U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bone Marrow Suppression

MedGen UID:
128928
•Concept ID:
C0280962
•
Disease or Syndrome
Synonyms: Bone Marrow Depression; Myelosuppression

Definition

A condition in which the production of red blood cells, white blood cells, and/or platelets by bone marrow stem cells is inhibited, usually as a side effect of treatment with various anti-cancer agents, radiation, or tumor development within the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Marrow Suppression

Professional guidelines

PubMed

Interstitial lung disease and CDK4/6 inhibitors in the treatment of breast cancer.
Schlam I, Giordano A, Tolaney SM
Expert Opin Drug Saf 2023 Jul-Dec;22(12):1149-1156. Epub 2023 Dec 18 doi: 10.1080/14740338.2023.2288147. PMID: 37994878
Neutropenic ulcers in oncology: terminology, diagnosis, and management.
Güneri P, Epstein JB, Bolukbasi G, Spielberger RT
Support Care Cancer 2023 Nov 22;31(12):716. doi: 10.1007/s00520-023-08187-3. PMID: 37991547
Principles of Surgical Management of Peritoneal Mesothelioma.
Steadman JA, Grotz TE
J Natl Compr Canc Netw 2023 Sep;21(9):981-986. doi: 10.6004/jnccn.2023.7055. PMID: 37673112

Recent clinical studies

Etiology

Acupuncture for cancer-related conditions: An overview of systematic reviews.
Zhang XW, Hou WB, Pu FL, Wang XF, Wang YR, Yang M, Cheng K, Wang Y, Robinson N, Liu JP
Phytomedicine 2022 Nov;106:154430. Epub 2022 Sep 5 doi: 10.1016/j.phymed.2022.154430. PMID: 36099656
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359
Thrombocytopenia in chronic liver disease.
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Clinical aspects of feline retroviruses: a review.
Hartmann K
Viruses 2012 Oct 31;4(11):2684-710. doi: 10.3390/v4112684. PMID: 23202500Free PMC Article
Osteopetrosis.
Stark Z, Savarirayan R
Orphanet J Rare Dis 2009 Feb 20;4:5. doi: 10.1186/1750-1172-4-5. PMID: 19232111Free PMC Article

Diagnosis

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Tumour extracellular vesicles and particles induce liver metabolic dysfunction.
Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F, Posada V, Oxley PR, Cioffi M, Kim HS, Wang H, Lauritzen P, Boudreau N, Shi Z, Burd CE, Zippin JH, Lo JC, Pitt GS, Hernandez J, Zambirinis CP, Hollingsworth MA, Grandgenett PM, Jain M, Batra SK, DiMaio DJ, Grem JL, Klute KA, Trippett TM, Egeblad M, Paul D, Bromberg J, Kelsen D, Rajasekhar VK, Healey JH, Matei IR, Jarnagin WR, Schwartz RE, Zhang H, Lyden D
Nature 2023 Jun;618(7964):374-382. Epub 2023 May 24 doi: 10.1038/s41586-023-06114-4. PMID: 37225988Free PMC Article
Methotrexate overdose in clinical practice.
Pannu AK
Curr Drug Metab 2019;20(9):714-719. doi: 10.2174/1389200220666190806140844. PMID: 31385765
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359
Osteopetrosis.
Stark Z, Savarirayan R
Orphanet J Rare Dis 2009 Feb 20;4:5. doi: 10.1186/1750-1172-4-5. PMID: 19232111Free PMC Article

Therapy

Neutropenia in pediatric solid organ transplant.
Harshman LA, Williams R, Engen RM
Pediatr Transplant 2022 Dec;26(8):e14378. Epub 2022 Aug 20 doi: 10.1111/petr.14378. PMID: 35986635
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article
Thrombocytopenia in chronic liver disease.
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Hydroxyurea.
Bowers M
BETA 1997 Mar:9-11. PMID: 11364534
Colchicine poisoning.
Hood RL
J Emerg Med 1994 Mar-Apr;12(2):171-7. doi: 10.1016/0736-4679(94)90695-5. PMID: 8207152

