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Bone Marrow Suppression

MedGen UID:
128928
•Concept ID:
C0280962
•
Disease or Syndrome
Synonyms: Bone Marrow Depression; Myelosuppression

Definition

A condition in which the production of red blood cells, white blood cells, and/or platelets by bone marrow stem cells is inhibited, usually as a side effect of treatment with various anti-cancer agents, radiation, or tumor development within the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Marrow Suppression

Professional guidelines

PubMed

Chinese expert consensus on intestinal microecology and management of digestive tract complications related to tumor treatment (version 2022).
Wang J, Liang J, He M, Xie Q, Wu Q, Shen G, Zhu B, Yu J, Yu L, Tan X, Wei L, Ren J, Lv Y, Deng L, Yin Q, Zhou H, Wu W, Zhang M, Yang W, Qiao M, Shu R, Xia Z, Li Z, Huang Z, Hu W, Wang L, Liu Z, Pi G, Ren H, Ji Y, Liu Z, Qi X, Chen P, Shao L, Chen F, Xu X, Chen W, Wang Q, Guo Z; Tumor and Microecology Committee of China Anti-Cancer Association
J Cancer Res Ther 2022 Dec;18(7):1835-1844. doi: 10.4103/jcrt.jcrt_1444_22. PMID: 36647940
Treatment of Idiopathic Membranous Nephropathy for Moderate or Severe Proteinuria: A Systematic Review and Network Meta-Analysis.
Chen M, Liu J, Xiong Y, Xu G
Int J Clin Pract 2022;2022:4996239. Epub 2022 Apr 23 doi: 10.1155/2022/4996239. PMID: 35685506Free PMC Article
The Treatment of Chronic Lymphatic Leukemia.
Tresckow JV, Eichhorst B, Bahlo J, Hallek M
Dtsch Arztebl Int 2019 Jan 25;116(4):41-46. doi: 10.3238/arztebl.2019.0041. PMID: 30855005Free PMC Article

Recent clinical studies

Etiology

Acupuncture for cancer-related conditions: An overview of systematic reviews.
Zhang XW, Hou WB, Pu FL, Wang XF, Wang YR, Yang M, Cheng K, Wang Y, Robinson N, Liu JP
Phytomedicine 2022 Nov;106:154430. Epub 2022 Sep 5 doi: 10.1016/j.phymed.2022.154430. PMID: 36099656
Drug-Induced Thrombocytopenia: Mechanisms and Laboratory Diagnostics.
Danese E, Montagnana M, Favaloro EJ, Lippi G
Semin Thromb Hemost 2020 Apr;46(3):264-274. Epub 2019 Sep 28 doi: 10.1055/s-0039-1697930. PMID: 31563127
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359
Thrombocytopenia in chronic liver disease.
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Osteopetrosis.
Stark Z, Savarirayan R
Orphanet J Rare Dis 2009 Feb 20;4:5. doi: 10.1186/1750-1172-4-5. PMID: 19232111Free PMC Article

Diagnosis

Drug-Induced Thrombocytopenia: Mechanisms and Laboratory Diagnostics.
Danese E, Montagnana M, Favaloro EJ, Lippi G
Semin Thromb Hemost 2020 Apr;46(3):264-274. Epub 2019 Sep 28 doi: 10.1055/s-0039-1697930. PMID: 31563127
Methotrexate overdose in clinical practice.
Pannu AK
Curr Drug Metab 2019;20(9):714-719. doi: 10.2174/1389200220666190806140844. PMID: 31385765
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359
Clinical aspects of feline retroviruses: a review.
Hartmann K
Viruses 2012 Oct 31;4(11):2684-710. doi: 10.3390/v4112684. PMID: 23202500Free PMC Article
Osteopetrosis.
Stark Z, Savarirayan R
Orphanet J Rare Dis 2009 Feb 20;4:5. doi: 10.1186/1750-1172-4-5. PMID: 19232111Free PMC Article

Therapy

Neutropenia in pediatric solid organ transplant.
Harshman LA, Williams R, Engen RM
Pediatr Transplant 2022 Dec;26(8):e14378. Epub 2022 Aug 20 doi: 10.1111/petr.14378. PMID: 35986635
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article
Thrombocytopenia in chronic liver disease.
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Hydroxyurea.
Bowers M
BETA 1997 Mar:9-11. PMID: 11364534
Colchicine poisoning.
Hood RL
J Emerg Med 1994 Mar-Apr;12(2):171-7. doi: 10.1016/0736-4679(94)90695-5. PMID: 8207152

