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Dicentric chromosome

MedGen UID:
137691
Concept ID:
C0333710
Cell or Molecular Dysfunction
Synonyms: Dicentric; Dicentric Chromosome
SNOMED CT: Dicentric chromosome (2289007)

Definition

An abnormal chromosome with two centromeres as opposed to the normal one centromere. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDicentric chromosome

Professional guidelines

PubMed

Lee YH, Yoon HJ, Yang SS, Lee IK, Jo WS, Jeong SK, Oh SJ, Kim J, Lee Y, Seong KM
Int J Radiat Biol 2024;100(5):709-714. Epub 2024 Feb 23 doi: 10.1080/09553002.2024.2316603. PMID: 38394348
M'kacher R, Colicchio B, Borie C, Junker S, Marquet V, Heidingsfelder L, Soehnlen K, Najar W, Hempel WM, Oudrhiri N, Wilhelm-Murer N, Miguet M, Arnoux M, Ferrapie C, Kerbrat W, Plesch A, Dieterlen A, Girinsky T, Voisin P, Deschenes G, Tabet AC, Yardin C, Bennaceur-Griscelli A, Fenech M, Carde P, Jeandidier E
Genes (Basel) 2020 Apr 27;11(5) doi: 10.3390/genes11050475. PMID: 32349350Free PMC Article
Chimeno JM, Sebastià N, Torres-Espallardo I, Balaguer J, Candela-Juan C, Loaiza JL, Adria M, Ibanez-Rosello B, Cañete A, Martí-Bonmatí L, Montoro A
Int J Radiat Biol 2019 Mar;95(3):314-320. Epub 2019 Jan 11 doi: 10.1080/09553002.2019.1549755. PMID: 30496023

Recent clinical studies

Etiology

Agarwal N, Rathi AK, Kapoor S, Singh K, Arora S, Jindal A, Prabhat K, Kaushik H
J Cancer Res Ther 2024 Jan 1;20(1):321-326. Epub 2023 Apr 6 doi: 10.4103/jcrt.jcrt_2058_22. PMID: 38554341
Ma Y, Guo L, Fang L, Hou D, Chen R, Wang X, Mao X, Zhao Z, Chen Y
Mutat Res Genet Toxicol Environ Mutagen 2023 Jul;889:503653. Epub 2023 Jun 24 doi: 10.1016/j.mrgentox.2023.503653. PMID: 37491112
Herate C, Sabatier L
Mutat Res Rev Mutat Res 2020 Jan-Mar;783:108287. Epub 2019 Nov 8 doi: 10.1016/j.mrrev.2019.108287. PMID: 32192645
Ozar M, Ozar E, Koylu S, Taskin M
J Neurosurg Sci 2014 Mar;58(1):1-8. PMID: 24614786
Zuffardi O, Bonaglia M, Ciccone R, Giorda R
Clin Genet 2009 Jun;75(6):505-13. doi: 10.1111/j.1399-0004.2009.01187.x. PMID: 19508415

Diagnosis

M'kacher R, Colicchio B, Borie C, Junker S, Marquet V, Heidingsfelder L, Soehnlen K, Najar W, Hempel WM, Oudrhiri N, Wilhelm-Murer N, Miguet M, Arnoux M, Ferrapie C, Kerbrat W, Plesch A, Dieterlen A, Girinsky T, Voisin P, Deschenes G, Tabet AC, Yardin C, Bennaceur-Griscelli A, Fenech M, Carde P, Jeandidier E
Genes (Basel) 2020 Apr 27;11(5) doi: 10.3390/genes11050475. PMID: 32349350Free PMC Article
Ryan TL, Escalona MB, Smith TL, Albanese J, Iddins CJ, Balajee AS
Mutat Res Genet Toxicol Environ Mutagen 2019 Nov;847:503087. Epub 2019 Sep 23 doi: 10.1016/j.mrgentox.2019.503087. PMID: 31699339
Park JG, Paul S, Briones N, Zeng J, Gillis K, Wallstrom G, LaBaer J, Amundson SA
Radiat Res 2017 Jun;187(6):708-721. Epub 2017 Mar 22 doi: 10.1667/RR14655.1. PMID: 28328310Free PMC Article
Flood AB, Williams BB, Schreiber W, Du G, Wood VA, Kmiec MM, Petryakov SV, Demidenko E, Swartz HM; EPR Center Tooth Dosimetry Project Team
Radiat Prot Dosimetry 2016 Dec;172(1-3):72-80. Epub 2016 Jul 15 doi: 10.1093/rpd/ncw165. PMID: 27421468Free PMC Article
Papenhausen PR, Griffin S, Tepperberg J
Exp Mol Pathol 2005 Oct;79(2):168-75. doi: 10.1016/j.yexmp.2005.05.007. PMID: 16026782

