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Ovarian sarcoma

MedGen UID:
128881
•Concept ID:
C0280746
•
Neoplastic Process
Synonyms: Ovarian Sarcoma; ovarian sarcoma; ovary sarcoma; Sarcoma of ovary; Sarcoma of Ovary; sarcoma of ovary; Sarcoma of the Ovary; sarcoma of the ovary
SNOMED CT: Sarcoma of ovary (423627007)
 
Monarch Initiative: MONDO:0002225

Definition

A rare, aggressive malignant mesenchymal neoplasm that arises from the ovary. The prognosis is poor. [from NCI]

Professional guidelines

PubMed

Incidence and treatment outcomes of ovarian sarcoma compared to epithelial ovarian cancer from the national cancer registry.
Ha HI, Cho SH, Lim J, Lee YJ, Yoo CW, Won YJ, Lim MC
Gynecol Oncol 2021 Dec;163(3):506-510. Epub 2021 Oct 1 doi: 10.1016/j.ygyno.2021.09.014. PMID: 34602286
Molecular imaging in the management of gynecologic malignancies.
Lai CH, Lin G, Yen TC, Liu FY
Gynecol Oncol 2014 Oct;135(1):156-62. Epub 2014 Jul 24 doi: 10.1016/j.ygyno.2014.07.092. PMID: 25065896
Malignant mixed mesodermal ovarian tumor treatment and prognosis: a 20-year experience.
Le T, Krepart GV, Lotocki RJ, Heywood MS
Gynecol Oncol 1997 May;65(2):237-40. doi: 10.1006/gyno.1997.4625. PMID: 9159331

Recent clinical studies

Etiology

Carcinosarcoma of the ovary: MR and clinical findings compared with high-grade serous carcinoma.
Saida T, Mori K, Tanaka YO, Sakai M, Amano T, Kikuchi S, Masuoka S, Yoshida M, Masumoto T, Satoh T, Minami M
Jpn J Radiol 2021 Apr;39(4):357-366. Epub 2020 Nov 20 doi: 10.1007/s11604-020-01072-7. PMID: 33216290
The Role of Hyperthermic Intraperitoneal Chemotherapy for Non-colorectal Peritoneal Surface Malignancies.
Morris MC, Cloyd JM, Hays J, Patel SH
J Gastrointest Surg 2021 Jan;25(1):303-318. Epub 2020 Aug 17 doi: 10.1007/s11605-020-04771-8. PMID: 32808135
Ovarian sarcoma carries a poorer prognosis than ovarian epithelial cancer throughout all FIGO stages: a single-center case-control matched study.
Bacalbasa N, Balescu I, Dima S, Popescu I
Anticancer Res 2014 Dec;34(12):7303-8. PMID: 25503164
Primary sarcoma of the ovary: clinicopathological characteristics, prognostic factors and evaluation of therapy.
Dai Y, Shen K, Lang JH, Huang HF, Pan LY, Wu M, Yang JX, Zhong DR
Chin Med J (Engl) 2011 May;124(9):1316-21. PMID: 21740740
Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents.
Sugiyama T, Sadzuka Y
Biochim Biophys Acta 2003 Dec 5;1653(2):47-59. doi: 10.1016/s0304-419x(03)00031-3. PMID: 14643924

Diagnosis

Primary ovarian endometrioid stromal sarcoma presenting with reno-ureteral colic.
Moral AIB, Jiménez JCV, Bañón CM, Díaz Huesca MJ, González MV, López JSJ
BMC Womens Health 2022 Dec 3;22(1):491. doi: 10.1186/s12905-022-02046-9. PMID: 36463169Free PMC Article
Primary ovarian synovial sarcoma.
Rahman MAU, Wadi KA, Nuqaydan A, Tallab R
BMJ Case Rep 2021 Nov 9;14(11) doi: 10.1136/bcr-2021-244756. PMID: 34753724Free PMC Article
Overview of non-epithelial ovarian tumours: Incidence and survival in the Netherlands, 1989-2015.
van der Hel OL, Timmermans M, van Altena AM, Kruitwagen RFPM, Slangen BFM, Sonke GS, van de Vijver KK, van der Aa MA
Eur J Cancer 2019 Sep;118:97-104. Epub 2019 Jul 18 doi: 10.1016/j.ejca.2019.06.005. PMID: 31326731
Primary sarcoma of the ovary: clinicopathological characteristics, prognostic factors and evaluation of therapy.
Dai Y, Shen K, Lang JH, Huang HF, Pan LY, Wu M, Yang JX, Zhong DR
Chin Med J (Engl) 2011 May;124(9):1316-21. PMID: 21740740
Early primary diagnosis of ovarian cancer and detection of recurrence by serum cystine aminopeptidase assay.
Kalinkov D, Buchholz R
Am J Obstet Gynecol 1980 Dec 15;138(8):1148-50. doi: 10.1016/s0002-9378(16)32782-x. PMID: 7446622

