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11q Aberration

MedGen UID:
1377373
•Concept ID:
C4329211
•
Cell or Molecular Dysfunction
Synonyms: 11q Abnormality; Aberration of 11q; Chromosome 11q Abnormality

Definition

A cytogenetic abnormality characterized by deregulation of genes in 11q. [from NCI]

Professional guidelines

PubMed

Comprehensive histopathological diagnostics of aggressive B-cell lymphomas based on the updated criteria of the World Health Organisation's 2017 classification.
Szumera-Ciećkiewicz A, Rymkiewicz G, Grygalewicz B, Jesionek-Kupnicka D, Gruchała A, Ziarkiewicz-Wróblewska B, Gałązka K, Reszeć J, Borg K, Prochorec-Sobieszek M
Pol J Pathol 2018;69(1):1-19. doi: 10.5114/pjp.2018.75332. PMID: 29895122
Management of Neuroblastoma: ICMR Consensus Document.
Bansal D, Totadri S, Chinnaswamy G, Agarwala S, Vora T, Arora B, Prasad M, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):446-455. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2298-0. PMID: 28367616

Recent clinical studies

Etiology

Aggressive B-cell non-Hodgkin lymphomas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology.
Rodriguez-Pinilla SM, Dojcinov S, Dotlic S, Gibson SE, Hartmann S, Klimkowska M, Sabattini E, Tousseyn TA, de Jong D, Hsi ED
Virchows Arch 2024 Jan;484(1):15-29. Epub 2023 Aug 2 doi: 10.1007/s00428-023-03579-6. PMID: 37530792Free PMC Article
Proteogenomic Profiling of High-Grade B-Cell Lymphoma With 11q Aberrations and Burkitt Lymphoma Reveals Lymphoid Enhancer Binding Factor 1 as a Novel Biomarker.
Hurwitz SN, Lockhart B, Önder Ö, Wu R, Sethi S, Aypar U, Siebert R, Dogan A, Pillai V, Elenitoba-Johnson KSJ, Lim MS
Mod Pathol 2023 Jul;36(7):100170. Epub 2023 Mar 29 doi: 10.1016/j.modpat.2023.100170. PMID: 36997001
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
The clinicopathologic spectrum of mature aggressive B cell lymphomas.
Rimsza L, Pittaluga S, Dirnhofer S, Copie-Bergman C, de Leval L, Facchetti F, Pileri S, Rosenwald A, Wotherspoon A, Fend F
Virchows Arch 2017 Oct;471(4):453-466. Epub 2017 Aug 26 doi: 10.1007/s00428-017-2199-7. PMID: 28844114
Management of Neuroblastoma: ICMR Consensus Document.
Bansal D, Totadri S, Chinnaswamy G, Agarwala S, Vora T, Arora B, Prasad M, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):446-455. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2298-0. PMID: 28367616

Diagnosis

Aggressive B-cell non-Hodgkin lymphomas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology.
Rodriguez-Pinilla SM, Dojcinov S, Dotlic S, Gibson SE, Hartmann S, Klimkowska M, Sabattini E, Tousseyn TA, de Jong D, Hsi ED
Virchows Arch 2024 Jan;484(1):15-29. Epub 2023 Aug 2 doi: 10.1007/s00428-023-03579-6. PMID: 37530792Free PMC Article
Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom.
Singh A, Obiorah IE
Semin Diagn Pathol 2023 Nov;40(6):392-400. Epub 2023 Jun 22 doi: 10.1053/j.semdp.2023.06.002. PMID: 37400280
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Management of Neuroblastoma: ICMR Consensus Document.
Bansal D, Totadri S, Chinnaswamy G, Agarwala S, Vora T, Arora B, Prasad M, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):446-455. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2298-0. PMID: 28367616

