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Elevated carcinoembryonic antigen level

MedGen UID:
1378758
•Concept ID:
C4476917
•
Finding
Synonym: Increased plasma CEA
 
HPO: HP:0031029

Definition

An increased blood concentration of the carcinoembryonic antigen (CEA). CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated carcinoembryonic antigen level

Professional guidelines

PubMed

Surgery for recurrent colon cancer: strategies for identifying resectable recurrence and success rates after resection. Eastern Cooperative Oncology Group, the North Central Cancer Treatment Group, and the Southwest Oncology Group.
Goldberg RM, Fleming TR, Tangen CM, Moertel CG, Macdonald JS, Haller DG, Laurie JA
Ann Intern Med 1998 Jul 1;129(1):27-35. doi: 10.7326/0003-4819-129-1-199807010-00007. PMID: 9652996

Recent clinical studies

Etiology

Primary Tumor Location and Survival in the General Population With Metastatic Colorectal Cancer.
Ahmed S, Pahwa P, Le D, Chalchal H, Chandra-Kanthan S, Iqbal N, Fields A
Clin Colorectal Cancer 2018 Jun;17(2):e201-e206. Epub 2017 Nov 21 doi: 10.1016/j.clcc.2017.11.001. PMID: 29221688
Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer.
Iizasa T, Suzuki M, Yoshida S, Motohashi S, Yasufuku K, Iyoda A, Shibuya K, Hiroshima K, Nakatani Y, Fujisawa T
Ann Thorac Surg 2006 Jul;82(1):254-60. doi: 10.1016/j.athoracsur.2006.02.027. PMID: 16798225
Outcome after curative resection for locally recurrent rectal cancer.
Bedrosian I, Giacco G, Pederson L, Rodriguez-Bigas MA, Feig B, Hunt KK, Ellis L, Curley SA, Vauthey JN, Delclos M, Crane CH, Janjan N, Skibber JM
Dis Colon Rectum 2006 Feb;49(2):175-82. doi: 10.1007/s10350-005-0276-5. PMID: 16392024
The implication of elevated carcinoembryonic antigen level in pleural fluid of patients with non-malignant pleural effusion.
Ryu JS, Lee HJ, Cho JH, Han HS, Lee HL
Respirology 2003 Dec;8(4):487-91. doi: 10.1046/j.1440-1843.2003.00502.x. PMID: 14629653
The role of computed tomographic scanning in diagnosing mediastinal node involvement in non-small cell lung cancer.
Takamochi K, Nagai K, Yoshida J, Suzuki K, Ohde Y, Nishimura M, Takahashi K, Nishiwaki Y
J Thorac Cardiovasc Surg 2000 Jun;119(6):1135-40. doi: 10.1067/mtc.2000.105830. PMID: 10838529

Diagnosis

Intrahepatic mass-forming cholangiocarcinoma growing in a giant hepatic hemangioma: A case report.
Zhou M, Ling W, Luo Y
Medicine (Baltimore) 2019 Jul;98(27):e16410. doi: 10.1097/MD.0000000000016410. PMID: 31277198Free PMC Article
Prognostic factors after resection of colorectal liver metastases: from morphology to biology.
Ribero D, Viganò L, Amisano M, Capussotti L
Future Oncol 2013 Jan;9(1):45-57. doi: 10.2217/fon.12.159. PMID: 23252563
Assessment of tumor recurrence in patients with colorectal cancer and elevated carcinoembryonic antigen level: FDG PET/CT versus contrast-enhanced 64-MDCT of the chest and abdomen.
Metser U, You J, McSweeney S, Freeman M, Hendler A
AJR Am J Roentgenol 2010 Mar;194(3):766-71. doi: 10.2214/AJR.09.3205. PMID: 20173157
The implication of elevated carcinoembryonic antigen level in pleural fluid of patients with non-malignant pleural effusion.
Ryu JS, Lee HJ, Cho JH, Han HS, Lee HL
Respirology 2003 Dec;8(4):487-91. doi: 10.1046/j.1440-1843.2003.00502.x. PMID: 14629653
The role of computed tomographic scanning in diagnosing mediastinal node involvement in non-small cell lung cancer.
Takamochi K, Nagai K, Yoshida J, Suzuki K, Ohde Y, Nishimura M, Takahashi K, Nishiwaki Y
J Thorac Cardiovasc Surg 2000 Jun;119(6):1135-40. doi: 10.1067/mtc.2000.105830. PMID: 10838529

