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B Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21

MedGen UID:
1374530
Concept ID:
C4329380
Neoplastic Process
Synonyms: B Acute Lymphoblastic Leukemia with iAMP21; B-ALL with iAMP21

Definition

B acute lymphoblastic leukemia characterized by amplification of a portion of chromosome 21. It usually occurs in children and is associated with an adverse prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21

Professional guidelines

PubMed

Moorman AV, Robinson H, Schwab C, Richards SM, Hancock J, Mitchell CD, Goulden N, Vora A, Harrison CJ
J Clin Oncol 2013 Sep 20;31(27):3389-96. Epub 2013 Aug 12 doi: 10.1200/JCO.2013.48.9377. PMID: 23940220

Recent clinical studies

Etiology

Gao Q, Ryan SL, Iacobucci I, Ghate PS, Cranston RE, Schwab C, Elsayed AH, Shi L, Pounds S, Lei S, Baviskar P, Pei D, Cheng C, Bashton M, Sinclair P, Bentley DR, Ross MT, Kingsbury Z, James T, Roberts KG, Devidas M, Fan Y, Chen W, Chang TC, Wu G, Carroll A, Heerema N, Valentine V, Valentine M, Yang W, Yang JJ, Moorman AV, Harrison CJ, Mullighan CG
Blood 2023 Aug 24;142(8):711-723. doi: 10.1182/blood.2022019094. PMID: 37216686Free PMC Article
Baloda V, Aggarwal N, Rosado FG, Mackey S, Felker J, Yatsenko SA
Cytogenet Genome Res 2022;162(5):231-236. Epub 2022 Dec 9 doi: 10.1159/000527025. PMID: 36502796
Zak T, Gao J, Behdad A, Mehta J, Altman JK, Ji P, Lu X, Sukhanova M
Leuk Lymphoma 2022 Dec;63(13):3200-3207. Epub 2022 Aug 22 doi: 10.1080/10428194.2022.2113524. PMID: 35995457
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Johnson RC, Weinberg OK, Cascio MJ, Dahl GV, Mitton BA, Silverman LB, Cherry AM, Arber DA, Ohgami RS
Am J Clin Pathol 2015 Jul;144(1):103-12. doi: 10.1309/AJCPLUYF11HQBYRB. PMID: 26071468

Diagnosis

Gao Q, Ryan SL, Iacobucci I, Ghate PS, Cranston RE, Schwab C, Elsayed AH, Shi L, Pounds S, Lei S, Baviskar P, Pei D, Cheng C, Bashton M, Sinclair P, Bentley DR, Ross MT, Kingsbury Z, James T, Roberts KG, Devidas M, Fan Y, Chen W, Chang TC, Wu G, Carroll A, Heerema N, Valentine V, Valentine M, Yang W, Yang JJ, Moorman AV, Harrison CJ, Mullighan CG
Blood 2023 Aug 24;142(8):711-723. doi: 10.1182/blood.2022019094. PMID: 37216686Free PMC Article
Baloda V, Aggarwal N, Rosado FG, Mackey S, Felker J, Yatsenko SA
Cytogenet Genome Res 2022;162(5):231-236. Epub 2022 Dec 9 doi: 10.1159/000527025. PMID: 36502796
Zak T, Gao J, Behdad A, Mehta J, Altman JK, Ji P, Lu X, Sukhanova M
Leuk Lymphoma 2022 Dec;63(13):3200-3207. Epub 2022 Aug 22 doi: 10.1080/10428194.2022.2113524. PMID: 35995457
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Johnson RC, Weinberg OK, Cascio MJ, Dahl GV, Mitton BA, Silverman LB, Cherry AM, Arber DA, Ohgami RS
Am J Clin Pathol 2015 Jul;144(1):103-12. doi: 10.1309/AJCPLUYF11HQBYRB. PMID: 26071468

Therapy

Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Attarbaschi A, Panzer-Grümayer R, Mann G, Möricke A, König M, Mecklenbräuker A, Teigler-Schlegel A, Bradtke J, Harbott J, Göhring G, Stanulla M, Schrappe M, Zimmermann M, Haas OA; Austrian and German ALL-BFM (Berlin-Frankfurt-Münster) Study Group
Klin Padiatr 2014 Nov;226(6-7):338-43. Epub 2014 Nov 28 doi: 10.1055/s-0034-1387795. PMID: 25431866
Heerema NA, Carroll AJ, Devidas M, Loh ML, Borowitz MJ, Gastier-Foster JM, Larsen EC, Mattano LA Jr, Maloney KW, Willman CL, Wood BL, Winick NJ, Carroll WL, Hunger SP, Raetz EA
J Clin Oncol 2013 Sep 20;31(27):3397-402. Epub 2013 Aug 12 doi: 10.1200/JCO.2013.49.1308. PMID: 23940221Free PMC Article
Moorman AV, Robinson H, Schwab C, Richards SM, Hancock J, Mitchell CD, Goulden N, Vora A, Harrison CJ
J Clin Oncol 2013 Sep 20;31(27):3389-96. Epub 2013 Aug 12 doi: 10.1200/JCO.2013.48.9377. PMID: 23940220
Moorman AV, Richards SM, Robinson HM, Strefford JC, Gibson BE, Kinsey SE, Eden TO, Vora AJ, Mitchell CD, Harrison CJ; UK Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP)
Blood 2007 Mar 15;109(6):2327-30. Epub 2006 Nov 9 doi: 10.1182/blood-2006-08-040436. PMID: 17095619

Prognosis

Baloda V, Aggarwal N, Rosado FG, Mackey S, Felker J, Yatsenko SA
Cytogenet Genome Res 2022;162(5):231-236. Epub 2022 Dec 9 doi: 10.1159/000527025. PMID: 36502796
Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2022 Sep;54(9):1376-1389. Epub 2022 Sep 1 doi: 10.1038/s41588-022-01159-z. PMID: 36050548Free PMC Article
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Kim J, Lyu CJ, Shin S, Lee ST, Choi JR
Ann Lab Med 2016 Sep;36(5):475-80. doi: 10.3343/alm.2016.36.5.475. PMID: 27374714Free PMC Article
Harrison CJ
Br J Haematol 2009 Jan;144(2):147-56. Epub 2008 Nov 1 doi: 10.1111/j.1365-2141.2008.07417.x. PMID: 19006567

Clinical prediction guides

Baloda V, Aggarwal N, Rosado FG, Mackey S, Felker J, Yatsenko SA
Cytogenet Genome Res 2022;162(5):231-236. Epub 2022 Dec 9 doi: 10.1159/000527025. PMID: 36502796
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Berhili A, Bensalah M, ElMalki J, Elyagoubi A, Seddik R
J Med Case Rep 2021 Oct 28;15(1):531. doi: 10.1186/s13256-021-03128-2. PMID: 34706776Free PMC Article
Sinclair PB, Blair HH, Ryan SL, Buechler L, Cheng J, Clayton J, Hanna R, Hollern S, Hawking Z, Bashton M, Schwab CJ, Jones L, Russell LJ, Marr H, Carey P, Halsey C, Heidenreich O, Moorman AV, Harrison CJ
Haematologica 2018 Apr;103(4):634-644. Epub 2018 Feb 15 doi: 10.3324/haematol.2017.172304. PMID: 29449437Free PMC Article
Wang Y, Miller S, Roulston D, Bixby D, Shao L
J Mol Diagn 2016 Jul;18(4):595-603. Epub 2016 May 6 doi: 10.1016/j.jmoldx.2016.03.004. PMID: 27161658

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