Therapy

Vaziri S, Mirzaei M, Saba F, Salehi Zahabi K, Salehi Zahabi S, Arab-Zozani M
Expert Rev Hematol 2022 Jul;15(7):645-656. Epub 2022 Jul 14 doi: 10.1080/17474086.2022.2096001. PMID: 35786240
Hayes JM, Olson JD, Chino Y, Bourland JD, Cline JM, Johnson TE
Int J Radiat Biol 2022;98(5):913-923. Epub 2021 Nov 11 doi: 10.1080/09553002.2021.1998708. PMID: 34699313Free PMC Article
Sarova I, Brezinova J, Zemanova Z, Ransdorfova S, Izakova S, Svobodova K, Pavlistova L, Berkova A, Cermak J, Jonasova A, Siskova M, Michalova K
Leuk Res 2016 Apr;43:51-7. Epub 2016 Jan 8 doi: 10.1016/j.leukres.2016.01.001. PMID: 26821593
Gruel G, Grégoire E, Lecas S, Martin C, Roch-Lefevre S, Vaurijoux A, Voisin P, Voisin P, Barquinero JF
Radiat Res 2013 May;179(5):557-69. Epub 2013 Apr 5 doi: 10.1667/RR3196.1. PMID: 23560627
García O, Di Giorgio M, Vallerga MB, Radl A, Taja MR, Seoane A, De Luca J, Stuck Oliveira M, Valdivia P, Lamadrid AI, González JE, Romero I, Mandina T, Pantelias G, Terzoudi G, Guerrero-Carbajal C, Arceo Maldonado C, Espinoza M, Oliveros N, Martínez-López W, Di Tomaso MV, Méndez-Acuña L, Puig R, Roy L, Barquinero JF
Radiat Prot Dosimetry 2013 Apr;154(1):18-25. Epub 2012 Aug 5 doi: 10.1093/rpd/ncs139. PMID: 22869818

Prognosis

Sholom S, McKeever SWS, Escalona MB, Ryan TL, Balajee AS
J Radiol Prot 2022 Mar 22;42(2) doi: 10.1088/1361-6498/ac5815. PMID: 35196651
Park JG, Paul S, Briones N, Zeng J, Gillis K, Wallstrom G, LaBaer J, Amundson SA
Radiat Res 2017 Jun;187(6):708-721. Epub 2017 Mar 22 doi: 10.1667/RR14655.1. PMID: 28328310Free PMC Article
Sarova I, Brezinova J, Zemanova Z, Ransdorfova S, Izakova S, Svobodova K, Pavlistova L, Berkova A, Cermak J, Jonasova A, Siskova M, Michalova K
Leuk Res 2016 Apr;43:51-7. Epub 2016 Jan 8 doi: 10.1016/j.leukres.2016.01.001. PMID: 26821593
Ozar M, Ozar E, Koylu S, Taskin M
J Neurosurg Sci 2014 Mar;58(1):1-8. PMID: 24614786
Fujiwara M, Kamasaki H, Morita Y, Kamada M
Acta Paediatr Jpn 1992 Oct;34(5):534-8. doi: 10.1111/j.1442-200x.1992.tb01002.x. PMID: 1442026

Clinical prediction guides

Ferreira-Lucena LR, Xavier AISF, Netto AM, Magnata SSLP, Siqueira Lima G, Amaral A
Int J Radiat Biol 2024;100(7):1029-1040. Epub 2024 May 24 doi: 10.1080/09553002.2024.2356545. PMID: 38787719
Lee JJ, Jung YL, Cheong TC, Espejo Valle-Inclan J, Chu C, Gulhan DC, Ljungström V, Jin H, Viswanadham VV, Watson EV, Cortés-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJ
Nature 2023 Jun;618(7967):1024-1032. Epub 2023 May 17 doi: 10.1038/s41586-023-06057-w. PMID: 37198482Free PMC Article
Sholom S, McKeever SWS, Escalona MB, Ryan TL, Balajee AS
J Radiol Prot 2022 Mar 22;42(2) doi: 10.1088/1361-6498/ac5815. PMID: 35196651
Park JG, Paul S, Briones N, Zeng J, Gillis K, Wallstrom G, LaBaer J, Amundson SA
Radiat Res 2017 Jun;187(6):708-721. Epub 2017 Mar 22 doi: 10.1667/RR14655.1. PMID: 28328310Free PMC Article
Maciejowski J, Li Y, Bosco N, Campbell PJ, de Lange T
Cell 2015 Dec 17;163(7):1641-54. doi: 10.1016/j.cell.2015.11.054. PMID: 26687355Free PMC Article

Recent systematic reviews

Vaziri S, Mirzaei M, Saba F, Salehi Zahabi K, Salehi Zahabi S, Arab-Zozani M
Expert Rev Hematol 2022 Jul;15(7):645-656. Epub 2022 Jul 14 doi: 10.1080/17474086.2022.2096001. PMID: 35786240

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