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Abnormal hippocampus morphology

MedGen UID:
1370323
Concept ID:
C4476590
Anatomical Abnormality
Synonyms: Abnormal morphology of the hippocampus; Abnormality of hippocampus morphology
 
HPO: HP:0025100

Definition

Any structural anomaly of the hippocampus, [from HPO]

Conditions with this feature

Mowat-Wilson syndrome
MedGen UID:
341067
Concept ID:
C1856113
Disease or Syndrome
Mowat-Wilson syndrome (MWS) is characterized by distinctive facial features (widely spaced eyes, broad eyebrows with a medial flare, low-hanging columella, prominent or pointed chin, open-mouth expression, and uplifted earlobes with a central depression), congenital heart defects with predilection for abnormalities of the pulmonary arteries and/or valves, Hirschsprung disease or chronic constipation, genitourinary anomalies (particularly hypospadias in males), and hypogenesis or agenesis of the corpus callosum. Most affected individuals have moderate-to-severe intellectual disability. Speech is typically limited to a few words or is absent, with relative preservation of receptive language skills. Growth restriction with microcephaly and seizure disorder are also common. Most affected people have a happy demeanor and a wide-based gait that can sometimes be confused with Angelman syndrome.

Professional guidelines

PubMed

Pacheco-Herrero M, Soto-Rojas LO, Reyes-Sabater H, Garcés-Ramirez L, de la Cruz López F, Villanueva-Fierro I, Luna-Muñoz J
J Alzheimers Dis 2021;84(3):917-935. doi: 10.3233/JAD-200863. PMID: 34633316Free PMC Article
Duman CH, Duman RS
Neurosci Lett 2015 Aug 5;601:20-9. Epub 2015 Jan 9 doi: 10.1016/j.neulet.2015.01.022. PMID: 25582786Free PMC Article
Tüzün E, Dalmau J
Neurologist 2007 Sep;13(5):261-71. doi: 10.1097/NRL.0b013e31813e34a5. PMID: 17848866

Recent clinical studies

Etiology

Miao Y, Zhang B, Sun X, Ma X, Fang D, Zhang W, Wu T, Xu X, Yu C, Hou Y, Ding Q, Yang S, Fu L, Zhang Z, Bi Y
J Clin Endocrinol Metab 2023 Nov 17;108(12):3239-3249. doi: 10.1210/clinem/dgad352. PMID: 37310344
Santos VR, Melo IS, Pacheco ALD, Castro OW
Epilepsy Behav 2021 Aug;121(Pt B):106595. Epub 2019 Nov 20 doi: 10.1016/j.yebeh.2019.106595. PMID: 31759972
Rocca MA, Barkhof F, De Luca J, Frisén J, Geurts JJG, Hulst HE, Sastre-Garriga J, Filippi M; MAGNIMS Study Group
Lancet Neurol 2018 Oct;17(10):918-926. Epub 2018 Sep 18 doi: 10.1016/S1474-4422(18)30309-0. PMID: 30264730
Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G; EEBB Consortium
N Engl J Med 2017 Oct 26;377(17):1648-1656. doi: 10.1056/NEJMoa1703784. PMID: 29069555
Giedd JN, Clasen LS, Lenroot R, Greenstein D, Wallace GL, Ordaz S, Molloy EA, Blumenthal JD, Tossell JW, Stayer C, Samango-Sprouse CA, Shen D, Davatzikos C, Merke D, Chrousos GP
Mol Cell Endocrinol 2006 Jul 25;254-255:154-62. Epub 2006 Jun 9 doi: 10.1016/j.mce.2006.04.016. PMID: 16765510

Diagnosis

Santos VR, Melo IS, Pacheco ALD, Castro OW
Epilepsy Behav 2021 Aug;121(Pt B):106595. Epub 2019 Nov 20 doi: 10.1016/j.yebeh.2019.106595. PMID: 31759972
Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G; EEBB Consortium
N Engl J Med 2017 Oct 26;377(17):1648-1656. doi: 10.1056/NEJMoa1703784. PMID: 29069555
Szabo K, Förster A, Gass A
Front Neurol Neurosci 2014;34:71-84. Epub 2014 Apr 16 doi: 10.1159/000357925. PMID: 24777132
Blümcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A, Bernasconi N, Bien CG, Cendes F, Coras R, Cross JH, Jacques TS, Kahane P, Mathern GW, Miyata H, Moshé SL, Oz B, Özkara Ç, Perucca E, Sisodiya S, Wiebe S, Spreafico R
Epilepsia 2013 Jul;54(7):1315-29. Epub 2013 May 20 doi: 10.1111/epi.12220. PMID: 23692496
Brambilla P, Hatch JP, Soares JC
Curr Psychiatry Rep 2008 Dec;10(6):505-9. doi: 10.1007/s11920-008-0080-8. PMID: 18980734

