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Acanthamoeba keratitis

MedGen UID:
1268
Concept ID:
C0000880
Disease or Syndrome
Synonyms: Acanthamoeba Keratitides; Acanthamoeba Keratitis; Keratitides, Acanthamoeba; Keratitis, Acanthamoeba
SNOMED CT: Acanthamoeba keratitis (231896005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005629
Orphanet: ORPHA67043

Definition

A rare corneal infection due to the protozoan <i>Acanthamoeba</i> that generally occurs in contact lens wearers and that is characterized by severe ocular pain, blepharospasm, photophobia, eye tearing, blurred vision and foreign body sensation. It can lead to impaired visual acuity if not treated promptly. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcanthamoeba keratitis
Follow this link to review classifications for Acanthamoeba keratitis in Orphanet.

Professional guidelines

PubMed

Büchele MLC, Nunes BF, Filippin-Monteiro FB, Caumo KS
Cont Lens Anterior Eye 2023 Aug;46(4):101844. Epub 2023 Apr 26 doi: 10.1016/j.clae.2023.101844. PMID: 37117130
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article

Recent clinical studies

Etiology

Dart JKG, Papa V, Rama P, Knutsson KA, Ahmad S, Hau S, Sanchez S, Franch A, Birattari F, Leon P, Fasolo A, Kominek EM, Jadczyk-Sorek K, Carley F, Hossain P, Minassian DC
Ophthalmology 2024 Mar;131(3):277-287. Epub 2023 Oct 5 doi: 10.1016/j.ophtha.2023.09.031. PMID: 37802392
Thibodeau AR, Niziol LM, Tannen BL, Ballouz D, Woodward MA
Cornea 2022 Apr 1;41(4):484-490. doi: 10.1097/ICO.0000000000002893. PMID: 34620771Free PMC Article
Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS
Eye (Lond) 2021 Apr;35(4):1084-1101. Epub 2021 Jan 7 doi: 10.1038/s41433-020-01339-3. PMID: 33414529Free PMC Article
Niederkorn JY
Exp Eye Res 2021 Jan;202:108365. Epub 2020 Nov 19 doi: 10.1016/j.exer.2020.108365. PMID: 33221372Free PMC Article
Raghavan A, Baidwal S, Venkatapathy N, Rammohan R
Am J Ophthalmol 2019 May;201:31-36. Epub 2019 Feb 2 doi: 10.1016/j.ajo.2019.01.024. PMID: 30721687

Diagnosis

Dart JKG, Papa V, Rama P, Knutsson KA, Ahmad S, Hau S, Sanchez S, Franch A, Birattari F, Leon P, Fasolo A, Kominek EM, Jadczyk-Sorek K, Carley F, Hossain P, Minassian DC
Ophthalmology 2024 Mar;131(3):277-287. Epub 2023 Oct 5 doi: 10.1016/j.ophtha.2023.09.031. PMID: 37802392
Cabrera-Aguas M, Khoo P, Watson SL
Clin Exp Ophthalmol 2022 Jul;50(5):543-562. Epub 2022 Jun 3 doi: 10.1111/ceo.14113. PMID: 35610943Free PMC Article
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Fu L, Gomaa A
N Engl J Med 2019 Jul 18;381(3):274. doi: 10.1056/NEJMicm1817678. PMID: 31314971
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article

Therapy

Dart JKG, Papa V, Rama P, Knutsson KA, Ahmad S, Hau S, Sanchez S, Franch A, Birattari F, Leon P, Fasolo A, Kominek EM, Jadczyk-Sorek K, Carley F, Hossain P, Minassian DC
Ophthalmology 2024 Mar;131(3):277-287. Epub 2023 Oct 5 doi: 10.1016/j.ophtha.2023.09.031. PMID: 37802392
Jeang L, Tuli SS
Curr Opin Ophthalmol 2022 Jul 1;33(4):282-289. doi: 10.1097/ICU.0000000000000861. PMID: 35779052
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS
Eye (Lond) 2021 Apr;35(4):1084-1101. Epub 2021 Jan 7 doi: 10.1038/s41433-020-01339-3. PMID: 33414529Free PMC Article
Lorenzo-Morales J, Khan NA, Walochnik J
Parasite 2015;22:10. Epub 2015 Feb 18 doi: 10.1051/parasite/2015010. PMID: 25687209Free PMC Article

