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Polyposis

MedGen UID:
137722
•Concept ID:
C0334108
•
Neoplastic Process
Synonyms: Multiple polyps; Multiple Polyps; multiple polyps; polyposis
SNOMED CT: Multiple polyps (9499001); Polyposis (9499001)
 
Monarch Initiative: MONDO:0000147

Definition

A condition characterized by the presence of numerous polyps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyposis

Professional guidelines

PubMed

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force, Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, Donahue KE, Doubeni CA, Krist AH, Kubik M, Li L, Ogedegbe G, Owens DK, Pbert L, Silverstein M, Stevermer J, Tseng CW, Wong JB
JAMA 2021 May 18;325(19):1965-1977. doi: 10.1001/jama.2021.6238. PMID: 34003218
Evidence-based clinical practice guidelines for management of colorectal polyps.
Tanaka S, Saitoh Y, Matsuda T, Igarashi M, Matsumoto T, Iwao Y, Suzuki Y, Nozaki R, Sugai T, Oka S, Itabashi M, Sugihara KI, Tsuruta O, Hirata I, Nishida H, Miwa H, Enomoto N, Shimosegawa T, Koike K
J Gastroenterol 2021 Apr;56(4):323-335. Epub 2021 Mar 12 doi: 10.1007/s00535-021-01776-1. PMID: 33710392Free PMC Article
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW; American College of Gastroenterology
Am J Gastroenterol 2015 Feb;110(2):223-62; quiz 263. Epub 2015 Feb 3 doi: 10.1038/ajg.2014.435. PMID: 25645574Free PMC Article

Recent clinical studies

Etiology

Management of familial adenomatous polyposis and MUTYH-associated polyposis; new insights.
Aelvoet AS, Buttitta F, Ricciardiello L, Dekker E
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101793. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101793. PMID: 35988966
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Update on genetic predisposition to colorectal cancer and polyposis.
Valle L, de Voer RM, Goldberg Y, Sjursen W, Försti A, Ruiz-Ponte C, Caldés T, Garré P, Olsen MF, Nordling M, Castellvi-Bel S, Hemminki K
Mol Aspects Med 2019 Oct;69:10-26. Epub 2019 Mar 18 doi: 10.1016/j.mam.2019.03.001. PMID: 30862463
Pathology and genetics of hereditary colorectal cancer.
Ma H, Brosens LAA, Offerhaus GJA, Giardiello FM, de Leng WWJ, Montgomery EA
Pathology 2018 Jan;50(1):49-59. Epub 2017 Nov 21 doi: 10.1016/j.pathol.2017.09.004. PMID: 29169633
Familial adenomatous polyposis.
Half E, Bercovich D, Rozen P
Orphanet J Rare Dis 2009 Oct 12;4:22. doi: 10.1186/1750-1172-4-22. PMID: 19822006Free PMC Article

Diagnosis

Management of familial adenomatous polyposis and MUTYH-associated polyposis; new insights.
Aelvoet AS, Buttitta F, Ricciardiello L, Dekker E
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101793. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101793. PMID: 35988966
Serrated polyposis syndrome; epidemiology and management.
Carballal S, Balaguer F, IJspeert JEG
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101791. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101791. PMID: 35988960
How many is too many? Polyposis syndromes and what to do next.
Gupta N, Drogan C, Kupfer SS
Curr Opin Gastroenterol 2022 Jan 1;38(1):39-47. doi: 10.1097/MOG.0000000000000796. PMID: 34839308Free PMC Article
Cronkhite-Canada Syndrome.
Kwon J, Fluxá-Cardenas D, Francis D
Clin Gastroenterol Hepatol 2022 Jun;20(6):e1224-e1225. Epub 2021 Sep 4 doi: 10.1016/j.cgh.2021.08.054. PMID: 34492384
MutYH-associated polyposis.
Toboeva MK, Shelygin YA, Frolov SA, Kuzminov MA, Tsukanov AS
Ter Arkh 2019 Mar 18;91(2):97-100. doi: 10.26442/00403660.2019.02.000124. PMID: 31094179

Therapy

Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: A randomized, placebo-controlled trial.
Bachert C, Han JK, Desrosiers MY, Gevaert P, Heffler E, Hopkins C, Tversky JR, Barker P, Cohen D, Emson C, Martin UJ, Shih VH, Necander S, Kreindler JL, Jison M, Werkström V
J Allergy Clin Immunol 2022 Apr;149(4):1309-1317.e12. Epub 2021 Sep 29 doi: 10.1016/j.jaci.2021.08.030. PMID: 34599979
Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases.
Hamilton JD, Harel S, Swanson BN, Brian W, Chen Z, Rice MS, Amin N, Ardeleanu M, Radin A, Shumel B, Ruddy M, Patel N, Pirozzi G, Mannent L, Graham NMH
Clin Exp Allergy 2021 Jul;51(7):915-931. Epub 2021 Jun 26 doi: 10.1111/cea.13954. PMID: 34037993Free PMC Article
Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.
Harrison TW, Chanez P, Menzella F, Canonica GW, Louis R, Cosio BG, Lugogo NL, Mohan A, Burden A, McDermott L, Garcia Gil E, Zangrilli JG; ANDHI study investigators
Lancet Respir Med 2021 Mar;9(3):260-274. Epub 2020 Dec 22 doi: 10.1016/S2213-2600(20)30414-8. PMID: 33357499
Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer.
Cheng X, Xu X, Chen D, Zhao F, Wang W
Biomed Pharmacother 2019 Feb;110:473-481. Epub 2018 Dec 6 doi: 10.1016/j.biopha.2018.11.082. PMID: 30530050
Celecoxib in Cancer Therapy and Prevention - Review.
Tołoczko-Iwaniuk N, Dziemiańczyk-Pakieła D, Nowaszewska BK, Celińska-Janowicz K, Miltyk W
Curr Drug Targets 2019;20(3):302-315. doi: 10.2174/1389450119666180803121737. PMID: 30073924

