U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Interstitial cystitis

MedGen UID:
129176
•Concept ID:
C0282488
•
Disease or Syndrome
Synonyms: Cystitides, Interstitial; Cystitis, Interstitial; Interstitial Cystitides; Interstitial Cystitis
SNOMED CT: Ulcerative cystitis (111409009); IC - Interstitial cystitis (197834003); Interstitial cystitis (197834003)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0018301
Orphanet: ORPHA37202

Definition

A rare non-infectious, chronic and most often progressive disease of the urinary bladder. It is characterized by varying combinations and extent of pain, urinary frequency (pollakisuria), nocturia and urgency. Interstitial cystitis (IC) has a broad intersection with Bladder Pain Syndrome (BPS) and Overactive Bladder (OAB). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInterstitial cystitis
Follow this link to review classifications for Interstitial cystitis in Orphanet.

Professional guidelines

PubMed

Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome.
Clemens JQ, Erickson DR, Varela NP, Lai HH
J Urol 2022 Jul;208(1):34-42. Epub 2022 May 10 doi: 10.1097/JU.0000000000002756. PMID: 35536143
Pelvic Floor Physical Therapy for Pelvic Floor Hypertonicity: A Systematic Review of Treatment Efficacy.
van Reijn-Baggen DA, Han-Geurts IJM, Voorham-van der Zalm PJ, Pelger RCM, Hagenaars-van Miert CHAC, Laan ETM
Sex Med Rev 2022 Apr;10(2):209-230. Epub 2021 Jun 12 doi: 10.1016/j.sxmr.2021.03.002. PMID: 34127429
Dysuria: Evaluation and Differential Diagnosis in Adults.
Michels TC, Sands JE
Am Fam Physician 2015 Nov 1;92(9):778-86. PMID: 26554471

Recent clinical studies

Etiology

An integrated machine learning framework for developing and validating a diagnostic model of major depressive disorder based on interstitial cystitis-related genes.
Chen B, Sun X, Huang H, Feng C, Chen W, Wu D
J Affect Disord 2024 Aug 15;359:22-32. Epub 2024 May 14 doi: 10.1016/j.jad.2024.05.061. PMID: 38754597
Multimodal Single-Cell Analyses Outline the Immune Microenvironment and Therapeutic Effectors of Interstitial Cystitis/Bladder Pain Syndrome.
Su F, Zhang W, Meng L, Zhang W, Liu X, Liu X, Chen M, Zhang Y, Xiao F
Adv Sci (Weinh) 2022 Jun;9(18):e2106063. Epub 2022 Apr 25 doi: 10.1002/advs.202106063. PMID: 35470584Free PMC Article
Bladder Pain Syndrome.
Huffman MM, Slack A, Hoke M
Prim Care 2019 Jun;46(2):213-221. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.002. PMID: 31030822
Interstitial Cystitis: An Update on the Disease Process and Treatment.
Daniels AM, Schulte AR, Herndon CM
J Pain Palliat Care Pharmacother 2018 Mar;32(1):49-58. Epub 2018 Sep 13 doi: 10.1080/15360288.2018.1476433. PMID: 30212267
Interstitial cystitis: epidemiology, pathophysiology, and clinical presentation.
McLennan MT
Obstet Gynecol Clin North Am 2014 Sep;41(3):385-95. Epub 2014 Jul 9 doi: 10.1016/j.ogc.2014.05.004. PMID: 25155120

Diagnosis

Broaden Horizons: The Advancement of Interstitial Cystitis/Bladder Pain Syndrome.
Li J, Yi X, Ai J
Int J Mol Sci 2022 Nov 23;23(23) doi: 10.3390/ijms232314594. PMID: 36498919Free PMC Article
Pathophysiology of interstitial cystitis.
Birder LA
Int J Urol 2019 Jun;26 Suppl 1:12-15. doi: 10.1111/iju.13985. PMID: 31144735
Bladder Pain Syndrome.
Huffman MM, Slack A, Hoke M
Prim Care 2019 Jun;46(2):213-221. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.002. PMID: 31030822
Interstitial Cystitis/Bladder Pain Syndrome.
Marcu I, Campian EC, Tu FF
Semin Reprod Med 2018 Mar;36(2):123-135. Epub 2018 Dec 19 doi: 10.1055/s-0038-1676089. PMID: 30566978
Interstitial cystitis.
Kelada E, Jones A
Arch Gynecol Obstet 2007 Apr;275(4):223-9. Epub 2006 Sep 22 doi: 10.1007/s00404-006-0247-7. PMID: 17021774

Therapy

Neuromodulation in urology, state of the art.
Ammirati E, Giammò A, Manassero A, Carone R
Urologia 2019 Nov;86(4):177-182. Epub 2019 Aug 1 doi: 10.1177/0391560319866075. PMID: 31368415
An evaluation of the pharmacotherapy for interstitial cystitis.
Giusto LL, Zahner PM, Shoskes DA
Expert Opin Pharmacother 2018 Jul;19(10):1097-1108. Epub 2018 Jul 4 doi: 10.1080/14656566.2018.1491968. PMID: 29972328
Intravesical liposome therapy for interstitial cystitis.
Tyagi P, Kashyap M, Majima T, Kawamorita N, Yoshizawa T, Yoshimura N
Int J Urol 2017 Apr;24(4):262-271. Epub 2017 Mar 4 doi: 10.1111/iju.13317. PMID: 28258657
Interstitial cystitis.
Kelada E, Jones A
Arch Gynecol Obstet 2007 Apr;275(4):223-9. Epub 2006 Sep 22 doi: 10.1007/s00404-006-0247-7. PMID: 17021774
Interstitial cystitis.
Hanno PM, Wein AJ
J Urol 1987 Sep;138(3):595-6. doi: 10.1016/s0022-5347(17)43268-x. PMID: 2442420

