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Pediatric angiosarcoma

MedGen UID:
124687
•Concept ID:
C0279988
•
Neoplastic Process
Synonyms: angiosarcoma (disease) of childhood; Childhood Angiosarcoma; childhood angiosarcoma; childhood angiosarcoma (disease); Childhood Hemangiosarcoma; childhood hemangiosarcoma; paediatric angiosarcoma (disease); paediatric hemangiosarcoma; Pediatric Angiosarcoma; pediatric angiosarcoma; pediatric angiosarcoma (disease); Pediatric Hemangiosarcoma; pediatric hemangiosarcoma
 
Monarch Initiative: MONDO:0003022

Definition

An angiosarcoma occurring in childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPediatric angiosarcoma

Professional guidelines

PubMed

Uncommon and peculiar soft tissue sarcomas: Multidisciplinary review and practical recommendations for diagnosis and treatment. Spanish group for Sarcoma research (GEIS - GROUP). Part I.
Martínez-Trufero J, Cruz Jurado J, Gómez-Mateo MC, Bernabeu D, Floría LJ, Lavernia J, Sebio A, García Del Muro X, Álvarez R, Correa R, Hernández-León CN, Marquina G, Hindi N, Redondo A, Martínez V, Asencio JM, Mata C, Valverde Morales CM, Martin-Broto J
Cancer Treat Rev 2021 Sep;99:102259. Epub 2021 Jul 11 doi: 10.1016/j.ctrv.2021.102259. PMID: 34311246
Hepatic hemangioendothelioma of infancy: clinical features of a large cohort of patients and proposed management.
Sana L, Betalli P, Bravi M, Stroppa P, Cheli M, Sonzogni A, Licini L, Agazzi R, Colledan M, Parolini F, Alberti D, D'Antiga L
Pediatr Surg Int 2021 Jun;37(6):791-797. Epub 2021 Jan 29 doi: 10.1007/s00383-021-04860-y. PMID: 33515109
Head and neck sarcomas: epidemiology, pathology, and management.
O'Neill JP, Bilsky MH, Kraus D
Neurosurg Clin N Am 2013 Jan;24(1):67-78. doi: 10.1016/j.nec.2012.08.010. PMID: 23174358

Recent clinical studies

Etiology

Hepatic vascular malignancies in children are associated with increased rates of surgical resection and improved overall survival compared with adults.
Commander SJ, Cerullo M, Leraas HJ, Reed CR, Achey MA, Wachsmuth LP, Schooler GR, Tracy ET
Pediatr Blood Cancer 2021 May;68(5):e28864. Epub 2021 Mar 4 doi: 10.1002/pbc.28864. PMID: 33661569Free PMC Article
Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Winer L, Macedo FI, Alfawaz A, Sommariva A, Cecchetto G, Podda A, Neville HL, Möller MG
J Pediatr Hematol Oncol 2018 Nov;40(8):e505-e510. doi: 10.1097/MPH.0000000000001231. PMID: 29863582

Diagnosis

A 15-Year-Old Male Baseball Player With a Mass in the Brachialis Muscle.
Golub IJ, Garcia RA, Wittig JC
Orthopedics 2016 May 1;39(3):e545-8. Epub 2016 Apr 5 doi: 10.3928/01477447-20160324-03. PMID: 27045482
Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity.
Ayadi L, Khabir A
Arch Pathol Lab Med 2010 Mar;134(3):481-5. doi: 10.5858/134.3.481. PMID: 20196675
Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature.
Nord KM, Kandel J, Lefkowitch JH, Lobritto SJ, Morel KD, North PE, Garzon MC
Pediatrics 2006 Sep;118(3):e907-13. Epub 2006 Jul 31 doi: 10.1542/peds.2006-0183. PMID: 16880251

Therapy

Discovery and functional characterization of the oncogenicity and targetability of a novel NOTCH1-ROS1 gene fusion in pediatric angiosarcoma.
Jain P, Iyer S, Straka J, Surrey LF, Pogoriler J, Han H, Smith T, Busch C, Fox E, Li M, Waanders AJ, Resnick A, Davare MA
Cold Spring Harb Mol Case Stud 2022 Oct;8(6) Epub 2022 Oct 28 doi: 10.1101/mcs.a006222. PMID: 36307212Free PMC Article
Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern.
Booth AM, LeGallo RD, Stoler MH, Waldron PE, Cerilli LA
Pediatr Dev Pathol 2001 Sep-Oct;4(5):490-5. doi: 10.1007/s10024001-0046-x. PMID: 11779052

Prognosis

Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Winer L, Macedo FI, Alfawaz A, Sommariva A, Cecchetto G, Podda A, Neville HL, Möller MG
J Pediatr Hematol Oncol 2018 Nov;40(8):e505-e510. doi: 10.1097/MPH.0000000000001231. PMID: 29863582
Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity.
Ayadi L, Khabir A
Arch Pathol Lab Med 2010 Mar;134(3):481-5. doi: 10.5858/134.3.481. PMID: 20196675
Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern.
Booth AM, LeGallo RD, Stoler MH, Waldron PE, Cerilli LA
Pediatr Dev Pathol 2001 Sep-Oct;4(5):490-5. doi: 10.1007/s10024001-0046-x. PMID: 11779052

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