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Decreased prealbumin level

MedGen UID:
1375131
•Concept ID:
C4476964
•
Finding
HPO: HP:0031085

Definition

A reduced concentration of prealbumin in the blood. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased prealbumin level

Professional guidelines

PubMed

COVID-19 associated EBV reactivation and effects of ganciclovir treatment.
Meng M, Zhang S, Dong X, Sun W, Deng Y, Li W, Li R, Annane D, Wu Z, Chen D
Immun Inflamm Dis 2022 Apr;10(4):e597. doi: 10.1002/iid3.597. PMID: 35349757Free PMC Article
Contribution of acute-phase reaction proteins to the diagnosis and treatment of 2019 novel coronavirus disease (COVID-19).
Li L, Chen C
Epidemiol Infect 2020 Jul 27;148:e164. doi: 10.1017/S095026882000165X. PMID: 32713370Free PMC Article
Preoperative nutritional risk assessment in patients undergoing cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for colorectal carcinomatosis.
Banaste N, Rousset P, Mercier F, Rieussec C, Valette PJ, Glehen O, Passot G
Int J Hyperthermia 2018 Aug;34(5):589-594. Epub 2017 Sep 3 doi: 10.1080/02656736.2017.1371342. PMID: 28828897

Recent clinical studies

Etiology

SGLT2 inhibitor therapy for transthyretin amyloid cardiomyopathy: early tolerance and clinical response to dapagliflozin.
Dobner S, Bernhard B, Asatryan B, Windecker S, Stortecky S, Pilgrim T, Gräni C, Hunziker L
ESC Heart Fail 2023 Feb;10(1):397-404. Epub 2022 Oct 19 doi: 10.1002/ehf2.14188. PMID: 36259276Free PMC Article
COVID-19 associated EBV reactivation and effects of ganciclovir treatment.
Meng M, Zhang S, Dong X, Sun W, Deng Y, Li W, Li R, Annane D, Wu Z, Chen D
Immun Inflamm Dis 2022 Apr;10(4):e597. doi: 10.1002/iid3.597. PMID: 35349757Free PMC Article
Early versus delayed oral feeding after gastrectomy for gastric cancer: A systematic review and meta-analysis.
He H, Ma Y, Zheng Z, Deng X, Zhu J, Wang Y
Int J Nurs Stud 2022 Feb;126:104120. Epub 2021 Oct 28 doi: 10.1016/j.ijnurstu.2021.104120. PMID: 34910976
Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
Kaufman MJ, Kanayama G, Hudson JI, Pope HG Jr
Neurosci Biobehav Rev 2019 May;100:180-207. Epub 2019 Feb 25 doi: 10.1016/j.neubiorev.2019.02.014. PMID: 30817935Free PMC Article
Perioperative Nutritional Optimization in Spine Surgery.
Qureshi R, Rasool M, Puvanesarajah V, Hassanzadeh H
Clin Spine Surg 2018 Apr;31(3):103-107. doi: 10.1097/BSD.0000000000000579. PMID: 29596212

Diagnosis

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.
Liberman K, Njemini R, Luiking Y, Forti LN, Verlaan S, Bauer JM, Memelink R, Brandt K, Donini LM, Maggio M, Mets T, Wijers SLJ, Sieber C, Cederholm T, Bautmans I
Aging Clin Exp Res 2019 Jun;31(6):845-854. Epub 2019 May 2 doi: 10.1007/s40520-019-01208-4. PMID: 31049877Free PMC Article
Plasma Transthyretin as A Biomarker of Sarcopenia in Elderly Subjects.
Ingenbleek Y
Nutrients 2019 Apr 21;11(4) doi: 10.3390/nu11040895. PMID: 31010086Free PMC Article
Association Between Serum Prealbumin Level and Outcomes in Prevalent Kidney Transplant Recipients.
Gaipov A, Jackson CD, Talwar M, Balaraman V, Chakravarty A, Cseprekal O, Mathe Z, Remport A, Kovesdy CP, Eason JD, Mucsi I, Molnar MZ
J Ren Nutr 2019 May;29(3):188-195. Epub 2019 Feb 26 doi: 10.1053/j.jrn.2019.01.003. PMID: 30819599
Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
Kaufman MJ, Kanayama G, Hudson JI, Pope HG Jr
Neurosci Biobehav Rev 2019 May;100:180-207. Epub 2019 Feb 25 doi: 10.1016/j.neubiorev.2019.02.014. PMID: 30817935Free PMC Article
Serum albumin and prealbumin do not predict recurrence in patients with breast cancer.
Fujii T, Yajima R, Takada T, Sutoh T, Morita H, Yamaguchi S, Tsutsumi S, Kuwano H
Anticancer Res 2014 Jul;34(7):3775-9. PMID: 24982401

