U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal cell morphology

MedGen UID:
1371574
•Concept ID:
C4476793
•
Anatomical Abnormality
HPO: HP:0025461

Definition

Any anomaly of cell structure. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal cell morphology

Professional guidelines

PubMed

Contemporary Management of Thyroid Nodules.
Kobaly K, Kim CS, Mandel SJ
Annu Rev Med 2022 Jan 27;73:517-528. Epub 2021 Aug 20 doi: 10.1146/annurev-med-042220-015032. PMID: 34416120
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Hyperleukocytosis and leukostasis: management of a medical emergency.
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252

Recent clinical studies

Etiology

DNA Methylation in Ovarian Tumors-a Comparison Between Fresh Tissue and FFPE Samples.
Oliveira DVNP, Hentze J, O'Rourke CJ, Andersen JB, Høgdall C, Høgdall EV
Reprod Sci 2021 Nov;28(11):3212-3218. Epub 2021 Apr 23 doi: 10.1007/s43032-021-00589-0. PMID: 33891290Free PMC Article
Genetic basis of myelodysplastic syndromes.
Ogawa S
Proc Jpn Acad Ser B Phys Biol Sci 2020;96(3):107-121. doi: 10.2183/pjab.96.009. PMID: 32161209Free PMC Article
TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques.
de Faria O Jr, Dhaunchak AS, Kamen Y, Roth AD, Kuhlmann T, Colman DR, Kennedy TE
Sci Rep 2019 Mar 5;9(1):3606. doi: 10.1038/s41598-019-40342-x. PMID: 30837646Free PMC Article
Hydroxycamptothecin-induced apoptosis in hepatoma SMMC-7721 cells and the role of mitochondrial pathway.
Fu YR, Yi ZJ, Yan YR, Qiu ZY
Mitochondrion 2006 Aug;6(4):211-7. Epub 2006 Aug 1 doi: 10.1016/j.mito.2006.07.005. PMID: 16926123

Diagnosis

Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease.
Li M, Zeng A, Tang X, Xu H, Xiong W, Guo Y
Sci Rep 2023 Nov 13;13(1):19807. doi: 10.1038/s41598-023-47189-3. PMID: 37957232Free PMC Article
DNA Methylation in Ovarian Tumors-a Comparison Between Fresh Tissue and FFPE Samples.
Oliveira DVNP, Hentze J, O'Rourke CJ, Andersen JB, Høgdall C, Høgdall EV
Reprod Sci 2021 Nov;28(11):3212-3218. Epub 2021 Apr 23 doi: 10.1007/s43032-021-00589-0. PMID: 33891290Free PMC Article
Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo.
Wan J, Wang JH, Liu T, Xie Z, Yu XF, Li W
Sci Rep 2015 Jun 22;5:11398. doi: 10.1038/srep11398. PMID: 26096816Free PMC Article
Monocytes and macrophages as biomarkers for the diagnosis of megalencephalic leukoencephalopathy with subcortical cysts.
Petrini S, Minnone G, Coccetti M, Frank C, Aiello C, Cutarelli A, Ambrosini E, Lanciotti A, Brignone MS, D'Oria V, Strippoli R, De Benedetti F, Bertini E, Bracci-Laudiero L
Mol Cell Neurosci 2013 Sep;56:307-21. Epub 2013 Jul 10 doi: 10.1016/j.mcn.2013.07.001. PMID: 23851226
Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form.
Beinhauer JD, Hagan IM, Hegemann JH, Fleig U
J Cell Biol 1997 Nov 3;139(3):717-28. doi: 10.1083/jcb.139.3.717. PMID: 9348288Free PMC Article