Therapy

Adjuvant Chemotherapy Is Associated With Improved Overall Survival in Locally Advanced Rectal Cancer After Achievement of a Pathologic Complete Response to Chemoradiation.
Shahab D, Gabriel E, Attwood K, Ma WW, Francescutti V, Nurkin S, Boland PM
Clin Colorectal Cancer 2017 Dec;16(4):300-307. Epub 2017 Mar 18 doi: 10.1016/j.clcc.2017.03.005. PMID: 28420585
Somatic mutations in epidermal growth factor receptor underlying complete responsiveness to gefitinib in a Taiwanese female patient with metastatic adenocarcinoma of lung.
Yeh KH, Yeh SH, Wan JP, Shen YC, Cheng AL
Anticancer Drugs 2005 Aug;16(7):739-42. doi: 10.1097/01.cad.0000171769.43940.58. PMID: 16027522

Prognosis

Primary Tumor Location and Survival in the General Population With Metastatic Colorectal Cancer.
Ahmed S, Pahwa P, Le D, Chalchal H, Chandra-Kanthan S, Iqbal N, Fields A
Clin Colorectal Cancer 2018 Jun;17(2):e201-e206. Epub 2017 Nov 21 doi: 10.1016/j.clcc.2017.11.001. PMID: 29221688
The combination of nuclear factor kappa B, cyclo-oxygenase-2 and vascular endothelial growth factor expression predicts poor prognosis in stage II and III colorectal cancer.
Kim NK, Park JK, Shin E, Kim YW
Anticancer Res 2014 Nov;34(11):6451-7. PMID: 25368245
Prognostic factors after resection of colorectal liver metastases: from morphology to biology.
Ribero D, Viganò L, Amisano M, Capussotti L
Future Oncol 2013 Jan;9(1):45-57. doi: 10.2217/fon.12.159. PMID: 23252563
Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer.
Iizasa T, Suzuki M, Yoshida S, Motohashi S, Yasufuku K, Iyoda A, Shibuya K, Hiroshima K, Nakatani Y, Fujisawa T
Ann Thorac Surg 2006 Jul;82(1):254-60. doi: 10.1016/j.athoracsur.2006.02.027. PMID: 16798225
The role of computed tomographic scanning in diagnosing mediastinal node involvement in non-small cell lung cancer.
Takamochi K, Nagai K, Yoshida J, Suzuki K, Ohde Y, Nishimura M, Takahashi K, Nishiwaki Y
J Thorac Cardiovasc Surg 2000 Jun;119(6):1135-40. doi: 10.1067/mtc.2000.105830. PMID: 10838529

Clinical prediction guides

Adjuvant Chemotherapy Is Associated With Improved Overall Survival in Locally Advanced Rectal Cancer After Achievement of a Pathologic Complete Response to Chemoradiation.
Shahab D, Gabriel E, Attwood K, Ma WW, Francescutti V, Nurkin S, Boland PM
Clin Colorectal Cancer 2017 Dec;16(4):300-307. Epub 2017 Mar 18 doi: 10.1016/j.clcc.2017.03.005. PMID: 28420585
Prognostic factors after resection of colorectal liver metastases: from morphology to biology.
Ribero D, Viganò L, Amisano M, Capussotti L
Future Oncol 2013 Jan;9(1):45-57. doi: 10.2217/fon.12.159. PMID: 23252563
Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer.
Iizasa T, Suzuki M, Yoshida S, Motohashi S, Yasufuku K, Iyoda A, Shibuya K, Hiroshima K, Nakatani Y, Fujisawa T
Ann Thorac Surg 2006 Jul;82(1):254-60. doi: 10.1016/j.athoracsur.2006.02.027. PMID: 16798225
Outcome after curative resection for locally recurrent rectal cancer.
Bedrosian I, Giacco G, Pederson L, Rodriguez-Bigas MA, Feig B, Hunt KK, Ellis L, Curley SA, Vauthey JN, Delclos M, Crane CH, Janjan N, Skibber JM
Dis Colon Rectum 2006 Feb;49(2):175-82. doi: 10.1007/s10350-005-0276-5. PMID: 16392024
The implication of elevated carcinoembryonic antigen level in pleural fluid of patients with non-malignant pleural effusion.
Ryu JS, Lee HJ, Cho JH, Han HS, Lee HL
Respirology 2003 Dec;8(4):487-91. doi: 10.1046/j.1440-1843.2003.00502.x. PMID: 14629653

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