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Gastric metaplasia

MedGen UID:
137713
•Concept ID:
C0334038
•
Cell or Molecular Dysfunction
Synonym: Gastric Metaplasia
SNOMED CT: Gastric metaplasia (67986001)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric metaplasia

Professional guidelines

PubMed

Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728
Helicobacter pylori: phenotypes, genotypes and virulence genes.
Proença-Modena JL, Acrani GO, Brocchi M
Future Microbiol 2009 Mar;4(2):223-40. doi: 10.2217/17460913.4.2.223. PMID: 19257848
The application of Prague C and M criteria in the diagnosis of Barrett's esophagus in an ethnic Chinese population.
Chang CY, Lee YC, Lee CT, Tu CH, Hwang JC, Chiang H, Tai CM, Chiang TH, Wu MS, Lin JT
Am J Gastroenterol 2009 Jan;104(1):13-20. doi: 10.1038/ajg.2008.43. PMID: 19098843

Recent clinical studies

Etiology

Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients.
Rugge M, Bricca L, Guzzinati S, Sacchi D, Pizzi M, Savarino E, Farinati F, Zorzi M, Fassan M, Dei Tos AP, Malfertheiner P, Genta RM, Graham DY
Gut 2023 Jan;72(1):30-38. Epub 2022 Jun 30 doi: 10.1136/gutjnl-2022-327827. PMID: 35772926
Single-Cell Transcriptional Analyses Identify Lineage-Specific Epithelial Responses to Inflammation and Metaplastic Development in the Gastric Corpus.
Bockerstett KA, Lewis SA, Noto CN, Ford EL, Saenz JB, Jackson NM, Ahn TH, Mills JC, DiPaolo RJ
Gastroenterology 2020 Dec;159(6):2116-2129.e4. Epub 2020 Aug 21 doi: 10.1053/j.gastro.2020.08.027. PMID: 32835664Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Gastric carcinogenesis.
Gomceli I, Demiriz B, Tez M
World J Gastroenterol 2012 Oct 7;18(37):5164-70. doi: 10.3748/wjg.v18.i37.5164. PMID: 23066309Free PMC Article
Peptic ulcer pathophysiology.
Mertz HR, Walsh JH
Med Clin North Am 1991 Jul;75(4):799-814. doi: 10.1016/s0025-7125(16)30412-6. PMID: 2072787

Diagnosis

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS
Cell 2021 Dec 22;184(26):6262-6280.e26. Epub 2021 Dec 14 doi: 10.1016/j.cell.2021.11.031. PMID: 34910928Free PMC Article
Gastritis: The clinico-pathological spectrum.
Rugge M, Savarino E, Sbaraglia M, Bricca L, Malfertheiner P
Dig Liver Dis 2021 Oct;53(10):1237-1246. Epub 2021 Mar 28 doi: 10.1016/j.dld.2021.03.007. PMID: 33785282
Single-Cell Transcriptional Analyses Identify Lineage-Specific Epithelial Responses to Inflammation and Metaplastic Development in the Gastric Corpus.
Bockerstett KA, Lewis SA, Noto CN, Ford EL, Saenz JB, Jackson NM, Ahn TH, Mills JC, DiPaolo RJ
Gastroenterology 2020 Dec;159(6):2116-2129.e4. Epub 2020 Aug 21 doi: 10.1053/j.gastro.2020.08.027. PMID: 32835664Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Gastric carcinogenesis.
Gomceli I, Demiriz B, Tez M
World J Gastroenterol 2012 Oct 7;18(37):5164-70. doi: 10.3748/wjg.v18.i37.5164. PMID: 23066309Free PMC Article

