U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased circulating beta-2-microglobulin level

MedGen UID:
1370111
•Concept ID:
C4476716
•
Finding
Synonym: Elevated circulating beta-2-microglobulin level
 
HPO: HP:0025346

Definition

Elevated concentration of beta-2-microglobulin in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating beta-2-microglobulin level

Professional guidelines

PubMed

Monitoring treatment response and disease progression in myeloma with circulating cell-free DNA.
Deshpande S, Tytarenko RG, Wang Y, Boyle EM, Ashby C, Schinke CD, Thanendrarajan S, Zangari M, Zhan F, Davies FE, Morgan GJ, van Rhee F, Walker BA
Eur J Haematol 2021 Feb;106(2):230-240. Epub 2020 Nov 10 doi: 10.1111/ejh.13541. PMID: 33107092
Reduction of circulating beta2-microglobulin level for the treatment of dialysis-related amyloidosis.
Kazama JJ, Maruyama H, Gejyo F
Nephrol Dial Transplant 2001;16 Suppl 4:31-5. doi: 10.1093/ndt/16.suppl_4.31. PMID: 11402095

Recent clinical studies

Etiology

Platelet-derived β2M regulates monocyte inflammatory responses.
Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante AA, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN
JCI Insight 2019 Mar 7;4(5) doi: 10.1172/jci.insight.122943. PMID: 30702442Free PMC Article
Does uremia cause vascular dysfunction?
Brunet P, Gondouin B, Duval-Sabatier A, Dou L, Cerini C, Dignat-George F, Jourde-Chiche N, Argiles A, Burtey S
Kidney Blood Press Res 2011;34(4):284-90. Epub 2011 Jun 21 doi: 10.1159/000327131. PMID: 21691132
Serum Beta-2-microglobulin levels in intrauterine growth-restricted and normal pregnancies.
Kontara L, Briana DD, Baka S, Boutsikou M, Marmarinos A, Gourgiotis D, Malamitsi-Puchner A
Fetal Diagn Ther 2008;24(3):220-4. Epub 2008 Aug 28 doi: 10.1159/000151342. PMID: 18753761
Reduction of circulating beta2-microglobulin level for the treatment of dialysis-related amyloidosis.
Kazama JJ, Maruyama H, Gejyo F
Nephrol Dial Transplant 2001;16 Suppl 4:31-5. doi: 10.1093/ndt/16.suppl_4.31. PMID: 11402095
Dialysis-related amyloidosis: pathogenesis focusing on AGE modification.
Niwa T
Semin Dial 2001 Mar-Apr;14(2):123-6. doi: 10.1046/j.1525-139x.2001.00031.x. PMID: 11264780

Diagnosis

Serum tumor markers for detection of bone metastases in patients with lung neuroendocrine neoplasms".
Rosiek V, Wójcik-Giertuga M, Kos-Kudła B
Cancer Treat Res Commun 2022;31:100533. Epub 2022 Feb 15 doi: 10.1016/j.ctarc.2022.100533. PMID: 35202905
Tracking the evolution of untreated high-intermediate/high-risk diffuse large B-cell lymphoma by circulating tumour DNA.
Zhang S, Zhang T, Liu H, Zhao J, Zhou H, Su X, Liu X, Li L, Qiu L, Qian Z, Zhou S, Gong W, Meng B, Ren X, He J, Wang X, Zhang H
Br J Haematol 2022 Feb;196(3):617-628. Epub 2021 Oct 19 doi: 10.1111/bjh.17894. PMID: 34664256
Monitoring treatment response and disease progression in myeloma with circulating cell-free DNA.
Deshpande S, Tytarenko RG, Wang Y, Boyle EM, Ashby C, Schinke CD, Thanendrarajan S, Zangari M, Zhan F, Davies FE, Morgan GJ, van Rhee F, Walker BA
Eur J Haematol 2021 Feb;106(2):230-240. Epub 2020 Nov 10 doi: 10.1111/ejh.13541. PMID: 33107092
Long non-coding RNA CCAT2 as a potential serum biomarker for diagnosis and prognosis of multiple myeloma.
Xu H, Yin Q, Shen X, Ju S
Ann Hematol 2020 Sep;99(9):2159-2171. Epub 2020 Jun 26 doi: 10.1007/s00277-020-04161-9. PMID: 32591878
Serum β2-Microglobulin is Associated with Mortality in Hospitalized Patients with Exacerbated Chronic Obstructive Pulmonary Disease.
Mao W, Wang J, Zhang L, Wang Y, Wang W, Zeng N, Zhang J, Li Q, Jiao F, Li J, Cui N, Mi S, Xue Y, Wang Z, Ying S, Huang K
Int J Chron Obstruct Pulmon Dis 2020;15:723-732. Epub 2020 Apr 7 doi: 10.2147/COPD.S243905. PMID: 32308380Free PMC Article

