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Pancreatic intraductal papillary-mucinous neoplasm

MedGen UID:
1373306
•Concept ID:
C4511687
•
Neoplastic Process
Synonyms: Intraductal Papillary Mucinous Neoplasm, Pancreatic; Intraductal Papillary Mucinous Neoplasms of the Pancreas; Intraductal Papillary-Mucinous Neoplasm, Pancreatic; IPMN, Pancreatic; Pancreatic Intraductal Papillary Mucinous Neoplasm; Pancreatic IPMN; Pancreatic IPMNs
SNOMED CT: Intraductal papillary mucinous neoplasm of pancreas (690771000119106)
 
HPO: HP:6000657
Monarch Initiative: MONDO:0004286

Definition

Intraductal papillary mucinous neoplasm (IPMN) is an exocrine neoplasm of the pancreas consisting of epithelial cells growing within the pancreatic ducts (main pancreatic duct or its major branches) and producing mucin. IPMN is a mucin-producing pancreatic cystic tumor. IPMN contains epithelial cells that can create papillary projections. [from HPO]

Professional guidelines

PubMed

Management of pancreatic intraductal papillary mucinous neoplasm.
Hoshi H, Zaheer A, El Abiad RG, Maxwell JE, Chu LC, Gerke H, Chan CH
Curr Probl Surg 2018 Apr;55(4):126-152. Epub 2018 Mar 14 doi: 10.1067/j.cpsurg.2018.03.001. PMID: 29753366
Criteria for Determining Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm Based on Computed Tomography.
Mönnings P, Belyaev O, Uhl W, Giese A, Tannapfel A, Köster O, Meier JJ
Digestion 2016;94(4):230-239. Epub 2016 Dec 29 doi: 10.1159/000452738. PMID: 28030856
Management of pancreatic intraductal papillary mucinous neoplasm in an academic hospital (2005-2010): what follow-up for unoperated patients?
Baiocchi GL, Portolani N, Grazioli L, Mazza G, Gheza F, Bartoli M, Vanzetti E, Giulini SM
Pancreas 2013 May;42(4):696-700. doi: 10.1097/MPA.0b013e318270b98b. PMID: 23160482

Recent clinical studies

Etiology

Interobserver Variability and Diagnostic Performance in Predicting Malignancy of Pancreatic Intraductal Papillary Mucinous Neoplasm with MRI.
Choi SY, Min JH, Kim JH, Park HJ, Kim YY, Han YE, Bae SH, Lee JH, Choi YH, Moon JE
Radiology 2023 Jul;308(1):e222463. doi: 10.1148/radiol.222463. PMID: 37489989
Clinical and Molecular Attributes and Evaluation of Pancreatic Cystic Neoplasm.
Raut P, Nimmakayala RK, Batra SK, Ponnusamy MP
Biochim Biophys Acta Rev Cancer 2023 Jan;1878(1):188851. Epub 2022 Dec 16 doi: 10.1016/j.bbcan.2022.188851. PMID: 36535512Free PMC Article
MRI follow-up for pancreatic intraductal papillary mucinous neoplasm: an ultrashort versus long protocol.
Johansson K, Mustonen H, Nieminen H, Haglund C, Lehtimäki TE, Seppänen H
Abdom Radiol (NY) 2022 Feb;47(2):727-737. Epub 2021 Dec 18 doi: 10.1007/s00261-021-03382-4. PMID: 34923598Free PMC Article
Intraductal papillary neoplasm of the bile duct: Radiologic findings in a new disease.
Rodríguez Vargas D, Parada Blázquez MJ, Vargas Serrano B
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):28-37. Epub 2019 Oct 9 doi: 10.1016/j.rx.2019.07.003. PMID: 31606127
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge?
Fritz S, Hackert T, Büchler MW
Dig Dis 2015;33(1):99-105. Epub 2014 Dec 17 doi: 10.1159/000368448. PMID: 25531503

Diagnosis

Interobserver Variability and Diagnostic Performance in Predicting Malignancy of Pancreatic Intraductal Papillary Mucinous Neoplasm with MRI.
Choi SY, Min JH, Kim JH, Park HJ, Kim YY, Han YE, Bae SH, Lee JH, Choi YH, Moon JE
Radiology 2023 Jul;308(1):e222463. doi: 10.1148/radiol.222463. PMID: 37489989
Computed high-b-value high-resolution DWI improves solid lesion detection in IPMN of the pancreas.
Harder FN, Jung E, Weiss K, Graf MM, Kamal O, McTavish S, Van AT, Demir IE, Friess H, Phillip V, Schmid RM, Lohöfer FK, Kaissis GA, Makowski MR, Karampinos DC, Braren RF
Eur Radiol 2023 Oct;33(10):6892-6901. Epub 2023 May 3 doi: 10.1007/s00330-023-09661-6. PMID: 37133518Free PMC Article
Clinical and Molecular Attributes and Evaluation of Pancreatic Cystic Neoplasm.
Raut P, Nimmakayala RK, Batra SK, Ponnusamy MP
Biochim Biophys Acta Rev Cancer 2023 Jan;1878(1):188851. Epub 2022 Dec 16 doi: 10.1016/j.bbcan.2022.188851. PMID: 36535512Free PMC Article
Intraductal papillary neoplasm of the bile duct: Radiologic findings in a new disease.
Rodríguez Vargas D, Parada Blázquez MJ, Vargas Serrano B
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):28-37. Epub 2019 Oct 9 doi: 10.1016/j.rx.2019.07.003. PMID: 31606127
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation.
Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A, Stoehr R, Haller F
Am J Surg Pathol 2018 Aug;42(8):1076-1082. doi: 10.1097/PAS.0000000000001080. PMID: 29738361

