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Finger flexor weakness

MedGen UID:
1378295
•Concept ID:
C4477022
•
Finding
HPO: HP:0031177

Definition

Reduced ability to flex (bend) the fingers. This can manifest as incomplete closure of the hand due to weakness in finger flexion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFinger flexor weakness

Professional guidelines

PubMed

Myositis with prominent B cell aggregates may meet classification criteria for sporadic inclusion body myositis.
Meyer A, Troyanov Y, Korathanakhun P, Landon-Cardinal O, Leclair V, Allard-Chamard H, Bourré-Tessier J, Makhzoum JP, Isabelle C, Larue S, Grand'Maison F, Massie R, Page ML, Mansour AM, Routhier N, Zarka F, Roy F, Sonnen J, Satoh M, Fritzler M, Hudson M, Senécal JL, Karamchandani J, Ellezam B, O'Ferrall E
Neuromuscul Disord 2023 Feb;33(2):169-182. Epub 2022 Dec 5 doi: 10.1016/j.nmd.2022.12.001. PMID: 36649672

Recent clinical studies

Etiology

Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis.
Lucchini M, Maggi L, Pegoraro E, Filosto M, Rodolico C, Antonini G, Garibaldi M, Valentino ML, Siciliano G, Tasca G, De Arcangelis V, De Fino C, Mirabella M
Cells 2021 May 10;10(5) doi: 10.3390/cells10051146. PMID: 34068623Free PMC Article
Myopathies with finger flexor weakness: Not only inclusion-body myositis.
Nicolau S, Liewluck T, Milone M
Muscle Nerve 2020 Oct;62(4):445-454. Epub 2020 Jun 1 doi: 10.1002/mus.26914. PMID: 32478919
ACTA1-myopathy with prominent finger flexor weakness and rimmed vacuoles.
Liewluck T, Niu Z, Moore SA, Alsharabati M, Milone M
Neuromuscul Disord 2019 May;29(5):388-391. Epub 2019 Mar 2 doi: 10.1016/j.nmd.2019.02.012. PMID: 30987788Free PMC Article
Late-onset Becker muscular dystrophy: Refining the clinical features and electrophysiological findings.
Beltran Papsdorf T, Howard JF Jr, Chahin N
Muscle Nerve 2015 Nov;52(5):885-7. Epub 2015 Sep 10 doi: 10.1002/mus.24773. PMID: 26179421
Inclusion body myositis mimicking motor neuron disease.
Dabby R, Lange DJ, Trojaborg W, Hays AP, Lovelace RE, Brannagan TH, Rowland LP
Arch Neurol 2001 Aug;58(8):1253-6. doi: 10.1001/archneur.58.8.1253. PMID: 11493165

Diagnosis

Myositis with prominent B cell aggregates may meet classification criteria for sporadic inclusion body myositis.
Meyer A, Troyanov Y, Korathanakhun P, Landon-Cardinal O, Leclair V, Allard-Chamard H, Bourré-Tessier J, Makhzoum JP, Isabelle C, Larue S, Grand'Maison F, Massie R, Page ML, Mansour AM, Routhier N, Zarka F, Roy F, Sonnen J, Satoh M, Fritzler M, Hudson M, Senécal JL, Karamchandani J, Ellezam B, O'Ferrall E
Neuromuscul Disord 2023 Feb;33(2):169-182. Epub 2022 Dec 5 doi: 10.1016/j.nmd.2022.12.001. PMID: 36649672
Finger Flexor Weakness in Myasthenia Gravis.
Alanazy MH, Alkhalidi H
J Coll Physicians Surg Pak 2022 Dec;32(12):SS168-SS170. doi: 10.29271/jcpsp.2022.Supp0.SS168. PMID: 36597328
Epidemiology, Survival, and Clinical Characteristics of Inclusion Body Myositis.
Lindgren U, Pullerits R, Lindberg C, Oldfors A
Ann Neurol 2022 Aug;92(2):201-212. Epub 2022 Jun 6 doi: 10.1002/ana.26412. PMID: 35596584Free PMC Article
Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis.
Lucchini M, Maggi L, Pegoraro E, Filosto M, Rodolico C, Antonini G, Garibaldi M, Valentino ML, Siciliano G, Tasca G, De Arcangelis V, De Fino C, Mirabella M
Cells 2021 May 10;10(5) doi: 10.3390/cells10051146. PMID: 34068623Free PMC Article
Myopathies with finger flexor weakness: Not only inclusion-body myositis.
Nicolau S, Liewluck T, Milone M
Muscle Nerve 2020 Oct;62(4):445-454. Epub 2020 Jun 1 doi: 10.1002/mus.26914. PMID: 32478919

Therapy

A cross-sectional study of hand function in inclusion body myositis: Implications for functional rating scale.
Lin AY, Clapp M, Karanja E, Dooley K, Weihl CC, Wang LH
Neuromuscul Disord 2020 Mar;30(3):200-206. Epub 2019 Dec 17 doi: 10.1016/j.nmd.2019.12.002. PMID: 32057637Free PMC Article

Prognosis

Epidemiology, Survival, and Clinical Characteristics of Inclusion Body Myositis.
Lindgren U, Pullerits R, Lindberg C, Oldfors A
Ann Neurol 2022 Aug;92(2):201-212. Epub 2022 Jun 6 doi: 10.1002/ana.26412. PMID: 35596584Free PMC Article
Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis.
Lucchini M, Maggi L, Pegoraro E, Filosto M, Rodolico C, Antonini G, Garibaldi M, Valentino ML, Siciliano G, Tasca G, De Arcangelis V, De Fino C, Mirabella M
Cells 2021 May 10;10(5) doi: 10.3390/cells10051146. PMID: 34068623Free PMC Article

Clinical prediction guides

Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis.
Lucchini M, Maggi L, Pegoraro E, Filosto M, Rodolico C, Antonini G, Garibaldi M, Valentino ML, Siciliano G, Tasca G, De Arcangelis V, De Fino C, Mirabella M
Cells 2021 May 10;10(5) doi: 10.3390/cells10051146. PMID: 34068623Free PMC Article
Myopathies with finger flexor weakness: Not only inclusion-body myositis.
Nicolau S, Liewluck T, Milone M
Muscle Nerve 2020 Oct;62(4):445-454. Epub 2020 Jun 1 doi: 10.1002/mus.26914. PMID: 32478919

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