Therapy

GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia.
Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Kurokawa K, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K
Gastroenterology 2020 May;158(6):1650-1666.e15. Epub 2020 Feb 4 doi: 10.1053/j.gastro.2020.01.046. PMID: 32032583Free PMC Article
MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia.
Li T, Guo H, Li H, Jiang Y, Zhuang K, Lei C, Wu J, Zhou H, Zhu R, Zhao X, Lu Y, Shi C, Nie Y, Wu K, Yuan Z, Fan DM, Shi Y
Gut 2019 Oct;68(10):1751-1763. Epub 2019 Jan 11 doi: 10.1136/gutjnl-2017-315318. PMID: 30635407Free PMC Article
Duodenal gastric metaplasia and Helicobacter pylori infection in patients with diffuse nodular duodenitis.
Li XB, Ge ZZ, Chen XY, Liu WZ
Braz J Med Biol Res 2007 Jul;40(7):897-902. doi: 10.1590/s0100-879x2006005000117. PMID: 17653441
Peptic ulcer and Helicobacter pylori: eradication and relapse.
Tytgat GN
Scand J Gastroenterol Suppl 1995;210:70-2. doi: 10.3109/00365529509090275. PMID: 8578212
Helicobacter-associated duodenitis and gastric metaplasia in duodenal ulcer patients.
Madsen JE, Vetvik K, Aase S
APMIS 1991 Nov;99(11):997-1000. doi: 10.1111/j.1699-0463.1991.tb01291.x. PMID: 1683540

Prognosis

Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients.
Rugge M, Bricca L, Guzzinati S, Sacchi D, Pizzi M, Savarino E, Farinati F, Zorzi M, Fassan M, Dei Tos AP, Malfertheiner P, Genta RM, Graham DY
Gut 2023 Jan;72(1):30-38. Epub 2022 Jun 30 doi: 10.1136/gutjnl-2022-327827. PMID: 35772926
Gastritis: The clinico-pathological spectrum.
Rugge M, Savarino E, Sbaraglia M, Bricca L, Malfertheiner P
Dig Liver Dis 2021 Oct;53(10):1237-1246. Epub 2021 Mar 28 doi: 10.1016/j.dld.2021.03.007. PMID: 33785282
Single-Cell Transcriptional Analyses Identify Lineage-Specific Epithelial Responses to Inflammation and Metaplastic Development in the Gastric Corpus.
Bockerstett KA, Lewis SA, Noto CN, Ford EL, Saenz JB, Jackson NM, Ahn TH, Mills JC, DiPaolo RJ
Gastroenterology 2020 Dec;159(6):2116-2129.e4. Epub 2020 Aug 21 doi: 10.1053/j.gastro.2020.08.027. PMID: 32835664Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728

Clinical prediction guides

Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients.
Rugge M, Bricca L, Guzzinati S, Sacchi D, Pizzi M, Savarino E, Farinati F, Zorzi M, Fassan M, Dei Tos AP, Malfertheiner P, Genta RM, Graham DY
Gut 2023 Jan;72(1):30-38. Epub 2022 Jun 30 doi: 10.1136/gutjnl-2022-327827. PMID: 35772926
SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.
Liu X, Li T, Ma Z, Riederer B, Yuan D, Zhu J, Li Y, An J, Wen G, Jin H, Yang X, Seidler U, Tuo B
Cell Oncol (Dordr) 2022 Jun;45(3):381-398. Epub 2022 Apr 14 doi: 10.1007/s13402-022-00672-x. PMID: 35426084Free PMC Article
Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa.
Caldwell B, Meyer AR, Weis JA, Engevik AC, Choi E
Gut 2022 Jun;71(6):1068-1077. Epub 2021 Sep 8 doi: 10.1136/gutjnl-2021-325310. PMID: 34497145Free PMC Article
Single-Cell Transcriptional Analyses Identify Lineage-Specific Epithelial Responses to Inflammation and Metaplastic Development in the Gastric Corpus.
Bockerstett KA, Lewis SA, Noto CN, Ford EL, Saenz JB, Jackson NM, Ahn TH, Mills JC, DiPaolo RJ
Gastroenterology 2020 Dec;159(6):2116-2129.e4. Epub 2020 Aug 21 doi: 10.1053/j.gastro.2020.08.027. PMID: 32835664Free PMC Article
Esophageal atresia: metaplasia, Barrett.
Schneider A, Michaud L, Gottrand F
Dis Esophagus 2013 May-Jun;26(4):425-7. doi: 10.1111/dote.12057. PMID: 23679037

Recent systematic reviews

Qualitative analysis of anatomopathological changes of gastric mucosa due to long term therapy with proton pump inhibitors: experimental studies x clinical studies.
de Souza IK, da Silva AL, de Araújo A Jr, Santos FC, Mendonça BP
Arq Bras Cir Dig 2013 Nov-Dec;26(4):328-34. doi: 10.1590/s0102-67202013000400015. PMID: 24510044

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