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Castration Resistance

MedGen UID:
1374223
Concept ID:
C4329620
Finding

Definition

A finding indicating that a prostate carcinoma continues to grow despite the surgical removal of the testes or medical intervention to block androgen production. [from NCI]

Professional guidelines

PubMed

Wang H, Li N, Liu Q, Guo J, Pan Q, Cheng B, Xu J, Dong B, Yang G, Yang B, Wang X, Gu Y, Zhang G, Lian Y, Zhang W, Zhang M, Li T, Zang Y, Tan M, Li Q, Wang X, Yu Z, Jiang J, Huang H, Qin J
Cancer Cell 2023 Jul 10;41(7):1345-1362.e9. Epub 2023 Jun 22 doi: 10.1016/j.ccell.2023.05.016. PMID: 37352863
Yamada Y, Beltran H
Cancer Lett 2021 Oct 28;519:20-29. Epub 2021 Jun 18 doi: 10.1016/j.canlet.2021.06.010. PMID: 34153403Free PMC Article
Mansinho A, Macedo D, Fernandes I, Costa L
Adv Exp Med Biol 2018;1096:117-133. doi: 10.1007/978-3-319-99286-0_7. PMID: 30324351

Recent clinical studies

Etiology

Gil V, Miranda S, Riisnaes R, Gurel B, D'Ambrosio M, Vasciaveo A, Crespo M, Ferreira A, Brina D, Troiani M, Sharp A, Sheehan B, Christova R, Seed G, Figueiredo I, Lambros M, Dolling D, Rekowski J, Alajati A, Clarke M, Pereira R, Flohr P, Fowler G, Boysen G, Sumanasuriya S, Bianchini D, Rescigno P, Aversa C, Tunariu N, Guo C, Paschalis A, Bertan C, Buroni L, Ning J, Carreira S, Workman P, Swain A, Califano A, Shen MM, Alimonti A, Neeb A, Welti J, Yuan W, de Bono J; PCF/SU2C International Prostate Cancer Dream Team
Cancer Res 2021 Dec 15;81(24):6207-6218. Epub 2021 Nov 9 doi: 10.1158/0008-5472.CAN-21-3360. PMID: 34753775Free PMC Article
Chi KN, Chowdhury S, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez A, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Brookman-May S, Mundle SD, McCarthy SA, Larsen JS, Sun W, Bevans KB, Zhang K, Bandyopadhyay N, Agarwal N
J Clin Oncol 2021 Jul 10;39(20):2294-2303. Epub 2021 Apr 29 doi: 10.1200/JCO.20.03488. PMID: 33914595
Hess-Busch Y, Hadaschik B, Hess J
World J Urol 2021 Feb;39(2):349-356. Epub 2019 Nov 5 doi: 10.1007/s00345-019-02997-z. PMID: 31691081
Armstrong AJ, Szmulewitz RZ, Petrylak DP, Holzbeierlein J, Villers A, Azad A, Alcaraz A, Alekseev B, Iguchi T, Shore ND, Rosbrook B, Sugg J, Baron B, Chen L, Stenzl A
J Clin Oncol 2019 Nov 10;37(32):2974-2986. Epub 2019 Jul 22 doi: 10.1200/JCO.19.00799. PMID: 31329516Free PMC Article
Mansinho A, Macedo D, Fernandes I, Costa L
Adv Exp Med Biol 2018;1096:117-133. doi: 10.1007/978-3-319-99286-0_7. PMID: 30324351

Diagnosis

Pernigoni N, Zagato E, Calcinotto A, Troiani M, Mestre RP, Calì B, Attanasio G, Troisi J, Minini M, Mosole S, Revandkar A, Pasquini E, Elia AR, Bossi D, Rinaldi A, Rescigno P, Flohr P, Hunt J, Neeb A, Buroni L, Guo C, Welti J, Ferrari M, Grioni M, Gauthier J, Gharaibeh RZ, Palmisano A, Lucchini GM, D'Antonio E, Merler S, Bolis M, Grassi F, Esposito A, Bellone M, Briganti A, Rescigno M, Theurillat JP, Jobin C, Gillessen S, de Bono J, Alimonti A
Science 2021 Oct 8;374(6564):216-224. Epub 2021 Oct 7 doi: 10.1126/science.abf8403. PMID: 34618582
Chi KN, Chowdhury S, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez A, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Brookman-May S, Mundle SD, McCarthy SA, Larsen JS, Sun W, Bevans KB, Zhang K, Bandyopadhyay N, Agarwal N
J Clin Oncol 2021 Jul 10;39(20):2294-2303. Epub 2021 Apr 29 doi: 10.1200/JCO.20.03488. PMID: 33914595
Yamada Y, Beltran H
Curr Oncol Rep 2021 Jan 12;23(2):15. doi: 10.1007/s11912-020-01003-9. PMID: 33433737Free PMC Article
Mateo J, Seed G, Bertan C, Rescigno P, Dolling D, Figueiredo I, Miranda S, Nava Rodrigues D, Gurel B, Clarke M, Atkin M, Chandler R, Messina C, Sumanasuriya S, Bianchini D, Barrero M, Petermolo A, Zafeiriou Z, Fontes M, Perez-Lopez R, Tunariu N, Fulton B, Jones R, McGovern U, Ralph C, Varughese M, Parikh O, Jain S, Elliott T, Sandhu S, Porta N, Hall E, Yuan W, Carreira S, de Bono JS
J Clin Invest 2020 Apr 1;130(4):1743-1751. doi: 10.1172/JCI132031. PMID: 31874108Free PMC Article
Armstrong AJ, Szmulewitz RZ, Petrylak DP, Holzbeierlein J, Villers A, Azad A, Alcaraz A, Alekseev B, Iguchi T, Shore ND, Rosbrook B, Sugg J, Baron B, Chen L, Stenzl A
J Clin Oncol 2019 Nov 10;37(32):2974-2986. Epub 2019 Jul 22 doi: 10.1200/JCO.19.00799. PMID: 31329516Free PMC Article

