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Elevated carcinoma antigen 125 level

MedGen UID:
1373345
•Concept ID:
C4476918
•
Finding
Synonym: Increased plasma CA125
 
HPO: HP:0031030

Definition

An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated carcinoma antigen 125 level

Professional guidelines

PubMed

Clinical characteristics and status of treatment of small-cell carcinoma of the ovary, hypercalcemic type in the Chinese population: a meta-analysis.
Zheng K, Gao Y, Xu C, Kang Y
J Gynecol Oncol 2024 Jul;35(4):e96. Epub 2024 Apr 17 doi: 10.3802/jgo.2024.35.e96. PMID: 38710530Free PMC Article
The differential diagnostic value and clinical significance of serum HE4 in ovarian disease with elevated CA125.
Li W, Wang D
Arch Gynecol Obstet 2020 May;301(5):1219-1225. Epub 2020 Apr 7 doi: 10.1007/s00404-020-05527-0. PMID: 32266526
Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma.
Eavarone DA, Al-Alem L, Lugovskoy A, Prendergast JM, Nazer RI, Stein JN, Dransfield DT, Behrens J, Rueda BR
PLoS One 2018;13(7):e0201314. Epub 2018 Jul 27 doi: 10.1371/journal.pone.0201314. PMID: 30052649Free PMC Article

Recent clinical studies

Etiology

Evaluation of circulating Dickkopf-1 as a prognostic biomarker in ovarian cancer patients.
Klotz DM, Link T, Goeckenjan M, Wimberger P, Poetsch AR, Jaschke N, Hofbauer LC, Göbel A, Rachner TD, Kuhlmann JD
Clin Chem Lab Med 2022 Jan 26;60(1):109-117. Epub 2021 Oct 25 doi: 10.1515/cclm-2021-0504. PMID: 34687595
Female Peritoneal Tuberculosis with Ascites, Pelvic Mass, or Elevated CA 125 Mimicking Advanced Ovarian Cancer: A Retrospective Study of 26 Cases.
Wang H, Qu X, Liu X, Ding L, Yue Y
J Coll Physicians Surg Pak 2019 Jun;29(6):588-589. doi: 10.29271/jcpsp.2019.06.588. PMID: 31133164
The value of serum bcl-2 levels in advanced epithelial ovarian cancer.
Tas F, Duranyildiz D, Oguz H, Camlica H, Yasasever V, Topuz E
Med Oncol 2006;23(2):213-7. doi: 10.1385/MO:23:2:213. PMID: 16720921
Elevated tumour markers prior to complete tumour removal in patients with pseudomyxoma peritonei predict early recurrence.
Alexander-Sefre F, Chandrakumaran K, Banerjee S, Sexton R, Thomas JM, Moran B
Colorectal Dis 2005 Jul;7(4):382-6. doi: 10.1111/j.1463-1318.2005.00773.x. PMID: 15932563
CA-125 in gynecological malignancies.
Meier W, Stieber P, Fateh-Moghadam A, Eiermann W, Hepp H
Eur J Cancer Clin Oncol 1987 Jun;23(6):713-7. doi: 10.1016/0277-5379(87)90267-7. PMID: 2443359

Diagnosis

Female Peritoneal Tuberculosis with Ascites, Pelvic Mass, or Elevated CA 125 Mimicking Advanced Ovarian Cancer: A Retrospective Study of 26 Cases.
Wang H, Qu X, Liu X, Ding L, Yue Y
J Coll Physicians Surg Pak 2019 Jun;29(6):588-589. doi: 10.29271/jcpsp.2019.06.588. PMID: 31133164
The value of serum bcl-2 levels in advanced epithelial ovarian cancer.
Tas F, Duranyildiz D, Oguz H, Camlica H, Yasasever V, Topuz E
Med Oncol 2006;23(2):213-7. doi: 10.1385/MO:23:2:213. PMID: 16720921
CA 72-4 serum marker--a new tool in the management of carcinoma patients.
Guadagni F, Roselli M, Cosimelli M, Ferroni P, Spila A, Cavaliere F, Casaldi V, Wappner G, Abbolito MR, Greiner JW
Cancer Invest 1995;13(2):227-38. doi: 10.3109/07357909509011692. PMID: 7874576
CA-125 in gynecological malignancies.
Meier W, Stieber P, Fateh-Moghadam A, Eiermann W, Hepp H
Eur J Cancer Clin Oncol 1987 Jun;23(6):713-7. doi: 10.1016/0277-5379(87)90267-7. PMID: 2443359
Serum levels of CA-125 in patients with endometriosis: a preliminary report.
Giudice LC, Jacobs A, Pineda J, Bell CE, Lippmann L
Fertil Steril 1986 Jun;45(6):876-8. doi: 10.1016/s0015-0282(16)49409-4. PMID: 3458595

