjuvant chemotherapy combined with surgery for the treatment of a rare primary vaginal adenocarcinoma.
Liu S, Li M, Zhang H
Asian J Surg 2024 Apr;47(4):2039-2040. Epub 2024 Jan 13 doi: 10.1016/j.asjsur.2024.01.030. PMID: 38220528
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Vaginal cytologic evaluation as a practical link between hormone blood levels and tumor hormone dependency in exclusive medroxyprogesterone treatment of recurrent or metastatic endometrial adenocarcinoma.
Bonte J, Decoster JM, Ide P
Acta Cytol 1977 Mar-Apr;21(2):218-24. PMID: 266331

Recent clinical studies

Etiology

Primary vaginal malignancies: a single oncology centre experience.
Lima M, Rio G, Horta M, Cunha TM
J Obstet Gynaecol 2019 Aug;39(6):827-832. Epub 2019 Apr 25 doi: 10.1080/01443615.2019.1579786. PMID: 31020870
A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran.
Mood NI, Eftekhar Z, Haratian A, Saeedi L, Rahimi-Moghaddam P, Yarandi F
Int J Gynecol Cancer 2006 Jan-Feb;16(1):257-61. doi: 10.1111/j.1525-1438.2006.00346.x. PMID: 16445641
Long-term cancer risk in women given diethylstilbestrol (DES) during pregnancy.
Titus-Ernstoff L, Hatch EE, Hoover RN, Palmer J, Greenberg ER, Ricker W, Kaufman R, Noller K, Herbst AL, Colton T, Hartge P
Br J Cancer 2001 Jan 5;84(1):126-33. doi: 10.1054/bjoc.2000.1521. PMID: 11139327Free PMC Article
Vaginal adenocarcinoma in a gravida with prenatal DES exposure.
Del Castillo H, Rubio PA, Farrell EM
Int J Gynaecol Obstet 1978-1979;16(4):271-3. doi: 10.1002/j.1879-3479.1979.tb00443.x. PMID: 35386
Transplacental chemical carcinogenesis in man.
Miller RW
J Natl Cancer Inst 1971 Dec;47(6):1169-71. PMID: 4330461

Diagnosis

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
Primary vaginal malignancies: a single oncology centre experience.
Lima M, Rio G, Horta M, Cunha TM
J Obstet Gynaecol 2019 Aug;39(6):827-832. Epub 2019 Apr 25 doi: 10.1080/01443615.2019.1579786. PMID: 31020870
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Primary vaginal adenocarcinoma of intestinal type arising from an adenoma.
Driss M, Abid L, Mrad K, Dhouib R, Romdhane KB
J Obstet Gynaecol 2007 Apr;27(3):332-3. doi: 10.1080/01443610701269325. PMID: 17464837
A case of pT4 vaginal adenocarcinoma in which surgery prolonged disease-free interval.
Mikami M, Nakamura M, Kurahashi T, Tanaka K, Komiyama S, Ishikawa M
Arch Gynecol Obstet 2003 Aug;268(3):214-6. Epub 2003 Jun 25 doi: 10.1007/s00404-003-0522-9. PMID: 12827390

Therapy

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
The history of Distilbène® (Diethylstilbestrol) told to grandchildren--the transgenerational effect.
Fénichel P, Brucker-Davis F, Chevalier N
Ann Endocrinol (Paris) 2015 Jul;76(3):253-9. Epub 2015 Apr 28 doi: 10.1016/j.ando.2015.03.008. PMID: 25934356
Epidemiology of vaginal adenocarcinoma and adenosis: current status.
Weiss K
J Am Med Womens Assoc (1972) 1975 Feb;30(2):59-63. PMID: 163267
The development of adenocarcinoma of the endometrium in young women receiving long-term sequential oral contraception.
Lyon FA
Am J Obstet Gynecol 1975 Oct 1;123(3):299-301. doi: 10.1016/0002-9378(75)90202-1. PMID: 52299
Vaginal adenocarcinoma in young women.
Lancet 1971 May 29;1(7709):1111-2. PMID: 4102630

Prognosis

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran.
Mood NI, Eftekhar Z, Haratian A, Saeedi L, Rahimi-Moghaddam P, Yarandi F
Int J Gynecol Cancer 2006 Jan-Feb;16(1):257-61. doi: 10.1111/j.1525-1438.2006.00346.x. PMID: 16445641
Vaginal adenocarcinoma in a gravida with prenatal DES exposure.
Del Castillo H, Rubio PA, Farrell EM
Int J Gynaecol Obstet 1978-1979;16(4):271-3. doi: 10.1002/j.1879-3479.1979.tb00443.x. PMID: 35386
Transplacental chemical carcinogenesis in man.
Miller RW
J Natl Cancer Inst 1971 Dec;47(6):1169-71. PMID: 4330461

Clinical prediction guides

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
Immunohistochemical Loss of DPC4 in Tumors With Mucinous Differentiation Arising in or Involving the Gynecologic Tract.
Kwon DH, Malpica A, Zaleski M, Euscher ED, Ramalingam P
Int J Gynecol Pathol 2021 Nov 1;40(6):523-532. doi: 10.1097/PGP.0000000000000754. PMID: 33405429
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Incidental vaginal müllerianosis.
Val-Bernal JF, Mayorga M
Pathol Res Pract 2016 Jun;212(6):568-72. Epub 2016 Feb 26 doi: 10.1016/j.prp.2016.02.023. PMID: 26970930
Immunoprofile of adenocarcinomas of the endometrium, endocervix, and ovary with mucinous differentiation.
Park KJ, Bramlage MP, Ellenson LH, Pirog EC
Appl Immunohistochem Mol Morphol 2009 Jan;17(1):8-11. doi: 10.1097/PAI.0b013e318174f012. PMID: 18776815

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...