Therapy

Wang H, Li N, Liu Q, Guo J, Pan Q, Cheng B, Xu J, Dong B, Yang G, Yang B, Wang X, Gu Y, Zhang G, Lian Y, Zhang W, Zhang M, Li T, Zang Y, Tan M, Li Q, Wang X, Yu Z, Jiang J, Huang H, Qin J
Cancer Cell 2023 Jul 10;41(7):1345-1362.e9. Epub 2023 Jun 22 doi: 10.1016/j.ccell.2023.05.016. PMID: 37352863
Pernigoni N, Zagato E, Calcinotto A, Troiani M, Mestre RP, Calì B, Attanasio G, Troisi J, Minini M, Mosole S, Revandkar A, Pasquini E, Elia AR, Bossi D, Rinaldi A, Rescigno P, Flohr P, Hunt J, Neeb A, Buroni L, Guo C, Welti J, Ferrari M, Grioni M, Gauthier J, Gharaibeh RZ, Palmisano A, Lucchini GM, D'Antonio E, Merler S, Bolis M, Grassi F, Esposito A, Bellone M, Briganti A, Rescigno M, Theurillat JP, Jobin C, Gillessen S, de Bono J, Alimonti A
Science 2021 Oct 8;374(6564):216-224. Epub 2021 Oct 7 doi: 10.1126/science.abf8403. PMID: 34618582
Yamada Y, Beltran H
Cancer Lett 2021 Oct 28;519:20-29. Epub 2021 Jun 18 doi: 10.1016/j.canlet.2021.06.010. PMID: 34153403Free PMC Article
Chi KN, Chowdhury S, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez A, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Brookman-May S, Mundle SD, McCarthy SA, Larsen JS, Sun W, Bevans KB, Zhang K, Bandyopadhyay N, Agarwal N
J Clin Oncol 2021 Jul 10;39(20):2294-2303. Epub 2021 Apr 29 doi: 10.1200/JCO.20.03488. PMID: 33914595
Armstrong AJ, Szmulewitz RZ, Petrylak DP, Holzbeierlein J, Villers A, Azad A, Alcaraz A, Alekseev B, Iguchi T, Shore ND, Rosbrook B, Sugg J, Baron B, Chen L, Stenzl A
J Clin Oncol 2019 Nov 10;37(32):2974-2986. Epub 2019 Jul 22 doi: 10.1200/JCO.19.00799. PMID: 31329516Free PMC Article

Prognosis

Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Gil V, Miranda S, Riisnaes R, Gurel B, D'Ambrosio M, Vasciaveo A, Crespo M, Ferreira A, Brina D, Troiani M, Sharp A, Sheehan B, Christova R, Seed G, Figueiredo I, Lambros M, Dolling D, Rekowski J, Alajati A, Clarke M, Pereira R, Flohr P, Fowler G, Boysen G, Sumanasuriya S, Bianchini D, Rescigno P, Aversa C, Tunariu N, Guo C, Paschalis A, Bertan C, Buroni L, Ning J, Carreira S, Workman P, Swain A, Califano A, Shen MM, Alimonti A, Neeb A, Welti J, Yuan W, de Bono J; PCF/SU2C International Prostate Cancer Dream Team
Cancer Res 2021 Dec 15;81(24):6207-6218. Epub 2021 Nov 9 doi: 10.1158/0008-5472.CAN-21-3360. PMID: 34753775Free PMC Article
Schmidt KT, Huitema ADR, Chau CH, Figg WD
Nat Rev Urol 2021 Apr;18(4):209-226. Epub 2021 Mar 19 doi: 10.1038/s41585-021-00438-4. PMID: 33742189
Yamada Y, Beltran H
Curr Oncol Rep 2021 Jan 12;23(2):15. doi: 10.1007/s11912-020-01003-9. PMID: 33433737Free PMC Article
Mateo J, Seed G, Bertan C, Rescigno P, Dolling D, Figueiredo I, Miranda S, Nava Rodrigues D, Gurel B, Clarke M, Atkin M, Chandler R, Messina C, Sumanasuriya S, Bianchini D, Barrero M, Petermolo A, Zafeiriou Z, Fontes M, Perez-Lopez R, Tunariu N, Fulton B, Jones R, McGovern U, Ralph C, Varughese M, Parikh O, Jain S, Elliott T, Sandhu S, Porta N, Hall E, Yuan W, Carreira S, de Bono JS
J Clin Invest 2020 Apr 1;130(4):1743-1751. doi: 10.1172/JCI132031. PMID: 31874108Free PMC Article

