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Acromegaly

MedGen UID:
1304
•Concept ID:
C0001206
•
Disease or Syndrome
Synonym: Pituitary giant
SNOMED CT: Acromegaly (74107003); Growth hormone hypersecretion syndrome (74107003); STH hypersecretion syndrome (74107003); Marie disease (74107003); Anterior pituitary adenoma syndrome (74107003); Acromegalia (74107003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019933
Orphanet: ORPHA963

Definition

A rare acquired endocrine disease related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcromegaly
Follow this link to review classifications for Acromegaly in Orphanet.

Professional guidelines

PubMed

Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Multidisciplinary management of acromegaly: A consensus.
Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch M, Mortini P, Pereira AM, Petersenn S, Post K, Puig-Domingo M, Salvatori R, Samson SL, Shimon I, Strasburger C, Swearingen B, Trainer P, Vance ML, Wass J, Wierman ME, Yuen KCJ, Zatelli MC, Melmed S
Rev Endocr Metab Disord 2020 Dec;21(4):667-678. Epub 2020 Sep 10 doi: 10.1007/s11154-020-09588-z. PMID: 32914330Free PMC Article

Recent clinical studies

Etiology

Acromegaly and cardiovascular outcomes: a cohort study.
Hong S, Kim KS, Han K, Park CY
Eur Heart J 2022 Apr 14;43(15):1491-1499. doi: 10.1093/eurheartj/ehab822. PMID: 34864952
Cardiovascular complications of acromegaly.
Kamenický P, Maione L, Chanson P
Ann Endocrinol (Paris) 2021 Jun;82(3-4):206-209. Epub 2020 Mar 18 doi: 10.1016/j.ando.2020.03.010. PMID: 33168155
A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update.
Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz096. PMID: 31606735
Hypertension and Acromegaly.
Puglisi S, Terzolo M
Endocrinol Metab Clin North Am 2019 Dec;48(4):779-793. Epub 2019 Sep 17 doi: 10.1016/j.ecl.2019.08.008. PMID: 31655776
Acromegaly: an endocrine society clinical practice guideline.
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808

Diagnosis

Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Hypertension and Acromegaly.
Puglisi S, Terzolo M
Endocrinol Metab Clin North Am 2019 Dec;48(4):779-793. Epub 2019 Sep 17 doi: 10.1016/j.ecl.2019.08.008. PMID: 31655776
Acromegaly and bone.
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Acromegaly: clinical features at diagnosis.
Vilar L, Vilar CF, Lyra R, Lyra R, Naves LA
Pituitary 2017 Feb;20(1):22-32. doi: 10.1007/s11102-016-0772-8. PMID: 27812777
Acromegaly: an endocrine society clinical practice guideline.
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808

Therapy

Innovative therapeutics in acromegaly.
Kasuki L, Gadelha MR
Best Pract Res Clin Endocrinol Metab 2022 Dec;36(6):101679. Epub 2022 May 27 doi: 10.1016/j.beem.2022.101679. PMID: 35688725
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
The Future of Somatostatin Receptor Ligands in Acromegaly.
Gadelha MR, Wildemberg LE, Kasuki L
J Clin Endocrinol Metab 2022 Jan 18;107(2):297-308. doi: 10.1210/clinem/dgab726. PMID: 34618894Free PMC Article
Insulin-Like Growth Factor Pathway and the Thyroid.
Smith TJ
Front Endocrinol (Lausanne) 2021;12:653627. Epub 2021 Jun 4 doi: 10.3389/fendo.2021.653627. PMID: 34149612Free PMC Article
Pegvisomant Treatment in Acromegaly.
Neggers SJ, Muhammad A, van der Lely AJ
Neuroendocrinology 2016;103(1):59-65. Epub 2015 Mar 19 doi: 10.1159/000381644. PMID: 25792221

Prognosis

Risk Factors for Colorectal Polyps and Cancer.
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
The Epidemiology of Pituitary Adenomas.
Daly AF, Beckers A
Endocrinol Metab Clin North Am 2020 Sep;49(3):347-355. Epub 2020 Jun 10 doi: 10.1016/j.ecl.2020.04.002. PMID: 32741475
Determinants of morbidities and mortality in acromegaly.
Kasuki L, Rocha PDS, Lamback EB, Gadelha MR
Arch Endocrinol Metab 2019 Nov-Dec;63(6):630-637. doi: 10.20945/2359-3997000000193. PMID: 31939488
Acromegaly and Heart Failure.
Colao A, Grasso LFS, Di Somma C, Pivonello R
Heart Fail Clin 2019 Jul;15(3):399-408. doi: 10.1016/j.hfc.2019.03.001. PMID: 31079698
Acromegaly.
Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R
Nat Rev Dis Primers 2019 Mar 21;5(1):20. doi: 10.1038/s41572-019-0071-6. PMID: 30899019

Clinical prediction guides

Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Clinical Characteristics and Management of Patients With McCune-Albright Syndrome With GH Excess and Precocious Puberty: A Case Series and Literature Review.
Zhai X, Duan L, Yao Y, Xing B, Deng K, Wang L, Feng F, Liang Z, You H, Yang H, Lu L, Chen S, Wang R, Pan H, Zhu H
Front Endocrinol (Lausanne) 2021;12:672394. Epub 2021 Oct 29 doi: 10.3389/fendo.2021.672394. PMID: 34777239Free PMC Article
Surgery for Acromegaly.
Sarkar S, Chacko AG
Neurol India 2020 May-Jun;68(Supplement):S44-S51. doi: 10.4103/0028-3886.287664. PMID: 32611892
Acromegaly and Heart Failure.
Colao A, Grasso LFS, Di Somma C, Pivonello R
Heart Fail Clin 2019 Jul;15(3):399-408. doi: 10.1016/j.hfc.2019.03.001. PMID: 31079698
Acromegaly and bone.
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058

Recent systematic reviews

Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review.
Ji X, Fu J, Li X, Yuan K, Sun X, Yao Q
Pituitary 2023 Feb;26(1):1-8. Epub 2022 Dec 21 doi: 10.1007/s11102-022-01287-z. PMID: 36542278
Questionnaire and tools: clinical powerful instrument in acromegaly diagnosis and management.
Camerini S, Wennberg A, Adriani M, Martin B, Vettor R, Maffei P, Dassie F
J Endocrinol Invest 2022 Oct;45(10):1823-1834. Epub 2022 Mar 23 doi: 10.1007/s40618-022-01782-x. PMID: 35322391Free PMC Article
Acromegaly and pregnancy: a systematic review and meta-analysis.
Bandeira DB, Olivatti TOF, Bolfi F, Boguszewski CL, Dos Santos Nunes-Nogueira V
Pituitary 2022 Jun;25(3):352-362. Epub 2022 Jan 30 doi: 10.1007/s11102-022-01208-0. PMID: 35098440
Preclinical markers of atherosclerosis in acromegaly: a systematic review and meta-analysis.
Parolin M, Dassie F, Martini C, Mioni R, Russo L, Fallo F, Rossato M, Vettor R, Maffei P, Pagano C
Pituitary 2018 Dec;21(6):653-662. doi: 10.1007/s11102-018-0911-5. PMID: 30225826
Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis.
Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS
Eur J Endocrinol 2018 Jul;179(1):59-71. Epub 2018 May 15 doi: 10.1530/EJE-18-0255. PMID: 29764907

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