U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated circulating carcinoembryonic antigen concentration

MedGen UID:
1378758
•Concept ID:
C4476917
•
Finding
Synonyms: Elevated carcinoembryonic antigen level; Increased plasma CEA
 
HPO: HP:0031029

Definition

Concentration of the carcinoembryonic antigen (CEA) in the blood circulation above the upper limit of normal. CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating carcinoembryonic antigen concentration

Professional guidelines

PubMed

Combined evaluation of some tumor associated antigens in the monitoring of integrated surgical and chemotherapeutic treatment of epithelial ovarian cancer.
Fioretti P, Gadducci A, Ferdeghini M, Bartolini T, Scatena P, Facchini V, Bianchi R
Eur J Gynaecol Oncol 1986;7(3):200-5. PMID: 3465535

Recent clinical studies

Etiology

Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.
Kim NH, Lee MY, Park JH, Park DI, Sohn CI, Choi K, Jung YS
Yonsei Med J 2017 Sep;58(5):918-924. doi: 10.3349/ymj.2017.58.5.918. PMID: 28792134Free PMC Article
Circulating antibodies to carcinoembryonic antigen related to improved recurrence-free survival of patients with colorectal carcinoma.
Wu XJ, Fang YJ, Lin JZ, Lu ZH, Li LR, Chen G, Ding PR, Kong LH, Pan ZZ, Wan DS
J Int Med Res 2011;39(3):838-45. doi: 10.1177/147323001103900317. PMID: 21819716
Vaginal fluid and serum CEA, CA125 and SCC in normal conditions and in benign and malignant diseases of the genital tract.
Sarandakou A, Phocas I, Botsis D, Rizos D, Trakakis E, Chryssikopoulos A
Acta Oncol 1997;36(7):755-9. doi: 10.3109/02841869709001350. PMID: 9490096
Occurrence of carcinoembryonic antigen in tumor tissue and serum of breast cancer patients.
Stratil P, Rejthar A, Lang BA, Kocent A, Pacovský Z, Matoska J
Neoplasma 1988;35(1):69-76. PMID: 3352839
Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease.
Shapiro B, Chakrabarty M, Cohn EM, Leon SA
Cancer 1983 Jun 1;51(11):2116-20. doi: 10.1002/1097-0142(19830601)51:11<2116::aid-cncr2820511127>3.0.co;2-s. PMID: 6188527

Diagnosis

CEA serum levels in non-neoplastic disease.
Ruibal Morell A
Int J Biol Markers 1992 Jul-Sep;7(3):160-6. doi: 10.1177/172460089200700307. PMID: 1431339
Comparison between tissue and serum content of CA 125, CA 19-9, and carcinoembryonic antigen in ovarian tumors.
Breitenecker G, Neunteufel W, Bieglmayer C, Kölbl H, Schieder K
Int J Gynecol Pathol 1989;8(2):97-102. doi: 10.1097/00004347-198906000-00002. PMID: 2714933
Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease.
Shapiro B, Chakrabarty M, Cohn EM, Leon SA
Cancer 1983 Jun 1;51(11):2116-20. doi: 10.1002/1097-0142(19830601)51:11<2116::aid-cncr2820511127>3.0.co;2-s. PMID: 6188527
Quantitation and immunochemical characterization of carcinoembryonic antigen and glucose phosphate isomerase in blood and washings of patients with gastric and colonic diseases.
Munjal D, Brady PG
Am J Dig Dis 1978 Jan;23(1):57-64. doi: 10.1007/BF01072576. PMID: 619627
Plasma CEA, tumor CEA, and tumor histology.
Boyd CR, Bivens BA, Kashmiri R, Parker JC Jr, Meeker WR Jr
J Surg Oncol 1976;8(6):507-12. doi: 10.1002/jso.2930080610. PMID: 994512