Clinical prediction guides

Lim EA, Schweizer MT, Chi KN, Aggarwal R, Agarwal N, Gulley J, Attiyeh E, Greger J, Wu S, Jaiprasart P, Loffredo J, Bandyopadhyay N, Xie H, Hansen AR
Clin Genitourin Cancer 2023 Jun;21(3):366-375. Epub 2023 Feb 28 doi: 10.1016/j.clgc.2023.02.010. PMID: 36948922Free PMC Article
Chowdhury S, Bjartell A, Agarwal N, Chung BH, Given RW, Pereira de Santana Gomes AJ, Merseburger AS, Özgüroğlu M, Juárez Soto Á, Uemura H, Ye D, Brookman-May SD, Londhe A, Bhaumik A, Mundle SD, Larsen JS, McCarthy SA, Chi KN
Ann Oncol 2023 May;34(5):477-485. Epub 2023 Feb 27 doi: 10.1016/j.annonc.2023.02.009. PMID: 36858151
Gil V, Miranda S, Riisnaes R, Gurel B, D'Ambrosio M, Vasciaveo A, Crespo M, Ferreira A, Brina D, Troiani M, Sharp A, Sheehan B, Christova R, Seed G, Figueiredo I, Lambros M, Dolling D, Rekowski J, Alajati A, Clarke M, Pereira R, Flohr P, Fowler G, Boysen G, Sumanasuriya S, Bianchini D, Rescigno P, Aversa C, Tunariu N, Guo C, Paschalis A, Bertan C, Buroni L, Ning J, Carreira S, Workman P, Swain A, Califano A, Shen MM, Alimonti A, Neeb A, Welti J, Yuan W, de Bono J; PCF/SU2C International Prostate Cancer Dream Team
Cancer Res 2021 Dec 15;81(24):6207-6218. Epub 2021 Nov 9 doi: 10.1158/0008-5472.CAN-21-3360. PMID: 34753775Free PMC Article
Chi KN, Chowdhury S, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez A, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Brookman-May S, Mundle SD, McCarthy SA, Larsen JS, Sun W, Bevans KB, Zhang K, Bandyopadhyay N, Agarwal N
J Clin Oncol 2021 Jul 10;39(20):2294-2303. Epub 2021 Apr 29 doi: 10.1200/JCO.20.03488. PMID: 33914595
Schmidt KT, Huitema ADR, Chau CH, Figg WD
Nat Rev Urol 2021 Apr;18(4):209-226. Epub 2021 Mar 19 doi: 10.1038/s41585-021-00438-4. PMID: 33742189

Recent systematic reviews

Ingrosso G, Bottero M, Becherini C, Caini S, Alì E, Lancia A, Ost P, Sanguineti G, Siva S, Zilli T, Francolini G, Bellavita R, Aristei C, Livi L, Detti B
Semin Oncol 2022 Oct;49(5):409-418. Epub 2022 Sep 24 doi: 10.1053/j.seminoncol.2022.09.005. PMID: 36192243
DE Nunzio C, Presicce F, Giacinti S, Bassanelli M, Tubaro A
Minerva Urol Nefrol 2018 Feb;70(1):22-41. Epub 2017 Jul 12 doi: 10.23736/S0393-2249.17.02976-9. PMID: 28707844
Morote J, Regis L, Celma A, Planas J
Actas Urol Esp 2016 Oct;40(8):477-84. Epub 2016 Feb 18 doi: 10.1016/j.acuro.2016.01.006. PMID: 26899928
Magnan S, Zarychanski R, Pilote L, Bernier L, Shemilt M, Vigneault E, Fradet V, Turgeon AF
JAMA Oncol 2015 Dec;1(9):1261-9. doi: 10.1001/jamaoncol.2015.2895. PMID: 26378418
Tilki D, Evans CP
Can J Urol 2014 Apr;21(2 Supp 1):7-13. PMID: 24775718

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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