U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased circulating prealbumin concentration

MedGen UID:
1375131
•Concept ID:
C4476964
•
Finding
Synonym: Decreased prealbumin level
 
HPO: HP:0031085

Definition

Concentration of prealbumin in the blood circulation below the lower limit of normal. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating prealbumin concentration

Recent clinical studies

Etiology

Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women.
Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC
J Clin Endocrinol Metab 2008 Jun;93(6):2263-8. Epub 2008 Mar 11 doi: 10.1210/jc.2007-2028. PMID: 18334592
Relationship between protein concentrations in embryological fluids and maternal serum and yolk sac size during human early pregnancy.
Jauniaux E, Gulbis B, Jurkovic D, Campbell S, Collins WP, Ooms HA
Hum Reprod 1994 Jan;9(1):161-6. doi: 10.1093/oxfordjournals.humrep.a138308. PMID: 8195341
In vivo modulation of coagulation and fibrinolysis by recombinant glycosylated human interleukin-6 in baboons.
Mestries JC, Kruithof EK, Gascon MP, Herodin F, Agay D, Ythier A
Eur Cytokine Netw 1994 May-Jun;5(3):275-81. PMID: 7948765
Albumin and labile-protein serum concentrations during very-low-calorie diets with different compositions.
Scalfi L, Laviano A, Reed LA, Borrelli R, Contaldo F
Am J Clin Nutr 1990 Mar;51(3):338-42. doi: 10.1093/ajcn/51.3.338. PMID: 2309640
The effect of propranolol on circulating thyroid hormone measurements in thyrotoxic and euthyroid subjects.
Franklyn JA, Wilkins MR, Wilkinson R, Ramsden DB, Sheppard MC
Acta Endocrinol (Copenh) 1985 Mar;108(3):351-5. doi: 10.1530/acta.0.1080351. PMID: 3920853

Diagnosis

Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown.
Yárnoz-Esquíroz P, Chopitea A, Olazarán L, Aguas-Ayesa M, Silva C, Vilalta-Lacarra A, Escalada J, Gil-Bazo I, Frühbeck G, Gómez-Ambrosi J
Nutrients 2022 Jul 2;14(13) doi: 10.3390/nu14132754. PMID: 35807934Free PMC Article
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.
Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW
Sci Transl Med 2017 Sep 13;9(407) doi: 10.1126/scitranslmed.aam7621. PMID: 28904227Free PMC Article
Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women.
Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC
J Clin Endocrinol Metab 2008 Jun;93(6):2263-8. Epub 2008 Mar 11 doi: 10.1210/jc.2007-2028. PMID: 18334592
Nutritional regulation of the insulin-like growth factors.
Thissen JP, Ketelslegers JM, Underwood LE
Endocr Rev 1994 Feb;15(1):80-101. doi: 10.1210/edrv-15-1-80. PMID: 8156941
Acute phase proteins and liver allograft rejection.
Maury CP, Teppo AM, Höckerstedt K
Liver 1988 Apr;8(2):75-9. doi: 10.1111/j.1600-0676.1988.tb00971.x. PMID: 2452954

Therapy

Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women.
Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC
J Clin Endocrinol Metab 2008 Jun;93(6):2263-8. Epub 2008 Mar 11 doi: 10.1210/jc.2007-2028. PMID: 18334592
Nutritional regulation of visceral markers in rat liver and cultured hepatoma cells.
Straus DS
Clin Chem Lab Med 2002 Dec;40(12):1274-80. doi: 10.1515/CCLM.2002.221. PMID: 12553431
Albumin and labile-protein serum concentrations during very-low-calorie diets with different compositions.
Scalfi L, Laviano A, Reed LA, Borrelli R, Contaldo F
Am J Clin Nutr 1990 Mar;51(3):338-42. doi: 10.1093/ajcn/51.3.338. PMID: 2309640
The short and long term effect of gastric partitioning surgery on serum protein levels.
Golner BB, Reinhold RB, Jacob RA, Sadowski JA, Russell RM
J Am Coll Nutr 1987 Jun;6(3):279-85. doi: 10.1080/07315724.1987.10720190. PMID: 3598025
Thyroid hormone resistance in a 35-year old man with recurrent goitre.
Lindstedt G, Lundberg PA, Sjögren B, Ernest I, Sundquist O
Scand J Clin Lab Invest 1982 Nov;42(7):585-93. PMID: 7156868

Prognosis

Plasma Transthyretin as a Biomarker of Lean Body Mass and Catabolic States.
Ingenbleek Y, Bernstein LH
Adv Nutr 2015 Sep;6(5):572-80. Epub 2015 Sep 15 doi: 10.3945/an.115.008508. PMID: 26374179Free PMC Article
Persistent organic pollutants and transthyretin-bound thyroxin in plasma of Inuit women of childbearing age.
Audet-Delage Y, Ouellet N, Dallaire R, Dewailly E, Ayotte P
Environ Sci Technol 2013 Nov 19;47(22):13086-92. Epub 2013 Nov 11 doi: 10.1021/es4027634. PMID: 24160776
Simultaneous measurements of serum insulin-like growth factor-I and leptin reflect the postoperative nutrition status of oral tumor patients.
Lo HC, Yang CS, Tsai LJ
Nutrition 2003 Apr;19(4):327-31. doi: 10.1016/s0899-9007(02)01012-2. PMID: 12679166
Familial oculoleptomeningeal amyloidosis. Report of a new family with unusual features.
Uitti RJ, Donat JR, Rozdilsky B, Schneider RJ, Koeppen AH
Arch Neurol 1988 Oct;45(10):1118-22. doi: 10.1001/archneur.1988.00520340072015. PMID: 3178532

Clinical prediction guides

Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown.
Yárnoz-Esquíroz P, Chopitea A, Olazarán L, Aguas-Ayesa M, Silva C, Vilalta-Lacarra A, Escalada J, Gil-Bazo I, Frühbeck G, Gómez-Ambrosi J
Nutrients 2022 Jul 2;14(13) doi: 10.3390/nu14132754. PMID: 35807934Free PMC Article
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.
Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW
Sci Transl Med 2017 Sep 13;9(407) doi: 10.1126/scitranslmed.aam7621. PMID: 28904227Free PMC Article
Plasma Transthyretin as a Biomarker of Lean Body Mass and Catabolic States.
Ingenbleek Y, Bernstein LH
Adv Nutr 2015 Sep;6(5):572-80. Epub 2015 Sep 15 doi: 10.3945/an.115.008508. PMID: 26374179Free PMC Article
In vivo modulation of coagulation and fibrinolysis by recombinant glycosylated human interleukin-6 in baboons.
Mestries JC, Kruithof EK, Gascon MP, Herodin F, Agay D, Ythier A
Eur Cytokine Netw 1994 May-Jun;5(3):275-81. PMID: 7948765
Albumin and labile-protein serum concentrations during very-low-calorie diets with different compositions.
Scalfi L, Laviano A, Reed LA, Borrelli R, Contaldo F
Am J Clin Nutr 1990 Mar;51(3):338-42. doi: 10.1093/ajcn/51.3.338. PMID: 2309640

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...