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Intraductal hyperplasia

MedGen UID:
137709
•Concept ID:
C0333994
•
Pathologic Function
Synonyms: Ductal Hyperplasia; Intraductal Hyperplasia
SNOMED CT: Intraductal hyperplasia (67617000)

Definition

A hyperplasia of the intraductal cells. [from NCI]

Professional guidelines

PubMed

Cytological criteria for the diagnosis of intraductal hyperplasia, ductal carcinoma in situ, and invasive carcinoma of the breast.
Bofin AM, Lydersen S, Hagmar BM
Diagn Cytopathol 2004 Oct;31(4):207-15. doi: 10.1002/dc.20098. PMID: 15452908
Diagnosis and management of cystic pancreatic tumours with mucin production.
Shima Y, Mori M, Takakura N, Kimura T, Yagi T, Tanaka N
Br J Surg 2000 Aug;87(8):1041-7. doi: 10.1046/j.1365-2168.2000.01496.x. PMID: 10931048
Intraductal proliferations of the breast: a review of histologic criteria for atypical intraductal hyperplasia and ductal carcinoma in situ, including apocrine and papillary lesions.
Purcell CA, Norris HJ
Ann Diagn Pathol 1998 Apr;2(2):135-45. doi: 10.1016/s1092-9134(98)80051-8. PMID: 9845731

Recent clinical studies

Etiology

Premalignant breast lesions: role for biological markers in predicting progression to cancer.
Stoll BA
Eur J Cancer 1999 May;35(5):693-7. doi: 10.1016/s0959-8049(99)00026-x. PMID: 10505026
Intraductal proliferations of the breast: a review of histologic criteria for atypical intraductal hyperplasia and ductal carcinoma in situ, including apocrine and papillary lesions.
Purcell CA, Norris HJ
Ann Diagn Pathol 1998 Apr;2(2):135-45. doi: 10.1016/s1092-9134(98)80051-8. PMID: 9845731
Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia.
Tavassoli FA
Mod Pathol 1998 Feb;11(2):140-54. PMID: 9504685
A comparison of the results of long-term follow-up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast.
Tavassoli FA, Norris HJ
Cancer 1990 Feb 1;65(3):518-29. doi: 10.1002/1097-0142(19900201)65:3<518::aid-cncr2820650324>3.0.co;2-o. PMID: 2297643
A comparative morphometric and cytophotometric study of intraductal hyperplasia and intraductal carcinoma of the breast.
Norris HJ, Bahr GF, Mikel UV
Anal Quant Cytol Histol 1988 Feb;10(1):1-9. PMID: 2833287

Diagnosis

C-Erb-b2 oncogene expression in intraductal proliferative lesions of the breast.
Eren F, Calay Z, Durak H, Eren B, Comunoğlu N, Aydin O
Bosn J Basic Med Sci 2012 Feb;12(1):41-50. doi: 10.17305/bjbms.2012.2533. PMID: 22364303Free PMC Article
DEK overexpression is correlated with the clinical features of breast cancer.
Liu S, Wang X, Sun F, Kong J, Li Z, Lin Z
Pathol Int 2012 Mar;62(3):176-81. Epub 2012 Jan 13 doi: 10.1111/j.1440-1827.2011.02775.x. PMID: 22360505
Cytological criteria for the diagnosis of intraductal hyperplasia, ductal carcinoma in situ, and invasive carcinoma of the breast.
Bofin AM, Lydersen S, Hagmar BM
Diagn Cytopathol 2004 Oct;31(4):207-15. doi: 10.1002/dc.20098. PMID: 15452908
Premalignant breast lesions: role for biological markers in predicting progression to cancer.
Stoll BA
Eur J Cancer 1999 May;35(5):693-7. doi: 10.1016/s0959-8049(99)00026-x. PMID: 10505026
Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia.
Tavassoli FA
Mod Pathol 1998 Feb;11(2):140-54. PMID: 9504685

Therapy

Giant fibroadenomatoid hyperplasia of the breast: a case report.
Zhang H, Wang XL, Ren WD, Shi TM
Gynecol Obstet Invest 2014;77(2):134-6. Epub 2014 Feb 5 doi: 10.1159/000357443. PMID: 24504257

Prognosis

C-Erb-b2 oncogene expression in intraductal proliferative lesions of the breast.
Eren F, Calay Z, Durak H, Eren B, Comunoğlu N, Aydin O
Bosn J Basic Med Sci 2012 Feb;12(1):41-50. doi: 10.17305/bjbms.2012.2533. PMID: 22364303Free PMC Article
DEK overexpression is correlated with the clinical features of breast cancer.
Liu S, Wang X, Sun F, Kong J, Li Z, Lin Z
Pathol Int 2012 Mar;62(3):176-81. Epub 2012 Jan 13 doi: 10.1111/j.1440-1827.2011.02775.x. PMID: 22360505
Genetic alterations in presumptive precursor lesions of breast carcinomas.
Aubele M, Werner M, Höfler H
Anal Cell Pathol 2002;24(2-3):69-76. doi: 10.1155/2002/371680. PMID: 12446956Free PMC Article
Premalignant breast lesions: role for biological markers in predicting progression to cancer.
Stoll BA
Eur J Cancer 1999 May;35(5):693-7. doi: 10.1016/s0959-8049(99)00026-x. PMID: 10505026
A comparison of the results of long-term follow-up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast.
Tavassoli FA, Norris HJ
Cancer 1990 Feb 1;65(3):518-29. doi: 10.1002/1097-0142(19900201)65:3<518::aid-cncr2820650324>3.0.co;2-o. PMID: 2297643

Clinical prediction guides

Acidophilic nuclear inclusions are specific for florid ductal hyperplasia among proliferative breast lesions.
Lauer S, Oprea-Ilies G, Cohen C, Adsay V, Adams AL
Arch Pathol Lab Med 2011 Jun;135(6):766-9. doi: 10.5858/2010-0377-OA.1. PMID: 21631270
Expression of CD44s, CD44v6, and hyaluronan across the spectrum of normal-hyperplasia-carcinoma in breast.
Afify A, McNiel MA, Braggin J, Bailey H, Paulino AF
Appl Immunohistochem Mol Morphol 2008 Mar;16(2):121-7. doi: 10.1097/PAI.0b013e318047df6d. PMID: 18227732
Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers.
Zhou X, Tan M, Stone Hawthorne V, Klos KS, Lan KH, Yang Y, Yang W, Smith TL, Shi D, Yu D
Clin Cancer Res 2004 Oct 15;10(20):6779-88. doi: 10.1158/1078-0432.CCR-04-0112. PMID: 15501954
Premalignant breast lesions: role for biological markers in predicting progression to cancer.
Stoll BA
Eur J Cancer 1999 May;35(5):693-7. doi: 10.1016/s0959-8049(99)00026-x. PMID: 10505026
Diagnostic error in breast disease.
Meyer KK
Am Surg 1975 Dec;41(12):774-85. PMID: 173216

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