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Dicentric chromosome

MedGen UID:
137691
Concept ID:
C0333710
Cell or Molecular Dysfunction
Synonyms: Dicentric; Dicentric Chromosome
SNOMED CT: Dicentric chromosome (2289007)

Definition

An abnormal chromosome with two centromeres as opposed to the normal one centromere. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDicentric chromosome

Professional guidelines

PubMed

M'kacher R, Colicchio B, Borie C, Junker S, Marquet V, Heidingsfelder L, Soehnlen K, Najar W, Hempel WM, Oudrhiri N, Wilhelm-Murer N, Miguet M, Arnoux M, Ferrapie C, Kerbrat W, Plesch A, Dieterlen A, Girinsky T, Voisin P, Deschenes G, Tabet AC, Yardin C, Bennaceur-Griscelli A, Fenech M, Carde P, Jeandidier E
Genes (Basel) 2020 Apr 27;11(5) doi: 10.3390/genes11050475. PMID: 32349350Free PMC Article
Chimeno JM, Sebastià N, Torres-Espallardo I, Balaguer J, Candela-Juan C, Loaiza JL, Adria M, Ibanez-Rosello B, Cañete A, Martí-Bonmatí L, Montoro A
Int J Radiat Biol 2019 Mar;95(3):314-320. Epub 2019 Jan 11 doi: 10.1080/09553002.2019.1549755. PMID: 30496023
Romm H, Wilkins RC, Coleman CN, Lillis-Hearne PK, Pellmar TC, Livingston GK, Awa AA, Jenkins MS, Yoshida MA, Oestreicher U, Prasanna PG
Radiat Res 2011 Mar;175(3):397-404. Epub 2011 Jan 4 doi: 10.1667/RR2321.1. PMID: 21388284

Recent clinical studies

Etiology

Endesfelder D, Oestreicher U, Bucher M, Beinke C, Siebenwirth C, Ainsbury E, Moquet J, Gruel G, Gregoire E, Martinez JS, Vral A, Baeyens A, Valente M, Montoro A, Terzoudi G, Triantopoulou S, Pantelias A, Monteiro Gil O, Prieto MJ, Domene MM, Zafiropoulos D, Barquinero JF, Pujol-Canadell M, Lumniczky K, Hargitai R, Kis E, Testa A, Patrono C, Sommer S, Hristova R, Kostova N, Atanasova M, Sevriukova O, Domínguez I, Pastor N, Güçlü I, Pajic J, Sabatier L, Brochard P, Tichy A, Milanova M, Finot F, Cuceu Petrenci C, Wilkins RC, Beaton-Green LA, Seong KM, Lee Y, Lee YH, Balajee AS, Maznyk N, Sypko T, Pham ND, Tran TM, Miura T, Suto Y, Akiyamam M, Tsuyama N, Abe Y, Goh VST, Chua CEL, Abend M, Port M
Radiat Res 2023 Jun 1;199(6):556-570. doi: 10.1667/RADE-22-00202.1. PMID: 37018160
Herate C, Sabatier L
Mutat Res Rev Mutat Res 2020 Jan-Mar;783:108287. Epub 2019 Nov 8 doi: 10.1016/j.mrrev.2019.108287. PMID: 32192645
Gomolka M, Oestreicher U, Rößler U, Samaga D, Endesfelder D, Lang P, Neumaier K, Belka C, Niemeyer M, Kiechle M, Hasbargen U, Hübener C, Kirlum HJ, Kulka U, Rosenberger A, Walsh L, Baatout S, Kesminiene A, Lindholm C
Int J Radiat Biol 2018 Mar;94(3):272-281. Epub 2018 Jan 25 doi: 10.1080/09553002.2018.1419302. PMID: 29319401
Oestreicher U, Samaga D, Ainsbury E, Antunes AC, Baeyens A, Barrios L, Beinke C, Beukes P, Blakely WF, Cucu A, De Amicis A, Depuydt J, De Sanctis S, Di Giorgio M, Dobos K, Dominguez I, Duy PN, Espinoza ME, Flegal FN, Figel M, Garcia O, Monteiro Gil O, Gregoire E, Guerrero-Carbajal C, Güçlü İ, Hadjidekova V, Hande P, Kulka U, Lemon J, Lindholm C, Lista F, Lumniczky K, Martinez-Lopez W, Maznyk N, Meschini R, M'kacher R, Montoro A, Moquet J, Moreno M, Noditi M, Pajic J, Radl A, Ricoul M, Romm H, Roy L, Sabatier L, Sebastià N, Slabbert J, Sommer S, Stuck Oliveira M, Subramanian U, Suto Y, Que T, Testa A, Terzoudi G, Vral A, Wilkins R, Yanti L, Zafiropoulos D, Wojcik A
Int J Radiat Biol 2017 Jan;93(1):20-29. Epub 2016 Oct 21 doi: 10.1080/09553002.2016.1233370. PMID: 27766931
Zuffardi O, Bonaglia M, Ciccone R, Giorda R
Clin Genet 2009 Jun;75(6):505-13. doi: 10.1111/j.1399-0004.2009.01187.x. PMID: 19508415