Therapy

SGLT2 inhibitor therapy for transthyretin amyloid cardiomyopathy: early tolerance and clinical response to dapagliflozin.
Dobner S, Bernhard B, Asatryan B, Windecker S, Stortecky S, Pilgrim T, Gräni C, Hunziker L
ESC Heart Fail 2023 Feb;10(1):397-404. Epub 2022 Oct 19 doi: 10.1002/ehf2.14188. PMID: 36259276Free PMC Article
COVID-19 associated EBV reactivation and effects of ganciclovir treatment.
Meng M, Zhang S, Dong X, Sun W, Deng Y, Li W, Li R, Annane D, Wu Z, Chen D
Immun Inflamm Dis 2022 Apr;10(4):e597. doi: 10.1002/iid3.597. PMID: 35349757Free PMC Article
Early versus delayed oral feeding after gastrectomy for gastric cancer: A systematic review and meta-analysis.
He H, Ma Y, Zheng Z, Deng X, Zhu J, Wang Y
Int J Nurs Stud 2022 Feb;126:104120. Epub 2021 Oct 28 doi: 10.1016/j.ijnurstu.2021.104120. PMID: 34910976
Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.
Liberman K, Njemini R, Luiking Y, Forti LN, Verlaan S, Bauer JM, Memelink R, Brandt K, Donini LM, Maggio M, Mets T, Wijers SLJ, Sieber C, Cederholm T, Bautmans I
Aging Clin Exp Res 2019 Jun;31(6):845-854. Epub 2019 May 2 doi: 10.1007/s40520-019-01208-4. PMID: 31049877Free PMC Article
Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?
Kaufman MJ, Kanayama G, Hudson JI, Pope HG Jr
Neurosci Biobehav Rev 2019 May;100:180-207. Epub 2019 Feb 25 doi: 10.1016/j.neubiorev.2019.02.014. PMID: 30817935Free PMC Article

Prognosis

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.
Liberman K, Njemini R, Luiking Y, Forti LN, Verlaan S, Bauer JM, Memelink R, Brandt K, Donini LM, Maggio M, Mets T, Wijers SLJ, Sieber C, Cederholm T, Bautmans I
Aging Clin Exp Res 2019 Jun;31(6):845-854. Epub 2019 May 2 doi: 10.1007/s40520-019-01208-4. PMID: 31049877Free PMC Article
Perioperative Nutritional Optimization in Spine Surgery.
Qureshi R, Rasool M, Puvanesarajah V, Hassanzadeh H
Clin Spine Surg 2018 Apr;31(3):103-107. doi: 10.1097/BSD.0000000000000579. PMID: 29596212
Serum micronutrients and prealbumin during development and recovery of chemotherapy-induced peripheral neuropathy.
Velasco R, Santos C, Soler G, Gil-Gil M, Pernas S, Galan M, Palmero R, Bruna J
J Peripher Nerv Syst 2016 Sep;21(3):134-41. doi: 10.1111/jns.12177. PMID: 27282616
Serum albumin and prealbumin do not predict recurrence in patients with breast cancer.
Fujii T, Yajima R, Takada T, Sutoh T, Morita H, Yamaguchi S, Tsutsumi S, Kuwano H
Anticancer Res 2014 Jul;34(7):3775-9. PMID: 24982401
Prealbumin is not sensitive indicator of nutrition and prognosis in critical ill patients.
Lim SH, Lee JS, Chae SH, Ahn BS, Chang DJ, Shin CS
Yonsei Med J 2005 Feb 28;46(1):21-6. doi: 10.3349/ymj.2005.46.1.21. PMID: 15744801Free PMC Article

