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Spermatocyte maturation arrest

MedGen UID:
1372736
•Concept ID:
C4476925
•
Finding
Synonym: Early spermatogenesis maturation arrest
 
HPO: HP:0031039

Definition

A type of spermatogenesis maturation arrest in which the block of developmental occurs in the spermatocyte stage. Testicular histology shows seminiferous tubules with Sertoli cells, spermatogonial cells and spermatocytes but no further differentiated cells like round spermatids. [from HPO]

Professional guidelines

PubMed

Induction of spermatogenesis in men with azoospermia or severe oligoteratoasthenospermia after antegrade internal spermatic vein sclerotherapy for the treatment of varicocele.
Poulakis V, Ferakis N, de Vries R, Witzsch U, Becht E
Asian J Androl 2006 Sep;8(5):613-9. doi: 10.1111/j.1745-7262.2006.00157.x. PMID: 16847530

Recent clinical studies

Etiology

Questioning the utility of round spermatid injections in men with non-obstructive azoospermia.
Barda S, Mano R, Lehavi O, Kleiman SE, Yossepowitch O, Azem F, Hauser R, Dekalo S
Andrology 2021 Jul;9(4):1145-1150. Epub 2021 Apr 13 doi: 10.1111/andr.13008. PMID: 33774922
Expression of BET genes in testis of men with different spermatogenic impairments.
Barda S, Paz G, Yogev L, Yavetz H, Lehavi O, Hauser R, Botchan A, Breitbart H, Kleiman SE
Fertil Steril 2012 Jan;97(1):46-52.e5. Epub 2011 Oct 28 doi: 10.1016/j.fertnstert.2011.10.010. PMID: 22035730
Role of poly(ADP-ribosyl)ation during human spermatogenesis.
Maymon BB, Cohen-Armon M, Yavetz H, Yogev L, Lifschitz-Mercer B, Kleiman SE, Botchan A, Hauser R, Paz G
Fertil Steril 2006 Nov;86(5):1402-7. Epub 2006 Sep 25 doi: 10.1016/j.fertnstert.2006.03.063. PMID: 16996513
Spermatogonial proliferation patterns in men with azoospermia of different etiologies.
Bar-Shira Maymon B, Yogev L, Yavetz H, Lifschitz-Mercer B, Schreiber L, Kleiman SE, Botchan A, Hauser R, Paz G
Fertil Steril 2003 Nov;80(5):1175-80. doi: 10.1016/s0015-0282(03)02161-7. PMID: 14607570
Sertoli cell maturation in men with azoospermia of different etiologies.
Maymon BB, Yogev L, Paz G, Kleiman SE, Schreiber L, Botchan A, Hauser R, Yavetz H
Fertil Steril 2002 May;77(5):904-9. doi: 10.1016/s0015-0282(02)03060-1. PMID: 12009342

Diagnosis

Questioning the utility of round spermatid injections in men with non-obstructive azoospermia.
Barda S, Mano R, Lehavi O, Kleiman SE, Yossepowitch O, Azem F, Hauser R, Dekalo S
Andrology 2021 Jul;9(4):1145-1150. Epub 2021 Apr 13 doi: 10.1111/andr.13008. PMID: 33774922
A recurrent ZSWIM7 mutation causes male infertility resulting from decreased meiotic recombination.
Li Y, Wu Y, Zhou J, Zhang H, Zhang Y, Ma H, Jiang X, Shi Q
Hum Reprod 2021 Apr 20;36(5):1436-1445. doi: 10.1093/humrep/deab046. PMID: 33713115
CDY1 and BOULE transcripts assessed in the same biopsy as predictive markers for successful testicular sperm retrieval.
Kleiman SE, Lehavi O, Hauser R, Botchan A, Paz G, Yavetz H, Yogev L
Fertil Steril 2011 Jun;95(7):2297-302, 2302.e1. Epub 2011 Apr 6 doi: 10.1016/j.fertnstert.2011.03.020. PMID: 21474125
Evaluation of meiotic impairment of azoospermic men by fluorescence in situ hybridization.
Yogev L, Gamzu R, Kleiman S, Botchan A, Hauser R, Yavetz H
Fertil Steril 2000 Aug;74(2):228-33. doi: 10.1016/s0015-0282(00)00634-8. PMID: 10927036
Absence of cyclic adenosine 3':5' monophosphate responsive element modulator expression at the spermatocyte arrest stage.
Lin WW, Lamb DJ, Lipshultz LI, Kim ED
Fertil Steril 1998 Mar;69(3):533-8. doi: 10.1016/s0015-0282(97)00535-5. PMID: 9531892

