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Elevated carcinoma antigen 125 level

MedGen UID:
1373345
•Concept ID:
C4476918
•
Finding
Synonym: Increased plasma CA125
 
HPO: HP:0031030

Definition

An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated carcinoma antigen 125 level

Professional guidelines

PubMed

The differential diagnostic value and clinical significance of serum HE4 in ovarian disease with elevated CA125.
Li W, Wang D
Arch Gynecol Obstet 2020 May;301(5):1219-1225. Epub 2020 Apr 7 doi: 10.1007/s00404-020-05527-0. PMID: 32266526
Outcome of elevated CA125 values from primary care following implementation of ovarian cancer guidelines.
Crawford SM, Evans C
Fam Pract 2018 Mar 27;35(2):199-202. doi: 10.1093/fampra/cmx096. PMID: 29029123
The serum assay of tumour markers in the prognostic evaluation, treatment monitoring and follow-up of patients with cervical cancer: a review of the literature.
Gadducci A, Tana R, Cosio S, Genazzani AR
Crit Rev Oncol Hematol 2008 Apr;66(1):10-20. Epub 2007 Oct 26 doi: 10.1016/j.critrevonc.2007.09.002. PMID: 17964182

Recent clinical studies

Etiology

Borderline ovarian tumors: Guidelines from the French national college of obstetricians and gynecologists (CNGOF).
Bourdel N, Huchon C, Abdel Wahab C, Azaïs H, Bendifallah S, Bolze PA, Brun JL, Canlorbe G, Chauvet P, Chereau E, Courbiere B, De La Motte Rouge T, Devouassoux-Shisheboran M, Eymerit-Morin C, Fauvet R, Gauroy E, Gauthier T, Grynberg M, Koskas M, Larouzee E, Lecointre L, Levêque J, Margueritte F, Mathieu D'argent E, Nyangoh-Timoh K, Ouldamer L, Raad J, Raimond E, Ramanah R, Rolland L, Rousset P, Rousset-Jablonski C, Thomassin-Naggara I, Uzan C, Zilliox M, Daraï E
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:492-501. Epub 2020 Nov 20 doi: 10.1016/j.ejogrb.2020.11.045. PMID: 33262005
Serum CA19-9, CA-125 and CEA as tumor markers for mucinous ovarian tumors.
Lertkhachonsuk AA, Buranawongtrakoon S, Lekskul N, Rermluk N, Wee-Stekly WW, Charakorn C
J Obstet Gynaecol Res 2020 Nov;46(11):2287-2291. Epub 2020 Aug 23 doi: 10.1111/jog.14427. PMID: 32830422Free PMC Article
Trousseau Syndrome Related Cerebral Infarction: Clinical Manifestations, Laboratory Findings and Radiological Features.
Bao L, Zhang S, Gong X, Cui G
J Stroke Cerebrovasc Dis 2020 Sep;29(9):104891. Epub 2020 Jun 30 doi: 10.1016/j.jstrokecerebrovasdis.2020.104891. PMID: 32807409
The emerging role of HE4 in the evaluation of epithelial ovarian and endometrial carcinomas.
Simmons AR, Baggerly K, Bast RC Jr
Oncology (Williston Park) 2013 Jun;27(6):548-56. PMID: 23909069Free PMC Article
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Diagnosis

Borderline ovarian tumors: Guidelines from the French national college of obstetricians and gynecologists (CNGOF).
Bourdel N, Huchon C, Abdel Wahab C, Azaïs H, Bendifallah S, Bolze PA, Brun JL, Canlorbe G, Chauvet P, Chereau E, Courbiere B, De La Motte Rouge T, Devouassoux-Shisheboran M, Eymerit-Morin C, Fauvet R, Gauroy E, Gauthier T, Grynberg M, Koskas M, Larouzee E, Lecointre L, Levêque J, Margueritte F, Mathieu D'argent E, Nyangoh-Timoh K, Ouldamer L, Raad J, Raimond E, Ramanah R, Rolland L, Rousset P, Rousset-Jablonski C, Thomassin-Naggara I, Uzan C, Zilliox M, Daraï E
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:492-501. Epub 2020 Nov 20 doi: 10.1016/j.ejogrb.2020.11.045. PMID: 33262005
Serum CA19-9, CA-125 and CEA as tumor markers for mucinous ovarian tumors.
Lertkhachonsuk AA, Buranawongtrakoon S, Lekskul N, Rermluk N, Wee-Stekly WW, Charakorn C
J Obstet Gynaecol Res 2020 Nov;46(11):2287-2291. Epub 2020 Aug 23 doi: 10.1111/jog.14427. PMID: 32830422Free PMC Article
Trousseau Syndrome Related Cerebral Infarction: Clinical Manifestations, Laboratory Findings and Radiological Features.
Bao L, Zhang S, Gong X, Cui G
J Stroke Cerebrovasc Dis 2020 Sep;29(9):104891. Epub 2020 Jun 30 doi: 10.1016/j.jstrokecerebrovasdis.2020.104891. PMID: 32807409
Variant prostate carcinoma and elevated serum CA-125.
Bilen MA, Reyes A, Bhowmick D, Maa A, Bast R Jr, Pisters LL, Lin SH, Logothetis CJ, Tu SM
Can J Urol 2014 Oct;21(5):7442-8. PMID: 25347368Free PMC Article
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Therapy