Prognosis

Broaden Horizons: The Advancement of Interstitial Cystitis/Bladder Pain Syndrome.
Li J, Yi X, Ai J
Int J Mol Sci 2022 Nov 23;23(23) doi: 10.3390/ijms232314594. PMID: 36498919Free PMC Article
Pathophysiology of interstitial cystitis.
Birder LA
Int J Urol 2019 Jun;26 Suppl 1:12-15. doi: 10.1111/iju.13985. PMID: 31144735
Interstitial Cystitis/Bladder Pain Syndrome.
Marcu I, Campian EC, Tu FF
Semin Reprod Med 2018 Mar;36(2):123-135. Epub 2018 Dec 19 doi: 10.1055/s-0038-1676089. PMID: 30566978
The Urinary Tract Microbiome in Health and Disease.
Aragón IM, Herrera-Imbroda B, Queipo-Ortuño MI, Castillo E, Del Moral JS, Gómez-Millán J, Yucel G, Lara MF
Eur Urol Focus 2018 Jan;4(1):128-138. Epub 2016 Nov 14 doi: 10.1016/j.euf.2016.11.001. PMID: 28753805
Common Questions About Chronic Prostatitis.
Holt JD, Garrett WA, McCurry TK, Teichman JM
Am Fam Physician 2016 Feb 15;93(4):290-6. PMID: 26926816

Clinical prediction guides

Compensatory coping and depression in women with interstitial cystitis/bladder pain syndrome.
Sutherland S, Grace Kelly A, Ryden A, Dmochowski RR, Reynolds WS, McKernan LC
Neurourol Urodyn 2023 Jan;42(1):322-329. Epub 2022 Nov 15 doi: 10.1002/nau.25089. PMID: 36378850Free PMC Article
Pathophysiology of interstitial cystitis.
Birder LA
Int J Urol 2019 Jun;26 Suppl 1:12-15. doi: 10.1111/iju.13985. PMID: 31144735
GAG replenishment therapy for bladder pain syndrome/interstitial cystitis.
Wyndaele JJJ, Riedl C, Taneja R, Lovász S, Ueda T, Cervigni M
Neurourol Urodyn 2019 Feb;38(2):535-544. Epub 2018 Dec 28 doi: 10.1002/nau.23900. PMID: 30592544
Gastrointestinal system involvement in systemic lupus erythematosus.
Li Z, Xu D, Wang Z, Wang Y, Zhang S, Li M, Zeng X
Lupus 2017 Oct;26(11):1127-1138. Epub 2017 May 19 doi: 10.1177/0961203317707825. PMID: 28523968
Interstitial cystitis: an update.
Oberpenning F, van Ophoven A, Hertle L
Curr Opin Urol 2002 Jul;12(4):321-32. doi: 10.1097/00042307-200207000-00011. PMID: 12072654

Recent systematic reviews

Neuromodulation for the management of chronic pelvic pain syndromes: A systematic review.
Gish B, Langford B, Sobey C, Singh C, Abdullah N, Walker J, Gray H, Hagedorn J, Ghosh P, Patel K, Deer T
Pain Pract 2024 Feb;24(2):321-340. Epub 2023 Sep 19 doi: 10.1111/papr.13295. PMID: 37726930
mHealth Intervention for Improving Pain, Quality of Life, and Functional Disability in Patients With Chronic Pain: Systematic Review.
Moreno-Ligero M, Moral-Munoz JA, Salazar A, Failde I
JMIR Mhealth Uhealth 2023 Feb 2;11:e40844. doi: 10.2196/40844. PMID: 36729570Free PMC Article
Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome.
Clemens JQ, Erickson DR, Varela NP, Lai HH
J Urol 2022 Jul;208(1):34-42. Epub 2022 May 10 doi: 10.1097/JU.0000000000002756. PMID: 35536143
Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review.
Liang AL, Gingher EL, Coleman JS
Obstet Gynecol 2022 Feb 1;139(2):287-296. doi: 10.1097/AOG.0000000000004656. PMID: 35104069
Pelvic Floor Physical Therapy for Pelvic Floor Hypertonicity: A Systematic Review of Treatment Efficacy.
van Reijn-Baggen DA, Han-Geurts IJM, Voorham-van der Zalm PJ, Pelger RCM, Hagenaars-van Miert CHAC, Laan ETM
Sex Med Rev 2022 Apr;10(2):209-230. Epub 2021 Jun 12 doi: 10.1016/j.sxmr.2021.03.002. PMID: 34127429

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On
    • Interstitial cystitis
      Interstitial cystitis
      MedGen
    • Abscess
      Abscess
      Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.<br/>
      MeSH

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...