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Abnormal circulating inhibin level

MedGen UID:
1378339
•Concept ID:
C4477101
•
Finding
HPO: HP:0031099

Definition

Any deviation from the normal concentration of inhibins, which are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins suppress the secretion of pituitary follicle-stimulating hormone. [from HPO]

Recent clinical studies

Etiology

Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study.
Pozza C, Sesti F, Tenuta M, Spaziani M, Tarantino C, Carlomagno F, Minnetti M, Pofi R, Paparella R, Lenzi A, Radicioni A, Isidori AM, Tarani L, Gianfrilli D
J Clin Endocrinol Metab 2023 Sep 18;108(10):2486-2499. doi: 10.1210/clinem/dgad205. PMID: 37043499Free PMC Article
Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study.
Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822
Testicular torsion: orchiectomy or orchiopexy?
Taskinen S, Taskinen M, Rintala R
J Pediatr Urol 2008 Jun;4(3):210-3. Epub 2008 Jan 11 doi: 10.1016/j.jpurol.2007.11.007. PMID: 18631928
Abnormal umbilical artery Doppler waveforms and cord blood inhibin a and inhibin B levels.
Florio P, Severi FM, Luisi S, Ignacchiti E, Calonaci G, Bocchi C, Petraglia F
Biol Neonate 2003;84(4):281-6. doi: 10.1159/000073635. PMID: 14593237

Diagnosis

Identification of clinical characteristics biomarkers for rheumatoid arthritis through targeted DNA methylation sequencing.
Zhao J, Xu L, Wei K, Jiang P, Chang C, Xu L, Shi Y, Zheng Y, Shan Y, Zheng Y, Shen Y, Liu J, Guo S, Wang R, He D
Int Immunopharmacol 2024 Apr 20;131:111860. Epub 2024 Mar 19 doi: 10.1016/j.intimp.2024.111860. PMID: 38508093
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822
Importance of Serum Testicular Protein Hormone Measurement in the Assessment of Disorders of Sex Development.
Freire AV, Grinspon RP, Rey RA
Sex Dev 2018;12(1-3):30-40. Epub 2017 Aug 30 doi: 10.1159/000479572. PMID: 28850950
Testicular torsion: orchiectomy or orchiopexy?
Taskinen S, Taskinen M, Rintala R
J Pediatr Urol 2008 Jun;4(3):210-3. Epub 2008 Jan 11 doi: 10.1016/j.jpurol.2007.11.007. PMID: 18631928
Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male.
Byrd W, Bennett MJ, Carr BR, Dong Y, Wians F, Rainey W
J Clin Endocrinol Metab 1998 Aug;83(8):2849-54. doi: 10.1210/jcem.83.8.5008. PMID: 9709958

Therapy

Identification of clinical characteristics biomarkers for rheumatoid arthritis through targeted DNA methylation sequencing.
Zhao J, Xu L, Wei K, Jiang P, Chang C, Xu L, Shi Y, Zheng Y, Shan Y, Zheng Y, Shen Y, Liu J, Guo S, Wang R, He D
Int Immunopharmacol 2024 Apr 20;131:111860. Epub 2024 Mar 19 doi: 10.1016/j.intimp.2024.111860. PMID: 38508093
Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study.
Pozza C, Sesti F, Tenuta M, Spaziani M, Tarantino C, Carlomagno F, Minnetti M, Pofi R, Paparella R, Lenzi A, Radicioni A, Isidori AM, Tarani L, Gianfrilli D
J Clin Endocrinol Metab 2023 Sep 18;108(10):2486-2499. doi: 10.1210/clinem/dgad205. PMID: 37043499Free PMC Article
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822
Anti-Müllerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH.
Bry-Gauillard H, Larrat-Ledoux F, Levaillant JM, Massin N, Maione L, Beau I, Binart N, Chanson P, Brailly-Tabard S, Hall JE, Young J
J Clin Endocrinol Metab 2017 Apr 1;102(4):1102-1111. doi: 10.1210/jc.2016-3799. PMID: 28324034
Circulating antimüllerian hormone levels in boys decline during early puberty and correlate with inhibin B.
Hero M, Tommiska J, Vaaralahti K, Laitinen EM, Sipilä I, Puhakka L, Dunkel L, Raivio T
Fertil Steril 2012 May;97(5):1242-7. Epub 2012 Mar 9 doi: 10.1016/j.fertnstert.2012.02.020. PMID: 22405597

Prognosis

Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study.
Pozza C, Sesti F, Tenuta M, Spaziani M, Tarantino C, Carlomagno F, Minnetti M, Pofi R, Paparella R, Lenzi A, Radicioni A, Isidori AM, Tarani L, Gianfrilli D
J Clin Endocrinol Metab 2023 Sep 18;108(10):2486-2499. doi: 10.1210/clinem/dgad205. PMID: 37043499Free PMC Article
Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study.
Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822
Importance of Serum Testicular Protein Hormone Measurement in the Assessment of Disorders of Sex Development.
Freire AV, Grinspon RP, Rey RA
Sex Dev 2018;12(1-3):30-40. Epub 2017 Aug 30 doi: 10.1159/000479572. PMID: 28850950
Anti-Müllerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH.
Bry-Gauillard H, Larrat-Ledoux F, Levaillant JM, Massin N, Maione L, Beau I, Binart N, Chanson P, Brailly-Tabard S, Hall JE, Young J
J Clin Endocrinol Metab 2017 Apr 1;102(4):1102-1111. doi: 10.1210/jc.2016-3799. PMID: 28324034

Clinical prediction guides

Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study.
Pozza C, Sesti F, Tenuta M, Spaziani M, Tarantino C, Carlomagno F, Minnetti M, Pofi R, Paparella R, Lenzi A, Radicioni A, Isidori AM, Tarani L, Gianfrilli D
J Clin Endocrinol Metab 2023 Sep 18;108(10):2486-2499. doi: 10.1210/clinem/dgad205. PMID: 37043499Free PMC Article
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Gaccioli F, Aye ILMH, Sovio U, Charnock-Jones DS, Smith GCS
Am J Obstet Gynecol 2018 Feb;218(2S):S725-S737. Epub 2017 Dec 22 doi: 10.1016/j.ajog.2017.12.002. PMID: 29275822
Importance of Serum Testicular Protein Hormone Measurement in the Assessment of Disorders of Sex Development.
Freire AV, Grinspon RP, Rey RA
Sex Dev 2018;12(1-3):30-40. Epub 2017 Aug 30 doi: 10.1159/000479572. PMID: 28850950
Circulating antimüllerian hormone levels in boys decline during early puberty and correlate with inhibin B.
Hero M, Tommiska J, Vaaralahti K, Laitinen EM, Sipilä I, Puhakka L, Dunkel L, Raivio T
Fertil Steril 2012 May;97(5):1242-7. Epub 2012 Mar 9 doi: 10.1016/j.fertnstert.2012.02.020. PMID: 22405597
Testicular torsion: orchiectomy or orchiopexy?
Taskinen S, Taskinen M, Rintala R
J Pediatr Urol 2008 Jun;4(3):210-3. Epub 2008 Jan 11 doi: 10.1016/j.jpurol.2007.11.007. PMID: 18631928

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