Therapy

Kidney Transplant T Cell-Mediated Rejection Occurring After Anti-CD19 CAR T-Cell Therapy for Refractory Aggressive Burkitt-like Lymphoma With 11q Aberration: A Case Report.
de Nattes T, Camus V, François A, Dallet G, Ferrand C, Guerrot D, Lemoine M, Morin F, Thieblemont C, Veresezan EL, Candon S, Latouche JB, Bertrand D
Am J Kidney Dis 2022 May;79(5):760-764. Epub 2021 Aug 27 doi: 10.1053/j.ajkd.2021.07.012. PMID: 34461166
Genetic progression of post-transplant Burkitt-like lymphoma case with 11q-Gain/Loss and MYC amplification.
Grygalewicz B, Woroniecka R, Rymkiewicz G, Rygier J, Malawska N, Blachnio K, Bystydzienski Z, Borysiuk A, Nowakowska B, Pienkowska-Grela B
Cancer Genet 2020 Jul;245:1-5. Epub 2020 May 18 doi: 10.1016/j.cancergen.2020.05.001. PMID: 32531723
Experience with provisional WHO-entities large B-cell lymphoma with IRF4-rearrangement and Burkitt-like lymphoma with 11q aberration in paediatric patients of the NHL-BFM group.
Au-Yeung RKH, Arias Padilla L, Zimmermann M, Oschlies I, Siebert R, Woessmann W, Burkhardt B, Klapper W
Br J Haematol 2020 Sep;190(5):753-763. Epub 2020 Apr 2 doi: 10.1111/bjh.16578. PMID: 32239695
Neuroblastoma in patients under 18 months. Single institution experience in Argentina.
Rossa A, Cacciavillano W, Rose A, Flores P, Chantada G, Zubizarreta P
Medicina (B Aires) 2019;79(4):280-283. PMID: 31487248

Prognosis

Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom.
Singh A, Obiorah IE
Semin Diagn Pathol 2023 Nov;40(6):392-400. Epub 2023 Jun 22 doi: 10.1053/j.semdp.2023.06.002. PMID: 37400280
Proteogenomic Profiling of High-Grade B-Cell Lymphoma With 11q Aberrations and Burkitt Lymphoma Reveals Lymphoid Enhancer Binding Factor 1 as a Novel Biomarker.
Hurwitz SN, Lockhart B, Önder Ö, Wu R, Sethi S, Aypar U, Siebert R, Dogan A, Pillai V, Elenitoba-Johnson KSJ, Lim MS
Mod Pathol 2023 Jul;36(7):100170. Epub 2023 Mar 29 doi: 10.1016/j.modpat.2023.100170. PMID: 36997001
Comprehensive histopathological diagnostics of aggressive B-cell lymphomas based on the updated criteria of the World Health Organisation's 2017 classification.
Szumera-Ciećkiewicz A, Rymkiewicz G, Grygalewicz B, Jesionek-Kupnicka D, Gruchała A, Ziarkiewicz-Wróblewska B, Gałązka K, Reszeć J, Borg K, Prochorec-Sobieszek M
Pol J Pathol 2018;69(1):1-19. doi: 10.5114/pjp.2018.75332. PMID: 29895122
Management of Neuroblastoma: ICMR Consensus Document.
Bansal D, Totadri S, Chinnaswamy G, Agarwala S, Vora T, Arora B, Prasad M, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):446-455. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2298-0. PMID: 28367616

Clinical prediction guides

Diagnostic Value of (18)F-FDG PET/CT-Based Radiomics Nomogram in Bone Marrow Involvement of Pediatric Neuroblastoma.
Feng L, Yang X, Lu X, Kan Y, Wang C, Zhang H, Wang W, Yang J
Acad Radiol 2023 May;30(5):940-951. Epub 2022 Sep 16 doi: 10.1016/j.acra.2022.08.021. PMID: 36117128
A Diagnostic Approach to the Identification of Burkitt-like Lymphoma With 11q Aberration in Aggressive B-Cell Lymphomas.
Horn H, Kalmbach S, Wagener R, Staiger AM, Hüttl K, Mottok A, Bens S, Traverse-Glehen A, Fontaine J, Siebert R, Rosenwald A, Ott G
Am J Surg Pathol 2021 Mar 1;45(3):356-364. doi: 10.1097/PAS.0000000000001613. PMID: 33136583
Comprehensive histopathological diagnostics of aggressive B-cell lymphomas based on the updated criteria of the World Health Organisation's 2017 classification.
Szumera-Ciećkiewicz A, Rymkiewicz G, Grygalewicz B, Jesionek-Kupnicka D, Gruchała A, Ziarkiewicz-Wróblewska B, Gałązka K, Reszeć J, Borg K, Prochorec-Sobieszek M
Pol J Pathol 2018;69(1):1-19. doi: 10.5114/pjp.2018.75332. PMID: 29895122
Management of Neuroblastoma: ICMR Consensus Document.
Bansal D, Totadri S, Chinnaswamy G, Agarwala S, Vora T, Arora B, Prasad M, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):446-455. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2298-0. PMID: 28367616
Significance of clinical and biologic features in Stage 3 neuroblastoma: a report from the International Neuroblastoma Risk Group project.
Meany HJ, London WB, Ambros PF, Matthay KK, Monclair T, Simon T, Garaventa A, Berthold F, Nakagawara A, Cohn SL, Pearson AD, Park JR
Pediatr Blood Cancer 2014 Nov;61(11):1932-9. Epub 2014 Jul 7 doi: 10.1002/pbc.25134. PMID: 25044743

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