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Microinvasive Squamous Cell Carcinoma

MedGen UID:
137733
•Concept ID:
C0334252
•
Neoplastic Process
Synonyms: Microinvasive squamous cell carcinoma; Squamous cell carcinoma, microinvasive
SNOMED CT: Microinvasive squamous cell carcinoma (12478003); Squamous cell carcinoma, microinvasive (12478003)

Definition

A squamous cell carcinoma with minimal stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicroinvasive Squamous Cell Carcinoma

Professional guidelines

PubMed

Conservative treatment of microinvasive squamous cell carcinoma of the cervix stage IA1: Defining conization height to an optimal oncological outcome.
Hartman CA, Bragança JF, Gurgel MSC, Zeferino LC, Andrade LALA, Teixeira JC
PLoS One 2021;16(7):e0253998. Epub 2021 Jul 20 doi: 10.1371/journal.pone.0253998. PMID: 34283862Free PMC Article
Clinical management of cervical intraepithelial neoplasia in pregnant and postpartum women.
Wu YM, Wang T, He Y, Song F, Wang Y, Zhu L, Kong WM, Duan W, Zhang WY
Arch Gynecol Obstet 2014 May;289(5):1071-7. Epub 2013 Nov 7 doi: 10.1007/s00404-013-3076-5. PMID: 24196304
Analysis of outcomes of microinvasive adenocarcinoma of the uterine cervix by treatment type.
Reynolds EA, Tierney K, Keeney GL, Felix JC, Weaver AL, Roman LD, Cliby WA
Obstet Gynecol 2010 Nov;116(5):1150-7. doi: 10.1097/AOG.0b013e3181f74062. PMID: 20966701

Recent clinical studies

Etiology

Conservative treatment of microinvasive squamous cell carcinoma of the cervix stage IA1: Defining conization height to an optimal oncological outcome.
Hartman CA, Bragança JF, Gurgel MSC, Zeferino LC, Andrade LALA, Teixeira JC
PLoS One 2021;16(7):e0253998. Epub 2021 Jul 20 doi: 10.1371/journal.pone.0253998. PMID: 34283862Free PMC Article
The oncological and obstetric outcomes of cervical squamous cell carcinoma at stage IA1 managed with the loop electrosurgical excision procedure.
Chen S, Liu J, Shi C, Gao X, Bai H
Taiwan J Obstet Gynecol 2021 Jul;60(4):718-722. doi: 10.1016/j.tjog.2021.05.023. PMID: 34247813
Analysis of outcomes of microinvasive adenocarcinoma of the uterine cervix by treatment type.
Reynolds EA, Tierney K, Keeney GL, Felix JC, Weaver AL, Roman LD, Cliby WA
Obstet Gynecol 2010 Nov;116(5):1150-7. doi: 10.1097/AOG.0b013e3181f74062. PMID: 20966701
Angiogenesis in squamous cell carcinoma in situ and microinvasive carcinoma of the uterine cervix.
Abulafia O, Triest WE, Sherer DM
Obstet Gynecol 1996 Dec;88(6):927-32. doi: 10.1016/s0029-7844(96)00334-1. PMID: 8942829
Carcinoma in situ and microinvasive squamous cell carcinoma of the vocal cords.
Rothfield RE, Myers EN, Johnson JT
Ann Otol Rhinol Laryngol 1991 Oct;100(10):793-6. doi: 10.1177/000348949110001002. PMID: 1952644

Diagnosis

Conservative treatment of microinvasive squamous cell carcinoma of the cervix stage IA1: Defining conization height to an optimal oncological outcome.
Hartman CA, Bragança JF, Gurgel MSC, Zeferino LC, Andrade LALA, Teixeira JC
PLoS One 2021;16(7):e0253998. Epub 2021 Jul 20 doi: 10.1371/journal.pone.0253998. PMID: 34283862Free PMC Article
The oncological and obstetric outcomes of cervical squamous cell carcinoma at stage IA1 managed with the loop electrosurgical excision procedure.
Chen S, Liu J, Shi C, Gao X, Bai H
Taiwan J Obstet Gynecol 2021 Jul;60(4):718-722. doi: 10.1016/j.tjog.2021.05.023. PMID: 34247813
Does Microinvasive Adenocarcinoma of Cervix Have Poorer Treatment Outcomes than Microinvasive Squamous Cell Carcinoma?
Ruengkhachorn I, Hanamornroongruang S, Leelaphatanadit C, Sangkarat S
Asian Pac J Cancer Prev 2016;17(8):4013-7. PMID: 27644654
Colposcopy and management of microinvasive squamous cell carcinoma.
Costa S
Minerva Ginecol 2012 Apr;64(2):121-36. PMID: 22481623
Microinvasive adenocarcinoma of the cervix.
Spoozak L, Lewin SN, Burke WM, Deutsch I, Sun X, Herzog TJ, Wright JD
Am J Obstet Gynecol 2012 Jan;206(1):80.e1-6. Epub 2011 Jul 22 doi: 10.1016/j.ajog.2011.07.029. PMID: 21939955