Therapy

Pinto B, Morelli G, Rastogi M, Savardi A, Fumagalli A, Petretto A, Bartolucci M, Varea E, Catelani T, Contestabile A, Perlini LE, Cancedda L
Neuron 2020 Dec 9;108(5):887-904.e12. Epub 2020 Oct 6 doi: 10.1016/j.neuron.2020.09.010. PMID: 33027640Free PMC Article
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article
Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145Free PMC Article
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF
Nat Rev Dis Primers 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598
Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ
Nat Med 2014 Aug;20(8):886-96. Epub 2014 Jun 29 doi: 10.1038/nm.3639. PMID: 24973918Free PMC Article

Prognosis

Middlebrooks EH, Gupta V, Agarwal AK, Freund BE, Messina SA, Tatum WO, Sabsevitz DS, Feyissa AM, Mirsattari SM, Galan FN, Quinones-Hinojosa A, Grewal SS, Murray JV
AJNR Am J Neuroradiol 2024 Sep 9;45(9):1185-1193. doi: 10.3174/ajnr.A8214. PMID: 38383054Free PMC Article
Isnard J, Bourdillon P
Rev Neurol (Paris) 2015 Mar;171(3):298-306. Epub 2015 Mar 2 doi: 10.1016/j.neurol.2014.12.002. PMID: 25744767
Cendes F, Sakamoto AC, Spreafico R, Bingaman W, Becker AJ
Acta Neuropathol 2014 Jul;128(1):21-37. Epub 2014 May 14 doi: 10.1007/s00401-014-1292-0. PMID: 24823761
Brambilla P, Hatch JP, Soares JC
Curr Psychiatry Rep 2008 Dec;10(6):505-9. doi: 10.1007/s11920-008-0080-8. PMID: 18980734
Valenstein E, Bowers D, Verfaellie M, Heilman KM, Day A, Watson RT
Brain 1987 Dec;110 ( Pt 6):1631-46. doi: 10.1093/brain/110.6.1631. PMID: 3427404

Clinical prediction guides

Liu R, Zhou H, Qu H, Chen Y, Bai Q, Guo F, Wang L, Jiang X, Mao H
J Affect Disord 2023 Nov 15;341:248-255. Epub 2023 Aug 25 doi: 10.1016/j.jad.2023.08.078. PMID: 37634821
Li Y, Liu P, Lin Q, Zhou D, An D
Epilepsia 2023 Nov;64(11):2845-2860. Epub 2023 Sep 30 doi: 10.1111/epi.17757. PMID: 37611927
Miao Y, Zhang B, Sun X, Ma X, Fang D, Zhang W, Wu T, Xu X, Yu C, Hou Y, Ding Q, Yang S, Fu L, Zhang Z, Bi Y
J Clin Endocrinol Metab 2023 Nov 17;108(12):3239-3249. doi: 10.1210/clinem/dgad352. PMID: 37310344
Kalmady SV, Shivakumar V, Arasappa R, Subramaniam A, Gautham S, Venkatasubramanian G, Gangadhar BN
Psychiatry Res Neuroimaging 2017 May 30;263:93-102. Epub 2017 Mar 29 doi: 10.1016/j.pscychresns.2017.03.014. PMID: 28371658
Cendes F, Sakamoto AC, Spreafico R, Bingaman W, Becker AJ
Acta Neuropathol 2014 Jul;128(1):21-37. Epub 2014 May 14 doi: 10.1007/s00401-014-1292-0. PMID: 24823761

Recent systematic reviews

Li Y, Liu P, Lin Q, Zhou D, An D
Epilepsia 2023 Nov;64(11):2845-2860. Epub 2023 Sep 30 doi: 10.1111/epi.17757. PMID: 37611927
Chen Y, Wang Y, Song Z, Fan Y, Gao T, Tang X
Ageing Res Rev 2023 Jun;87:101911. Epub 2023 Mar 15 doi: 10.1016/j.arr.2023.101911. PMID: 36931328
Haukvik UK, Tamnes CK, Söderman E, Agartz I
J Psychiatr Res 2018 Sep;104:217-226. Epub 2018 Aug 7 doi: 10.1016/j.jpsychires.2018.08.012. PMID: 30107268
Xavier RM, Vorderstrasse A
Nurs Res 2016 May-Jun;65(3):224-37. doi: 10.1097/NNR.0000000000000159. PMID: 27124258
Roda Â, Chendo I, Kunz M
Trends Psychiatry Psychother 2015 Jan-Mar;37(1):3-11. Epub 2014 Dec 9 doi: 10.1590/2237-6089-2014-0002. PMID: 25860561

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