Therapy

Malignant conversion and peritoneal dissemination after endoscopic ultrasound-guided ethanol ablation in intraductal papillary mucinous neoplasm of the pancreas.
Jang JY, Byun Y, Han Y, Kim H, Kwon W
J Hepatobiliary Pancreat Sci 2019 Oct;26(10):467-472. Epub 2019 Sep 5 doi: 10.1002/jhbp.663. PMID: 31419024
Molecular and clinical patterns of local progression in the pancreatic remnant following resection of pancreatic intraductal papillary mucinous neoplasm (IPMN).
Sereni E, Luchini C, Salvia R, Pea A
Chin Clin Oncol 2019 Apr;8(2):21. doi: 10.21037/cco.2019.04.03. PMID: 31070041
Incisional Malignant Evolution of Pancreatic Intraductal Papillary Mucinous Neoplasm.
Daigle HJ, Oh JS, Heneidi S, Spartz H, Kruse EJ
Am Surg 2018 Sep 1;84(9):e398-e400. PMID: 30454512
Favorable response after gemcitabine-radiotherapy for invasive pancreatic intraductal papillary mucinous neoplasm: a case report.
Ochiai T, Igari K, Furuyama T, Ito H, Mitsunori Y, Aihara A, Kumagai Y, Iida M, Odajima H, Tanaka S, Arii S, Yamazaki S
Int Surg 2013 Oct-Dec;98(4):340-5. doi: 10.9738/INTSURG-D-13-00031.1. PMID: 24229021Free PMC Article

Prognosis

Interobserver Variability and Diagnostic Performance in Predicting Malignancy of Pancreatic Intraductal Papillary Mucinous Neoplasm with MRI.
Choi SY, Min JH, Kim JH, Park HJ, Kim YY, Han YE, Bae SH, Lee JH, Choi YH, Moon JE
Radiology 2023 Jul;308(1):e222463. doi: 10.1148/radiol.222463. PMID: 37489989
MRI follow-up for pancreatic intraductal papillary mucinous neoplasm: an ultrashort versus long protocol.
Johansson K, Mustonen H, Nieminen H, Haglund C, Lehtimäki TE, Seppänen H
Abdom Radiol (NY) 2022 Feb;47(2):727-737. Epub 2021 Dec 18 doi: 10.1007/s00261-021-03382-4. PMID: 34923598Free PMC Article
Intraductal papillary neoplasm of the bile duct: Radiologic findings in a new disease.
Rodríguez Vargas D, Parada Blázquez MJ, Vargas Serrano B
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):28-37. Epub 2019 Oct 9 doi: 10.1016/j.rx.2019.07.003. PMID: 31606127
Molecular and clinical patterns of local progression in the pancreatic remnant following resection of pancreatic intraductal papillary mucinous neoplasm (IPMN).
Sereni E, Luchini C, Salvia R, Pea A
Chin Clin Oncol 2019 Apr;8(2):21. doi: 10.21037/cco.2019.04.03. PMID: 31070041
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge?
Fritz S, Hackert T, Büchler MW
Dig Dis 2015;33(1):99-105. Epub 2014 Dec 17 doi: 10.1159/000368448. PMID: 25531503

Clinical prediction guides

Interobserver Variability and Diagnostic Performance in Predicting Malignancy of Pancreatic Intraductal Papillary Mucinous Neoplasm with MRI.
Choi SY, Min JH, Kim JH, Park HJ, Kim YY, Han YE, Bae SH, Lee JH, Choi YH, Moon JE
Radiology 2023 Jul;308(1):e222463. doi: 10.1148/radiol.222463. PMID: 37489989
The malignant potential of pancreatic intraductal papillary mucinous neoplasm is reflected in expression levels of fucosylated glycans in α(1) -acid glycoprotein.
Kubo N, Yazawa S, Yokobori T, Sano R, Eguchi H, Kobayashi S, Akita H, Mitsufuji S, Yamashita YI, Nakao Y, Fujii T, Okumura T, Shibuya K, Hoshino Y, Yamada S, Hayashi M, Shimokawa M, Shirabe K
J Hepatobiliary Pancreat Sci 2023 Apr;30(4):503-513. Epub 2022 Jul 12 doi: 10.1002/jhbp.1208. PMID: 35776060
Hyalinized stroma is a characteristic feature of pancreatic intraductal oncocytic papillary neoplasm: An immunohistochemical study.
Hirabayashi K, Kawanishi A, Morimachi M, Yamada M, Takanashi Y, Hori S, Serizawa A, Saika T, Nakagohri T, Nakamura N
Ann Diagn Pathol 2020 Dec;49:151639. Epub 2020 Oct 8 doi: 10.1016/j.anndiagpath.2020.151639. PMID: 33069084
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation.
Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A, Stoehr R, Haller F
Am J Surg Pathol 2018 Aug;42(8):1076-1082. doi: 10.1097/PAS.0000000000001080. PMID: 29738361
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge?
Fritz S, Hackert T, Büchler MW
Dig Dis 2015;33(1):99-105. Epub 2014 Dec 17 doi: 10.1159/000368448. PMID: 25531503

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