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Glandular hyperplasia

MedGen UID:
137710
•Concept ID:
C0334000
•
Pathologic Function
Synonyms: Adenomatoid hyperplasia; Adenomatous hyperplasia; Glandular Hyperplasia
SNOMED CT: Glandular hyperplasia (23290009); Adenomatous hyperplasia (23290009); Adenomatoid hyperplasia (23290009)

Definition

Proliferation of the glandular epithelial cells. [from NCI]

Professional guidelines

PubMed

Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports.
Meserve EE, Nucci MR
Surg Pathol Clin 2016 Jun;9(2):243-68. doi: 10.1016/j.path.2016.01.006. PMID: 27241107
Histopathology, pathophysiology, and indications for surgical treatment of renal hyperparathyroidism.
Tominaga Y, Tanaka Y, Sato K, Nagasaka T, Takagi H
Semin Surg Oncol 1997 Mar-Apr;13(2):78-86. doi: 10.1002/(sici)1098-2388(199703/04)13:2<78::aid-ssu3>3.0.co;2-z. PMID: 9088063
Goserelin treatment in glandular hyperplasia.
Garozzo G, La Greca M, Lomeo E, Panella M
Clin Exp Obstet Gynecol 1993;20(4):268-72. PMID: 8281712

Recent clinical studies

Etiology

Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.
Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Chronic rhinosinusitis and age: is the pathogenesis different?
Mahdavinia M, Grammer LC 3rd
Expert Rev Anti Infect Ther 2013 Oct;11(10):1029-40. Epub 2013 Sep 27 doi: 10.1586/14787210.2013.839380. PMID: 24073878
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
Pathology of endometrioid carcinoma.
Albertini AF, Devouassoux-Shisheboran M, Genestie C
Bull Cancer 2012 Jan;99(1):7-12. doi: 10.1684/bdc.2011.1526. PMID: 22231875

Diagnosis

Biology and management of lobular endocervical glandular hyperplasia.
Miyamoto T, Kobara H, Shiozawa T
J Obstet Gynaecol Res 2022 Dec;48(12):3056-3067. Epub 2022 Sep 30 doi: 10.1111/jog.15441. PMID: 36177810Free PMC Article
The Evolving Spectrum of Precursor Lesions of Cervical Adenocarcinomas.
Stolnicu S, Talia KL, McCluggage WG
Adv Anat Pathol 2020 Sep;27(5):278-293. doi: 10.1097/PAP.0000000000000266. PMID: 32482967
Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.
Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Diffuse sebaceous-gland hyperplasia.
Gittler J, Penn L, Terushkin V, Brinster N
Dermatol Online J 2016 Dec 15;22(12) PMID: 28329552

Therapy

Progestogens versus oestrogens and progestogens for irregular uterine bleeding associated with anovulation.
Hickey M, Higham J, Fraser IS
Cochrane Database Syst Rev 2007 Oct 17;(4):CD001895. doi: 10.1002/14651858.CD001895.pub2. PMID: 17943761
Hormonal pathology of the endometrium.
Deligdisch L
Mod Pathol 2000 Mar;13(3):285-94. doi: 10.1038/modpathol.3880050. PMID: 10757339
Prevention of renal osteodystrophy in peritoneal dialysis.
Weinreich T
Kidney Int 1998 Dec;54(6):2226-33. doi: 10.1046/j.1523-1755.1998.00182.x. PMID: 9853289
Endometrial histology and biochemistry in climacteric women during oestrogen and oestrogen/progestogen therapy.
Whitehead MI, King RJ, McQueen J, Campbell S
J R Soc Med 1979 May;72(5):322-7. doi: 10.1177/014107687907200504. PMID: 552525Free PMC Article
Oestrogen-induced endometrial hyperplasia in gonadal dysgenesis.
de Koos EB
Proc R Soc Med 1974 Jun;67(7):590-1. PMID: 4853428Free PMC Article

Prognosis

Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.
Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
Pathology of endometrioid carcinoma.
Albertini AF, Devouassoux-Shisheboran M, Genestie C
Bull Cancer 2012 Jan;99(1):7-12. doi: 10.1684/bdc.2011.1526. PMID: 22231875

Clinical prediction guides

Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis.
Ko EK, Anderson A, D'souza C, Zou J, Huang S, Cho S, Alawi F, Prouty S, Lee V, Yoon S, Krick K, Horiuchi Y, Ge K, Seykora JT, Capell BC
Dev Cell 2024 Jan 22;59(2):187-198.e7. Epub 2024 Jan 9 doi: 10.1016/j.devcel.2023.12.007. PMID: 38198888Free PMC Article
Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics.
Holmes AD, Steinhoff M
Exp Dermatol 2017 Aug;26(8):659-667. Epub 2016 Oct 9 doi: 10.1111/exd.13143. PMID: 27376863
Characterization of fibrillar collagens and extracellular matrix of glandular benign prostatic hyperplasia nodules.
Bauman TM, Nicholson TM, Abler LL, Eliceiri KW, Huang W, Vezina CM, Ricke WA
PLoS One 2014;9(10):e109102. Epub 2014 Oct 2 doi: 10.1371/journal.pone.0109102. PMID: 25275645Free PMC Article
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085
Polypoid mucosa with eosinophilia and glandular hyperplasia in chronic sinusitis: a histopathological and immunohistochemical study.
Berger G, Kattan A, Bernheim J, Ophir D
Laryngoscope 2002 Apr;112(4):738-45. doi: 10.1097/00005537-200204000-00026. PMID: 12150532

Recent systematic reviews

Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines.
Gordhandas SB, Kahn R, Sassine D, Aviki EM, Baltich Nelson B, Catchings A, Liu YL, Lakhman Y, Abu-Rustum NR, Park KJ, Mueller JJ
Int J Gynecol Cancer 2022 Jan;32(1):79-88. Epub 2021 Dec 13 doi: 10.1136/ijgc-2021-002997. PMID: 34903560
Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: A Systematic Review.
Lee S, Sahasrabuddhe VV, Mendoza-Cervantes D, Zhao R, Duggan MA
Int J Gynecol Pathol 2018 Mar;37(2):128-140. doi: 10.1097/PGP.0000000000000406. PMID: 28582347
Progestogens versus oestrogens and progestogens for irregular uterine bleeding associated with anovulation.
Hickey M, Higham J, Fraser IS
Cochrane Database Syst Rev 2007 Oct 17;(4):CD001895. doi: 10.1002/14651858.CD001895.pub2. PMID: 17943761
Progestogens versus oestrogens and progestogens for irregular uterine bleeding associated with anovulation.
Hickey M, Higham J, Fraser IS
Cochrane Database Syst Rev 2000;(2):CD001895. doi: 10.1002/14651858.CD001895. PMID: 10796833

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