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Elevated carcinoma antigen 125 level

MedGen UID:
1373345
•Concept ID:
C4476918
•
Finding
Synonym: Increased plasma CA125
 
HPO: HP:0031030

Definition

An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated carcinoma antigen 125 level

Professional guidelines

PubMed

The differential diagnostic value and clinical significance of serum HE4 in ovarian disease with elevated CA125.
Li W, Wang D
Arch Gynecol Obstet 2020 May;301(5):1219-1225. Epub 2020 Apr 7 doi: 10.1007/s00404-020-05527-0. PMID: 32266526
Outcome of elevated CA125 values from primary care following implementation of ovarian cancer guidelines.
Crawford SM, Evans C
Fam Pract 2018 Mar 27;35(2):199-202. doi: 10.1093/fampra/cmx096. PMID: 29029123
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article

Recent clinical studies

Etiology

Identifying tumor markers-stratified subtypes (CA-125/CA19-9/carcinoembryonic antigen) in cervical adenocarcinoma.
Zhang Z, Li Y, Wu Y, Bi R, Wu X, Ke G, Zhu J
Int J Biol Markers 2023 Dec;38(3-4):223-232. Epub 2023 Nov 7 doi: 10.1177/03936155231206839. PMID: 37933442
Clinical characteristics and laparoscopic surgical outcomes of ovarian dermoid cysts complicated by spontaneous rupture: nine cases and a literature review.
Takeda A, Koike W
J Int Med Res 2023 May;51(5):3000605231171023. doi: 10.1177/03000605231171023. PMID: 37138472Free PMC Article
Diagnostic role and prognostic value of tumor markers in high-grade gastro-enteropancreatic neuroendocrine neoplasms.
Gao C, Fan Z, Yang J, Shi M, Li Y, Zhan H
Pancreatology 2023 Mar;23(2):204-212. Epub 2023 Jan 18 doi: 10.1016/j.pan.2023.01.009. PMID: 36710224
The emerging role of HE4 in the evaluation of epithelial ovarian and endometrial carcinomas.
Simmons AR, Baggerly K, Bast RC Jr
Oncology (Williston Park) 2013 Jun;27(6):548-56. PMID: 23909069Free PMC Article
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Diagnosis

Diagnostic role and prognostic value of tumor markers in high-grade gastro-enteropancreatic neuroendocrine neoplasms.
Gao C, Fan Z, Yang J, Shi M, Li Y, Zhan H
Pancreatology 2023 Mar;23(2):204-212. Epub 2023 Jan 18 doi: 10.1016/j.pan.2023.01.009. PMID: 36710224
Meigs syndrome presenting with severely elevated CA-125 level.
Palmieri A, ElSahwi K, Hicks V
BMJ Case Rep 2021 Mar 2;14(3) doi: 10.1136/bcr-2020-238931. PMID: 33653838Free PMC Article
Variant prostate carcinoma and elevated serum CA-125.
Bilen MA, Reyes A, Bhowmick D, Maa A, Bast R Jr, Pisters LL, Lin SH, Logothetis CJ, Tu SM
Can J Urol 2014 Oct;21(5):7442-8. PMID: 25347368Free PMC Article
Serum tumour markers in gynaecological cancers.
Aggarwal P, Kehoe S
Maturitas 2010 Sep;67(1):46-53. Epub 2010 May 26 doi: 10.1016/j.maturitas.2010.04.017. PMID: 20510555
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Therapy

Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications.
Chen W, Zhong S, Shan B, Zhou S, Wu X, Yang H, Ye S
J Ovarian Res 2020 Aug 8;13(1):89. doi: 10.1186/s13048-020-00693-w. PMID: 32771026Free PMC Article
Primary peritoneal serous papillary carcinoma: a case series.
Blontzos N, Vafias E, Vorgias G, Kalinoglou N, Iavazzo C
Arch Gynecol Obstet 2019 Oct;300(4):1023-1028. Epub 2019 Sep 5 doi: 10.1007/s00404-019-05280-z. PMID: 31486887
Variant prostate carcinoma and elevated serum CA-125.
Bilen MA, Reyes A, Bhowmick D, Maa A, Bast R Jr, Pisters LL, Lin SH, Logothetis CJ, Tu SM
Can J Urol 2014 Oct;21(5):7442-8. PMID: 25347368Free PMC Article
Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.
Kobayashi H
Int J Clin Oncol 2009 Oct;14(5):378-82. Epub 2009 Oct 25 doi: 10.1007/s10147-009-0931-2. PMID: 19856043
CA 125 may not reflect disease status in patients with uterine serous carcinoma.
Price FV, Chambers SK, Carcangiu ML, Kohorn EI, Schwartz PE, Chambers JT
Cancer 1998 May 1;82(9):1720-5. doi: 10.1002/(sici)1097-0142(19980501)82:9<1720::aid-cncr19>3.0.co;2-6. PMID: 9576294

