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Stage III Childhood Large Cell Lymphoma

MedGen UID:
129082
•Concept ID:
C0281705
•
Neoplastic Process

Definition

Stage III: Involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage III Childhood Large Cell Lymphoma

Professional guidelines

PubMed

Perspectives of the management of childhood lymphoma: experience at Tygerberg Hospital, Western Cape, South Africa.
Wessels G, Bernard Hesseling P
Transfus Apher Sci 2005 Feb;32(1):27-31. Epub 2005 Jan 22 doi: 10.1016/j.transci.2004.10.003. PMID: 15737871
Management of pediatric non-Hodgkin's lymphoma.
Blay JY, Louis D, Bouffet E, Thiesse P, Biron P, Favrot MC, Brunat-Mentigny M, Philip T
Blood Rev 1991 Jun;5(2):90-7. doi: 10.1016/0268-960x(91)90040-j. PMID: 1912759
Childhood non-Hodgkin's lymphoma involving the testis: clinical features and treatment outcome.
Kellie SJ, Pui CH, Murphy SB
J Clin Oncol 1989 Aug;7(8):1066-70. doi: 10.1200/JCO.1989.7.8.1066. PMID: 2666589

Recent clinical studies

Etiology

Outcome and prognostic factors in childhood B non-Hodgkin lymphoma from India: Report by the Indian Pediatric Oncology Group (InPOG-NHL-16-01 study).
Rahiman EA, Bakhshi S, Deepam Pushpam, Ramamoorthy J, Das A, Ghara N, Kalra M, Kapoor G, Meena JP, Siddaigarhi S, Thulkar S, Sharma MC, Srinivasan R, Trehan A
Pediatr Hematol Oncol 2022 Aug;39(5):391-405. Epub 2022 Jan 3 doi: 10.1080/08880018.2021.2002485. PMID: 34978257
Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.
Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
Burkitt Lymphoma/Leukaemia in Children & Young Adolescents.
O'Rourke E, Malone A, O'Marcaigh A, Storey L, Betts D, McDermott M, Smith OP
Ir Med J 2020 Jan 16;113(1):6. PMID: 32298568
Pediatric follicular lymphoma in Japan.
Kobayashi R, Tanaka F, Nakazawa A, Ueyama JI, Sunami S, Mitsui T, Koga Y, Mori T, Osumi T, Fukano R, Ohki K, Sekimizu M, Fujita N, Kamei M, Mori T; Lymphoma Committee and Japanese Pediatric Leukemia/Lymphoma Study Group
Int J Hematol 2017 Jun;105(6):849-853. Epub 2017 Mar 7 doi: 10.1007/s12185-017-2209-1. PMID: 28271414
Anaplastic large cell lymphoma in childhood: analysis of 72 patients treated on The United Kingdom Children's Cancer Study Group chemotherapy regimens.
Williams DM, Hobson R, Imeson J, Gerrard M, McCarthy K, Pinkerton CR; United Kingdom Children's Cancer Study Group
Br J Haematol 2002 Jun;117(4):812-20. doi: 10.1046/j.1365-2141.2002.03482.x. PMID: 12060115

Diagnosis

Comparison of chemotherapy with or without asparaginase for extranodal nasal NK/T-cell lymphoma in children and adolescents.
Zhen Z, Huang H, Lin T, Li Z, Zhen X, Xia Z, Zhu J, Lu S, Sun F, Wang J, Huang J, Sun X
Pediatr Blood Cancer 2021 May;68(5):e28901. Epub 2021 Jan 23 doi: 10.1002/pbc.28901. PMID: 33484107
Pediatric follicular lymphoma in Japan.
Kobayashi R, Tanaka F, Nakazawa A, Ueyama JI, Sunami S, Mitsui T, Koga Y, Mori T, Osumi T, Fukano R, Ohki K, Sekimizu M, Fujita N, Kamei M, Mori T; Lymphoma Committee and Japanese Pediatric Leukemia/Lymphoma Study Group
Int J Hematol 2017 Jun;105(6):849-853. Epub 2017 Mar 7 doi: 10.1007/s12185-017-2209-1. PMID: 28271414
Challenge of pediatric oncology in Africa.
Hadley LG, Rouma BS, Saad-Eldin Y
Semin Pediatr Surg 2012 May;21(2):136-41. doi: 10.1053/j.sempedsurg.2012.01.006. PMID: 22475119
Anaplastic large cell lymphoma in childhood: analysis of 72 patients treated on The United Kingdom Children's Cancer Study Group chemotherapy regimens.
Williams DM, Hobson R, Imeson J, Gerrard M, McCarthy K, Pinkerton CR; United Kingdom Children's Cancer Study Group
Br J Haematol 2002 Jun;117(4):812-20. doi: 10.1046/j.1365-2141.2002.03482.x. PMID: 12060115
Management of pediatric non-Hodgkin's lymphoma.
Blay JY, Louis D, Bouffet E, Thiesse P, Biron P, Favrot MC, Brunat-Mentigny M, Philip T
Blood Rev 1991 Jun;5(2):90-7. doi: 10.1016/0268-960x(91)90040-j. PMID: 1912759

