U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acromegaly

MedGen UID:
1304
Concept ID:
C0001206
Disease or Syndrome
Synonym: Pituitary giant
SNOMED CT: Acromegaly (74107003); Growth hormone hypersecretion syndrome (74107003); STH hypersecretion syndrome (74107003); Marie disease (74107003); Anterior pituitary adenoma syndrome (74107003); Acromegalia (74107003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019933
Orphanet: ORPHA963

Definition

A rare acquired endocrine disease related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcromegaly
Follow this link to review classifications for Acromegaly in Orphanet.

Professional guidelines

PubMed

Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696

Recent clinical studies

Etiology

Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S; Acromegaly Consensus Group
Pituitary 2024 Feb;27(1):7-22. Epub 2023 Nov 3 doi: 10.1007/s11102-023-01360-1. PMID: 37923946Free PMC Article
Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz096. PMID: 31606735
Puglisi S, Terzolo M
Endocrinol Metab Clin North Am 2019 Dec;48(4):779-793. Epub 2019 Sep 17 doi: 10.1016/j.ecl.2019.08.008. PMID: 31655776
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808

Diagnosis

Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Puglisi S, Terzolo M
Endocrinol Metab Clin North Am 2019 Dec;48(4):779-793. Epub 2019 Sep 17 doi: 10.1016/j.ecl.2019.08.008. PMID: 31655776
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808
Melmed S
J Clin Invest 2009 Nov;119(11):3189-202. Epub 2009 Nov 2 doi: 10.1172/JCI39375. PMID: 19884662Free PMC Article

Therapy

Gadelha MR, Gordon MB, Doknic M, Mezősi E, Tóth M, Randeva H, Marmon T, Jochelson T, Luo R, Monahan M, Madan A, Ferrara-Cook C, Struthers RS, Krasner A
J Clin Endocrinol Metab 2023 Apr 13;108(5):e148-e159. doi: 10.1210/clinem/dgac643. PMID: 36353760Free PMC Article
Kasuki L, Gadelha MR
Best Pract Res Clin Endocrinol Metab 2022 Dec;36(6):101679. Epub 2022 May 27 doi: 10.1016/j.beem.2022.101679. PMID: 35688725
Gadelha MR, Wildemberg LE, Kasuki L
J Clin Endocrinol Metab 2022 Jan 18;107(2):297-308. doi: 10.1210/clinem/dgab726. PMID: 34618894Free PMC Article
Antunes X, Kasuki L, Gadelha MR
Expert Opin Pharmacother 2021 Aug;22(12):1615-1623. Epub 2021 Apr 8 doi: 10.1080/14656566.2021.1908998. PMID: 33783289
Maffezzoni F, Porcelli T, Delbarba A, Pezzaioli L, Cappelli C, Ferlin A
Protein Pept Lett 2020;27(12):1231-1245. doi: 10.2174/0929866527666200420103816. PMID: 32310036

Prognosis

Danilowicz K, Sosa S
Arch Med Res 2023 Dec;54(8):102914. Epub 2023 Nov 24 doi: 10.1016/j.arcmed.2023.102914. PMID: 38007382
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
Daly AF, Beckers A
Endocrinol Metab Clin North Am 2020 Sep;49(3):347-355. Epub 2020 Jun 10 doi: 10.1016/j.ecl.2020.04.002. PMID: 32741475
Colao A, Grasso LFS, Di Somma C, Pivonello R
Heart Fail Clin 2019 Jul;15(3):399-408. doi: 10.1016/j.hfc.2019.03.001. PMID: 31079698
Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R
Nat Rev Dis Primers 2019 Mar 21;5(1):20. doi: 10.1038/s41572-019-0071-6. PMID: 30899019

Clinical prediction guides

Giustina A
Endocrinol Metab (Seoul) 2023 Dec;38(6):655-666. Epub 2023 Dec 22 doi: 10.3803/EnM.2023.601. PMID: 38164073Free PMC Article
Danilowicz K, Sosa S
Arch Med Res 2023 Dec;54(8):102914. Epub 2023 Nov 24 doi: 10.1016/j.arcmed.2023.102914. PMID: 38007382
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Nabarro JD
Clin Endocrinol (Oxf) 1987 Apr;26(4):481-512. doi: 10.1111/j.1365-2265.1987.tb00805.x. PMID: 3308190

Recent systematic reviews

Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Ji X, Fu J, Li X, Yuan K, Sun X, Yao Q
Pituitary 2023 Feb;26(1):1-8. Epub 2022 Dec 21 doi: 10.1007/s11102-022-01287-z. PMID: 36542278
Camerini S, Wennberg A, Adriani M, Martin B, Vettor R, Maffei P, Dassie F
J Endocrinol Invest 2022 Oct;45(10):1823-1834. Epub 2022 Mar 23 doi: 10.1007/s40618-022-01782-x. PMID: 35322391Free PMC Article
Bandeira DB, Olivatti TOF, Bolfi F, Boguszewski CL, Dos Santos Nunes-Nogueira V
Pituitary 2022 Jun;25(3):352-362. Epub 2022 Jan 30 doi: 10.1007/s11102-022-01208-0. PMID: 35098440
Bolfi F, Neves AF, Boguszewski CL, Nunes-Nogueira VS
Eur J Endocrinol 2018 Jul;179(1):59-71. Epub 2018 May 15 doi: 10.1530/EJE-18-0255. PMID: 29764907

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...