Prognosis

Effectiveness of Acupuncture for Relieving Chemotherapy-Induced Bone Marrow Suppression: A Systematic Review with a Meta-analysis and Trial Sequential Analysis.
Shih YW, Wang MH, Monsen KA, Chang CW, Rias YA, Tsai HT
J Integr Complement Med 2023 Oct;29(10):621-636. Epub 2023 May 10 doi: 10.1089/jicm.2022.0735. PMID: 37163212
Platelets as a Gauge of Liver Disease Kinetics?
Chen SH, Tsai SC, Lu HC
Int J Mol Sci 2022 Sep 28;23(19) doi: 10.3390/ijms231911460. PMID: 36232759Free PMC Article
Research Status and Molecular Mechanism of the Traditional Chinese Medicine and Antitumor Therapy Combined Strategy Based on Tumor Microenvironment.
Zhang Y, Lou Y, Wang J, Yu C, Shen W
Front Immunol 2020;11:609705. Epub 2021 Jan 21 doi: 10.3389/fimmu.2020.609705. PMID: 33552068Free PMC Article
The Treatment of Chronic Lymphatic Leukemia.
Tresckow JV, Eichhorst B, Bahlo J, Hallek M
Dtsch Arztebl Int 2019 Jan 25;116(4):41-46. doi: 10.3238/arztebl.2019.0041. PMID: 30855005Free PMC Article
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article

Clinical prediction guides

Tumour extracellular vesicles and particles induce liver metabolic dysfunction.
Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F, Posada V, Oxley PR, Cioffi M, Kim HS, Wang H, Lauritzen P, Boudreau N, Shi Z, Burd CE, Zippin JH, Lo JC, Pitt GS, Hernandez J, Zambirinis CP, Hollingsworth MA, Grandgenett PM, Jain M, Batra SK, DiMaio DJ, Grem JL, Klute KA, Trippett TM, Egeblad M, Paul D, Bromberg J, Kelsen D, Rajasekhar VK, Healey JH, Matei IR, Jarnagin WR, Schwartz RE, Zhang H, Lyden D
Nature 2023 Jun;618(7964):374-382. Epub 2023 May 24 doi: 10.1038/s41586-023-06114-4. PMID: 37225988Free PMC Article
Research Status and Molecular Mechanism of the Traditional Chinese Medicine and Antitumor Therapy Combined Strategy Based on Tumor Microenvironment.
Zhang Y, Lou Y, Wang J, Yu C, Shen W
Front Immunol 2020;11:609705. Epub 2021 Jan 21 doi: 10.3389/fimmu.2020.609705. PMID: 33552068Free PMC Article
Methotrexate overdose in clinical practice.
Pannu AK
Curr Drug Metab 2019;20(9):714-719. doi: 10.2174/1389200220666190806140844. PMID: 31385765
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article

Recent systematic reviews

Effectiveness of Acupuncture for Relieving Chemotherapy-Induced Bone Marrow Suppression: A Systematic Review with a Meta-analysis and Trial Sequential Analysis.
Shih YW, Wang MH, Monsen KA, Chang CW, Rias YA, Tsai HT
J Integr Complement Med 2023 Oct;29(10):621-636. Epub 2023 May 10 doi: 10.1089/jicm.2022.0735. PMID: 37163212
Transcutaneous electronic acupoint stimulation improves bone marrow suppression in lung cancer patients following chemotherapy: A systematic review and meta-analysis of randomized controlled trials.
Wei Y, Zheng Y
Medicine (Baltimore) 2023 Apr 21;102(16):e33571. doi: 10.1097/MD.0000000000033571. PMID: 37083807Free PMC Article
Treatment of Idiopathic Membranous Nephropathy for Moderate or Severe Proteinuria: A Systematic Review and Network Meta-Analysis.
Chen M, Liu J, Xiong Y, Xu G
Int J Clin Pract 2022;2022:4996239. Epub 2022 Apr 23 doi: 10.1155/2022/4996239. PMID: 35685506Free PMC Article
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article
Adverse Event Profile of Pyrimethamine-Based Therapy in Toxoplasmosis: A Systematic Review.
Ben-Harari RR, Goodwin E, Casoy J
Drugs R D 2017 Dec;17(4):523-544. doi: 10.1007/s40268-017-0206-8. PMID: 28879584Free PMC Article

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