Therapy

Outcome and prognostic factors in childhood B non-Hodgkin lymphoma from India: Report by the Indian Pediatric Oncology Group (InPOG-NHL-16-01 study).
Rahiman EA, Bakhshi S, Deepam Pushpam, Ramamoorthy J, Das A, Ghara N, Kalra M, Kapoor G, Meena JP, Siddaigarhi S, Thulkar S, Sharma MC, Srinivasan R, Trehan A
Pediatr Hematol Oncol 2022 Aug;39(5):391-405. Epub 2022 Jan 3 doi: 10.1080/08880018.2021.2002485. PMID: 34978257
Comparison of chemotherapy with or without asparaginase for extranodal nasal NK/T-cell lymphoma in children and adolescents.
Zhen Z, Huang H, Lin T, Li Z, Zhen X, Xia Z, Zhu J, Lu S, Sun F, Wang J, Huang J, Sun X
Pediatr Blood Cancer 2021 May;68(5):e28901. Epub 2021 Jan 23 doi: 10.1002/pbc.28901. PMID: 33484107
Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.
Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
Anaplastic large cell lymphoma in childhood: analysis of 72 patients treated on The United Kingdom Children's Cancer Study Group chemotherapy regimens.
Williams DM, Hobson R, Imeson J, Gerrard M, McCarthy K, Pinkerton CR; United Kingdom Children's Cancer Study Group
Br J Haematol 2002 Jun;117(4):812-20. doi: 10.1046/j.1365-2141.2002.03482.x. PMID: 12060115
Management of pediatric non-Hodgkin's lymphoma.
Blay JY, Louis D, Bouffet E, Thiesse P, Biron P, Favrot MC, Brunat-Mentigny M, Philip T
Blood Rev 1991 Jun;5(2):90-7. doi: 10.1016/0268-960x(91)90040-j. PMID: 1912759

Prognosis

Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.
Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
Burkitt Lymphoma/Leukaemia in Children & Young Adolescents.
O'Rourke E, Malone A, O'Marcaigh A, Storey L, Betts D, McDermott M, Smith OP
Ir Med J 2020 Jan 16;113(1):6. PMID: 32298568
Pediatric follicular lymphoma in Japan.
Kobayashi R, Tanaka F, Nakazawa A, Ueyama JI, Sunami S, Mitsui T, Koga Y, Mori T, Osumi T, Fukano R, Ohki K, Sekimizu M, Fujita N, Kamei M, Mori T; Lymphoma Committee and Japanese Pediatric Leukemia/Lymphoma Study Group
Int J Hematol 2017 Jun;105(6):849-853. Epub 2017 Mar 7 doi: 10.1007/s12185-017-2209-1. PMID: 28271414
Challenge of pediatric oncology in Africa.
Hadley LG, Rouma BS, Saad-Eldin Y
Semin Pediatr Surg 2012 May;21(2):136-41. doi: 10.1053/j.sempedsurg.2012.01.006. PMID: 22475119
Management of pediatric non-Hodgkin's lymphoma.
Blay JY, Louis D, Bouffet E, Thiesse P, Biron P, Favrot MC, Brunat-Mentigny M, Philip T
Blood Rev 1991 Jun;5(2):90-7. doi: 10.1016/0268-960x(91)90040-j. PMID: 1912759

Clinical prediction guides

Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.
Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
Burkitt Lymphoma/Leukaemia in Children & Young Adolescents.
O'Rourke E, Malone A, O'Marcaigh A, Storey L, Betts D, McDermott M, Smith OP
Ir Med J 2020 Jan 16;113(1):6. PMID: 32298568
Pediatric follicular lymphoma in Japan.
Kobayashi R, Tanaka F, Nakazawa A, Ueyama JI, Sunami S, Mitsui T, Koga Y, Mori T, Osumi T, Fukano R, Ohki K, Sekimizu M, Fujita N, Kamei M, Mori T; Lymphoma Committee and Japanese Pediatric Leukemia/Lymphoma Study Group
Int J Hematol 2017 Jun;105(6):849-853. Epub 2017 Mar 7 doi: 10.1007/s12185-017-2209-1. PMID: 28271414
Challenge of pediatric oncology in Africa.
Hadley LG, Rouma BS, Saad-Eldin Y
Semin Pediatr Surg 2012 May;21(2):136-41. doi: 10.1053/j.sempedsurg.2012.01.006. PMID: 22475119
Anaplastic large cell lymphoma in childhood: analysis of 72 patients treated on The United Kingdom Children's Cancer Study Group chemotherapy regimens.
Williams DM, Hobson R, Imeson J, Gerrard M, McCarthy K, Pinkerton CR; United Kingdom Children's Cancer Study Group
Br J Haematol 2002 Jun;117(4):812-20. doi: 10.1046/j.1365-2141.2002.03482.x. PMID: 12060115

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