Therapy

Human papilloma virus-associated squamous cell carcinoma of the larynx in an 18-year-old woman.
Hotz MA, Christen B, Sahli R, Arnold AM
Head Neck 2019 Apr;41(4):E59-E61. Epub 2018 Dec 27 doi: 10.1002/hed.25572. PMID: 30589154
Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy.
Ahn PH, Finlay JC, Gallagher-Colombo SM, Quon H, O'Malley BW Jr, Weinstein GS, Chalian A, Malloy K, Sollecito T, Greenberg M, Simone CB 2nd, McNulty S, Lin A, Zhu TC, Livolsi V, Feldman M, Mick R, Cengel KA, Busch TM
Photodiagnosis Photodyn Ther 2018 Mar;21:28-35. Epub 2017 Nov 4 doi: 10.1016/j.pdpdt.2017.10.015. PMID: 29113960Free PMC Article
Effect of Methyl Aminolevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: A Randomized Clinical Trial.
Choi SH, Kim KH, Song KH
JAMA Dermatol 2017 Mar 1;153(3):289-295. doi: 10.1001/jamadermatol.2016.4463. PMID: 28199463
Photodynamic therapy for the treatment of microinvasive squamous cell carcinoma of the lower lip: a case report.
Fargnoli MC, Kostaki D, Piccioni A, Di Stefani A, Peris K
G Ital Dermatol Venereol 2015 Jun;150(3):331-5. Epub 2014 Jun 30 PMID: 24975947
Ovarian squamous cell carcinoma which metastasized 8 years after cervical conization for early microinvasive cervical cancer: a case report.
Hidaka T, Nakashima A, Hasegawa T, Nomoto K, Ishizawa S, Tsuneyama K, Takano Y, Saito S
Jpn J Clin Oncol 2011 Jun;41(6):807-10. Epub 2011 Apr 5 doi: 10.1093/jjco/hyr041. PMID: 21467082

Prognosis

Conservative treatment of microinvasive squamous cell carcinoma of the cervix stage IA1: Defining conization height to an optimal oncological outcome.
Hartman CA, Bragança JF, Gurgel MSC, Zeferino LC, Andrade LALA, Teixeira JC
PLoS One 2021;16(7):e0253998. Epub 2021 Jul 20 doi: 10.1371/journal.pone.0253998. PMID: 34283862Free PMC Article
Analysis of Conservative Surgical Treatment and Prognosis of Microinvasive Squamous Cell Carcinoma of the Cervix Stage IA1: Results of Follow-Up to 20 Years.
Hartman CA, Teixeira JC, Barbosa SB, Figueiredo SM, Andrade LA, Bastos JF
Int J Gynecol Cancer 2017 Feb;27(2):357-363. doi: 10.1097/IGC.0000000000000887. PMID: 27984378
Does Microinvasive Adenocarcinoma of Cervix Have Poorer Treatment Outcomes than Microinvasive Squamous Cell Carcinoma?
Ruengkhachorn I, Hanamornroongruang S, Leelaphatanadit C, Sangkarat S
Asian Pac J Cancer Prev 2016;17(8):4013-7. PMID: 27644654
Prognosis and recurrence risk for patients with cervical squamous intraepithelial lesions diagnosed during pregnancy.
Kaplan KJ, Dainty LA, Dolinsky B, Rose GS, Carlson J, McHale M, Elkas JC
Cancer 2004 Aug 25;102(4):228-32. doi: 10.1002/cncr.20428. PMID: 15368314
Carcinoma in situ and microinvasive squamous cell carcinoma of the vocal cords.
Rothfield RE, Myers EN, Johnson JT
Ann Otol Rhinol Laryngol 1991 Oct;100(10):793-6. doi: 10.1177/000348949110001002. PMID: 1952644

Clinical prediction guides

Conservative treatment of microinvasive squamous cell carcinoma of the cervix stage IA1: Defining conization height to an optimal oncological outcome.
Hartman CA, Bragança JF, Gurgel MSC, Zeferino LC, Andrade LALA, Teixeira JC
PLoS One 2021;16(7):e0253998. Epub 2021 Jul 20 doi: 10.1371/journal.pone.0253998. PMID: 34283862Free PMC Article
Photodynamic therapy for the treatment of microinvasive squamous cell carcinoma of the lower lip: a case report.
Fargnoli MC, Kostaki D, Piccioni A, Di Stefani A, Peris K
G Ital Dermatol Venereol 2015 Jun;150(3):331-5. Epub 2014 Jun 30 PMID: 24975947
Colposcopy and management of microinvasive squamous cell carcinoma.
Costa S
Minerva Ginecol 2012 Apr;64(2):121-36. PMID: 22481623
Outcome of conservatively treated microinvasive squamous cell carcinoma of the uterine cervix during a 10-year follow-up.
Costa S, Marra E, Martinelli GN, Santini D, Casadio P, Formelli G, Pelusi C, Ghi T, Syrjänen K, Pelusi G
Int J Gynecol Cancer 2009 Jan;19(1):33-8. doi: 10.1111/IGC.0b013e318197f53b. PMID: 19258938
The issue of microinvasive squamous cell carcinoma of the vulva: an evaluation of the criteria of diagnosis and methods of therapy.
Zucker PK, Berkowitz RS
Obstet Gynecol Surv 1985 Mar;40(3):136-43. doi: 10.1097/00006254-198503000-00002. PMID: 3883258

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