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Interictal EEG abnormality

MedGen UID:
1377364
Concept ID:
C4476738
Finding
HPO: HP:0025373

Definition

Interictal refers to a period of time between epileptic seizures. Electroencephalographic (EEG) patterns are important in the differential diagnosis of epilepsy, and the EEG is almost always abnormal during a seizure. Some persons with seizures may show EEG abnormalities between seizures, while others do not. In some cases, multiple interictal EEGs must be recorded before an abnormality is observed. In most cases the electrographic pattern of seizure onset is completely different from the activity recorded during interictal discharge. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Interictal EEG abnormality

Conditions with this feature

X-linked sideroblastic anemia with ataxia
MedGen UID:
335078
Concept ID:
C1845028
Disease or Syndrome
X-linked spinocerebellar ataxia-6 with or without sideroblastic anemia (SCAX6) is an X-linked recessive disorder characterized by delayed motor development apparent in infancy with delayed walking (often by several years) due to ataxia and poor coordination. Additional features may include dysmetria, dysarthria, spasticity of the lower limbs, hyperreflexia, dysdiadochokinesis, strabismus, and nystagmus. The disorder is slowly progressive, and patients often lose ambulation. Brain imaging usually shows cerebellar atrophy. Most affected individuals have mild hypochromic, microcytic sideroblastic anemia, which may be asymptomatic. Laboratory studies show increased free erythrocyte protoporphyrin (FEP) and ringed sideroblasts on bone marrow biopsy. Female carriers do not have neurologic abnormalities, but may have subtle findings on peripheral blood smear (Pagon et al., 1985; D'Hooghe et al., 2012). For a discussion of genetic heterogeneity of X-linked spinocerebellar ataxia (SCAX), see SCAX1 (302500).

Professional guidelines

PubMed

Montouris G, Aboumatar S, Burdette D, Kothare S, Kuzniecky R, Rosenfeld W, Chung S
Epilepsy Behav 2020 Sep;110:107146. Epub 2020 Jun 18 doi: 10.1016/j.yebeh.2020.107146. PMID: 32563898
Gardella E, Møller RS
Epilepsia 2019 Dec;60 Suppl 3:S77-S85. doi: 10.1111/epi.16319. PMID: 31904124
Crumrine PK
Paediatr Drugs 2011 Apr 1;13(2):107-18. doi: 10.2165/11536940-000000000-00000. PMID: 21351810

Recent clinical studies

Etiology

Arvio M, Oksanen V, Autio S, Gaily E, Sainio K
Acta Neurol Scand 1993 May;87(5):342-4. doi: 10.1111/j.1600-0404.1993.tb04114.x. PMID: 8333236

Diagnosis

Quesney LF, Gloor P
Electroencephalogr Clin Neurophysiol Suppl 1985;37:165-200. PMID: 3924559
Pedley TA, Tharp BR, Herman K
Ann Neurol 1981 Feb;9(2):142-9. doi: 10.1002/ana.410090207. PMID: 6786207

Therapy

Arvio M, Oksanen V, Autio S, Gaily E, Sainio K
Acta Neurol Scand 1993 May;87(5):342-4. doi: 10.1111/j.1600-0404.1993.tb04114.x. PMID: 8333236

Prognosis

Arvio M, Oksanen V, Autio S, Gaily E, Sainio K
Acta Neurol Scand 1993 May;87(5):342-4. doi: 10.1111/j.1600-0404.1993.tb04114.x. PMID: 8333236
Pedley TA, Tharp BR, Herman K
Ann Neurol 1981 Feb;9(2):142-9. doi: 10.1002/ana.410090207. PMID: 6786207

Clinical prediction guides

Pedley TA, Tharp BR, Herman K
Ann Neurol 1981 Feb;9(2):142-9. doi: 10.1002/ana.410090207. PMID: 6786207

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