Therapy

Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: a single-arm phase II study.
Vermeij R, Leffers N, Hoogeboom BN, Hamming IL, Wolf R, Reyners AK, Molmans BH, Hollema H, Bart J, Drijfhout JW, Oostendorp J, van der Zee AG, Melief CJ, van der Burg SH, Daemen T, Nijman HW
Int J Cancer 2012 Sep 1;131(5):E670-80. Epub 2012 Jan 31 doi: 10.1002/ijc.27388. PMID: 22139992
Serum HE4 level is an independent prognostic factor in epithelial ovarian cancer.
Kong SY, Han MH, Yoo HJ, Hwang JH, Lim MC, Seo SS, Yoo CW, Kim JH, Park SY, Kang S
Ann Surg Oncol 2012 May;19(5):1707-12. Epub 2011 Jul 21 doi: 10.1245/s10434-011-1943-5. PMID: 21833668
High titers of CA-125 may be associated with recurrent ischemic strokes in patients with cancer.
Jovin TG, Boosupalli V, Zivkovic SA, Wechsler LR, Gebel JM
Neurology 2005 Jun 14;64(11):1944-5. doi: 10.1212/01.WNL.0000163850.07976.63. PMID: 15955949
Elevated tumour markers prior to complete tumour removal in patients with pseudomyxoma peritonei predict early recurrence.
Alexander-Sefre F, Chandrakumaran K, Banerjee S, Sexton R, Thomas JM, Moran B
Colorectal Dis 2005 Jul;7(4):382-6. doi: 10.1111/j.1463-1318.2005.00773.x. PMID: 15932563
Clinical assessment of 111In-CYT-103 immunoscintigraphy in ovarian cancer.
Surwit EA, Childers JM, Krag DN, Katterhagen JG, Gallion HH, Waggoner S, Mann WJ Jr
Gynecol Oncol 1993 Mar;48(3):285-92. doi: 10.1006/gyno.1993.1051. PMID: 8462896

Prognosis

Evaluation of circulating Dickkopf-1 as a prognostic biomarker in ovarian cancer patients.
Klotz DM, Link T, Goeckenjan M, Wimberger P, Poetsch AR, Jaschke N, Hofbauer LC, Göbel A, Rachner TD, Kuhlmann JD
Clin Chem Lab Med 2022 Jan 26;60(1):109-117. Epub 2021 Oct 25 doi: 10.1515/cclm-2021-0504. PMID: 34687595
The value of serum bcl-2 levels in advanced epithelial ovarian cancer.
Tas F, Duranyildiz D, Oguz H, Camlica H, Yasasever V, Topuz E
Med Oncol 2006;23(2):213-7. doi: 10.1385/MO:23:2:213. PMID: 16720921
Elevated tumour markers prior to complete tumour removal in patients with pseudomyxoma peritonei predict early recurrence.
Alexander-Sefre F, Chandrakumaran K, Banerjee S, Sexton R, Thomas JM, Moran B
Colorectal Dis 2005 Jul;7(4):382-6. doi: 10.1111/j.1463-1318.2005.00773.x. PMID: 15932563
CA 72-4 serum marker--a new tool in the management of carcinoma patients.
Guadagni F, Roselli M, Cosimelli M, Ferroni P, Spila A, Cavaliere F, Casaldi V, Wappner G, Abbolito MR, Greiner JW
Cancer Invest 1995;13(2):227-38. doi: 10.3109/07357909509011692. PMID: 7874576
Serum levels of CA-125 in patients with endometriosis: a preliminary report.
Giudice LC, Jacobs A, Pineda J, Bell CE, Lippmann L
Fertil Steril 1986 Jun;45(6):876-8. doi: 10.1016/s0015-0282(16)49409-4. PMID: 3458595

Clinical prediction guides

Evaluation of circulating Dickkopf-1 as a prognostic biomarker in ovarian cancer patients.
Klotz DM, Link T, Goeckenjan M, Wimberger P, Poetsch AR, Jaschke N, Hofbauer LC, Göbel A, Rachner TD, Kuhlmann JD
Clin Chem Lab Med 2022 Jan 26;60(1):109-117. Epub 2021 Oct 25 doi: 10.1515/cclm-2021-0504. PMID: 34687595
The value of serum bcl-2 levels in advanced epithelial ovarian cancer.
Tas F, Duranyildiz D, Oguz H, Camlica H, Yasasever V, Topuz E
Med Oncol 2006;23(2):213-7. doi: 10.1385/MO:23:2:213. PMID: 16720921
Elevated tumour markers prior to complete tumour removal in patients with pseudomyxoma peritonei predict early recurrence.
Alexander-Sefre F, Chandrakumaran K, Banerjee S, Sexton R, Thomas JM, Moran B
Colorectal Dis 2005 Jul;7(4):382-6. doi: 10.1111/j.1463-1318.2005.00773.x. PMID: 15932563
CA 72-4 serum marker--a new tool in the management of carcinoma patients.
Guadagni F, Roselli M, Cosimelli M, Ferroni P, Spila A, Cavaliere F, Casaldi V, Wappner G, Abbolito MR, Greiner JW
Cancer Invest 1995;13(2):227-38. doi: 10.3109/07357909509011692. PMID: 7874576
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Recent systematic reviews

Diagnostic Accuracy of Clinical Biomarkers for Preoperative Prediction of Lymph Node Metastasis in Endometrial Carcinoma: A Systematic Review and Meta-Analysis.
Reijnen C, IntHout J, Massuger LFAG, Strobbe F, Küsters-Vandevelde HVN, Haldorsen IS, Snijders MPLM, Pijnenborg JMA
Oncologist 2019 Sep;24(9):e880-e890. Epub 2019 Jun 11 doi: 10.1634/theoncologist.2019-0117. PMID: 31186375Free PMC Article
Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival of epithelial ovarian cancer: a systematic review and meta-analysis of observational studies.
Yang Z, Gu JH, Guo CS, Li XH, Yang WC
Oncotarget 2017 Jul 11;8(28):46414-46424. doi: 10.18632/oncotarget.16793. PMID: 28423365Free PMC Article
Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review.
Han SN, Lotgerink A, Gziri MM, Van Calsteren K, Hanssens M, Amant F
BMC Med 2012 Aug 8;10:86. doi: 10.1186/1741-7015-10-86. PMID: 22873292Free PMC Article

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