Therapy

Circulating antibodies to carcinoembryonic antigen related to improved recurrence-free survival of patients with colorectal carcinoma.
Wu XJ, Fang YJ, Lin JZ, Lu ZH, Li LR, Chen G, Ding PR, Kong LH, Pan ZZ, Wan DS
J Int Med Res 2011;39(3):838-45. doi: 10.1177/147323001103900317. PMID: 21819716
Tumor-necrosis factor can enhance radio-antibody uptake in human colon carcinoma xenografts by increasing vascular permeability.
Folli S, Pèlegrin A, Chalandon Y, Yao X, Buchegger F, Lienard D, Lejeune F, Mach JP
Int J Cancer 1993 Mar 12;53(5):829-36. doi: 10.1002/ijc.2910530521. PMID: 8449608
Circulating tumor markers and assessment of response to intrahepatic chemotherapy of colon carcinoma.
Sears HF, Shen JW, Herlyn M, Atkinson B, Engstrom PF, Koprowski H
Am J Clin Oncol 1985 Apr;8(2):108-17. doi: 10.1097/00000421-198504000-00002. PMID: 2939709
Elevated levels of circulating carcinoembryonic antigen in hypothyroidism.
Amino N, Kuro R, Yabu Y, Takai SI, Kawashima M, Morimoto S, Ichihara K, Miyai K, Kumahara Y
J Clin Endocrinol Metab 1981 Mar;52(3):457-62. doi: 10.1210/jcem-52-3-457. PMID: 6893991
Circulating immune complexes in patients following clinically curative resection of colorectal cancer.
Steele G Jr, Sonis S, Stelos P, Rittgers R, Zamcheck N, Finn D, Maltz J, Mayer R, Lokich J, Wilson RE
Surgery 1978 Jun;83(6):648-54. PMID: 205963

Prognosis

Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.
Kim NH, Lee MY, Park JH, Park DI, Sohn CI, Choi K, Jung YS
Yonsei Med J 2017 Sep;58(5):918-924. doi: 10.3349/ymj.2017.58.5.918. PMID: 28792134Free PMC Article
Circulating antibodies to carcinoembryonic antigen related to improved recurrence-free survival of patients with colorectal carcinoma.
Wu XJ, Fang YJ, Lin JZ, Lu ZH, Li LR, Chen G, Ding PR, Kong LH, Pan ZZ, Wan DS
J Int Med Res 2011;39(3):838-45. doi: 10.1177/147323001103900317. PMID: 21819716
Comparison between tissue and serum content of CA 125, CA 19-9, and carcinoembryonic antigen in ovarian tumors.
Breitenecker G, Neunteufel W, Bieglmayer C, Kölbl H, Schieder K
Int J Gynecol Pathol 1989;8(2):97-102. doi: 10.1097/00004347-198906000-00002. PMID: 2714933
Circulating immune complexes (CIC), carcinoembryonic antigen (CEA) and CIC containing CEA as markers for colorectal cancer.
Chester KA, Begent RH
Clin Exp Immunol 1984 Dec;58(3):685-93. PMID: 6509799Free PMC Article
Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease.
Shapiro B, Chakrabarty M, Cohn EM, Leon SA
Cancer 1983 Jun 1;51(11):2116-20. doi: 10.1002/1097-0142(19830601)51:11<2116::aid-cncr2820511127>3.0.co;2-s. PMID: 6188527

Clinical prediction guides

Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.
Kim NH, Lee MY, Park JH, Park DI, Sohn CI, Choi K, Jung YS
Yonsei Med J 2017 Sep;58(5):918-924. doi: 10.3349/ymj.2017.58.5.918. PMID: 28792134Free PMC Article
Circulating antibodies to carcinoembryonic antigen related to improved recurrence-free survival of patients with colorectal carcinoma.
Wu XJ, Fang YJ, Lin JZ, Lu ZH, Li LR, Chen G, Ding PR, Kong LH, Pan ZZ, Wan DS
J Int Med Res 2011;39(3):838-45. doi: 10.1177/147323001103900317. PMID: 21819716
Occurrence of carcinoembryonic antigen in tumor tissue and serum of breast cancer patients.
Stratil P, Rejthar A, Lang BA, Kocent A, Pacovský Z, Matoska J
Neoplasma 1988;35(1):69-76. PMID: 3352839
Circulating immune complexes (CIC), carcinoembryonic antigen (CEA) and CIC containing CEA as markers for colorectal cancer.
Chester KA, Begent RH
Clin Exp Immunol 1984 Dec;58(3):685-93. PMID: 6509799Free PMC Article
Elevated levels of circulating carcinoembryonic antigen in hypothyroidism.
Amino N, Kuro R, Yabu Y, Takai SI, Kawashima M, Morimoto S, Ichihara K, Miyai K, Kumahara Y
J Clin Endocrinol Metab 1981 Mar;52(3):457-62. doi: 10.1210/jcem-52-3-457. PMID: 6893991

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...