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Decreased circulating prealbumin concentration

MedGen UID:
1375131
Concept ID:
C4476964
Finding
Synonym: Decreased prealbumin level
 
HPO: HP:0031085

Definition

Concentration of prealbumin in the blood circulation below the lower limit of normal. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating prealbumin concentration

Recent clinical studies

Etiology

Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC
J Clin Endocrinol Metab 2008 Jun;93(6):2263-8. Epub 2008 Mar 11 doi: 10.1210/jc.2007-2028. PMID: 18334592
Jauniaux E, Gulbis B, Jurkovic D, Campbell S, Collins WP, Ooms HA
Hum Reprod 1994 Jan;9(1):161-6. doi: 10.1093/oxfordjournals.humrep.a138308. PMID: 8195341
Mestries JC, Kruithof EK, Gascon MP, Herodin F, Agay D, Ythier A
Eur Cytokine Netw 1994 May-Jun;5(3):275-81. PMID: 7948765
Scalfi L, Laviano A, Reed LA, Borrelli R, Contaldo F
Am J Clin Nutr 1990 Mar;51(3):338-42. doi: 10.1093/ajcn/51.3.338. PMID: 2309640
Franklyn JA, Wilkins MR, Wilkinson R, Ramsden DB, Sheppard MC
Acta Endocrinol (Copenh) 1985 Mar;108(3):351-5. doi: 10.1530/acta.0.1080351. PMID: 3920853

Diagnosis

Yárnoz-Esquíroz P, Chopitea A, Olazarán L, Aguas-Ayesa M, Silva C, Vilalta-Lacarra A, Escalada J, Gil-Bazo I, Frühbeck G, Gómez-Ambrosi J
Nutrients 2022 Jul 2;14(13) doi: 10.3390/nu14132754. PMID: 35807934Free PMC Article
Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW
Sci Transl Med 2017 Sep 13;9(407) doi: 10.1126/scitranslmed.aam7621. PMID: 28904227Free PMC Article
Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC
J Clin Endocrinol Metab 2008 Jun;93(6):2263-8. Epub 2008 Mar 11 doi: 10.1210/jc.2007-2028. PMID: 18334592
Lo HC, Yang CS, Tsai LJ
Nutrition 2003 Apr;19(4):327-31. doi: 10.1016/s0899-9007(02)01012-2. PMID: 12679166
Thissen JP, Ketelslegers JM, Underwood LE
Endocr Rev 1994 Feb;15(1):80-101. doi: 10.1210/edrv-15-1-80. PMID: 8156941

Therapy

Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC
J Clin Endocrinol Metab 2008 Jun;93(6):2263-8. Epub 2008 Mar 11 doi: 10.1210/jc.2007-2028. PMID: 18334592
Straus DS
Clin Chem Lab Med 2002 Dec;40(12):1274-80. doi: 10.1515/CCLM.2002.221. PMID: 12553431
Scalfi L, Laviano A, Reed LA, Borrelli R, Contaldo F
Am J Clin Nutr 1990 Mar;51(3):338-42. doi: 10.1093/ajcn/51.3.338. PMID: 2309640
Golner BB, Reinhold RB, Jacob RA, Sadowski JA, Russell RM
J Am Coll Nutr 1987 Jun;6(3):279-85. doi: 10.1080/07315724.1987.10720190. PMID: 3598025
Lindstedt G, Lundberg PA, Sjögren B, Ernest I, Sundquist O
Scand J Clin Lab Invest 1982 Nov;42(7):585-93. PMID: 7156868

Prognosis

Ingenbleek Y, Bernstein LH
Adv Nutr 2015 Sep;6(5):572-80. Epub 2015 Sep 15 doi: 10.3945/an.115.008508. PMID: 26374179Free PMC Article
Audet-Delage Y, Ouellet N, Dallaire R, Dewailly E, Ayotte P
Environ Sci Technol 2013 Nov 19;47(22):13086-92. Epub 2013 Nov 11 doi: 10.1021/es4027634. PMID: 24160776
Lo HC, Yang CS, Tsai LJ
Nutrition 2003 Apr;19(4):327-31. doi: 10.1016/s0899-9007(02)01012-2. PMID: 12679166
Uitti RJ, Donat JR, Rozdilsky B, Schneider RJ, Koeppen AH
Arch Neurol 1988 Oct;45(10):1118-22. doi: 10.1001/archneur.1988.00520340072015. PMID: 3178532

Clinical prediction guides

Yárnoz-Esquíroz P, Chopitea A, Olazarán L, Aguas-Ayesa M, Silva C, Vilalta-Lacarra A, Escalada J, Gil-Bazo I, Frühbeck G, Gómez-Ambrosi J
Nutrients 2022 Jul 2;14(13) doi: 10.3390/nu14132754. PMID: 35807934Free PMC Article
Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW
Sci Transl Med 2017 Sep 13;9(407) doi: 10.1126/scitranslmed.aam7621. PMID: 28904227Free PMC Article
Ingenbleek Y, Bernstein LH
Adv Nutr 2015 Sep;6(5):572-80. Epub 2015 Sep 15 doi: 10.3945/an.115.008508. PMID: 26374179Free PMC Article
Mestries JC, Kruithof EK, Gascon MP, Herodin F, Agay D, Ythier A
Eur Cytokine Netw 1994 May-Jun;5(3):275-81. PMID: 7948765
Scalfi L, Laviano A, Reed LA, Borrelli R, Contaldo F
Am J Clin Nutr 1990 Mar;51(3):338-42. doi: 10.1093/ajcn/51.3.338. PMID: 2309640

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