Prognosis

Zhang Y, Xu X, Wei Z, Cao K, Zhang Z, Liang Q
J Infect Public Health 2023 Jun;16(6):841-852. Epub 2023 Mar 23 doi: 10.1016/j.jiph.2023.03.020. PMID: 37030037
Kaufman AR, Tu EY
Ocul Surf 2022 Jul;25:26-36. Epub 2022 Apr 22 doi: 10.1016/j.jtos.2022.04.003. PMID: 35462076
Niederkorn JY
Exp Eye Res 2021 Jan;202:108365. Epub 2020 Nov 19 doi: 10.1016/j.exer.2020.108365. PMID: 33221372Free PMC Article
Bonini S, Di Zazzo A, Varacalli G, Coassin M
Curr Eye Res 2021 Jun;46(6):771-776. Epub 2020 Nov 29 doi: 10.1080/02713683.2020.1846753. PMID: 33151784
Stapleton F
Clin Exp Optom 2020 Jul;103(4):408-417. Epub 2020 May 4 doi: 10.1111/cxo.13082. PMID: 32363626

Clinical prediction guides

Vilares-Morgado R, Ferreira AM, Marques-Couto P, Madeira C, Moreira R, Torrão L, Neves-Cardoso P, Cunha AM, Rebelo S, Pinheiro-Costa J
Cont Lens Anterior Eye 2024 Apr;47(2):102119. Epub 2024 Jan 13 doi: 10.1016/j.clae.2023.102119. PMID: 38220498
Keenan JD
Cornea 2023 Nov 1;42(11):1333-1339. Epub 2023 Jul 4 doi: 10.1097/ICO.0000000000003340. PMID: 38112645Free PMC Article
Büchele MLC, Nunes BF, Filippin-Monteiro FB, Caumo KS
Cont Lens Anterior Eye 2023 Aug;46(4):101844. Epub 2023 Apr 26 doi: 10.1016/j.clae.2023.101844. PMID: 37117130
Bonini S, Di Zazzo A, Varacalli G, Coassin M
Curr Eye Res 2021 Jun;46(6):771-776. Epub 2020 Nov 29 doi: 10.1080/02713683.2020.1846753. PMID: 33151784
Alkharashi M, Lindsley K, Law HA, Sikder S
Cochrane Database Syst Rev 2015 Feb 24;2015(2):CD010792. doi: 10.1002/14651858.CD010792.pub2. PMID: 25710134Free PMC Article

Recent systematic reviews

Diehl MLN, Paes J, Rott MB
Parasitol Res 2021 Sep;120(9):3051-3063. Epub 2021 Aug 5 doi: 10.1007/s00436-021-07261-1. PMID: 34351492Free PMC Article
Ting DSJ, Henein C, Said DG, Dua HS
Sci Rep 2021 Jun 21;11(1):13007. doi: 10.1038/s41598-021-92366-x. PMID: 34155280Free PMC Article
Shing B, Balen M, McKerrow JH, Debnath A
Expert Rev Anti Infect Ther 2021 Nov;19(11):1427-1441. Epub 2021 May 19 doi: 10.1080/14787210.2021.1924673. PMID: 33929276Free PMC Article
Alkharashi M, Lindsley K, Law HA, Sikder S
Cochrane Database Syst Rev 2015 Feb 24;2015(2):CD010792. doi: 10.1002/14651858.CD010792.pub2. PMID: 25710134Free PMC Article
Kokot J, Dobrowolski D, Lyssek-Boroń A, Milka M, Smedowski A, Wójcik Ł, Wowra B, Wyligała E
Klin Oczna 2012;114(4):311-6. PMID: 23461162

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