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Tissue Kallikrein Deficiency

MedGen UID:
Concept ID:
Disease or Syndrome


A disorder characterized by the partial or complete absence of tissue-type kallikrein activity in the tissues and glandular secretions where it is normally present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTissue Kallikrein Deficiency

Professional guidelines


de Maat S, Sanrattana W, Mailer RK, Parr NMJ, Hessing M, Koetsier RM, Meijers JCM, Pasterkamp G, Renné T, Maas C
Blood 2019 Nov 7;134(19):1658-1669. doi: 10.1182/blood.2019000481. PMID: 31366623Free PMC Article
Stolz LE, Horn PT
Drugs Today (Barc) 2010 Aug;46(8):547-55. doi: 10.1358/dot.2010.46.8.1507205. PMID: 20830315
Scott BT, Bovill EG, Callas PW, Hasstedt SJ, Leppert MF, Valliere JE, Varvil TS, Long GL
Thromb Haemost 2001 Jan;85(1):82-7. PMID: 11204593

Recent clinical studies


Potier L, Waeckel L, Fumeron F, Bodin S, Fysekidis M, Chollet C, Bellili N, Bonnet F, Gusto G, Velho G, Marre M, Alhenc-Gelas F, Roussel R, Bouby N; DESIR Study Group
J Endocrinol 2014 May;221(2):297-308. Epub 2014 Apr 22 doi: 10.1530/JOE-13-0529. PMID: 24599937


Monteiro JS, Blanchard A, Curis E, Chambrey R, Jeunemaitre X, Azizi M
Kidney Int 2013 Dec;84(6):1271-7. Epub 2013 Jun 12 doi: 10.1038/ki.2013.224. PMID: 23760292

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