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Hypothalamic gliosis

MedGen UID:
1370041
•Concept ID:
C4476558
•
Finding
HPO: HP:0025037

Definition

Focal proliferation of glial cells in the hypothalamus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypothalamic gliosis

Professional guidelines

PubMed

Acute intranasal treatment with nerve growth factor limits the onset of traumatic brain injury in young rats.
Manni L, Leotta E, Mollica I, Serafino A, Pignataro A, Salvatori I, Conti G, Chiaretti A, Soligo M
Br J Pharmacol 2023 Aug;180(15):1949-1964. Epub 2023 Mar 1 doi: 10.1111/bph.16056. PMID: 36780920
Neuropathological criteria of anti-IgLON5-related tauopathy.
Gelpi E, Höftberger R, Graus F, Ling H, Holton JL, Dawson T, Popovic M, Pretnar-Oblak J, Högl B, Schmutzhard E, Poewe W, Ricken G, Santamaria J, Dalmau J, Budka H, Revesz T, Kovacs GG
Acta Neuropathol 2016 Oct;132(4):531-43. Epub 2016 Jun 29 doi: 10.1007/s00401-016-1591-8. PMID: 27358064Free PMC Article
Unilateral thalamic Vim and GPi stimulation for the treatment of Holmes' tremor caused by midbrain cavernoma: case report and review of the literature.
Aydin S, Abuzayed B, Kiziltan G, Gunduz A, Yagci S, Mengi M, Kizilkilic O, Uzan M, Hanci M
J Neurol Surg A Cent Eur Neurosurg 2013 Jul;74(4):271-6. Epub 2013 Jan 14 doi: 10.1055/s-0032-1322549. PMID: 23319330

Recent clinical studies

Etiology

In utero exposure to maternal diabetes or hypertension and childhood hypothalamic gliosis.
Olerich KLW, Sewaybricker LE, Kee S, Melhorn SJ, Chandrasekaran S, Schur EA
Int J Obes (Lond) 2024 Apr;48(4):594-597. Epub 2024 Jan 25 doi: 10.1038/s41366-024-01463-0. PMID: 38273035
Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice.
Dorfman MD, Monfeuga T, Melhorn SJ, Kanter JE, Frey JM, Fasnacht RD, Chandran A, Lala E, Velasco I, Rubinow KB, Meek TH, Schur EA, Bornfeldt KE, Thaler JP
Am J Physiol Endocrinol Metab 2023 May 1;324(5):E461-E475. Epub 2023 Apr 13 doi: 10.1152/ajpendo.00059.2023. PMID: 37053049Free PMC Article
Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity.
Rosenbaum JL, Melhorn SJ, Schoen S, Webb MF, De Leon MRB, Humphreys M, Utzschneider KM, Schur EA
Diabetes Care 2022 Feb 1;45(2):416-424. doi: 10.2337/dc21-1535. PMID: 34848489Free PMC Article
Salience network connectivity is reduced by a meal and influenced by genetic background and hypothalamic gliosis.
Sewaybricker LE, Melhorn SJ, Askren MK, Webb MF, Tyagi V, De Leon MRB, Grabowski TJ, Seeley WW, Schur EA
Int J Obes (Lond) 2020 Jan;44(1):167-177. Epub 2019 Apr 9 doi: 10.1038/s41366-019-0361-9. PMID: 30967608Free PMC Article
Initial evidence for hypothalamic gliosis in children with obesity by quantitative T2 MRI and implications for blood oxygen-level dependent response to glucose ingestion.
Sewaybricker LE, Schur EA, Melhorn SJ, Campos BM, Askren MK, Nogueira GAS, Zambon MP, Antonio MARGM, Cendes F, Velloso LA, Guerra-Junior G
Pediatr Obes 2019 Feb;14(2):e12486. Epub 2018 Dec 10 doi: 10.1111/ijpo.12486. PMID: 30537237Free PMC Article