Diagnosis

M'kacher R, Colicchio B, Borie C, Junker S, Marquet V, Heidingsfelder L, Soehnlen K, Najar W, Hempel WM, Oudrhiri N, Wilhelm-Murer N, Miguet M, Arnoux M, Ferrapie C, Kerbrat W, Plesch A, Dieterlen A, Girinsky T, Voisin P, Deschenes G, Tabet AC, Yardin C, Bennaceur-Griscelli A, Fenech M, Carde P, Jeandidier E
Genes (Basel) 2020 Apr 27;11(5) doi: 10.3390/genes11050475. PMID: 32349350Free PMC Article
Herate C, Sabatier L
Mutat Res Rev Mutat Res 2020 Jan-Mar;783:108287. Epub 2019 Nov 8 doi: 10.1016/j.mrrev.2019.108287. PMID: 32192645
Ryan TL, Escalona MB, Smith TL, Albanese J, Iddins CJ, Balajee AS
Mutat Res Genet Toxicol Environ Mutagen 2019 Nov;847:503087. Epub 2019 Sep 23 doi: 10.1016/j.mrgentox.2019.503087. PMID: 31699339
De Amicis A, De Sanctis S, Di Cristofaro S, Franchini V, Regalbuto E, Mammana G, Lista F
Health Phys 2014 Jun;106(6):787-97. doi: 10.1097/HP.0000000000000097. PMID: 24776913
Zuffardi O, Bonaglia M, Ciccone R, Giorda R
Clin Genet 2009 Jun;75(6):505-13. doi: 10.1111/j.1399-0004.2009.01187.x. PMID: 19508415

Therapy

Balajee AS, Smith T, Ryan T, Escalona M, Dainiak N
Radiat Prot Dosimetry 2018 Dec 1;182(1):139-145. doi: 10.1093/rpd/ncy127. PMID: 30247729
Gomolka M, Oestreicher U, Rößler U, Samaga D, Endesfelder D, Lang P, Neumaier K, Belka C, Niemeyer M, Kiechle M, Hasbargen U, Hübener C, Kirlum HJ, Kulka U, Rosenberger A, Walsh L, Baatout S, Kesminiene A, Lindholm C
Int J Radiat Biol 2018 Mar;94(3):272-281. Epub 2018 Jan 25 doi: 10.1080/09553002.2018.1419302. PMID: 29319401
Abe Y, Miura T, Yoshida MA, Ujiie R, Kurosu Y, Kato N, Katafuchi A, Tsuyama N, Ohba T, Inamasu T, Shishido F, Noji H, Ogawa K, Yokouchi H, Kanazawa K, Ishida T, Muto S, Ohsugi J, Suzuki H, Ishikawa T, Kamiya K, Sakai A
Sci Rep 2015 Sep 9;5:13882. doi: 10.1038/srep13882. PMID: 26349546Free PMC Article
Andersen MK, Pedersen-Bjergaard J
Leukemia 2000 Jan;14(1):105-11. doi: 10.1038/sj.leu.2401594. PMID: 10637484
Vig BK
Southeast Asian J Trop Med Public Health 1995;26 Suppl 1:68-76. PMID: 8629145

Prognosis

Ingles ED, Deakin JE
Genes (Basel) 2020 Apr 28;11(5) doi: 10.3390/genes11050480. PMID: 32354058Free PMC Article
Shen X, Qi Y, Ma T, Zhou Z
Sci Rep 2019 Feb 19;9(1):2285. doi: 10.1038/s41598-019-38614-7. PMID: 30783206Free PMC Article
MacKinnon RN, Duivenvoorden HM, Campbell LJ, Wall M
Cytogenet Genome Res 2016;150(3-4):262-272. Epub 2017 Mar 4 doi: 10.1159/000456677. PMID: 28259884
Jarosova M, Volejnikova J, Porizkova I, Holzerova M, Pospisilova D, Novak Z, Vrbkova J, Mihal V
Cancer Genet 2016 Jul-Aug;209(7-8):340-7. Epub 2016 Jun 11 doi: 10.1016/j.cancergen.2016.06.004. PMID: 27341996
Li Y, Knoll JH, Wilkins RC, Flegal FN, Rogan PK
Microsc Res Tech 2016 May;79(5):393-402. Epub 2016 Mar 1 doi: 10.1002/jemt.22642. PMID: 26929213

Clinical prediction guides

Lee JJ, Jung YL, Cheong TC, Espejo Valle-Inclan J, Chu C, Gulhan DC, Ljungström V, Jin H, Viswanadham VV, Watson EV, Cortés-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJ
Nature 2023 Jun;618(7967):1024-1032. Epub 2023 May 17 doi: 10.1038/s41586-023-06057-w. PMID: 37198482Free PMC Article
Lee Y, Kim SH, Lee YH, Yang SS, Yoon HJ, Wilkins RC, Jang S
Front Public Health 2022;10:1002501. Epub 2022 Oct 20 doi: 10.3389/fpubh.2022.1002501. PMID: 36339161Free PMC Article
M'kacher R, Colicchio B, Borie C, Junker S, Marquet V, Heidingsfelder L, Soehnlen K, Najar W, Hempel WM, Oudrhiri N, Wilhelm-Murer N, Miguet M, Arnoux M, Ferrapie C, Kerbrat W, Plesch A, Dieterlen A, Girinsky T, Voisin P, Deschenes G, Tabet AC, Yardin C, Bennaceur-Griscelli A, Fenech M, Carde P, Jeandidier E
Genes (Basel) 2020 Apr 27;11(5) doi: 10.3390/genes11050475. PMID: 32349350Free PMC Article
Kato TA
Methods Mol Biol 2019;1984:1-6. doi: 10.1007/978-1-4939-9432-8_1. PMID: 31267414
Shen X, Qi Y, Ma T, Zhou Z
Sci Rep 2019 Feb 19;9(1):2285. doi: 10.1038/s41598-019-38614-7. PMID: 30783206Free PMC Article

Recent systematic reviews

Vaziri S, Mirzaei M, Saba F, Salehi Zahabi K, Salehi Zahabi S, Arab-Zozani M
Expert Rev Hematol 2022 Jul;15(7):645-656. Epub 2022 Jul 14 doi: 10.1080/17474086.2022.2096001. PMID: 35786240

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