Prognosis

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Current status of CAR-T cell therapy for pediatric hematologic malignancies.
Hiramatsu H
Int J Clin Oncol 2023 Jun;28(6):729-735. Epub 2023 May 8 doi: 10.1007/s10147-023-02346-6. PMID: 37154980
Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review.
Schutte T, Embaby A, Steeghs N, van der Mierden S, van Driel W, Rijlaarsdam M, Huitema A, Opdam F
Cancer Treat Rev 2023 Apr;115:102531. Epub 2023 Mar 3 doi: 10.1016/j.ctrv.2023.102531. PMID: 36893690
Research Status and Molecular Mechanism of the Traditional Chinese Medicine and Antitumor Therapy Combined Strategy Based on Tumor Microenvironment.
Zhang Y, Lou Y, Wang J, Yu C, Shen W
Front Immunol 2020;11:609705. Epub 2021 Jan 21 doi: 10.3389/fimmu.2020.609705. PMID: 33552068Free PMC Article
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article

Clinical prediction guides

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Tumour extracellular vesicles and particles induce liver metabolic dysfunction.
Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F, Posada V, Oxley PR, Cioffi M, Kim HS, Wang H, Lauritzen P, Boudreau N, Shi Z, Burd CE, Zippin JH, Lo JC, Pitt GS, Hernandez J, Zambirinis CP, Hollingsworth MA, Grandgenett PM, Jain M, Batra SK, DiMaio DJ, Grem JL, Klute KA, Trippett TM, Egeblad M, Paul D, Bromberg J, Kelsen D, Rajasekhar VK, Healey JH, Matei IR, Jarnagin WR, Schwartz RE, Zhang H, Lyden D
Nature 2023 Jun;618(7964):374-382. Epub 2023 May 24 doi: 10.1038/s41586-023-06114-4. PMID: 37225988Free PMC Article
Research Status and Molecular Mechanism of the Traditional Chinese Medicine and Antitumor Therapy Combined Strategy Based on Tumor Microenvironment.
Zhang Y, Lou Y, Wang J, Yu C, Shen W
Front Immunol 2020;11:609705. Epub 2021 Jan 21 doi: 10.3389/fimmu.2020.609705. PMID: 33552068Free PMC Article
Methotrexate overdose in clinical practice.
Pannu AK
Curr Drug Metab 2019;20(9):714-719. doi: 10.2174/1389200220666190806140844. PMID: 31385765
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359

Recent systematic reviews

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer.
Newhouse R, Nelissen E, El-Shakankery KH, Rogozińska E, Bain E, Veiga S, Morrison J
Cochrane Database Syst Rev 2023 Jul 5;7(7):CD006910. doi: 10.1002/14651858.CD006910.pub3. PMID: 37407274Free PMC Article
Effectiveness of Acupuncture for Relieving Chemotherapy-Induced Bone Marrow Suppression: A Systematic Review with a Meta-analysis and Trial Sequential Analysis.
Shih YW, Wang MH, Monsen KA, Chang CW, Rias YA, Tsai HT
J Integr Complement Med 2023 Oct;29(10):621-636. Epub 2023 May 10 doi: 10.1089/jicm.2022.0735. PMID: 37163212
Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review.
Schutte T, Embaby A, Steeghs N, van der Mierden S, van Driel W, Rijlaarsdam M, Huitema A, Opdam F
Cancer Treat Rev 2023 Apr;115:102531. Epub 2023 Mar 3 doi: 10.1016/j.ctrv.2023.102531. PMID: 36893690
Treatment of Idiopathic Membranous Nephropathy for Moderate or Severe Proteinuria: A Systematic Review and Network Meta-Analysis.
Chen M, Liu J, Xiong Y, Xu G
Int J Clin Pract 2022;2022:4996239. Epub 2022 Apr 23 doi: 10.1155/2022/4996239. PMID: 35685506Free PMC Article
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...