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Blue urine

MedGen UID:
1372500
•Concept ID:
C4477103
•
Finding
HPO: HP:0040317

Definition

An abnormal blue color of the urine. [from HPO]

Professional guidelines

PubMed

Assessment and clinical management of internal contamination.
Dainiak N, Albanese J
J Radiol Prot 2022 Nov 24;42(4) doi: 10.1088/1361-6498/aca0a7. PMID: 36343358
Efficacy and safety of methylene blue in the treatment of malaria: a systematic review.
Lu G, Nagbanshi M, Goldau N, Mendes Jorge M, Meissner P, Jahn A, Mockenhaupt FP, Müller O
BMC Med 2018 Apr 25;16(1):59. doi: 10.1186/s12916-018-1045-3. PMID: 29690878Free PMC Article
Recent advances in the diagnosis and treatment of bladder cancer.
Cheung G, Sahai A, Billia M, Dasgupta P, Khan MS
BMC Med 2013 Jan 17;11:13. doi: 10.1186/1741-7015-11-13. PMID: 23327481Free PMC Article

Recent clinical studies

Etiology

Complete ureteropelvic-junction disruption following renal trauma: conservative management.
Oliver Vall-Llosera MB, Gander R, Royo Gomes G, Aguilera Pujabet M, Rocha Guzmán O, López Paredes M, Asensio Lorente M
Cir Pediatr 2024 Jul 9;37(3):141-144. doi: 10.54847/cp.2024.03.18. PMID: 39034881
Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial.
Dicko A, Roh ME, Diawara H, Mahamar A, Soumare HM, Lanke K, Bradley J, Sanogo K, Kone DT, Diarra K, Keita S, Issiaka D, Traore SF, McCulloch C, Stone WJR, Hwang J, Müller O, Brown JM, Srinivasan V, Drakeley C, Gosling R, Chen I, Bousema T
Lancet Infect Dis 2018 Jun;18(6):627-639. Epub 2018 Feb 6 doi: 10.1016/S1473-3099(18)30044-6. PMID: 29422384Free PMC Article

Diagnosis

A Curious Case of Methemoglobinemia Complicating a Pediatric Live Donor Liver Transplantation Surgery.
Somasundaram S, Motati H, Ahuja A, Vijai A
Transplant Proc 2023 Jun;55(5):1319-1323. Epub 2023 Mar 30 doi: 10.1016/j.transproceed.2023.02.044. PMID: 37002147
Greenish-blue discoloration of the brain and heart after treatment with methylene blue.
Durão C, Pedrosa F, Dinis-Oliveira RJ
Forensic Sci Med Pathol 2021 Mar;17(1):148-151. Epub 2020 Sep 17 doi: 10.1007/s12024-020-00316-2. PMID: 32940886
Purple urine bag syndrome in end-stage chronic kidney disease.
Delgado G, Martínez-Reséndez M, Camacho-Ortiz A
J Bras Nefrol 2014 Oct-Dec;36(4):542-4. doi: 10.5935/0101-2800.20140077. PMID: 25517285
Methylene blue-induced Heinz body hemolytic anemia.
Sills MR, Zinkham WH
Arch Pediatr Adolesc Med 1994 Mar;148(3):306-10. doi: 10.1001/archpedi.1994.02170030076017. PMID: 8130867
Use of methylene blue in suspected colovesical fistula.
Deshmukh AS, Bansal NK, Kropp KA
J Urol 1977 Nov;118(5):819-20. doi: 10.1016/s0022-5347(17)58206-3. PMID: 72169

Therapy

A Curious Case of Methemoglobinemia Complicating a Pediatric Live Donor Liver Transplantation Surgery.
Somasundaram S, Motati H, Ahuja A, Vijai A
Transplant Proc 2023 Jun;55(5):1319-1323. Epub 2023 Mar 30 doi: 10.1016/j.transproceed.2023.02.044. PMID: 37002147
Greenish-blue discoloration of the brain and heart after treatment with methylene blue.
Durão C, Pedrosa F, Dinis-Oliveira RJ
Forensic Sci Med Pathol 2021 Mar;17(1):148-151. Epub 2020 Sep 17 doi: 10.1007/s12024-020-00316-2. PMID: 32940886
Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial.
Dicko A, Roh ME, Diawara H, Mahamar A, Soumare HM, Lanke K, Bradley J, Sanogo K, Kone DT, Diarra K, Keita S, Issiaka D, Traore SF, McCulloch C, Stone WJR, Hwang J, Müller O, Brown JM, Srinivasan V, Drakeley C, Gosling R, Chen I, Bousema T
Lancet Infect Dis 2018 Jun;18(6):627-639. Epub 2018 Feb 6 doi: 10.1016/S1473-3099(18)30044-6. PMID: 29422384Free PMC Article
Fever, shivering...and blue urine.
Prischl FC, Hofinger I, Kramar R
Nephrol Dial Transplant 1999 Sep;14(9):2245-6. doi: 10.1093/ndt/14.9.2245. PMID: 10489243
Methylene blue-induced Heinz body hemolytic anemia.
Sills MR, Zinkham WH
Arch Pediatr Adolesc Med 1994 Mar;148(3):306-10. doi: 10.1001/archpedi.1994.02170030076017. PMID: 8130867

Prognosis

Delayed immunosuppressive treatment in life-threatening paraquat ingestion: a case report.
Descatha A, Mégarbane B, Garcia V, Baud F
J Med Toxicol 2009 Jun;5(2):76-9. doi: 10.1007/BF03161092. PMID: 19415592Free PMC Article
Phase I investigation of ametantrone.
Loesch DM, Von Hoff DD, Kuhn J, Coltman CA, Tio F, Chaudhuri TK, Bender JF, Grillo-Lopez AJ
Cancer Treat Rep 1983 Nov;67(11):987-91. PMID: 6640557

Clinical prediction guides

Complete ureteropelvic-junction disruption following renal trauma: conservative management.
Oliver Vall-Llosera MB, Gander R, Royo Gomes G, Aguilera Pujabet M, Rocha Guzmán O, López Paredes M, Asensio Lorente M
Cir Pediatr 2024 Jul 9;37(3):141-144. doi: 10.54847/cp.2024.03.18. PMID: 39034881
A Curious Case of Methemoglobinemia Complicating a Pediatric Live Donor Liver Transplantation Surgery.
Somasundaram S, Motati H, Ahuja A, Vijai A
Transplant Proc 2023 Jun;55(5):1319-1323. Epub 2023 Mar 30 doi: 10.1016/j.transproceed.2023.02.044. PMID: 37002147
Greenish-blue discoloration of the brain and heart after treatment with methylene blue.
Durão C, Pedrosa F, Dinis-Oliveira RJ
Forensic Sci Med Pathol 2021 Mar;17(1):148-151. Epub 2020 Sep 17 doi: 10.1007/s12024-020-00316-2. PMID: 32940886
On some exotic urine colors in ancient and Byzantine Greek literature.
Goudas PC, Diamandopoulos AA
J Nephrol 2011 May-Jun;24 Suppl 17:S114-22. doi: 10.5301/JN.2011.6496. PMID: 21614792
Delayed immunosuppressive treatment in life-threatening paraquat ingestion: a case report.
Descatha A, Mégarbane B, Garcia V, Baud F
J Med Toxicol 2009 Jun;5(2):76-9. doi: 10.1007/BF03161092. PMID: 19415592Free PMC Article

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