Clinical prediction guides

SGLT2 inhibitor therapy for transthyretin amyloid cardiomyopathy: early tolerance and clinical response to dapagliflozin.
Dobner S, Bernhard B, Asatryan B, Windecker S, Stortecky S, Pilgrim T, Gräni C, Hunziker L
ESC Heart Fail 2023 Feb;10(1):397-404. Epub 2022 Oct 19 doi: 10.1002/ehf2.14188. PMID: 36259276Free PMC Article
Mental health status and quality of life in patients with end-stage renal disease undergoing maintenance hemodialysis.
Ma SJ, Wang WJ, Tang M, Chen H, Ding F
Ann Palliat Med 2021 Jun;10(6):6112-6121. Epub 2021 May 26 doi: 10.21037/apm-20-2211. PMID: 34118836
Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.
Liberman K, Njemini R, Luiking Y, Forti LN, Verlaan S, Bauer JM, Memelink R, Brandt K, Donini LM, Maggio M, Mets T, Wijers SLJ, Sieber C, Cederholm T, Bautmans I
Aging Clin Exp Res 2019 Jun;31(6):845-854. Epub 2019 May 2 doi: 10.1007/s40520-019-01208-4. PMID: 31049877Free PMC Article
Association Between Serum Prealbumin Level and Outcomes in Prevalent Kidney Transplant Recipients.
Gaipov A, Jackson CD, Talwar M, Balaraman V, Chakravarty A, Cseprekal O, Mathe Z, Remport A, Kovesdy CP, Eason JD, Mucsi I, Molnar MZ
J Ren Nutr 2019 May;29(3):188-195. Epub 2019 Feb 26 doi: 10.1053/j.jrn.2019.01.003. PMID: 30819599
Perioperative Nutritional Optimization in Spine Surgery.
Qureshi R, Rasool M, Puvanesarajah V, Hassanzadeh H
Clin Spine Surg 2018 Apr;31(3):103-107. doi: 10.1097/BSD.0000000000000579. PMID: 29596212

Recent systematic reviews

Early versus delayed oral feeding after gastrectomy for gastric cancer: A systematic review and meta-analysis.
He H, Ma Y, Zheng Z, Deng X, Zhu J, Wang Y
Int J Nurs Stud 2022 Feb;126:104120. Epub 2021 Oct 28 doi: 10.1016/j.ijnurstu.2021.104120. PMID: 34910976
The association between serum prealbumin and poor outcome in COVID-19 - Systematic review and meta-analysis.
Akbar MR, Pranata R, Wibowo A, Lim MA, Sihite TA, Martha JW
Eur Rev Med Pharmacol Sci 2021 May;25(10):3879-3885. doi: 10.26355/eurrev_202105_25955. PMID: 34109596
Impact of Early Enteral Nutrition on Nutritional and Immunological Outcomes of Gastric Cancer Patients Undergoing Gastrostomy: A Systematic Review and Meta-Analysis.
Nikniaz Z, Somi MH, Nagashi S, Nikniaz L
Nutr Cancer 2017 Jul;69(5):693-701. Epub 2017 Jun 1 doi: 10.1080/01635581.2017.1324996. PMID: 28569563
Androgens for the anaemia of chronic kidney disease in adults.
Yang Q, Abudou M, Xie XS, Wu T
Cochrane Database Syst Rev 2014 Oct 9;(10):CD006881. doi: 10.1002/14651858.CD006881.pub2. PMID: 25300168
Effect of statins on chronic inflammation and nutrition status in renal dialysis patients: a systematic review and meta-analysis.
Deng J, Wu Q, Liao Y, Huo D, Yang Z
Nephrology (Carlton) 2012 Aug;17(6):545-51. doi: 10.1111/j.1440-1797.2012.01597.x. PMID: 22429568

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