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Elevated circulating carcinoembryonic antigen concentration

MedGen UID:
1378758
Concept ID:
C4476917
Finding
Synonyms: Elevated carcinoembryonic antigen level; Increased plasma CEA
 
HPO: HP:0031029

Definition

Concentration of the carcinoembryonic antigen (CEA) in the blood circulation above the upper limit of normal. CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating carcinoembryonic antigen concentration

Professional guidelines

PubMed

Fioretti P, Gadducci A, Ferdeghini M, Bartolini T, Scatena P, Facchini V, Bianchi R
Eur J Gynaecol Oncol 1986;7(3):200-5. PMID: 3465535

Recent clinical studies

Etiology

Bajenova O, Stolper E, Gapon S, Sundina N, Zimmer R, Thomas P
Exp Cell Res 2003 Nov 15;291(1):228-41. doi: 10.1016/s0014-4827(03)00373-2. PMID: 14597422
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Acta Oncol 1997;36(7):755-9. doi: 10.3109/02841869709001350. PMID: 9490096
Wieskopf B, Demangeat C, Purohit A, Stenger R, Gries P, Kreisman H, Quoix E
Chest 1995 Jul;108(1):163-9. doi: 10.1378/chest.108.1.163. PMID: 7541742
Pacini F, Basolo F, Elisei R, Fugazzola L, Cola A, Pinchera A
Am J Clin Pathol 1991 Mar;95(3):300-8. doi: 10.1093/ajcp/95.3.300. PMID: 1996540
Stratil P, Rejthar A, Lang BA, Kocent A, Pacovský Z, Matoska J
Neoplasma 1988;35(1):69-76. PMID: 3352839

Diagnosis

Kotowicz B, Fuksiewicz M, Kowalska M, Jonska-Gmyrek J, Bidzinski M, Kaminska J
Int J Gynecol Cancer 2008 Nov-Dec;18(6):1279-84. Epub 2008 Jan 22 doi: 10.1111/j.1525-1438.2007.01176.x. PMID: 18217970
Habal N, Gupta RK, Bilchik AJ, Johnson T, Morton DL
Ann Surg Oncol 2000 Jun;7(5):352-6. doi: 10.1007/s10434-000-0352-y. PMID: 10864342
Ruibal Morell A
Int J Biol Markers 1992 Jul-Sep;7(3):160-6. doi: 10.1177/172460089200700307. PMID: 1431339
Munjal D, Brady PG
Am J Dig Dis 1978 Jan;23(1):57-64. doi: 10.1007/BF01072576. PMID: 619627
Boyd CR, Bivens BA, Kashmiri R, Parker JC Jr, Meeker WR Jr
J Surg Oncol 1976;8(6):507-12. doi: 10.1002/jso.2930080610. PMID: 994512

Therapy

Wu XJ, Fang YJ, Lin JZ, Lu ZH, Li LR, Chen G, Ding PR, Kong LH, Pan ZZ, Wan DS
J Int Med Res 2011;39(3):838-45. doi: 10.1177/147323001103900317. PMID: 21819716
Toiyama Y, Miki C, Inoue Y, Okugawa Y, Koike Y, Yokoe T, Tanaka K, Kusunoki M
Ann Surg Oncol 2008 Jun;15(6):1617-24. Epub 2008 Mar 27 doi: 10.1245/s10434-008-9874-5. PMID: 18368454
Folli S, Pèlegrin A, Chalandon Y, Yao X, Buchegger F, Lienard D, Lejeune F, Mach JP
Int J Cancer 1993 Mar 12;53(5):829-36. doi: 10.1002/ijc.2910530521. PMID: 8449608
Sears HF, Shen JW, Herlyn M, Atkinson B, Engstrom PF, Koprowski H
Am J Clin Oncol 1985 Apr;8(2):108-17. doi: 10.1097/00000421-198504000-00002. PMID: 2939709
Amino N, Kuro R, Yabu Y, Takai SI, Kawashima M, Morimoto S, Ichihara K, Miyai K, Kumahara Y
J Clin Endocrinol Metab 1981 Mar;52(3):457-62. doi: 10.1210/jcem-52-3-457. PMID: 6893991

Prognosis

Kristiansen S, Jørgensen LM, Hansen MH, Nielsen D, Sölétormos G
Biomed Res Int 2015;2015:986024. Epub 2015 Aug 3 doi: 10.1155/2015/986024. PMID: 26339655Free PMC Article
Habal N, Gupta RK, Bilchik AJ, Johnson T, Morton DL
Ann Surg Oncol 2000 Jun;7(5):352-6. doi: 10.1007/s10434-000-0352-y. PMID: 10864342
Wieskopf B, Demangeat C, Purohit A, Stenger R, Gries P, Kreisman H, Quoix E
Chest 1995 Jul;108(1):163-9. doi: 10.1378/chest.108.1.163. PMID: 7541742
Pacini F, Basolo F, Elisei R, Fugazzola L, Cola A, Pinchera A
Am J Clin Pathol 1991 Mar;95(3):300-8. doi: 10.1093/ajcp/95.3.300. PMID: 1996540
Boyd CR, Bivens BA, Kashmiri R, Parker JC Jr, Meeker WR Jr
J Surg Oncol 1976;8(6):507-12. doi: 10.1002/jso.2930080610. PMID: 994512

Clinical prediction guides

Kristiansen S, Jørgensen LM, Hansen MH, Nielsen D, Sölétormos G
Biomed Res Int 2015;2015:986024. Epub 2015 Aug 3 doi: 10.1155/2015/986024. PMID: 26339655Free PMC Article
Habal N, Gupta RK, Bilchik AJ, Johnson T, Morton DL
Ann Surg Oncol 2000 Jun;7(5):352-6. doi: 10.1007/s10434-000-0352-y. PMID: 10864342
Pacini F, Basolo F, Elisei R, Fugazzola L, Cola A, Pinchera A
Am J Clin Pathol 1991 Mar;95(3):300-8. doi: 10.1093/ajcp/95.3.300. PMID: 1996540
Ohuchi N, Takahashi K, Matoba N, Sato T, Taira Y, Sakai N, Masuda M, Mori S
Jpn J Clin Oncol 1989 Sep;19(3):242-8. PMID: 2810823
Stratil P, Rejthar A, Lang BA, Kocent A, Pacovský Z, Matoska J
Neoplasma 1988;35(1):69-76. PMID: 3352839

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