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Acromegaly

MedGen UID:
1304
•Concept ID:
C0001206
•
Disease or Syndrome
Synonym: Pituitary giant
SNOMED CT: Acromegaly (74107003); Growth hormone hypersecretion syndrome (74107003); STH hypersecretion syndrome (74107003); Marie disease (74107003); Anterior pituitary adenoma syndrome (74107003); Acromegalia (74107003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019933
Orphanet: ORPHA963

Definition

A rare acquired endocrine disease related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcromegaly
Follow this link to review classifications for Acromegaly in Orphanet.

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696

Recent clinical studies

Etiology

Consensus on criteria for acromegaly diagnosis and remission.
Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S; Acromegaly Consensus Group
Pituitary 2024 Feb;27(1):7-22. Epub 2023 Nov 3 doi: 10.1007/s11102-023-01360-1. PMID: 37923946Free PMC Article
A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update.
Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz096. PMID: 31606735
Hypertension and Acromegaly.
Puglisi S, Terzolo M
Endocrinol Metab Clin North Am 2019 Dec;48(4):779-793. Epub 2019 Sep 17 doi: 10.1016/j.ecl.2019.08.008. PMID: 31655776
Acromegaly and bone.
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Acromegaly: an endocrine society clinical practice guideline.
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808

Diagnosis

Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Hypertension and Acromegaly.
Puglisi S, Terzolo M
Endocrinol Metab Clin North Am 2019 Dec;48(4):779-793. Epub 2019 Sep 17 doi: 10.1016/j.ecl.2019.08.008. PMID: 31655776
Acromegaly and bone.
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Acromegaly: an endocrine society clinical practice guideline.
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808
Acromegaly pathogenesis and treatment.
Melmed S
J Clin Invest 2009 Nov;119(11):3189-202. Epub 2009 Nov 2 doi: 10.1172/JCI39375. PMID: 19884662Free PMC Article

Therapy

ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly.
Gadelha MR, Gordon MB, Doknic M, Mezősi E, Tóth M, Randeva H, Marmon T, Jochelson T, Luo R, Monahan M, Madan A, Ferrara-Cook C, Struthers RS, Krasner A
J Clin Endocrinol Metab 2023 Apr 13;108(5):e148-e159. doi: 10.1210/clinem/dgac643. PMID: 36353760Free PMC Article
Innovative therapeutics in acromegaly.
Kasuki L, Gadelha MR
Best Pract Res Clin Endocrinol Metab 2022 Dec;36(6):101679. Epub 2022 May 27 doi: 10.1016/j.beem.2022.101679. PMID: 35688725
The Future of Somatostatin Receptor Ligands in Acromegaly.
Gadelha MR, Wildemberg LE, Kasuki L
J Clin Endocrinol Metab 2022 Jan 18;107(2):297-308. doi: 10.1210/clinem/dgab726. PMID: 34618894Free PMC Article
New and emerging pharmacological treatment options for acromegaly.
Antunes X, Kasuki L, Gadelha MR
Expert Opin Pharmacother 2021 Aug;22(12):1615-1623. Epub 2021 Apr 8 doi: 10.1080/14656566.2021.1908998. PMID: 33783289
Biomarkers of Acromegaly and Growth Hormone Action.
Maffezzoni F, Porcelli T, Delbarba A, Pezzaioli L, Cappelli C, Ferlin A
Protein Pept Lett 2020;27(12):1231-1245. doi: 10.2174/0929866527666200420103816. PMID: 32310036

Prognosis

Acromegaly and Cancer: An Update.
Danilowicz K, Sosa S
Arch Med Res 2023 Dec;54(8):102914. Epub 2023 Nov 24 doi: 10.1016/j.arcmed.2023.102914. PMID: 38007382
Risk Factors for Colorectal Polyps and Cancer.
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
The Epidemiology of Pituitary Adenomas.
Daly AF, Beckers A
Endocrinol Metab Clin North Am 2020 Sep;49(3):347-355. Epub 2020 Jun 10 doi: 10.1016/j.ecl.2020.04.002. PMID: 32741475
Acromegaly and Heart Failure.
Colao A, Grasso LFS, Di Somma C, Pivonello R
Heart Fail Clin 2019 Jul;15(3):399-408. doi: 10.1016/j.hfc.2019.03.001. PMID: 31079698
Acromegaly.
Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R
Nat Rev Dis Primers 2019 Mar 21;5(1):20. doi: 10.1038/s41572-019-0071-6. PMID: 30899019

Clinical prediction guides

Acromegaly and Bone: An Update.
Giustina A
Endocrinol Metab (Seoul) 2023 Dec;38(6):655-666. Epub 2023 Dec 22 doi: 10.3803/EnM.2023.601. PMID: 38164073Free PMC Article
Acromegaly and Cancer: An Update.
Danilowicz K, Sosa S
Arch Med Res 2023 Dec;54(8):102914. Epub 2023 Nov 24 doi: 10.1016/j.arcmed.2023.102914. PMID: 38007382
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Acromegaly and bone.
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Acromegaly.
Nabarro JD
Clin Endocrinol (Oxf) 1987 Apr;26(4):481-512. doi: 10.1111/j.1365-2265.1987.tb00805.x. PMID: 3308190

Recent systematic reviews

Metabolomics in acromegaly: a systematic review.
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review.
Ji X, Fu J, Li X, Yuan K, Sun X, Yao Q
Pituitary 2023 Feb;26(1):1-8. Epub 2022 Dec 21 doi: 10.1007/s11102-022-01287-z. PMID: 36542278
Questionnaire and tools: clinical powerful instrument in acromegaly diagnosis and management.
Camerini S, Wennberg A, Adriani M, Martin B, Vettor R, Maffei P, Dassie F
J Endocrinol Invest 2022 Oct;45(10):1823-1834. Epub 2022 Mar 23 doi: 10.1007/s40618-022-01782-x. PMID: 35322391Free PMC Article
Acromegaly and pregnancy: a systematic review and meta-analysis.
Bandeira DB, Olivatti TOF, Bolfi F, Boguszewski CL, Dos Santos Nunes-Nogueira V
Pituitary 2022 Jun;25(3):352-362. Epub 2022 Jan 30 doi: 10.1007/s11102-022-01208-0. PMID: 35098440
Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis.
Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS
Eur J Endocrinol 2018 Jul;179(1):59-71. Epub 2018 May 15 doi: 10.1530/EJE-18-0255. PMID: 29764907

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