Trousseau Syndrome Related Cerebral Infarction: Clinical Manifestations, Laboratory Findings and Radiological Features.
Bao L, Zhang S, Gong X, Cui G
J Stroke Cerebrovasc Dis 2020 Sep;29(9):104891. Epub 2020 Jun 30 doi: 10.1016/j.jstrokecerebrovasdis.2020.104891. PMID: 32807409
Variant prostate carcinoma and elevated serum CA-125.
Bilen MA, Reyes A, Bhowmick D, Maa A, Bast R Jr, Pisters LL, Lin SH, Logothetis CJ, Tu SM
Can J Urol 2014 Oct;21(5):7442-8. PMID: 25347368Free PMC Article
Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.
Kobayashi H
Int J Clin Oncol 2009 Oct;14(5):378-82. Epub 2009 Oct 25 doi: 10.1007/s10147-009-0931-2. PMID: 19856043
Sarcoidosis associated with an elevated serum CA 125 level: description of a case and a review of the literature.
Kalluri M, Judson MA
Am J Med Sci 2007 Dec;334(6):441-3. doi: 10.1097/MAJ.0b013e3180f60bc4. PMID: 18091365
CA 125 may not reflect disease status in patients with uterine serous carcinoma.
Price FV, Chambers SK, Carcangiu ML, Kohorn EI, Schwartz PE, Chambers JT
Cancer 1998 May 1;82(9):1720-5. doi: 10.1002/(sici)1097-0142(19980501)82:9<1720::aid-cncr19>3.0.co;2-6. PMID: 9576294

Prognosis

The prognostic and diagnostic potential of kallikrein-related peptidases in ovarian cancer.
Riedel M, Bronger H, Magdolen V, Dreyer T
Expert Rev Mol Diagn 2021 Jun;21(6):535-545. Epub 2021 May 14 doi: 10.1080/14737159.2021.1924680. PMID: 33947310
Serum CA19-9, CA-125 and CEA as tumor markers for mucinous ovarian tumors.
Lertkhachonsuk AA, Buranawongtrakoon S, Lekskul N, Rermluk N, Wee-Stekly WW, Charakorn C
J Obstet Gynaecol Res 2020 Nov;46(11):2287-2291. Epub 2020 Aug 23 doi: 10.1111/jog.14427. PMID: 32830422Free PMC Article
Trousseau Syndrome Related Cerebral Infarction: Clinical Manifestations, Laboratory Findings and Radiological Features.
Bao L, Zhang S, Gong X, Cui G
J Stroke Cerebrovasc Dis 2020 Sep;29(9):104891. Epub 2020 Jun 30 doi: 10.1016/j.jstrokecerebrovasdis.2020.104891. PMID: 32807409
Variant prostate carcinoma and elevated serum CA-125.
Bilen MA, Reyes A, Bhowmick D, Maa A, Bast R Jr, Pisters LL, Lin SH, Logothetis CJ, Tu SM
Can J Urol 2014 Oct;21(5):7442-8. PMID: 25347368Free PMC Article
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Clinical prediction guides

Borderline ovarian tumors: Guidelines from the French national college of obstetricians and gynecologists (CNGOF).
Bourdel N, Huchon C, Abdel Wahab C, Azaïs H, Bendifallah S, Bolze PA, Brun JL, Canlorbe G, Chauvet P, Chereau E, Courbiere B, De La Motte Rouge T, Devouassoux-Shisheboran M, Eymerit-Morin C, Fauvet R, Gauroy E, Gauthier T, Grynberg M, Koskas M, Larouzee E, Lecointre L, Levêque J, Margueritte F, Mathieu D'argent E, Nyangoh-Timoh K, Ouldamer L, Raad J, Raimond E, Ramanah R, Rolland L, Rousset P, Rousset-Jablonski C, Thomassin-Naggara I, Uzan C, Zilliox M, Daraï E
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:492-501. Epub 2020 Nov 20 doi: 10.1016/j.ejogrb.2020.11.045. PMID: 33262005
Serum CA19-9, CA-125 and CEA as tumor markers for mucinous ovarian tumors.
Lertkhachonsuk AA, Buranawongtrakoon S, Lekskul N, Rermluk N, Wee-Stekly WW, Charakorn C
J Obstet Gynaecol Res 2020 Nov;46(11):2287-2291. Epub 2020 Aug 23 doi: 10.1111/jog.14427. PMID: 32830422Free PMC Article
Trousseau Syndrome Related Cerebral Infarction: Clinical Manifestations, Laboratory Findings and Radiological Features.
Bao L, Zhang S, Gong X, Cui G
J Stroke Cerebrovasc Dis 2020 Sep;29(9):104891. Epub 2020 Jun 30 doi: 10.1016/j.jstrokecerebrovasdis.2020.104891. PMID: 32807409
Cancer antigen-125 and ICAM-1 are together responsible for ascites in liver cirrhosis.
Chowdhury MA, Xiubin Z, Wei H, Chenghao G
Clin Lab 2014;60(4):653-8. doi: 10.7754/clin.lab.2013.130403. PMID: 24779300
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Recent systematic reviews

Diagnostic Accuracy of Clinical Biomarkers for Preoperative Prediction of Lymph Node Metastasis in Endometrial Carcinoma: A Systematic Review and Meta-Analysis.
Reijnen C, IntHout J, Massuger LFAG, Strobbe F, Küsters-Vandevelde HVN, Haldorsen IS, Snijders MPLM, Pijnenborg JMA
Oncologist 2019 Sep;24(9):e880-e890. Epub 2019 Jun 11 doi: 10.1634/theoncologist.2019-0117. PMID: 31186375Free PMC Article
Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival of epithelial ovarian cancer: a systematic review and meta-analysis of observational studies.
Yang Z, Gu JH, Guo CS, Li XH, Yang WC
Oncotarget 2017 Jul 11;8(28):46414-46424. doi: 10.18632/oncotarget.16793. PMID: 28423365Free PMC Article

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