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BCL2 Gene Amplification

MedGen UID:
1373572
•Concept ID:
C4329387
•
Cell or Molecular Dysfunction
Synonyms: B-Cell CLL-Lymphoma 2 Gene Amplification; B-Cell CLL/Lymphoma 2 Gene Amplification; Bcl-2 Gene Amplification; BCL2, Apoptosis Regulator Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the BCL2 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBCL2 Gene Amplification

Professional guidelines

PubMed

Management of Patients with MYC-Altered Lymphomas.
Landsburg DJ
Curr Hematol Malig Rep 2016 Jun;11(3):208-17. doi: 10.1007/s11899-016-0320-7. PMID: 26983958
Are we ready to stratify treatment for diffuse large B-cell lymphoma using molecular hallmarks?
Barton S, Hawkes EA, Wotherspoon A, Cunningham D
Oncologist 2012;17(12):1562-73. Epub 2012 Oct 18 doi: 10.1634/theoncologist.2012-0218. PMID: 23086691Free PMC Article
Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer.
Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Del Tacca M, Danesi R
Mol Cancer Ther 2006 Jun;5(6):1387-95. doi: 10.1158/1535-7163.MCT-06-0004. PMID: 16818496

Recent clinical studies

Etiology

Does MRD have a role in the management of iNHL?
Giudice ID, Starza ID, Foà R
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):320-330. doi: 10.1182/hematology.2021000312. PMID: 34889425Free PMC Article
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia.
Li J, Dai Y, Wu L, Zhang M, Ouyang W, Huang J, Chen S
Front Med 2021 Jun;15(3):347-371. Epub 2021 Jan 5 doi: 10.1007/s11684-020-0821-6. PMID: 33400146
New molecular insights into osteosarcoma targeted therapy.
Yang J, Zhang W
Curr Opin Oncol 2013 Jul;25(4):398-406. doi: 10.1097/CCO.0b013e3283622c1b. PMID: 23666471
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, López-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project
N Engl J Med 2002 Jun 20;346(25):1937-47. doi: 10.1056/NEJMoa012914. PMID: 12075054
Gastric adenocarcinoma: pathomorphology and molecular pathology.
Werner M, Becker KF, Keller G, Höfler H
J Cancer Res Clin Oncol 2001 Apr;127(4):207-16. doi: 10.1007/s004320000195. PMID: 11315254

Diagnosis

Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified c-Kit.
Sabbah M, Krayem M, Najem A, Sales F, Miller W, Del Rincon S, Awada A, Ghanem GE, Journe F
Mol Cancer Res 2021 Jul;19(7):1221-1233. Epub 2021 Mar 19 doi: 10.1158/1541-7786.MCR-20-1040. PMID: 33741716
Management of Patients with MYC-Altered Lymphomas.
Landsburg DJ
Curr Hematol Malig Rep 2016 Jun;11(3):208-17. doi: 10.1007/s11899-016-0320-7. PMID: 26983958
MYC alterations in diffuse large B-cell lymphomas.
Karube K, Campo E
Semin Hematol 2015 Apr;52(2):97-106. Epub 2015 Jan 21 doi: 10.1053/j.seminhematol.2015.01.009. PMID: 25805589
New molecular insights into osteosarcoma targeted therapy.
Yang J, Zhang W
Curr Opin Oncol 2013 Jul;25(4):398-406. doi: 10.1097/CCO.0b013e3283622c1b. PMID: 23666471
Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma.
Stegh AH, DePinho RA
Cell Cycle 2011 Jan 1;10(1):33-8. doi: 10.4161/cc.10.1.14365. PMID: 21200141Free PMC Article

Therapy

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy.
Thijssen R, Tian L, Anderson MA, Flensburg C, Jarratt A, Garnham AL, Jabbari JS, Peng H, Lew TE, Teh CE, Gouil Q, Georgiou A, Tan T, Djajawi TM, Tam CS, Seymour JF, Blombery P, Gray DHD, Majewski IJ, Ritchie ME, Roberts AW, Huang DCS
Blood 2022 Nov 17;140(20):2127-2141. doi: 10.1182/blood.2022016040. PMID: 35709339Free PMC Article
It's time to die: BH3 mimetics in solid tumors.
Kehr S, Vogler M
Biochim Biophys Acta Mol Cell Res 2021 Apr;1868(5):118987. Epub 2021 Feb 15 doi: 10.1016/j.bbamcr.2021.118987. PMID: 33600840
The Spectrum of MYC Alterations in Diffuse Large B-Cell Lymphoma.
Xia Y, Zhang X
Acta Haematol 2020;143(6):520-528. Epub 2020 Feb 19 doi: 10.1159/000505892. PMID: 32074595
Management of Patients with MYC-Altered Lymphomas.
Landsburg DJ
Curr Hematol Malig Rep 2016 Jun;11(3):208-17. doi: 10.1007/s11899-016-0320-7. PMID: 26983958
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, López-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project
N Engl J Med 2002 Jun 20;346(25):1937-47. doi: 10.1056/NEJMoa012914. PMID: 12075054

Prognosis

Does MRD have a role in the management of iNHL?
Giudice ID, Starza ID, Foà R
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):320-330. doi: 10.1182/hematology.2021000312. PMID: 34889425Free PMC Article
The Spectrum of MYC Alterations in Diffuse Large B-Cell Lymphoma.
Xia Y, Zhang X
Acta Haematol 2020;143(6):520-528. Epub 2020 Feb 19 doi: 10.1159/000505892. PMID: 32074595
MYC alterations in diffuse large B-cell lymphomas.
Karube K, Campo E
Semin Hematol 2015 Apr;52(2):97-106. Epub 2015 Jan 21 doi: 10.1053/j.seminhematol.2015.01.009. PMID: 25805589
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, López-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project
N Engl J Med 2002 Jun 20;346(25):1937-47. doi: 10.1056/NEJMoa012914. PMID: 12075054
Genetics of small lymphocyte disorders.
Panayiotidis P, Kotsi P
Semin Hematol 1999 Apr;36(2):171-7. PMID: 10319386

Clinical prediction guides

Does MRD have a role in the management of iNHL?
Giudice ID, Starza ID, Foà R
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):320-330. doi: 10.1182/hematology.2021000312. PMID: 34889425Free PMC Article
Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified c-Kit.
Sabbah M, Krayem M, Najem A, Sales F, Miller W, Del Rincon S, Awada A, Ghanem GE, Journe F
Mol Cancer Res 2021 Jul;19(7):1221-1233. Epub 2021 Mar 19 doi: 10.1158/1541-7786.MCR-20-1040. PMID: 33741716
The Spectrum of MYC Alterations in Diffuse Large B-Cell Lymphoma.
Xia Y, Zhang X
Acta Haematol 2020;143(6):520-528. Epub 2020 Feb 19 doi: 10.1159/000505892. PMID: 32074595
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.
Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, López-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project
N Engl J Med 2002 Jun 20;346(25):1937-47. doi: 10.1056/NEJMoa012914. PMID: 12075054
Genetics of small lymphocyte disorders.
Panayiotidis P, Kotsi P
Semin Hematol 1999 Apr;36(2):171-7. PMID: 10319386

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