Prognosis

MMP12 serves as an immune cell-related marker of disease status and prognosis in lung squamous cell carcinoma.
Zhang W, Li GS, Gan XY, Huang ZG, He RQ, Huang H, Li DM, Tang YL, Tang D, Zou W, Liu J, Dang YW, Chen G, Zhou HF, Kong JL, Lu HP
PeerJ 2023;11:e15598. Epub 2023 Aug 16 doi: 10.7717/peerj.15598. PMID: 37601247Free PMC Article
Diagnostic role and prognostic value of tumor markers in high-grade gastro-enteropancreatic neuroendocrine neoplasms.
Gao C, Fan Z, Yang J, Shi M, Li Y, Zhan H
Pancreatology 2023 Mar;23(2):204-212. Epub 2023 Jan 18 doi: 10.1016/j.pan.2023.01.009. PMID: 36710224
The prognostic and diagnostic potential of kallikrein-related peptidases in ovarian cancer.
Riedel M, Bronger H, Magdolen V, Dreyer T
Expert Rev Mol Diagn 2021 Jun;21(6):535-545. Epub 2021 May 14 doi: 10.1080/14737159.2021.1924680. PMID: 33947310
Variant prostate carcinoma and elevated serum CA-125.
Bilen MA, Reyes A, Bhowmick D, Maa A, Bast R Jr, Pisters LL, Lin SH, Logothetis CJ, Tu SM
Can J Urol 2014 Oct;21(5):7442-8. PMID: 25347368Free PMC Article
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Clinical prediction guides

Identifying tumor markers-stratified subtypes (CA-125/CA19-9/carcinoembryonic antigen) in cervical adenocarcinoma.
Zhang Z, Li Y, Wu Y, Bi R, Wu X, Ke G, Zhu J
Int J Biol Markers 2023 Dec;38(3-4):223-232. Epub 2023 Nov 7 doi: 10.1177/03936155231206839. PMID: 37933442
Clinical characteristics and laparoscopic surgical outcomes of ovarian dermoid cysts complicated by spontaneous rupture: nine cases and a literature review.
Takeda A, Koike W
J Int Med Res 2023 May;51(5):3000605231171023. doi: 10.1177/03000605231171023. PMID: 37138472Free PMC Article
Diagnostic role and prognostic value of tumor markers in high-grade gastro-enteropancreatic neuroendocrine neoplasms.
Gao C, Fan Z, Yang J, Shi M, Li Y, Zhan H
Pancreatology 2023 Mar;23(2):204-212. Epub 2023 Jan 18 doi: 10.1016/j.pan.2023.01.009. PMID: 36710224
Cancer antigen-125 and ICAM-1 are together responsible for ascites in liver cirrhosis.
Chowdhury MA, Xiubin Z, Wei H, Chenghao G
Clin Lab 2014;60(4):653-8. doi: 10.7754/clin.lab.2013.130403. PMID: 24779300
Tumor markers.
Seleznick MJ
Prim Care 1992 Dec;19(4):715-26. PMID: 1281552

Recent systematic reviews

Diagnostic Accuracy of Clinical Biomarkers for Preoperative Prediction of Lymph Node Metastasis in Endometrial Carcinoma: A Systematic Review and Meta-Analysis.
Reijnen C, IntHout J, Massuger LFAG, Strobbe F, Küsters-Vandevelde HVN, Haldorsen IS, Snijders MPLM, Pijnenborg JMA
Oncologist 2019 Sep;24(9):e880-e890. Epub 2019 Jun 11 doi: 10.1634/theoncologist.2019-0117. PMID: 31186375Free PMC Article
Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival of epithelial ovarian cancer: a systematic review and meta-analysis of observational studies.
Yang Z, Gu JH, Guo CS, Li XH, Yang WC
Oncotarget 2017 Jul 11;8(28):46414-46424. doi: 10.18632/oncotarget.16793. PMID: 28423365Free PMC Article
Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review.
Han SN, Lotgerink A, Gziri MM, Van Calsteren K, Hanssens M, Amant F
BMC Med 2012 Aug 8;10:86. doi: 10.1186/1741-7015-10-86. PMID: 22873292Free PMC Article

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