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Colon adenocarcinoma

MedGen UID:
137834
Concept ID:
C0338106
Neoplastic Process
Synonyms: Adenocarcinoma of the colon; Colonic adenocarcinoma
 
HPO: HP:0040276
Monarch Initiative: MONDO:0002271

Definition

An adenocarcinoma arising from the colon. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [from NCI]

Conditions with this feature

Mismatch repair cancer syndrome 1
MedGen UID:
1748029
Concept ID:
C5399763
Disease or Syndrome
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.
Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition
MedGen UID:
1824057
Concept ID:
C5774284
Disease or Syndrome
Mosaic variegated aneuploidy syndrome-7 with inflammation and tumor predisposition (MVA7) is an autosomal recessive disorder characterized by increased susceptibility to benign and malignant neoplasms beginning in early childhood. Affected individuals show dysmorphic facies and may have early developmental delay. Patient cells show a high level of aneuploidy due to defects in cell division (Villarroya-Beltri et al., 2022). For a discussion of genetic heterogeneity of MVA, see MVA1 (257300).

Professional guidelines

PubMed

Lee B, Lee C, Moon HM, Jo SY, Jang SJ, Suh YA
Cells 2023 Dec 18;12(24) doi: 10.3390/cells12242859. PMID: 38132178Free PMC Article
Brunetti J, Piantini S, Fragai M, Scali S, Cipriani G, Depau L, Pini A, Falciani C, Menichetti S, Bracci L
Molecules 2020 Feb 28;25(5) doi: 10.3390/molecules25051088. PMID: 32121130Free PMC Article
Cabo J, Shu X, Shu XO, Parikh A, Bailey C
J Surg Res 2020 Jan;245:265-272. Epub 2019 Aug 14 doi: 10.1016/j.jss.2019.07.059. PMID: 31421372

Recent clinical studies

Etiology

Hu G, Yao H, Wei Z, Li L, Yu Z, Li J, Luo X, Guo Z
Sci Rep 2023 Jul 31;13(1):12403. doi: 10.1038/s41598-023-39563-y. PMID: 37524774Free PMC Article
Wang L, Cao Y, Guo W, Xu J
J Cancer Res Clin Oncol 2023 Jan;149(1):15-24. Epub 2022 Sep 29 doi: 10.1007/s00432-022-04382-7. PMID: 36173462Free PMC Article
Liu C, Liu D, Wang F, Liu Y, Xie J, Xie J, Xie Y
Front Immunol 2022;13:1038927. Epub 2022 Nov 14 doi: 10.3389/fimmu.2022.1038927. PMID: 36451813Free PMC Article
Qiu C, Shi W, Wu H, Zou S, Li J, Wang D, Liu G, Song Z, Xu X, Hu J, Geng H
Front Immunol 2021;12:769685. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.769685. PMID: 35003085Free PMC Article
Jiang C, Liu Y, Wen S, Xu C, Gu L
Pharmacol Res 2021 Jul;169:105644. Epub 2021 Apr 30 doi: 10.1016/j.phrs.2021.105644. PMID: 33940186

Diagnosis

Hu G, Yao H, Wei Z, Li L, Yu Z, Li J, Luo X, Guo Z
Sci Rep 2023 Jul 31;13(1):12403. doi: 10.1038/s41598-023-39563-y. PMID: 37524774Free PMC Article
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Jiang C, Liu Y, Wen S, Xu C, Gu L
Pharmacol Res 2021 Jul;169:105644. Epub 2021 Apr 30 doi: 10.1016/j.phrs.2021.105644. PMID: 33940186
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article
Ruan GT, Zhu LC, Gong YZ, Liao XW, Wang XK, Liao C, Wang S, Yan L, Xie HL, Zhou X, Li YZ, Gao F
J Cell Biochem 2020 Jun;121(5-6):3145-3161. Epub 2019 Dec 30 doi: 10.1002/jcb.29582. PMID: 31886580

Therapy

Feagan BG, Sands BE, Sandborn WJ, Germinaro M, Vetter M, Shao J, Sheng S, Johanns J, Panés J; VEGA Study Group
Lancet Gastroenterol Hepatol 2023 Apr;8(4):307-320. Epub 2023 Feb 1 doi: 10.1016/S2468-1253(22)00427-7. PMID: 36738762
Garrido Sanabria ER, Zahid A, Britton J, Kraus GJ, López-Chiriboga AS, Zekeridou A, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Dubey D
Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032
Jiang Y, Pei J, Zheng Y, Miao YJ, Duan BZ, Huang LF
Chin J Integr Med 2022 Jul;28(7):661-671. Epub 2021 Nov 10 doi: 10.1007/s11655-021-3345-2. PMID: 34755289
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article
Rosenberg SA, Spiess P, Lafreniere R
Science 1986 Sep 19;233(4770):1318-21. doi: 10.1126/science.3489291. PMID: 3489291

Prognosis

Wang L, Cao Y, Guo W, Xu J
J Cancer Res Clin Oncol 2023 Jan;149(1):15-24. Epub 2022 Sep 29 doi: 10.1007/s00432-022-04382-7. PMID: 36173462Free PMC Article
Liu C, Liu D, Wang F, Liu Y, Xie J, Xie J, Xie Y
Front Immunol 2022;13:1038927. Epub 2022 Nov 14 doi: 10.3389/fimmu.2022.1038927. PMID: 36451813Free PMC Article
Qiu C, Shi W, Wu H, Zou S, Li J, Wang D, Liu G, Song Z, Xu X, Hu J, Geng H
Front Immunol 2021;12:769685. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.769685. PMID: 35003085Free PMC Article
Jiang C, Liu Y, Wen S, Xu C, Gu L
Pharmacol Res 2021 Jul;169:105644. Epub 2021 Apr 30 doi: 10.1016/j.phrs.2021.105644. PMID: 33940186
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article

Clinical prediction guides

Hu G, Yao H, Wei Z, Li L, Yu Z, Li J, Luo X, Guo Z
Sci Rep 2023 Jul 31;13(1):12403. doi: 10.1038/s41598-023-39563-y. PMID: 37524774Free PMC Article
Liu C, Liu D, Wang F, Liu Y, Xie J, Xie J, Xie Y
Front Immunol 2022;13:1038927. Epub 2022 Nov 14 doi: 10.3389/fimmu.2022.1038927. PMID: 36451813Free PMC Article
Qiu C, Shi W, Wu H, Zou S, Li J, Wang D, Liu G, Song Z, Xu X, Hu J, Geng H
Front Immunol 2021;12:769685. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.769685. PMID: 35003085Free PMC Article
Jiang C, Liu Y, Wen S, Xu C, Gu L
Pharmacol Res 2021 Jul;169:105644. Epub 2021 Apr 30 doi: 10.1016/j.phrs.2021.105644. PMID: 33940186
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article

Recent systematic reviews

Athanasiou C, Pitt J, Malik A, Crabtree M, Markides GA
Surg Innov 2020 Apr;27(2):235-243. Epub 2019 Dec 19 doi: 10.1177/1553350619893232. PMID: 31854262
Chen F, Li Z, Zhou H
J Cell Biochem 2019 Jun;120(6):9839-9849. Epub 2018 Dec 9 doi: 10.1002/jcb.28264. PMID: 30536901
Ito F, Inokuchi R, Matsumoto A, Kumada Y, Yokoyama H, Ishida T, Hashimoto K, Narita M, Shinohara K
J Med Case Rep 2017 Sep 21;11(1):268. doi: 10.1186/s13256-017-1422-0. PMID: 28931420Free PMC Article

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