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Graft-Versus-Tumor Induction

MedGen UID:
129056
•Concept ID:
C0281604
•
Pathologic Function
Synonyms: graft versus host disease induction; graft versus tumor induction

Definition

An immune response that involves a reaction by immune cells that are present in transplanted tissue, such as bone marrow or peripheral blood, to a recipient''s tumor cells. The introduction or transplantation of immune-sensitive moieties to a host are being evaluated in several clinical trials as a primary therapy for patients with malignancies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGraft-Versus-Tumor Induction

Professional guidelines

PubMed

Proteasome inhibitor clioquinol as a candidate drug in prophylaxis and treatment of acute graft-versus-host disease.
Liang Y, Mao X, Liu H
Med Hypotheses 2011 Mar;76(3):400-2. Epub 2010 Nov 30 doi: 10.1016/j.mehy.2010.11.002. PMID: 21122999
Non-myeloablative stem cell transplantation for the treatment of cancer and life-threatening non-malignant disorders; past accomplishments and future goals.
Slavin S, Aker M, Shapira MY, Panigrahi S, Gabriel C, Or R
Transfus Apher Sci 2002 Oct;27(2):159-66. doi: 10.1016/s1473-0502(02)00038-1. PMID: 12350051

Recent clinical studies

Therapy

Graft-versus-tumor induction with donor leukocyte infusions as primary therapy for patients with malignancies.
Porter DL, Connors JM, Van Deerlin VM, Duffy KM, McGarigle C, Saidman SL, Leonard DG, Antin JH
J Clin Oncol 1999 Apr;17(4):1234. doi: 10.1200/JCO.1999.17.4.1234. PMID: 10561184

Prognosis

Graft-versus-tumor induction with donor leukocyte infusions as primary therapy for patients with malignancies.
Porter DL, Connors JM, Van Deerlin VM, Duffy KM, McGarigle C, Saidman SL, Leonard DG, Antin JH
J Clin Oncol 1999 Apr;17(4):1234. doi: 10.1200/JCO.1999.17.4.1234. PMID: 10561184

Clinical prediction guides

Graft-versus-tumor induction with donor leukocyte infusions as primary therapy for patients with malignancies.
Porter DL, Connors JM, Van Deerlin VM, Duffy KM, McGarigle C, Saidman SL, Leonard DG, Antin JH
J Clin Oncol 1999 Apr;17(4):1234. doi: 10.1200/JCO.1999.17.4.1234. PMID: 10561184

Supplemental Content

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    Practice guidelines

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