Prognosis

Colorectal Cancer in Younger Adults.
Dharwadkar P, Zaki TA, Murphy CC
Hematol Oncol Clin North Am 2022 Jun;36(3):449-470. Epub 2022 May 13 doi: 10.1016/j.hoc.2022.02.005. PMID: 35577711Free PMC Article
Vasculitis of the upper airways.
Pagnoux C, Wolter NE
Swiss Med Wkly 2012;142:w13541. Epub 2012 Mar 19 doi: 10.4414/smw.2012.13541. PMID: 22430874
Familial adenomatous polyposis.
Galiatsatos P, Foulkes WD
Am J Gastroenterol 2006 Feb;101(2):385-98. doi: 10.1111/j.1572-0241.2006.00375.x. PMID: 16454848
Muir-Torre syndrome.
Ponti G, Ponz de Leon M
Lancet Oncol 2005 Dec;6(12):980-7. doi: 10.1016/S1470-2045(05)70465-4. PMID: 16321766
Desmoid tumors.
Biermann JS
Curr Treat Options Oncol 2000 Aug;1(3):262-6. doi: 10.1007/s11864-000-0038-5. PMID: 12057169

Clinical prediction guides

A comparative analysis of endoscopic sinus surgery versus biologics for treatment of chronic rhinosinusitis with nasal polyposis.
Miglani A, Soler ZM, Smith TL, Mace JC, Schlosser RJ
Int Forum Allergy Rhinol 2023 Feb;13(2):116-128. Epub 2022 Sep 4 doi: 10.1002/alr.23059. PMID: 35980852Free PMC Article
Biologic Therapies for Allergic Rhinitis and Nasal Polyposis.
Geng B, Dilley M, Anterasian C
Curr Allergy Asthma Rep 2021 Jun 10;21(6):36. doi: 10.1007/s11882-021-01013-y. PMID: 34110505
Hereditary and familial colon cancer.
Jasperson KW, Tuohy TM, Neklason DW, Burt RW
Gastroenterology 2010 Jun;138(6):2044-58. doi: 10.1053/j.gastro.2010.01.054. PMID: 20420945Free PMC Article
Hamartomatous polyposis syndromes.
Gammon A, Jasperson K, Kohlmann W, Burt RW
Best Pract Res Clin Gastroenterol 2009;23(2):219-31. doi: 10.1016/j.bpg.2009.02.007. PMID: 19414148Free PMC Article
MUTYH-associated polyposis.
Sampson JR, Jones N
Best Pract Res Clin Gastroenterol 2009;23(2):209-18. doi: 10.1016/j.bpg.2009.03.006. PMID: 19414147

Recent systematic reviews

Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review.
Neagu N, Dianzani C, Avallone G, Dell'Aquila C, Morariu SH, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2022 Jun;36(6):820-835. Epub 2022 Feb 17 doi: 10.1111/jdv.17981. PMID: 35122335
Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.
Oykhman P, Paramo FA, Bousquet J, Kennedy DW, Brignardello-Petersen R, Chu DK
J Allergy Clin Immunol 2022 Apr;149(4):1286-1295. Epub 2021 Sep 17 doi: 10.1016/j.jaci.2021.09.009. PMID: 34543652
Eosinophils and eosinophil-associated diseases: An update.
O'Sullivan JA, Bochner BS
J Allergy Clin Immunol 2018 Feb;141(2):505-517. Epub 2017 Oct 16 doi: 10.1016/j.jaci.2017.09.022. PMID: 29045815Free PMC Article
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Peutz-Jeghers syndrome: a systematic review and recommendations for management.
Beggs AD, Latchford AR, Vasen HF, Moslein G, Alonso A, Aretz S, Bertario L, Blanco I, Bülow S, Burn J, Capella G, Colas C, Friedl W, Møller P, Hes FJ, Järvinen H, Mecklin JP, Nagengast FM, Parc Y, Phillips RK, Hyer W, Ponz de Leon M, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Tejpar S, Thomas HJ, Wijnen JT, Clark SK, Hodgson SV
Gut 2010 Jul;59(7):975-86. doi: 10.1136/gut.2009.198499. PMID: 20581245

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