Therapy

The Role of Hyperthermic Intraperitoneal Chemotherapy for Non-colorectal Peritoneal Surface Malignancies.
Morris MC, Cloyd JM, Hays J, Patel SH
J Gastrointest Surg 2021 Jan;25(1):303-318. Epub 2020 Aug 17 doi: 10.1007/s11605-020-04771-8. PMID: 32808135
Angiosarcomas of Primary Gynecologic Origin - A Case Series and Review of the Literature.
Chinczewski L, Taube ET, Feldhaus FW, DrÖge LA, Chekerov R, Muallem MZ, Pietzner K, Sehouli J, Alavi S
Anticancer Res 2020 Oct;40(10):5743-5750. doi: 10.21873/anticanres.14590. PMID: 32988901
Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents.
Sugiyama T, Sadzuka Y
Biochim Biophys Acta 2003 Dec 5;1653(2):47-59. doi: 10.1016/s0304-419x(03)00031-3. PMID: 14643924
Ovarian sarcoma with pathologic features of clear cell sarcoma of the kidney.
Finn LS, Patterson K
Pediatr Dev Pathol 2000 Sep-Oct;3(5):487-91. doi: 10.1007/s100240010095. PMID: 10890934
Primary ovarian sarcoma: analysis of prognostic variables and the role of surgical cytoreduction.
Sood AK, Sorosky JI, Gelder MS, Buller RE, Anderson B, Wilkinson EJ, Benda JA, Morgan LS
Cancer 1998 May 1;82(9):1731-7. PMID: 9576296

Prognosis

Incidence and treatment outcomes of ovarian sarcoma compared to epithelial ovarian cancer from the national cancer registry.
Ha HI, Cho SH, Lim J, Lee YJ, Yoo CW, Won YJ, Lim MC
Gynecol Oncol 2021 Dec;163(3):506-510. Epub 2021 Oct 1 doi: 10.1016/j.ygyno.2021.09.014. PMID: 34602286
The Role of Hyperthermic Intraperitoneal Chemotherapy for Non-colorectal Peritoneal Surface Malignancies.
Morris MC, Cloyd JM, Hays J, Patel SH
J Gastrointest Surg 2021 Jan;25(1):303-318. Epub 2020 Aug 17 doi: 10.1007/s11605-020-04771-8. PMID: 32808135
Overview of non-epithelial ovarian tumours: Incidence and survival in the Netherlands, 1989-2015.
van der Hel OL, Timmermans M, van Altena AM, Kruitwagen RFPM, Slangen BFM, Sonke GS, van de Vijver KK, van der Aa MA
Eur J Cancer 2019 Sep;118:97-104. Epub 2019 Jul 18 doi: 10.1016/j.ejca.2019.06.005. PMID: 31326731
Ovarian sarcoma carries a poorer prognosis than ovarian epithelial cancer throughout all FIGO stages: a single-center case-control matched study.
Bacalbasa N, Balescu I, Dima S, Popescu I
Anticancer Res 2014 Dec;34(12):7303-8. PMID: 25503164
Ovarian sarcoma.
Anderson B, Turner DA, Benda J
Gynecol Oncol 1987 Feb;26(2):183-92. doi: 10.1016/0090-8258(87)90272-1. PMID: 3643159

Clinical prediction guides

Primary ovarian endometrioid stromal sarcoma presenting with reno-ureteral colic.
Moral AIB, Jiménez JCV, Bañón CM, Díaz Huesca MJ, González MV, López JSJ
BMC Womens Health 2022 Dec 3;22(1):491. doi: 10.1186/s12905-022-02046-9. PMID: 36463169Free PMC Article
Carcinosarcoma of the ovary: MR and clinical findings compared with high-grade serous carcinoma.
Saida T, Mori K, Tanaka YO, Sakai M, Amano T, Kikuchi S, Masuoka S, Yoshida M, Masumoto T, Satoh T, Minami M
Jpn J Radiol 2021 Apr;39(4):357-366. Epub 2020 Nov 20 doi: 10.1007/s11604-020-01072-7. PMID: 33216290
Primary Ovarian Fibrosarcoma-An Unusual Tumor in an Adolescent: Case Report and Review of the Pediatric Literature.
Kurtmen BT, Dokumcu Z, Divarci E, Serin G, Ergun O, Ozok G, Celik A
J Pediatr Adolesc Gynecol 2017 Dec;30(6):655-658. Epub 2017 May 11 doi: 10.1016/j.jpag.2017.05.003. PMID: 28502829
Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents.
Sugiyama T, Sadzuka Y
Biochim Biophys Acta 2003 Dec 5;1653(2):47-59. doi: 10.1016/s0304-419x(03)00031-3. PMID: 14643924
Primary ovarian sarcoma: analysis of prognostic variables and the role of surgical cytoreduction.
Sood AK, Sorosky JI, Gelder MS, Buller RE, Anderson B, Wilkinson EJ, Benda JA, Morgan LS
Cancer 1998 May 1;82(9):1731-7. PMID: 9576296

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