Therapy

A recurrent ZSWIM7 mutation causes male infertility resulting from decreased meiotic recombination.
Li Y, Wu Y, Zhou J, Zhang H, Zhang Y, Ma H, Jiang X, Shi Q
Hum Reprod 2021 Apr 20;36(5):1436-1445. doi: 10.1093/humrep/deab046. PMID: 33713115

Prognosis

MicroRNAs expression in semen and testis of azoospermic men.
Wainstein A, Hassan S, Barda S, Lehavi O, Azem F, Ben-Dov IZ, Hauser R, Kleiman SE
Andrology 2023 May;11(4):687-697. Epub 2023 Feb 6 doi: 10.1111/andr.13394. PMID: 36695179
CDY1 and BOULE transcripts assessed in the same biopsy as predictive markers for successful testicular sperm retrieval.
Kleiman SE, Lehavi O, Hauser R, Botchan A, Paz G, Yavetz H, Yogev L
Fertil Steril 2011 Jun;95(7):2297-302, 2302.e1. Epub 2011 Apr 6 doi: 10.1016/j.fertnstert.2011.03.020. PMID: 21474125
Evaluation of meiotic impairment of azoospermic men by fluorescence in situ hybridization.
Yogev L, Gamzu R, Kleiman S, Botchan A, Hauser R, Yavetz H
Fertil Steril 2000 Aug;74(2):228-33. doi: 10.1016/s0015-0282(00)00634-8. PMID: 10927036

Clinical prediction guides

MicroRNAs expression in semen and testis of azoospermic men.
Wainstein A, Hassan S, Barda S, Lehavi O, Azem F, Ben-Dov IZ, Hauser R, Kleiman SE
Andrology 2023 May;11(4):687-697. Epub 2023 Feb 6 doi: 10.1111/andr.13394. PMID: 36695179
CDY1 and BOULE transcripts assessed in the same biopsy as predictive markers for successful testicular sperm retrieval.
Kleiman SE, Lehavi O, Hauser R, Botchan A, Paz G, Yavetz H, Yogev L
Fertil Steril 2011 Jun;95(7):2297-302, 2302.e1. Epub 2011 Apr 6 doi: 10.1016/j.fertnstert.2011.03.020. PMID: 21474125
Spontaneous regression over time of the germinal epithelium in a Y chromosome-microdeleted patient: Case report.
Calogero AE, Garofalo MR, Barone N, De Palma A, Vicari E, Romeo R, Tumino S, D'Agata R
Hum Reprod 2001 Sep;16(9):1845-8. doi: 10.1093/humrep/16.9.1845. PMID: 11527886
Absence of cyclic adenosine 3':5' monophosphate responsive element modulator expression at the spermatocyte arrest stage.
Lin WW, Lamb DJ, Lipshultz LI, Kim ED
Fertil Steril 1998 Mar;69(3):533-8. doi: 10.1016/s0015-0282(97)00535-5. PMID: 9531892
Immunohistochemical localization of calmodulin in the testes of patients with idiopathic male infertility.
Tsuji Y, Sano M, Nagahama M, Tsutsui Y, Yamamoto M, Miyake K
Int J Androl 1993 Jun;16(3):215-9. doi: 10.1111/j.1365-2605.1993.tb01182.x. PMID: 8359937

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