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Hypothalamic atrophy

MedGen UID:
1370750
•Concept ID:
C4476574
•
Finding
Synonym: Atrophy of the hypothalamus
 
HPO: HP:0025058

Definition

Partial or complete wasting (loss) of hypothalamus tissue that was once present. [from HPO]

Professional guidelines

PubMed

Oral hormonal therapy as treatment option for abnormal uterine bleeding.
Selmi C, La Marca A
Eur J Contracept Reprod Health Care 2023 Dec;28(6):285-294. Epub 2023 Nov 30 doi: 10.1080/13625187.2023.2270098. PMID: 37955241
Is Hormonal Treatment of Congenital Undescended Testes Justified? A Debate.
Hadziselimovic F
Sex Dev 2019;13(1):3-10. Epub 2019 Jan 26 doi: 10.1159/000496418. PMID: 30721907
Treatment strategies for endometriosis.
Rodgers AK, Falcone T
Expert Opin Pharmacother 2008 Feb;9(2):243-55. doi: 10.1517/14656566.9.2.243. PMID: 18201147

Recent clinical studies

Etiology

Hypothalamic atrophy and structural covariance in amnestic mild cognitive impairment and Alzheimer's dementia.
Pecher H, Storch M, Beyer F, Witte V, Baasner CF, Schönknecht P, Weise CM; Alzheimer’s Disease Neuroimaging Initiative
Neuroimage Clin 2024;44:103687. Epub 2024 Oct 11 doi: 10.1016/j.nicl.2024.103687. PMID: 39406040Free PMC Article
Hypothalamic involvement in multiple system atrophy: A structural MRI study.
Pasquini J, Firbank MJ, Best L, Foster V, Galley D, Silani V, Ceravolo R, Petrides G, Brooks DJ, Anderson KN, Pavese N
J Neurol Sci 2024 May 15;460:122985. Epub 2024 Apr 2 doi: 10.1016/j.jns.2024.122985. PMID: 38581741
AI-assisted quantification of hypothalamic atrophy in amyotrophic lateral sclerosis by convolutional neural network-based automatic segmentation.
Vernikouskaya I, Müller HP, Roselli F, Ludolph AC, Kassubek J, Rasche V
Sci Rep 2023 Dec 6;13(1):21505. doi: 10.1038/s41598-023-48649-6. PMID: 38057503Free PMC Article
Investigation of serum adropin levels and its relationship with hypothalamic atrophy in patients with multiple sclerosis.
Demirdöğen F, Akdağ T, Gündüz ZB, Odabaş FÖ
Mult Scler Relat Disord 2022 Nov;67:103999. Epub 2022 Jul 5 doi: 10.1016/j.msard.2022.103999. PMID: 35940018
The cause-effect relationship between bone loss and Alzheimer's disease using statistical modeling.
Loskutova N, Watts AS, Burns JM
Med Hypotheses 2019 Jan;122:92-97. Epub 2018 Oct 29 doi: 10.1016/j.mehy.2018.10.024. PMID: 30593432Free PMC Article

Diagnosis

Hypothalamic atrophy and structural covariance in amnestic mild cognitive impairment and Alzheimer's dementia.
Pecher H, Storch M, Beyer F, Witte V, Baasner CF, Schönknecht P, Weise CM; Alzheimer’s Disease Neuroimaging Initiative
Neuroimage Clin 2024;44:103687. Epub 2024 Oct 11 doi: 10.1016/j.nicl.2024.103687. PMID: 39406040Free PMC Article
Investigation of serum adropin levels and its relationship with hypothalamic atrophy in patients with multiple sclerosis.
Demirdöğen F, Akdağ T, Gündüz ZB, Odabaş FÖ
Mult Scler Relat Disord 2022 Nov;67:103999. Epub 2022 Jul 5 doi: 10.1016/j.msard.2022.103999. PMID: 35940018
Hypothalamic symptoms of frontotemporal dementia disorders.
Ahmed RM, Halliday G, Hodges JR
Handb Clin Neurol 2021;182:269-280. doi: 10.1016/B978-0-12-819973-2.00019-8. PMID: 34266598
The cause-effect relationship between bone loss and Alzheimer's disease using statistical modeling.
Loskutova N, Watts AS, Burns JM
Med Hypotheses 2019 Jan;122:92-97. Epub 2018 Oct 29 doi: 10.1016/j.mehy.2018.10.024. PMID: 30593432Free PMC Article
Hypothalamic atrophy.
Kelts KA, Hoehn MM
J Clin Psychiatry 1978 Apr;39(4):357-8, 363-5. PMID: 580284

Therapy

Hypothalamic atrophy.
Kelts KA, Hoehn MM
J Clin Psychiatry 1978 Apr;39(4):357-8, 363-5. PMID: 580284

Clinical prediction guides

Hypothalamic atrophy and structural covariance in amnestic mild cognitive impairment and Alzheimer's dementia.
Pecher H, Storch M, Beyer F, Witte V, Baasner CF, Schönknecht P, Weise CM; Alzheimer’s Disease Neuroimaging Initiative
Neuroimage Clin 2024;44:103687. Epub 2024 Oct 11 doi: 10.1016/j.nicl.2024.103687. PMID: 39406040Free PMC Article
Hypothalamic involvement in multiple system atrophy: A structural MRI study.
Pasquini J, Firbank MJ, Best L, Foster V, Galley D, Silani V, Ceravolo R, Petrides G, Brooks DJ, Anderson KN, Pavese N
J Neurol Sci 2024 May 15;460:122985. Epub 2024 Apr 2 doi: 10.1016/j.jns.2024.122985. PMID: 38581741
The cause-effect relationship between bone loss and Alzheimer's disease using statistical modeling.
Loskutova N, Watts AS, Burns JM
Med Hypotheses 2019 Jan;122:92-97. Epub 2018 Oct 29 doi: 10.1016/j.mehy.2018.10.024. PMID: 30593432Free PMC Article
Hypothalamic dysfunction is related to sleep impairment and CSF biomarkers in Alzheimer's disease.
Liguori C, Chiaravalloti A, Nuccetelli M, Izzi F, Sancesario G, Cimini A, Bernardini S, Schillaci O, Mercuri NB, Fabio P
J Neurol 2017 Nov;264(11):2215-2223. Epub 2017 Sep 12 doi: 10.1007/s00415-017-8613-x. PMID: 28900724
Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis.
Gorges M, Vercruysse P, Müller HP, Huppertz HJ, Rosenbohm A, Nagel G, Weydt P, Petersén Å, Ludolph AC, Kassubek J, Dupuis L
J Neurol Neurosurg Psychiatry 2017 Dec;88(12):1033-1041. Epub 2017 Jun 8 doi: 10.1136/jnnp-2017-315795. PMID: 28596251

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