Diagnosis

Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity.
Rosenbaum JL, Melhorn SJ, Schoen S, Webb MF, De Leon MRB, Humphreys M, Utzschneider KM, Schur EA
Diabetes Care 2022 Feb 1;45(2):416-424. doi: 10.2337/dc21-1535. PMID: 34848489Free PMC Article
Effect of pioglitazone treatment on brown adipose tissue volume and activity and hypothalamic gliosis in patients with type 2 diabetes mellitus: a proof-of-concept study.
de-Lima-Júnior JC, Rodovalho S, Van de Sande-Lee S, Monfort-Pires M, Rachid B, Cintra RM, Ramos CD, Cendes F, Folli F, Velloso LA
Acta Diabetol 2019 Dec;56(12):1333-1339. Epub 2019 Sep 10 doi: 10.1007/s00592-019-01418-2. PMID: 31506721
Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans.
Schur EA, Melhorn SJ, Oh SK, Lacy JM, Berkseth KE, Guyenet SJ, Sonnen JA, Tyagi V, Rosalynn M, De Leon B, Webb MF, Gonsalves ZT, Fligner CL, Schwartz MW, Maravilla KR
Obesity (Silver Spring) 2015 Nov;23(11):2142-8. doi: 10.1002/oby.21248. PMID: 26530930Free PMC Article

Therapy

Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice.
Dorfman MD, Monfeuga T, Melhorn SJ, Kanter JE, Frey JM, Fasnacht RD, Chandran A, Lala E, Velasco I, Rubinow KB, Meek TH, Schur EA, Bornfeldt KE, Thaler JP
Am J Physiol Endocrinol Metab 2023 May 1;324(5):E461-E475. Epub 2023 Apr 13 doi: 10.1152/ajpendo.00059.2023. PMID: 37053049Free PMC Article
Effect of pioglitazone treatment on brown adipose tissue volume and activity and hypothalamic gliosis in patients with type 2 diabetes mellitus: a proof-of-concept study.
de-Lima-Júnior JC, Rodovalho S, Van de Sande-Lee S, Monfort-Pires M, Rachid B, Cintra RM, Ramos CD, Cendes F, Folli F, Velloso LA
Acta Diabetol 2019 Dec;56(12):1333-1339. Epub 2019 Sep 10 doi: 10.1007/s00592-019-01418-2. PMID: 31506721

Prognosis

Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity.
Rosenbaum JL, Melhorn SJ, Schoen S, Webb MF, De Leon MRB, Humphreys M, Utzschneider KM, Schur EA
Diabetes Care 2022 Feb 1;45(2):416-424. doi: 10.2337/dc21-1535. PMID: 34848489Free PMC Article
Greater radiologic evidence of hypothalamic gliosis predicts adiposity gain in children at risk for obesity.
Sewaybricker LE, Kee S, Melhorn SJ, Schur EA
Obesity (Silver Spring) 2021 Nov;29(11):1770-1779. doi: 10.1002/oby.23286. PMID: 34734493Free PMC Article

Clinical prediction guides

Exposure to Gestational Diabetes Mellitus Prior to 26 Weeks Is Related to the Presence of Mediobasal Hypothalamic Gliosis in Children.
Chandrasekaran S, Melhorn S, Olerich KLW, Angelo B, Chow T, Xiang A, Schur EA, Page KA
Diabetes 2022 Dec 1;71(12):2552-2556. doi: 10.2337/db22-0448. PMID: 36095276Free PMC Article
Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity.
Rosenbaum JL, Melhorn SJ, Schoen S, Webb MF, De Leon MRB, Humphreys M, Utzschneider KM, Schur EA
Diabetes Care 2022 Feb 1;45(2):416-424. doi: 10.2337/dc21-1535. PMID: 34848489Free PMC Article
Greater radiologic evidence of hypothalamic gliosis predicts adiposity gain in children at risk for obesity.
Sewaybricker LE, Kee S, Melhorn SJ, Schur EA
Obesity (Silver Spring) 2021 Nov;29(11):1770-1779. doi: 10.1002/oby.23286. PMID: 34734493Free PMC Article
Pilot multi-site and reproducibility study of hypothalamic gliosis in children.
Sewaybricker LE, Melhorn SJ, Papantoni A, Webb MF, Hua J, Roth CL, Carnell S, Schur EA
Pediatr Obes 2021 Apr;16(4):e12732. Epub 2020 Oct 20 doi: 10.1111/ijpo.12732. PMID: 33084253Free PMC Article

Supplemental Content

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