Therapy

Tracking the evolution of untreated high-intermediate/high-risk diffuse large B-cell lymphoma by circulating tumour DNA.
Zhang S, Zhang T, Liu H, Zhao J, Zhou H, Su X, Liu X, Li L, Qiu L, Qian Z, Zhou S, Gong W, Meng B, Ren X, He J, Wang X, Zhang H
Br J Haematol 2022 Feb;196(3):617-628. Epub 2021 Oct 19 doi: 10.1111/bjh.17894. PMID: 34664256
HIV infection, antiretroviral therapy, and measures of endothelial function, inflammation, metabolism, and oxidative stress.
Dysangco A, Liu Z, Stein JH, Dubé MP, Gupta SK
PLoS One 2017;12(8):e0183511. Epub 2017 Aug 17 doi: 10.1371/journal.pone.0183511. PMID: 28817706Free PMC Article
Benefits of preserving residual renal function in peritoneal dialysis.
Marrón B, Remón C, Pérez-Fontán M, Quirós P, Ortíz A
Kidney Int Suppl 2008 Apr;(108):S42-51. doi: 10.1038/sj.ki.5002600. PMID: 18379546
Reduction of circulating beta2-microglobulin level for the treatment of dialysis-related amyloidosis.
Kazama JJ, Maruyama H, Gejyo F
Nephrol Dial Transplant 2001;16 Suppl 4:31-5. doi: 10.1093/ndt/16.suppl_4.31. PMID: 11402095
Dialysis-related amyloidosis: pathogenesis focusing on AGE modification.
Niwa T
Semin Dial 2001 Mar-Apr;14(2):123-6. doi: 10.1046/j.1525-139x.2001.00031.x. PMID: 11264780

Prognosis

Tracking the evolution of untreated high-intermediate/high-risk diffuse large B-cell lymphoma by circulating tumour DNA.
Zhang S, Zhang T, Liu H, Zhao J, Zhou H, Su X, Liu X, Li L, Qiu L, Qian Z, Zhou S, Gong W, Meng B, Ren X, He J, Wang X, Zhang H
Br J Haematol 2022 Feb;196(3):617-628. Epub 2021 Oct 19 doi: 10.1111/bjh.17894. PMID: 34664256
Monitoring treatment response and disease progression in myeloma with circulating cell-free DNA.
Deshpande S, Tytarenko RG, Wang Y, Boyle EM, Ashby C, Schinke CD, Thanendrarajan S, Zangari M, Zhan F, Davies FE, Morgan GJ, van Rhee F, Walker BA
Eur J Haematol 2021 Feb;106(2):230-240. Epub 2020 Nov 10 doi: 10.1111/ejh.13541. PMID: 33107092
Serum β2-Microglobulin is Associated with Mortality in Hospitalized Patients with Exacerbated Chronic Obstructive Pulmonary Disease.
Mao W, Wang J, Zhang L, Wang Y, Wang W, Zeng N, Zhang J, Li Q, Jiao F, Li J, Cui N, Mi S, Xue Y, Wang Z, Ying S, Huang K
Int J Chron Obstruct Pulmon Dis 2020;15:723-732. Epub 2020 Apr 7 doi: 10.2147/COPD.S243905. PMID: 32308380Free PMC Article
Evidence for a Causal Role of the SH2B3-β(2)M Axis in Blood Pressure Regulation.
Keefe JA, Hwang SJ, Huan T, Mendelson M, Yao C, Courchesne P, Saleh MA, Madhur MS, Levy D
Hypertension 2019 Feb;73(2):497-503. doi: 10.1161/HYPERTENSIONAHA.118.12094. PMID: 30624993Free PMC Article
Elevated vWF Antigen Serum Levels Are Associated With Poor Prognosis, and Decreased Circulating ADAMTS-13 Antigen Levels Are Associated With Increased IgM Levels and Features of WM but not Increased vWF Levels in Patients With Symptomatic WM.
Gavriatopoulou M, Terpos E, Ntanasis-Stathopoulos I, Papasotiriou I, Fotiou D, Migkou M, Roussou M, Kanellias N, Ziogas D, Dialoupi I, Eleutherakis Papaiakovou E, Kastritis E, Dimopoulos MA
Clin Lymphoma Myeloma Leuk 2019 Jan;19(1):23-28. Epub 2018 Aug 23 doi: 10.1016/j.clml.2018.07.294. PMID: 30224328

Clinical prediction guides

Tracking the evolution of untreated high-intermediate/high-risk diffuse large B-cell lymphoma by circulating tumour DNA.
Zhang S, Zhang T, Liu H, Zhao J, Zhou H, Su X, Liu X, Li L, Qiu L, Qian Z, Zhou S, Gong W, Meng B, Ren X, He J, Wang X, Zhang H
Br J Haematol 2022 Feb;196(3):617-628. Epub 2021 Oct 19 doi: 10.1111/bjh.17894. PMID: 34664256
Monitoring treatment response and disease progression in myeloma with circulating cell-free DNA.
Deshpande S, Tytarenko RG, Wang Y, Boyle EM, Ashby C, Schinke CD, Thanendrarajan S, Zangari M, Zhan F, Davies FE, Morgan GJ, van Rhee F, Walker BA
Eur J Haematol 2021 Feb;106(2):230-240. Epub 2020 Nov 10 doi: 10.1111/ejh.13541. PMID: 33107092
Serum Beta-2-microglobulin levels in intrauterine growth-restricted and normal pregnancies.
Kontara L, Briana DD, Baka S, Boutsikou M, Marmarinos A, Gourgiotis D, Malamitsi-Puchner A
Fetal Diagn Ther 2008;24(3):220-4. Epub 2008 Aug 28 doi: 10.1159/000151342. PMID: 18753761
Dialysis-related amyloidosis: pathogenesis focusing on AGE modification.
Niwa T
Semin Dial 2001 Mar-Apr;14(2):123-6. doi: 10.1046/j.1525-139x.2001.00031.x. PMID: 11264780
Dissociation between beta-2 microglobulin and IL-1 production in hemodialyzed patients.
Carreno MP, Rousseau Y, Poignet JL, Jahns G, Cholley B, Kazatchkine MD, Haeffner-Cavaillon N
Nephrol Dial Transplant 1997 Nov;12(11):2365-74. doi: 10.1093/ndt/12.11.2365. PMID: 9394324

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...