Therapy

The adverse effect of anticancer drug toremifene on vascular smooth muscle cells is an important aspect of its tumor growth inhibition.
Wang H, Liu J, Wang M, Yang C, Wang G, Hu T
J Cancer Res Clin Oncol 2023 Aug;149(10):7837-7848. Epub 2023 Apr 10 doi: 10.1007/s00432-023-04744-9. PMID: 37036506
DNA Methylation in Ovarian Tumors-a Comparison Between Fresh Tissue and FFPE Samples.
Oliveira DVNP, Hentze J, O'Rourke CJ, Andersen JB, Høgdall C, Høgdall EV
Reprod Sci 2021 Nov;28(11):3212-3218. Epub 2021 Apr 23 doi: 10.1007/s43032-021-00589-0. PMID: 33891290Free PMC Article
Different cell death mechanisms are induced by a hydrophobic flavin in human tumor cells after visible light irradiation.
Muñoz MA, Pacheco A, Becker MI, Silva E, Ebensperger R, Garcia AM, De Ioannes AE, Edwards AM
J Photochem Photobiol B 2011 Apr 4;103(1):57-67. Epub 2011 Jan 19 doi: 10.1016/j.jphotobiol.2011.01.012. PMID: 21306911
Therapy-related myelodysplastic syndrome following cyclophosphamide pulse and/or methotrexate therapy in a patient with systemic lupus erythematosus.
Iwadate H, Kobayashi H, Yano K, Watanabe H, Ikeda K, Ogawa K, Ohira H
Fukushima J Med Sci 2010 Dec;56(2):121-7. doi: 10.5387/fms.56.121. PMID: 21502712
Aneuploidy, the somatic mutation that makes cancer a species of its own.
Duesberg P, Rasnick D
Cell Motil Cytoskeleton 2000 Oct;47(2):81-107. doi: 10.1002/1097-0169(200010)47:2<81::AID-CM1>3.0.CO;2-#. PMID: 11013390

Prognosis

Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease.
Li M, Zeng A, Tang X, Xu H, Xiong W, Guo Y
Sci Rep 2023 Nov 13;13(1):19807. doi: 10.1038/s41598-023-47189-3. PMID: 37957232Free PMC Article
Genetic basis of myelodysplastic syndromes.
Ogawa S
Proc Jpn Acad Ser B Phys Biol Sci 2020;96(3):107-121. doi: 10.2183/pjab.96.009. PMID: 32161209Free PMC Article
What does the future hold for the treatment of Fuchs endothelial dystrophy; will 'keratoplasty' still be a valid procedure?
Bruinsma M, Tong CM, Melles GR
Eye (Lond) 2013 Oct;27(10):1115-22. Epub 2013 Jul 12 doi: 10.1038/eye.2013.153. PMID: 23846374Free PMC Article
A unifying model for reconstructing radiosensitivity from micronucleus formation, apoptosis and abnormal morphology.
Akudugu JM, Abend M, Böhm L
Radiat Environ Biophys 2002 Dec;41(4):267-74. Epub 2002 Dec 20 doi: 10.1007/s00411-002-0176-1. PMID: 12541072

Clinical prediction guides

Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease.
Li M, Zeng A, Tang X, Xu H, Xiong W, Guo Y
Sci Rep 2023 Nov 13;13(1):19807. doi: 10.1038/s41598-023-47189-3. PMID: 37957232Free PMC Article
Antimicrobial and anti-biofilm activity of thymoquinone against Shigella flexneri.
Fan Q, Yuan Y, Jia H, Zeng X, Wang Z, Hu Z, Gao Z, Yue T
Appl Microbiol Biotechnol 2021 Jun;105(11):4709-4718. Epub 2021 May 20 doi: 10.1007/s00253-021-11295-x. PMID: 34014346
Pbx proteins in Cryptococcus neoformans cell wall remodeling and capsule assembly.
Kumar P, Heiss C, Santiago-Tirado FH, Black I, Azadi P, Doering TL
Eukaryot Cell 2014 May;13(5):560-71. Epub 2014 Feb 28 doi: 10.1128/EC.00290-13. PMID: 24585882Free PMC Article
Monocytes and macrophages as biomarkers for the diagnosis of megalencephalic leukoencephalopathy with subcortical cysts.
Petrini S, Minnone G, Coccetti M, Frank C, Aiello C, Cutarelli A, Ambrosini E, Lanciotti A, Brignone MS, D'Oria V, Strippoli R, De Benedetti F, Bertini E, Bracci-Laudiero L
Mol Cell Neurosci 2013 Sep;56:307-21. Epub 2013 Jul 10 doi: 10.1016/j.mcn.2013.07.001. PMID: 23851226
Different cell death mechanisms are induced by a hydrophobic flavin in human tumor cells after visible light irradiation.
Muñoz MA, Pacheco A, Becker MI, Silva E, Ebensperger R, Garcia AM, De Ioannes AE, Edwards AM
J Photochem Photobiol B 2011 Apr 4;103(1):57-67. Epub 2011 Jan 19 doi: 10.1016/j.jphotobiol.2011.01.012. PMID: 21306911

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...